Heterocycles with Nitrogen (N)

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>

<p>Applications 3-Bromo-2,4,6-trimethylpyridine<br></p>

<p>Applications 2-Mercapto-5-nitrobenzimidazole is useful for treating giardiasis. Antigiardial drug.<br>References Hernandez-Ochoa, B., et al.: Molecules, 25, 3979 (2020)<br></p>

<p>Applications 1-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazol-3-one is also used in the synthesis of antifungal, oxazolidinon-based strobilurin analogues. Also used in the preparation of heterologous haptens for the synthesis of high-affinity anti-pyraclostrobin antibody generation.<br>References Li, Y. et al.: Bull. Kor. Chem. Soc., 31, 3341 (2010); Mercader, J. et al.: Org. Biomol. Chem., 9, 1443 (2011);<br></p>

<p>Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 1-​Pyrrolidineacetic Acid is a useful reactant and reagent in organic reactions. It can be found used in cosmetic products such as wrinkle-​preventive​/ameliorating products.<br>References Londregan, A.T., et al.: ACS Comb. Sci., 18, 651-54 (2016); Tsunenaga, M., et al.: PCT Int. Appl. (2007), WO 2007013662 A1<br></p>

<p>Applications 2-Bromo-6-chloro-4-pyridinecarboxylic Acid Methyl Ester, can be used as an intermediate in the preparation of Trifluoromethyl-Substituted pyridines, possessing wide range of bioactivites.<br>References Cottet, F., et al.: Eur. J. Org. Chem., 327 (2002);<br></p>

<p>Applications Ethyl 4-aminopiperidine-1-carboxylate is a reagent used in various biosynthetic reactions.<br>References Fang, R.Q., et al.: Bioorg. Medn. Chem. Letters., 22, 5134 (2012);<br></p>

<p>Applications Methyl 4-Methylpyrrole-2-carboxylate is a useful reagent for preparation of (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives, a novel class of glycine site antagonists.<br>References Balsamini, C., et al.: J. Med. Chem., 41, 808 (1998);<br></p>

<p>Applications 2,5,6-Triaminopyrimidin-4(1H)-one sulphate (cas# 39267-74-8) is a useful research chemical.<br></p>

<p>Applications N-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds.<br>References Carceller, E. et al.: J. Med. Chem., 39, 487 (1996);<br></p>

<p>Applications 2-Hydroxyethylbenzimidazolidinone-2 (cas# 63388-01-2) is a compound useful in organic synthesis.<br></p>

<p>Applications imidazo[1,2-a]pyridin-7-amine hydrobromide (cas# 1630906-80-7) is a useful research chemical.<br></p>

<p>Applications 6-Phenoxypyridin-3-amine (cas# 25194-67-6) is a useful research chemical.<br></p>

<p>Applications (2R,4S)-4-Aminopyrrolidine-2-carboxylic acid dihydrochloride (cas# 263407-17-6) is a useful research chemical.<br></p>

<p>Applications 2,6-Dibromo-3-fluoropyridine is a useful reagent for making GLP-1 receptor agonists.<br>References Aspnes, G. E., et al.: PCT Int. Appl. (2019), WO 2019239371 A1<br></p>

<p>Applications 2-[3-(chloromethyl)phenyl]pyrimidine (cas# 898289-51-5) is a useful research chemical.<br></p>

<p>Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.<br></p>

<p>Applications 1-(4-Chlorophenyl)pyrazole-4-carboxylic Acid (cas# 138907-80-9) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethyl-1-phenyl-1H-pyrazole is a reactant used in the synthesis of hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.<br>References Chenna, V., et. al.: J. Environ. Sci. Heal. A., 49, 641 (2014)<br></p>

<p>Applications Pyridazinone derivatives are useful as intermediates for preparing compounds having excellent herbicidal activity.<br>References Hackler, et al.: J. Agric. Food Chem., 38, 508 (1990)<br></p>

<p>Stability Moisture Sensitive<br>Applications 5-Bromo-pyridine-2-sulfonyl chloride<br></p>

<p>Applications 2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.<br>References Li, J. et al.: J. Med. Chem., 56, 6216 (2013); James, C. et al.: Bioorg. Med. Chem. Lett., 23, 2781 (2013);<br></p>

<p>Applications 4,4-Difluoropiperidine<br></p>

<p>Applications 4-Phenyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(1-(4-Bromophenyl)-1H-1,2,3-triazol-4-yl)propan-2-ol<br></p>