Heterocycles with Nitrogen (N)

<p>Please enquire for more information about (αR)-α-(2-Chlorophenyl)-2H-tetrazole-2-ethanol  including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Ethylpiperazine is an acid that is resistant to hydrochloric acid and has been shown to have a constant pH of 4.8-6.0 in vitro assays. It has been shown to inhibit the growth of sildenafil-resistant mutants, which can be attributed to its ability to inhibit bacterial DNA gyrase, topoisomerase IV, and protein synthesis. N-Ethylpiperazine binds to the receptor binding site of the enzyme with a molecular docking analysis and prevents the formation of an active complex with the enzyme by competitive inhibition. This inhibits the activity of these enzymes, which are necessary for DNA replication and protein synthesis.</p>

<p>5-Hydroxypyrazine-2-carboxylic acid is a drug that inhibits the activation of proteins involved in cell signaling pathways. It has been shown to have an inhibitory effect on the activation of protein kinase C, which plays a key role in the proliferation and differentiation of cells. 5-Hydroxypyrazine-2-carboxylic acid also inhibits sorafenib, a drug used for the treatment of cancer. Sorafenib is metabolized in rats by cytochrome P450 (CYP) enzymes, which are found in human liver tissue as well. The metabolism rate of sorafenib can be reduced by coadministration with caffeine or other substances that induce CYP activity. 5-Hydroxypyrazine-2-carboxylic acid is not active against pyrazinoic acid and pyrazine-2 carboxylate, which are metabolites produced by CYP enzymes.</p>

<p>3-Pyridineboronic acid is an antimicrobial agent that is used to treat bacterial and fungal infections. 3-Pyridineboronic acid is a prodrug that is metabolized to its active form, pyridinium boronate. This drug has been shown to be effective in the treatment of hypoxic tumors in mice, which are resistant to other anticancer drugs. 3-Pyridineboronic acid also has acidic properties and can be used as an antiseptic for the treatment of skin and eye infections. It can also be used as a hydrogen bonding partner when combined with halides, such as chloride or bromide ions. The drug binds to human serum proteins and forms an acidic complex that prevents bacterial growth by inhibiting protein synthesis. 3-Pyridineboronic acid also inhibits prostate cancer cells by competitively inhibiting the enzyme 4-pyridinylboronic acid reductase (4PBAR).</p>

<p>1-(4,4'-Difluorobenzhydry)piperazine (1-DFBP) is a potential antitumor agent that has been shown to inhibit the growth of leukemia cells. It may be an inhibitor of apoptotic cell death, as it has been shown to induce hydrogen bond formation with coumarin derivatives. 1-DFBP has also been shown to have inhibitory activities against leukemia HL-60 cells, and is a competitive inhibitor of cinnarizine. The catalytic mechanism for 1-DFBP is not known, although kinetic data suggest that it involves hydrogen bonding and/or pi stacking interactions.</p>

<p>Orotic acid hydrate is a synthetic compound that is designed to be a growth regulator. Orotic acid hydrate is synthesized by reacting the orotate with pyridoxine hydrochloride, followed by crystallizing the product. Hydrogen bonds form between the water molecules and fatty acids in the crystals of OA hydrate. These hydrogen bonds stabilize the crystal structure and allow for its use as a growth regulator. The stability of this molecule can also be attributed to its ability to form hydrogen bonds with other molecules such as α-tocopherol, calcium carbonate, and synthetic cannabinoids. Orotic acid hydrate has been shown to have an effect on cancer cells because it reacts with daunorubicin in solution and inhibits DNA synthesis, inhibiting cell growth.</p>

<p>Please enquire for more information about 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Cbz-aminopiperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Bromo-3-(trifluoromethoxy)pyridine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Acetylpiperidine-4-carboxylic acid (ACPC) is a synthetic compound that has been shown to be a potent inhibitor of the neurokinin-1 receptor. ACPC has been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. It has also been shown to have antipsychotic effects and could be an effective treatment for psychotic disorders. The pharmacophore of ACPC is based on the cyclohexane ring and piperidine moieties, which are thought to provide affinity for the neurokinin-1 receptor.</p>

<p>(-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine is a novel analog of benzyl alcohols that binds to the delta opioid receptor. The compound was found to be an agonist in vitro and in vivo. It showed no affinity for other opioid receptors or for the benzodiazepine receptor. (-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine was found to have high affinity for the human cloned delta opioid receptor with a Ki value of 0.6 nM. This compound is also a potent alkylate inhibitor with an IC50 of 6 microM against ethoxy radical formation and an IC50 of 25 microM against lipid peroxidation induced by H2O2.</p>

<p>5-Bromo-2-nitropyridine is a hydrogen bond donor. It is an organic molecule with the chemical formula C5H5BrN3. The compound has been used in the synthesis of other molecules, such as nicotinic acetylcholine and mitochondrial membrane potential inhibitors. 5-Bromo-2-nitropyridine is also a good candidate for cancer treatment due to its ability to inhibit cell cycle progression at G2/M phase. 5-Bromo-2-nitropyridine can be synthesized by reacting 2,4,6-trinitrobenzenesulfonic acid with bromine and potassium carbonate in a reaction vessel at 200 °C for about 30 minutes.</p>

<p>2-Pyrimidine-carboxylic acid is a biologically active molecule that can be found in the human body. It is a derivative of pyrimidine, which belongs to the group of purines. 2-Pyrimidine-carboxylic acid has been shown to inhibit the nicotinic acetylcholine receptor and α7 nicotinic acetylcholine receptor, which are receptors for acetylcholine. This molecule also has antihypertensive activity and has been shown to have therapeutic effects in psychotic disorders. 2-Pyrimidine-carboxylic acid binds to picolinic acid, which is an important intermediate in the metabolism of tryptophan, and hydroxyl group, which is essential for many biological functions. It also reacts with copper ions and forms a complex that is x-ray crystal structure confirmed. This complex may be used as a herbicide resistance inducer or as a chemical species for receptor binding studies or chemical reactions.</p>

<p>Please enquire for more information about 6,​7-​Dichloro-​1-​cyclopropyl-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about rac-Demiditraz including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Amino-6-chloropurine is a nucleophilic substituent that is used in the synthesis of 2-amino-6-chloropurine. It reacts with hydroxyl groups to form a palladium-catalyzed coupling reaction solution, which is then treated with hydrochloric acid and trifluoroacetic acid. The product is purified by crystallization and recrystallization. This compound has potent antitumor activity against carcinoma cell lines, but it has not been shown to have any effect against Mycobacterium tuberculosis.</p>

<p>2,5-Diaminopyridine is an organic compound that is expressed in the human body. It has been shown to inhibit the growth of cells in culture by binding to their DNA and preventing the production of hydrogen bonds. 2,5-Diaminopyridine has also been used clinically to treat inflammatory diseases such as rheumatoid arthritis. The hydrogen bond formation and inhibition of cell growth occurs at a low concentration of 2,5-Diaminopyridine. This drug may have potential as a therapeutic agent for cancer treatment because it inhibits the transcription factor CXCR4.</p>

<p>1-Methylpiperidine-4-carboxylic acid hydrochloride is a betaine. Betaines are intermediates in the biosynthesis of phosphocholine, which is an important component of all cell membranes. 1-Methylpiperidine-4-carboxylic acid hydrochloride has been analyzed and quantified in fruits and plants such as beets, bananas, oranges, and tomatoes. It can be found in the roots of plants and has been shown to inhibit abiotic stress. This compound is also present in the human body as a result of its ingestion from food sources. 1-Methylpiperidine-4-carboxylic acid hydrochloride inhibits proline synthesis by competing with glycine for the enzyme choline acetyltransferase. It also inhibits synthesis of pipecolic acid (a precursor for histamine) by competing with glycine for the enzyme choline acetyltransferase.</p>

<p>Please enquire for more information about tert-Butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (2R,4R)-1-[(2S)-5-Amino-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic a cid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about [4,4'-Di-t-butyl-2,2'-bipyridine][bis[5-(t-butyl)-2-[4-(t-butyl)-2-pyridinyl-kN]phenyl-kC]iridium(III) hexafluorophosphate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5-Methylpyrimidine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,2', 2'' -Terpyridine is a chelate ligand that is used in wastewater treatment. It can be synthesized by reacting 2-aminopyridine with ethylene diamine and 2,4-dichloro-1,3-dithiolane. The x-ray crystal structures of the ligand show that it has a coordination geometry of octahedral and its reaction mechanism is an oxidation. The chelate ligand binds to the metal ion in the same way as other ligands and stabilizes it by forming hydrogen bonds. This compound has significant cytotoxicity against carcinoma cell lines and also inhibits the mitochondrial membrane potential (MMP). 2,2', 2'' -Terpyridine is classified as group p2 due to its redox potentials and cytotoxicity.</p>

<p>4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium tetrafluoroborate, most commonly known as Bobbitt's salt, is a cheap and benign oxidant. It’s an oxoamonium salt that is used in oxidative cleveage of C-C and C-O bonds. The most common application of Bobbitt's salts is as a catalyst for the synthesis of dimethylbenzoquinones or DMBQs.</p>

<p>Please enquire for more information about 6-Chloro-pyridazine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Benzopyrazine-6-boronic acidHCl including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Deschloro amlodipine maleate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Chloro-2-methoxycarbonyl pyrazine is a linker that is used to connect two pharmacophores. β-Lactamase, which is an enzyme that degrades β-lactams antibiotics, was inhibited by 5-chloro-2-methoxycarbonyl pyrazine in vitro and in vivo. The inhibitory potency of 5-chloro-2-methoxycarbonyl pyrazine was increased when it was combined with other molecules. This molecule has shown antibacterial activity against Enterobacter cloacae, methicillin resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis.</p>

<p>8-Hydroxyquinoline is a sweet, water soluble, and heat stable inhibitor that has been used in the treatment of kidney disease. 8-Hydoxyquinoline has been shown to inhibit the growth of the rootstock Asiaticus by interfering with cell metabolism. It is also an insecticide that kills insects by causing damage to their cells. 8-Hydoxyquinoline inhibits polymerase chain reaction (PCR) by binding to DNA polymerase, blocking its activity and reducing its ability to synthesize DNA. This drug is also a potent blocker of angiotensinogen synthesis, which leads to reduced blood pressure levels.</p>

<p>2-lodo-3-hydroxypyridine is a chemical compound that is used as a solvent and as a reagent in organic synthesis. 2-Lodo-3-hydroxypyridine has shown potent inhibition against influenza A and B viruses, which are the causative agents of the flu. It also has prognostic value in patients with chronic hepatitis B virus infection. The structure of 2-lodo-3-hydroxypyridine is similar to that of the nucleoside ribonucleotide, which can be synthesized by reacting with compounds such as magnesium ion, phenolate ion, and hydroxylamine. This reaction is known to occur through an electrophilic substitution mechanism, in which the nucleophile attacks the electrophilic carbocation intermediate to form a covalent bond. The optical properties of 2-lodo-3-hydroxypyridine were found by this research group to be sensitive to its environment; they found that when</p>

<p>5-Aminopyridine-3-carboxylic acid (5APC) is a structural analog of nicotinic acid that has been shown to have anti-inflammatory effects. 5APC inhibits the production of inflammatory cytokines, such as IL-10 and IL-17, by inhibiting the activation of NFκB and MAPK pathways. This drug also has significant inhibitory activities against dextran sulfate sodium (DSS)-induced acute colitis in experimental models. 5APC is thought to act by interrupting the assembly of p38 mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NFκB) signaling complexes.</p>

<p>Please enquire for more information about (R)-4-N-Boc-2-hydroxymethyl-piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Fluoropyridine-5-carboxaldehyde is a reactive chemical that can be used as an acceptor in organic synthesis. It has been shown to have antibacterial properties, and is also a synthon for the production of prosthetic groups. 2-Fluoropyridine-5-carboxaldehyde reacts with dopamine to form diphenyl ethers, which are used as labels for immunoassays. This chemical can be catalysed and has been shown to be resistant to catalysis. 2-Fluoropyridine-5-carboxaldehyde can also be used in the synthesis of cycloalkanes.</p>

<p>Bioavailable form of vitamin B6; coenzyme; food supplement</p>

<p>5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine is a drug that inhibits serotonin reuptake. It has been used to treat a number of neurological disorders including depression and Parkinson's disease. This drug is a nonselective inhibitor of serotonin uptake and also inhibits the reuptake of norepinephrine. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to enhance cardiac contractility without altering heart rate or rhythm in anesthetized dogs with experimental coronary artery occlusion. The drug also reversibly inhibits epileptic seizures in rats when administered intravenously at a dose of 1 mg/kg. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine has been shown to have insulin resistance effects in mice with diabetes mellitus and may be useful as a pharmaceutical</p>

<p>3-Bromoimidazo[1,2-b]pyridazine (BIPM) is an analog of etoposide and has been shown to be a potent inhibitor of tyrosine kinases. BIPM selectively inhibits the activity of multikinase enzymes such as c-kit, PDGFRβ, and VEGFR2. In addition, BIPM has been shown to inhibit the proliferation of cancer cells by inducing apoptosis and cell cycle arrest in mcf-7 cells. This drug is not toxic to normal cells and shows a favorable safety profile when tested on animals.</p>

<p>Please enquire for more information about 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-alpha-Fmoc-beta-(1-boc-piperidin-4-yl)-dl-alanine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Chloro-2-formylpyridine is a peroxide that reacts with pyridine rings to form epoxides. It has been shown to be a potent oxidant and is used in the synthesis of epoxides. 5-Chloro-2-formylpyridine can also react with imidazoles and form tetradentate ligands, which are compounds that bind to metals. This chemical has selectivity for carboxylic acid groups, hydrogen peroxide, alkene, and piperazine. Irradiation of 5-chloro-2-formylpyridine yields an epoxide group on the pyridine ring.</p>

<p>Intermediate in the synthesis of tofacitinib</p>

<p>2-(1,3-Benzodioxol-5-yl)-4,6-bis(trichloromethyl)-1,3,5-triazine is a triazine compound that contains a hydroxyl group and a carboxylic acid. It is used as a polymerization initiator for cationic polymerization. 2-(1,3-Benzodioxol-5-yl)-4,6-bis(trichloromethyl)-1,3,5-triazine is also used as a chemical treatment for water supplies and wastewater. This compound can absorb many organic compounds that are harmful to the environment such as pesticides and herbicides. 2-(1,3-Benzodioxol-5-yl)-4,6-bis(trichloromethyl)-1,3,5-triazine has been shown to function as an antiinflammatory agent through its hydrogen bonding properties.</p>

<p>Piperonyl acetone is an organic solvent that has been shown to have an anti-aging effect on skin cells. It inhibits the growth of bacteria by binding to the carbonyl group in the molecule and preventing them from producing proteins, which are needed for cell division. Piperonyl acetone has been shown to be a good deodorizer, with a target pest of insects. This agent also has a high boiling point and can be used as an organic solvent in analytical toxicology. Piperonyl acetone is metabolized into piperonal and ethanol extracts when it is administered orally or intravenously. Piperonyl acetone may interact with certain drugs; therefore, it should be taken with caution if you are taking other medications.</p>

<p>5-Pyrimidinemethanamine is a synthetic chemical that belongs to the group of carbonitriles. It is used as an adsorbent and has been shown to be selective for quinoline derivatives. 5-Pyrimidinemethanamine has been shown to have high yield in reactions with trimethyl, enolate, carbonyl, high yields, and vitamin B1. The reaction product can be used at temperatures up to 150 degrees Celsius. This compound can also be prepared by reacting hydrochloric acid with alkali metal temperatures.</p>

<p>Please enquire for more information about 3-Bromo-2-methyl-5-nitropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-di oxane-4-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Chloro-5-iodopyridine is a synthetic compound that binds to nicotinic acetylcholine receptors, and is an agonist of these receptors. It has been shown to bind selectively to the alpha4beta2 subtype of these receptors. 2-Chloro-5-iodopyridine binds to the receptor by means of hydrogen bonding and chelation, which results in the activation of the receptor. This process leads to increased levels of catecholamines and other neurotransmitters, which causes changes in the heart rate and blood pressure. 2-Chloro-5-iodopyridine is a halogenated organic molecule that can be synthesized from sodium trifluoroacetate in two steps: first with chlorination followed by iodination. The synthesis can be carried out using copper (II) chloride as a catalyst or copper (I) iodide as an oxidant, followed by reduction with sodium borohydride.</p>

<p>Lercanidipine is a calcium antagonist that binds to the calcium channels in the membranes of cells, preventing the entry of calcium ions. Lercanidipine is water soluble and can be synthesized using techniques such as elemental analysis and pharmacological techniques. It is also an ionizable drug, which means that its affinity for chloride varies with pH. Lercanidipine has been shown to have strong affinity for erythrocyte membranes and thus has a high selectivity for vascular smooth muscle cells. This drug also has a low toxicity profile and does not affect tissues other than vascular smooth muscle cells.</p>

<p>Metal-chelating agent</p>

<p>Gabapentin is a pharmaceutical preparation that is used for the treatment of epilepsy and neuropathic pain. It is also used for postherpetic neuralgia, bipolar disorder, and anxiety disorders. Gabapentin has been shown to bind reversibly to the enzyme adenylate cyclase, which regulates the production of the second messenger cAMP. The binding of gabapentin to this enzyme prevents the conversion of ATP into cAMP and blocks signal transduction. This leads to an increase in intracellular levels of adenine nucleotides (ATP) and suppression of neuronal activity. Gabapentin has high values in kinetic tests because it is a reversible inhibitor with a low Km value. It binds irreversibly to nucleophilic substitutions, which are enzymes that catalyze reactions involving hydrolysis or transfer of one or more hydrogen ions from one molecule to another in a chemical reaction. A fluorine atom on gabapentin's structure may account for its</p>

<p>1-Methyl-3-phenylpiperazine is a molecule with the chemical formula C6H14N2. It is an amide that belongs to the group of hexanes. 1-Methyl-3-phenylpiperazine is a colorless liquid with a strong ammonia odor and an irritating effect on skin. The molecule has been tested in vivo and found to be irritants when applied to the skin of rabbits, and can cause severe irritation when injected into the eyes of rabbits or rats. 1-Methyl-3-phenylpiperazine is not soluble in water but can be dissolved in ethanolamine, dimethyl sulfoxide, acetone, or chloroform.</p>