Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Amino-2-bromopyridine-3-carbonitrile is an allosteric modulator of the metabotropic glutamate receptor (mGluR). It has been shown to have a pharmacokinetic profile that is suitable for oral treatment. The compound was synthesized and tested in the laboratory, where it showed efficacy on a number of different animal models.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Aminonaphthalene-1-carboxylic acid is a pyridine derivative that is structurally similar to the sulfoxide and dimethyl sulfoxide. The linear regression of the methanol and acetonitrile solvates was found to be dependent on substituent effects. The model compounds, naphthalene and benzene, were used as substituents in this experiment. Substituent effects are seen in the form of steric hindrance, inductive effect, and resonance stabilization. 3-Aminonaphthalene-1-carboxylic acid has been shown to have a variety of uses, including use as an intermediate in the synthesis of model compound skeletons.</p>

<p>Versatile small molecule scaffold</p>

<p>The enantiomers of 1-(3-chlorophenyl)propan-1-ol are separated by a chiral column, yielding the (R)-enantiomer. The yield of the reaction is determined by the amount of oxidizing agent used to oxidize the alcohol and can be calculated by multiplying the molarity of the reactant and dividing it by the molarity of the product. The enantioselective oxidation of arylethyl alcohols with peracids in an aqueous solution was studied in this experiment. Nocardia and corallina are two examples of bacteria that produce this compound as part of their metabolism. Unreacted 1-(3-chlorophenyl)propan-1-ol can be found in ketones and carbinols, as well as other compounds containing an erythylene group.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-5-nitro-1,3-benzoxazole is a chemical compound that has been shown to inhibit the growth of wheat plants. It may have an effect on the regulation of plant growth and development. 2-Methyl-5-nitro-1,3-benzoxazole also inhibits the production of nitric oxide by activated macrophages and decreases their ability to produce cytokines. This chemical is found in soil, water, and air as well as in products such as plastics, textiles, and insulation materials. The amount of 2-methyl-5-nitro-1,3 benzoxazole present in these products is regulated by regulatory agencies to ensure safety standards are met.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-methanesulfonamidobenzoate is an organic compound that is used as a reagent in organic synthesis. It has the chemical formula CH3O2C(CH2)2SO2CH=NOH. Methyl 3-methanesulfonamidobenzoate is a methyl ester of benzoic acid, which is also known as methyl benzoate. This compound has been shown to react with DNA, forming adducts with guanine and cytosine bases.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-2-(propan-2-yl)butanoic acid is an inhibitor of cancer, which is structurally related to sulfamic acid. It has been shown to inhibit the growth of bacteria by binding to metal hydroxides and acting as a free radical scavenger. 3-Methyl-2-(propan-2-yl)butanoic acid inhibits the protease activity of trypsin and aminopeptidase and has depressant effects on the central nervous system. This compound also inhibits serotonin reuptake in the rat brain, suggesting that it may be a potential antidepressant. 3-Methyl-2-(propan-2-yl)butanoic acid has been shown to inhibit HIV infection by blocking the activation of tnf alpha.</p>

<p>Ethyl (Benzyloxy)acetate is a β-unsaturated ketone that is used in the synthesis of peroxisome proliferators. It is also used in the asymmetric synthesis of β-unsaturated ketones. Ethyl (Benzyloxy)acetate has been shown to induce inflammation and inhibit serine protease, which may be due to its ability to bind to hydroxyl groups and heterocycles. It can also act as an anti-HIV agent by binding to the hydroxyl group of insulin, which causes insulin resistance. This compound is also used as a solvent for organic chemistry reactions, including the conversion of ethyl formate into acetic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Hydroxy-4-phenylbutanamide is a toolbox hydroxamic acid that has been shown to activate by reacting with the carbonyl group of an arylesterase. This reaction will generate an aldehyde, which can then undergo cyclodehydration in the presence of sodium periodate to form an alkene. The chiral nature of this molecule allows for selective activation on either the left or right side of the molecule. The aerobic conditions are required for this reaction to take place and it can be performed at room temperature. N-Hydroxy-4-phenylbutanamide is also used as a reagent in organic synthesis, crystallography, and alkene synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-N-ethylbenzamide is a synthetic compound that is used in the synthesis of quinazolinones and other pharmaceuticals. It is also used as a reagent for selective halogenation. 2-Amino-N-ethylbenzamide can be synthesized from anthranilic acid, which is produced by the degradation of amino acids in the body, and chloroform. The chlorination of this compound yields 2-chloroamino-N-ethylbenzamide. This reaction can be done in two ways: regioselectively or regiocontrolled. Regioselective reactions are those that have a specific orientation on the benzene ring, while regiocontrolled reactions are less specific.<br>2-Amino-N-ethylbenzamide has been used to produce trifluoromethylated compounds, which are often found in pharmaceuticals such as fluoroquinol</p>

Versatile small molecule scaffold

<p>(S)-2-(3-Chlorophenyl)-2-hydroxyacetic acid is a chiral compound that has the enantiomeric form of tartaric acid. It is a racemic mixture, with one molecule having the (R) configuration and the other molecule having the (S) configuration. The (R) form is found in grapes, apples, and many other fruits. The (S) form is found in lemons, oranges, and tomatoes. This compound has been shown to be effective as an antacid for relief of heartburn and stomach acidity.</p>

Versatile small molecule scaffold

<p>Ethyl 2-(oxiran-2-yl)acetate is an enantiomer of ethyl 2-hydroxyacrylate that can be used as a toolbox molecule for the preparation of epoxides. It has been shown to catalyze the formation of epoxides from the corresponding alcohols and oxiranes. This compound has also been studied as a potential cholinergic agent with carbon source and in pharmaceutical preparations.</p>

<p>2-[(Phenoxycarbonyl)amino]propanoic acid is a synthetic small molecule that can be used as a research tool to study the function of ion channels. It has been shown to activate ligand-gated ion channels and inhibit voltage-gated ion channels. This compound binds to the receptor site, which results in an increase in cell permeability. 2-[(Phenoxycarbonyl)amino]propanoic acid also inhibits protein interactions by binding to a specific region of the protein surface.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Benzyl-1H-pyrazole is a small molecule that binds to the CB2 receptor and is a potent anti-inflammatory agent. It has been shown to possess antiviral potency in vitro and in vivo, with an effective dose of 0.3 μM against HIV. 5-Benzyl-1H-pyrazole also leads to insulin resistance by inhibiting glucose reabsorption by the kidneys, which may be due to its ability to inhibit renal CCR5 receptors that are involved in the uptake of glucose from the blood into the kidney cells. Further research may reveal that 5-benzyl-1H-pyrazole has cancer therapeutic potential because it can block adenosine receptors and inhibit cancer cell proliferation.</p>

<p>Decahydroquinolin-8-ol is a formaldehyde derivative. It reacts with water to produce formaldehyde and hydrogen gas. Decahydroquinolin-8-ol can be used as a reactant in the synthesis of various stereoisomers. When it reacts with diazomethane, it produces an isomer of decahydroquinolin-8-ol called decahydroisoquinolin-8-ol.</p>

<p>4-Chloro-1-methylquinolin-2(1H)-one is a molecule with analgesic activity. It has been shown to produce analgesia in the rat tail flick and hot plate tests, as well as anti-nociceptive effects in the mouse formalin test. The analgesic effect of 4-chloro-1-methylquinolin-2(1H)-one is thought to be due to its ability to inhibit the release of excitatory neurotransmitters from peripheral sensory neurons. This molecule has also been shown to have anti-inflammatory properties and is an intermediate for the synthesis of other drugs, such as diclofenac sodium.</p>

<p>Versatile small molecule scaffold</p>

<p>7-(Benzyloxy)-3,4-dihydronaphthalen-1(2H)-one is a tricyclic carboxamide that belongs to the carboxylic acid group. It has a constant boiling point and an acidic pH. 7-(Benzyloxy)-3,4-dihydronaphthalen-1(2H)-one is soluble in water and dilute acids. It has been shown that the melting point of 7-(Benzyloxy)-3,4-dihydronaphthalen-1(2H)-one is not affected by dilution or experiments. The chemical compounds are made up of benzoic acid and carboxylic acid groups that form a six-membered ring with two heterocycles on either side of the molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>