Building Blocks

<p>Applications N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bassam, B.J., et al.: BioTechniques, 19, 568 (1995), Moham, D., et al.: J. Chromatogr., 979, 271 (2002),<br></p>

<p>Applications 1,1,3,3-Tetaramethylguanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation of alcohols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, S. et al.: Bull. Chem. Soc., 5, 205 (1984); Ishikawa, T. et al.: Sunthesis, 2006, 737 (2006);<br></p>

<p>Applications 3-Ethyl-2,4-dimethyl-1H-pyrrole is a important diagnostic compound for pyrrole disorder or pyroluria, an abnormality in biochemistry resulting in overproduction of pyrrole molecules and resulting in improper hemoglobin synthesis.<br>References Walsh, W.J., et al.: Physiol. Behav., 82, 835 (2004); Inrvine, D.G., et al.: Clin. Chem., 24, 2069 (1978);<br></p>

<p>Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.<br>References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)<br></p>

<p>Applications 4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.<br>References Zhang, K. et al.: Chin. J. Chem., 28, 509 (2010); Zhao, S. et al.: Tetra. Lett., 52, 2702 (2011);<br></p>

<p>Applications 2-Nitrosopyridine is a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Xing, et al.: J. of Org. Chem., 84(7), 4402-4412 (2019);Zhang, Jingchuan, et al.: Chem. - A Euro. J., 24(17), 4289-4293 (2018)<br></p>

<p>Applications Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present severe side effects.<br>References Abuin, G., et al.: Mol. Biochem. Parasitol ., 35, 229 (1989), Arora, P., et al.: J. Biol. Chem., 270, 6042 (1995), Campos, M., et al.: J. Immunol., 167, 416 (2001), Faundez, M., et al.: Antimicrob. Agents Chemother., 49, 126 (2005),<br></p>

<p>Stability Air Sensitive, Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications N-Acetyl-4-benzoquinone Imine (NAPQI) is a toxic metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). N-Acetyl-4-benzoquinone Imine can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (A161255) (4).<br>References (1) Jaeschke, H., et al.: Toxicol. Sci., 89, 31 (2006) (2) O’Malley G. F., et al.: J Med Toxicol. 11, 317 (2015)(3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(4) Frey, S. M., et al.: J Med Toxicol. 11, 218 (2015)<br></p>

<p>Stability Light Sensitive, Very Hygroscopic<br>Applications An antioxidant for grape and apple juice.<br>References Kim, K., et al.: Agric. Biol. Chem., 38, 53 (1974), Vichi, S., et al.: Food Chem., 102, 1260 (2007),<br></p>

<p>Impurity Albendazole EP Impurity G / Fenbendazole EP /Impurity B / USP Fenbendazole Related Compound B<br>Applications Methyl [5(6)-chlorobenzimidazole-2-yl]carbamate is an impurity for Fenbendazole (F246750), an anthelmintic (Nematodes). (Albendazole Impurity H)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baeder, C., et al.: Experientia, 30, 753 (1974), Van der Put, E., et al.: J. Immunol., 173, 818 (2004), Frasca, D., et al.: J. Immunol., 175, 6633 (2005),<br></p>

<p>Applications 3,4-Dihydroxybenzoic Acid 3-O-Sulfate is a metabolite of 3,4-Dihydroxybenzoic Acid (D451680).<br>References Pennings, Ed.J.M, et al.: Biochem. J., 193, 869 (1981),<br></p>

<p>Applications 2,3-Dihydroxybenzoic Acid is a selected phenol as MMP (Matrix Metalloproteinase) inhibitor.<br>References Rubino, M.T., et al.: Archiv der Pharmazie, 344, 557 (2011),<br></p>

<p>Stability Unstable in solution<br>Applications Inhibits cancinogenesis at the initiation stage. A metabolite of 3-methylindole<br>References Stresser, D.M., et al.: J. Biochem. Toxicol., 10, 191 (1995), Bailey, G.S., et al.: J. Natl. Cancer Inst., 78, 931 (1987), D’Agostino et. al. Drug Metabolism and Disp. 27: 2018 (2009)<br></p>

<p>Impurity Imatinib EP Impurity I<br>Stability Hygroscopic<br>Applications Dimethylamine hydrochloride (Imatinib EP Impurity I) is a precursor to several industrially significant compounds. It is a COVID19-related research product.<br>References Burton, P., et al.: Biochem. J., 432, 575 (2010); Shim, K.S., et al.: DNA Repair., 5, 718 (2006); Robacker, D.C., et al.: J. Chem. Ecol., 23, 1263 (1997);<br></p>