Building Blocks

<p>Applications Diaminomaleonitrile is a reagent used for the synthesis of 1,4-diazepine-2,3-dicarbonitrile dervatives. Also, it is used for the synthesis of Diaminomaleonitrile-based Schiff bases with a donor-acceptor structure and an aggregation-enhanced emission feature.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wieczorek, E., et al.: Tetrahedron Lett., 58, 758-761 (2017); Han, T., et al.: J. Mater. Chem. C Mater. Opt. Electron Devices, 4, 10430-10434 (2016);<br></p>

<p>Applications 2-Amino-2-methylpropanenitrile (cas# 19355-69-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oesterlin, R., et al.: J. Med. Chem., 20, 1068 (1977), Battmann, T., et al.: J. Steroid Biochem. Mol. Biol., 48, 55 (1994),<br></p>

<p>Applications 2-Aminoimidazole Sulfate (cas# 1450-93-7) is a compound useful in organic synthesis.<br></p>

<p>Applications trans-Cyclohexane-1,4-diamine (cas# 2615-25-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Methylphenylboronic acid (cas# 16419-60-6) is a useful research chemical.<br></p>

<p>Applications 3-Methoxypropionitrile (cas# 110-67-8) is a useful research chemical.<br></p>

<p>Applications Methyl β,β-Dimethoxypropionate is used as a reactant in the preparation of tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents.<br>References Zheng, C., et. al.: J. Med. Chem., 57, 600 (2014)<br></p>

<p>Applications An impurity of Atorvastatin.<br>References Graul, A., et al.: Drugs Fut. 22, 956 (1997),<br></p>

<p>Applications A precursor to 3-Methyl-2-butenyl-1-thiol which is very unstable. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An intermediate for the synthesis of many biologically active molecules including receptor ligands and enzyme inhibitors<br>References Miyashita, A., et al.: Chem. Pharm. Bull., 45, 1235 (1997), Collins, I., et al.: J. Med. Chem., 45, 1887 (2002), Miller, W.H., et al.: Bioorg. Med. Chem. Lett., 13, 1483 (2003),<br></p>

<p>Applications 3-(Methylthio)propylamine (cas# 4104-45-4) is a useful research chemical.<br></p>

<p>Applications 3-Methoxyphenylacetic Acid (cas# 1798-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of Carvedilol derivatives.<br>References Mewshaw, R., et al.: J. Med. Chem., 47, 3823 (2004),<br></p>

<p>Applications 1-(5-Bromo-2-hydroxyphenyl)ethanone<br></p>

<p>Applications 3-[(tert-Butyldimethylsilyl)oxy]-1-propanol (cas# 73842-99-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent.<br>References Ferguson, C., et al.: Macromolecules, 35, 9243 (2002); Ferguson, C., et al.: Macromolecules, 38, 2191 (2005);<br></p>

<p>Applications 3-Methoxybenzyl chloride is a chemical reagent used to benzylate sugars (e.g. 2-Deoxy-D-ribose [D252000]) and also used to alkylate amides (e.g. Benzyl acetoacetic amide [B222950]).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, M., et al.: Org. Biomol. Chem., 4, 510 (2006); Martin, O., et al.: J. Org. Chem., 53, 3287 (1988)<br></p>

<p>Applications 4,4,4-Trifluoro-3-oxobutanoic Acid Ethyl Ester is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References He, J.Y., et al.: Biotechnol. J., 2, 260 (2007); Mize, P.D., et al.: Anal. Biochem., 179, 229 (1989);<br></p>

<p>Stability Moisture Sensitive<br>Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.<br>References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications N-methyl-2-phenylpropan-1-amine (cas# 93-88-9) is a useful research chemical.<br></p>

<p>Applications 3-Bromoquinoline (cas# 5332-24-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Isopropyl-2-decahydronaphthalenol, is a fragrance raw material, used in the perfumery industry.<br>References Ford, R. A, et al.: Food and Chemical Toxicology, 23, 367 (1988);<br></p>

<p>Applications 2,4,6-Trichlorobenzoyl Chloride, can be used for the preparation of large-ring lactones in high yields. It is used for the syntheisis of cytotoxic marine natural product Amphidinolide X and Jasplakinolide (J210700).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fieser, M. Reagents for Organic Synthesis New York 16, 353, (1992); Lepage, O., et al.: J. Amer. Chem. Scoi., 126 (49), 15970<br></p>

<p>Applications Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications 5-Oxo-5-phenylvaleric Acid is used in various synthetic preparations. It is used in the synthesis of fulleroid and methanofullerene derivatives. Also used in tertiary amino urea-catalyzed enantioselective iodolactonization.<br>References Hummelen, J., et al.: J. Org. Chem., 60, 532 (1995); Veitch, G., Jacobsen, E.: Angew. Chem. Int. Ed., 49, 7332 (2010);<br></p>

<p>Applications: N'-Hydroxypyridine-3-carboximidamide<br></p>

<p>Applications TRIPHENYLSILANE (cas# 789-25-3) is a useful research chemical.<br></p>

<p>Applications 1-Piperonylpiperazine (cas# 32231-06-4) is a compound useful in organic synthesis.<br>References Min, J. Z. et at., Biom. Chrom. 24, 1287 (2010); Mitrea, N. et al., Bioanalysis 2, 1211 (2010)<br></p>

<p>Applications 2-Phenylpropionitrile (cas# 1823-91-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Insecticidal activity.<br>References Durden, J. et al.; J. Agr. Food Chem. 17, 94 (1969)<br></p>

<p>Applications 3,4,5-TRIHYDROXYBENZALDEHYDE HYDRATE (cas# 207742-88-9) is a useful research chemical.<br></p>

<p>Applications 9-Oxo-9H-fluorene-4-carboxylic acid (cas# 6223-83-2) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-2-pyrrolidone (cas# 4641-57-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-methyl-3-oxoheptanenitrile (cas# 1039833-22-1) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-3'-hydroxyacetophenone (cas# 2491-37-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Nitrobenzoyl Chloride is an useful building block reagent in the preparation of organic compounds of research interest.<br>References Guimond, N, et. al.: J. Am. Chem. Soc., 132, 6908 (2010);Mortimer, C., et. al.: J. Med. Chem., 49, 179 (2006);Shiradkar, M., et. al.: Bioorg. Med. Chem., 15, 3997 (2007)<br></p>

<p>Applications 4-Bromocinnamic Acid (cas# 1200-07-3) is a compound useful in organic synthesis.<br>References Patel, C., et al.: Bioorg. Med. Chem. Lett., 16, 4752 (2006), Ghorai, P., et al.: J. Med. Chem., 51, 7193 (2008),<br></p>

<p>Applications 4-Methylbenzyl alcohol (cas# 589-18-4) is a useful research chemical.<br></p>

<p>Applications (cas# 1993-11-08) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Dimethyl Phosphite is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.<br>References Suleimen, E.M., et al.: Chem. Nat. Compd., 50, 846 (2014); Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014)<br></p>

<p>Applications 2-Formylphenylboronic acid (cas# 40138-16-7) is a useful research chemical.<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications 2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.<br>References Baker, W., et al.: J. Chem. Soc., 2303 (1948);Friden-Saxin, M., et al.: J. Med. Chem., 55, 7104 (2012)<br></p>

<p>Applications Diethyl Phosphite, is an phosphorous precursor used for the synthesis of various organophosphorus compounds, acting as insecticide, and pesticides.<br>References Kjoelholt, J., et al.: Chemosphere, 14, 1763 (1985); Zhou, Q., et al.: Atmospheric Environ., 43, 4163 (2009);<br></p>

<p>Applications N-METHYLETHYLENEDIAMINE (cas# 109-81-9) is a useful research chemical.<br></p>

<p>Applications A regent used for the synthesis of HIV-1 protease inhibitors and antiplasmin drugs<br>References Isoda, S., et al.: Chem. Pharm. Bull., 28, 2329-36 (1980), Melnick, M., et al.: J. Med. Chem., 39, 2795 (1996),<br></p>

<p>Applications 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical is a highly reactive spin-label compound.<br></p>

<p>Applications Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Iodoanisole (cas# 766-85-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(2,2,2-Trichloroethyl) Phosphorochloridate acts as a reagent for the preparation, anticancer, and structure-activity relationship of norcantharidin analogs. Preparation and antiviral activity of amino-nucleosides and nucleotides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tarleton, M., et al.: Eur. J. Med. Chem., 54, 573 (2012); McGuigan, C., et al.: Bioorg. Med. Chem. Lett., 6, 2445 (1996)<br></p>

<p>Applications trans-(1R,2R)-N,N’-Bismethyl-1,2-cyclohexanediamine is a useful research chemical for organic synthesis and other chemical processes.<br>References Bollenbach, M., et al.: Chem. Eur. J., 23, 13676 (2017); Thaisrivongs, D. A., et al.: Org. Lett., 18, 5780 (2016)<br></p>

<p>Applications Diethyl Phenylmalonate is a reagent used in the synthesis of antituberculosis agents.<br>References Ng, P. S., et al.: J. Med. Chem., 106, 144-156 (2015)<br></p>

<p>Applications 1-(Benzyloxy)propan-2-one (cas# 22539-93-1) is a useful research chemical.<br></p>

<p>Applications 4-Benzyloxybenzoic Acid is a chemical reagent in the preparation of anticancer leads such as quinolin-4-one derivatives.<br>References Cheng, Y. et al.: Bioorg. Med. Chem. Lett., 23, 5223 (2013);<br></p>

<p>Applications Isobutyric Anhydride is used as a highly reactive and non-water producing acyl donor for hydrolase-catalyzed enantioselective esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, J.-H., et al.: Appl. Microbiol. Biot., 43, 402 (1995)<br></p>

<p>Applications N,N-DIMETHYLFORMAMIDE DINEOPENTYL ACETAL (cas# 4909-78-8) is a useful research chemical.<br></p>

<p>Applications Triethyltin Bromide is used as an endocrine disrupting compound, inducing adipogenesis through RXR and PPARγ activation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Grun, F. et al.: Mol. Endocrinol., 20, 2141 (2006); Yano, K. et al.: J. Health Sci., 49, 195 (2003)<br></p>

<p>Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.<br></p>

<p>Applications Isopropyl Acetoacetate (cas# 542-08-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 10,12-TRICOSADIYNOIC ACID (cas# 66990-30-5) is a useful research chemical.<br></p>

<p>Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boettecher, B. &amp; Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)<br></p>

<p>Applications o-Isopropylaniline was used in the synthesis of a colorless amine-coordinated zinc complex.<br>References Li, D., et al.: Org. Biomol. Chem., 8, 1816 (2010)<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level.<br>References Yin, L., et al.: PLoS One., 7, 48048 (2012); Rodriguez, J.D.,e t al.: Chem. Biochem. Engin. Quart., 20, 173 (2006);<br></p>

<p>Applications Pyridine hydrobromide (cas# 18820-82-1) is a useful research chemical.<br></p>

<p>Applications Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic Anhydride is used in the synthesis of a wide range of organic compounds including some dyes. Benzoic Anhydride is also used as an arylation agent in the Heck reaction.<br>References Lewis, D.M. et al.: J. Soc. Dyes Col., 99, 354 (1983); Shmidt, A.F. et al.: Kin. Catal., 41, 743 (2000);<br></p>

<p>Applications N-METHYLTHIOUREA (cas# 598-52-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,4-Diidobenzene is used in single molecular bridging of Au nanogaps. It can also form copolymers with ethynylbenzenes in sponge to give elastic hydrophobic materials.<br>References Komoto, Yuki., et al.: J. Phys. Chem. C, 117(46), 24277-24282 (2013)<br></p>

<p>Applications 2-Amino-5-bromo-4,6-dimethylpyridine (cas# 89856-44-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Pinacol is used in the synthesis of organic reagents such as alkenylphenylphosphonates and alkenylboronates.<br>References Peng, A. et al.: J. Fluor. Chem., 151, 58 (2013); Mazzacano, T. et al.: J. Am. Chem. Soc., 135, 17258 (2013);<br></p>

<p>Applications 4-Chloropyridine n-oxide (cas# 1121-76-2) is a useful research chemical.<br></p>

<p>Applications 2-chloro-1-(4-chlorophenyl)ethanone (cas# 937-20-2) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of Mepivacaine (M225060) metabolites as well as pyrrolizidine derivatives with antiarrhythmic activity.<br></p>

<p>Applications Salicylaldoxime (cas# 94-67-7) is a useful research chemical.<br></p>