Building Blocks

<p>Applications 2-Acetylanthracene is an organic fluorophore.<br>References Burstein, E., et al.: Photochem. Photobiol., 64, 316 (1996), Patil, S., et al.: Bioorg. Med. Chem., 15, 1212 (2007),<br></p>

<p>Applications Adipoyl Chloride can be used in the synthesis of nylon. Also it is used in the synthesis of chiral polymer for membrane application.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaymans, R. et al.: J. Polym. Sci., 15, 535 (1977); Hazarika, S. et al.: Polym. J., 41, 1067 (2009);<br></p>

<p>Applications 2-Amino-5-bromo-4,6-dimethylpyridine (cas# 89856-44-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-​Amino-​6-​methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Kα).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miller, M. S., et al.: Bioorg. Med. Chem., 25, 1481-1486 (2017);<br></p>

<p>Stability Air Sensitive, Stench<br>Applications Allyl Mercaptan (&gt;75%) can be used to treat Alzheimer's, stroke, cardiovascular and other amyloid related diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Postrel, R., U.S. Pat. Appl. Publ. US 20200215009 A1, 10, (2020);<br></p>

<p>Applications 4-methyl-3-oxoheptanenitrile (cas# 1039833-22-1) is a useful research chemical.<br></p>

<p>Applications 1-Propylpiperazine dihydrobromide (cas# 64262-23-3) is a useful research chemical.<br></p>

<p>Applications Sodium 4-methylbenzenesulfinate (cas# 824-79-3) is a useful research chemical.<br></p>

<p>Applications 2-Bromobenzoic acid is a sterically hindered ortho-bromo compound that is used as a starting material to synthesize quinazolinones (e.g. 8-Hydroxy-2-methyl-4(3H)-quinazolinone [H948330]).<br>References Liu, X., et al.: Angew. Chem. Int. Edit., 121, 354 (2009); Lu, G., et al.: Tetrahedron Lett., 46, 4255 (2005)<br></p>

<p>Applications N-(4-Bromobutyl)phthalimide is used in the preparation of β-cyclodextrin derivatives that block the pore formed by protective antigen for the inhibition of the action of anthrax toxin.<br>References Karginov, V.A., et. al.: Bioorg. Med. Chem., 14, 33 (2006)<br></p>

<p>Applications Trimethylboroxin is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications 3,4,5-Trimethoxybenzoyl Chloride is used as a reagent in the synthesis of 2-methyl-8-(3,4,5-trimethoxybenzamido)-1,2,3,4-tetrahydroisoquinoline and its analogs which display great antihypertensive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mathison, I.W., et al.: J. Med. Chem., 16, 332 (1973)<br></p>

<p>Applications 3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.<br>References Clutterbuck, L. A., et al.: J. Med. Chem., 52, 2694 (2009);<br></p>

<p>Applications 2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.<br>References Shi, D., et al.: J. Med. Chem., 44, 4509 (2001); Rami, H., et al.: Bioorg. Med. Chem. Lett., 16, 3287 (2006)<br></p>

<p>Applications 2-Bromoethyl-d4-amine HBr (CAS# 918633-70-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4,5-TRIHYDROXYBENZALDEHYDE HYDRATE (cas# 207742-88-9) is a useful research chemical.<br></p>

<p>Applications 3,5-Diiodosalicylic Acid is an metabolite of Aspirin (A187780), an anti-inflammatory, anti-platelet and cancer-preventive agent. 3,5-Diiodosalicylic Acid was shown to exhibit agonist activity at GPR35, a orphan G protein coupled receptor.<br>References Deng, H.Y., et al.: Arch. Pharmacol., 385, 729 (2012); Blandin, V., et al.: Molec. Pharmacol., 58, 1461 (2000);<br></p>

<p>Applications 1-Bromohexadecane is used in the preparation of soluble carbon nano-onions by covalent functionalization with hexadecyl chains. It is also used to synthesize [2-(methacryloyloxy)ethyl]dimethylhexadecylammonium bromide monomer, required for the synthesis of novel methacrylate based adsorbents.<br>References Molina-Ontoria, A., et al.: Chem. Comm., 49, 2406 (2013); Shu, M., et al.: Analyst, 137, 2143 (2012)<br></p>

<p>Applications TRIPHENYLSILANE (cas# 789-25-3) is a useful research chemical.<br></p>

<p>Applications Diethyl Butylethylmalonate-d5 is the isotope labelled analog of Diethyl Butylethylmalonate, a derivative of Diethyl 2-n-Butylmalonate (D443880) which is a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications 3-Methoxypropionitrile (cas# 110-67-8) is a useful research chemical.<br></p>

<p>Applications Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic Anhydride is used in the synthesis of a wide range of organic compounds including some dyes. Benzoic Anhydride is also used as an arylation agent in the Heck reaction.<br>References Lewis, D.M. et al.: J. Soc. Dyes Col., 99, 354 (1983); Shmidt, A.F. et al.: Kin. Catal., 41, 743 (2000);<br></p>

<p>Applications 4-Hydroxyphenylacetonitrile (cas# 14191-95-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Chloromethyl)benzoyl Chloride is used in the synthetic preparation of various compounds and pharmaceuticals. 4-(Chloromethyl)benzoyl Chloride was used in the synthesis of several imidazo[2,1-b]thiazoles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bratulescu, G., et al.: Asian. J. Chem., 24, 350 (2012);<br></p>

<p>Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.<br></p>

<p>Applications 4-Chloropyridine n-oxide (cas# 1121-76-2) is a useful research chemical.<br></p>

<p>Applications 2,6-Dibromopyridine is used as a starting material to synthesize 2,2’-bipyridines (such as 5-Cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-2-carboxylic Acid [C979150]) via a Stille-type cross-coupling reaction. 2,6-Dibromopyridine is also used as a reagent to synthesize pyridylpyrimidine fungicides, compounds that eliminate fungi by cycling copper through the cell membrane, where it reaches toxic levels.<br>References Hargreaves, S., et al.: Tetrahedron Lett., 41, 1653 (2000); Heller, M. &amp; Schubert, U.: J. Org. Chem., 67, 8269 (2002); Simkovsky, N., et al.: J. Chem. Soc. Perk. Trans. 1, 16, 1847 (2002)<br></p>

<p>Applications 5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.<br>References Hasegawa, M., et al.: J. Med. Chem., 50, 4453 (2007); Okaniwa, M., et al.: J. Med. Chem., 55, 3452 (2012)<br></p>

<p>Applications 8-Bromooctanoic Acid (cas# 17696-11-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethyl-d5 2-Methylbutyrate is the labeled analogue of Ethyl 2-Methylbutyrate (E923200), an ester that has a sweet, apple-like aroma. Ethyl 2-methylbutyrate is naturally found in apples, cherries and orange juice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho, I., et al.: J. Agr. Food Chem., 54, 6332 (2006); Mattheis, J., et al.: J. Agr. Food Chem., 45, 212 (1997); Moshonas, M. &amp; Shaw, P.: J. Agr. Food Chem., 35, 161 (1987); Willaert, G., et al.: J. Agr. Food Chem., 31, 809 (1983)<br></p>

<p>Applications 3-[(tert-Butyldimethylsilyl)oxy]-1-propanol (cas# 73842-99-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-​Chloroiodobenzene is used in the synthesis of is a common organic reagent used i the synthesis of a prostacyclin agonist actin in the treatment of pulmonary hypertension.<br>References Tran, T. et al.: J. Med. Chem., 60, 913 (2017);<br></p>

<p>Applications tert-Butyl Perbenzoate is used as a catalyst in the preparation of paper strengthening agents for papermaking.<br>References Xuan. S., et al.: Faming Zhuanli Shenqing. 6pp. (2020)<br></p>

<p>Applications Butyric Anhydride is a chemical reagent used in the synthesis of amidoamine dendron-based co-adsorbents used in the improvement of dye-sensitized solar cells. Also used in the synthesis of allopurinol derivatives for their activity against Trypanosoma cruzi.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, J. et al.: J. Mat. Chem. Mat. Energy Sust., 1, 14524 (2013); Raviolo, M. et al.: 69, 455 (2013);<br></p>

<p>Applications 2-Methoxy-4-aminobenzoic Acid (cas# 2486-80-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,4-Di(bromomethyl)benzene (cas# 623-24-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(5-Bromo-2-hydroxyphenyl)ethanone<br></p>

<p>Applications Diphenyl Chlorophosphonate, is a building block used for the synthesis of various chemical compounds. It can be used for the synthesis of phosphate esters of polyhedral hydroxyboranes, showing enhanced tumor uptake.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bechtold, R., et al.: J. Med. Chem., 18, 371 (1975);<br></p>

<p>Stability Moisture Sensitive<br>Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.<br>References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)<br></p>

<p>Applications (1R,2S)-rel-1,2-Cyclopentanedicarboxylic Acid is a Possible inhibitor of prolidase.<br>References Mock, W. et al.; J. Biol. Chem. 265, 19606 (1990)<br></p>

<p>Applications Ethyl 2-bromobutyrate is used in synthetic chemistry as a polymerization initiator. Ethyl 2-bromobutyrate is also used as a reagent to synthesize Efaroxan, an imidazoline α 2-antagonist that stimulated insulin secretion in rat pancreatic cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, A., et al.: Pharm. Res., 42, 575 (2000); Bibiao. J. et al.: Eur. Polym. J., 42, 179 (2006); Chan, S. &amp; Morgan, N.: Eur. J. Pharm., 176, 97 (1990); Xu, W., et al.: Eur. Polym. J., 39, 1349 (2003)<br></p>

<p>Applications (4-Fluorophenyl)hydrazine, HCl<br></p>

<p>Applications 1-Heptyne can be used for cycloisomerization of alkynyl imines and alkynylation of oxiranes.<br>References Kel’in, A. V., et al.: J. Am. Chem. Soc. 123, 2074 (2001); Yamaguichi, M., et al.: Tetrahedron Lett. 24, 391 (1983)<br></p>

<p>Stability Hygroscopic<br>Applications Dimethyl Phosphite is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.<br>References Suleimen, E.M., et al.: Chem. Nat. Compd., 50, 846 (2014); Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014)<br></p>

<p>Applications trans-Cyclohexane-1,4-diamine (cas# 2615-25-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diethyl Benzylmalonate (cas# 607-81-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,6-Dibromohexane is used as a reagent in the synthesis of novel benzo[b]xanthone derivatives which have potential antitumor activity. It is also used as a cross-linker for the cross-linking of glycuronans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Luo, L., et al.: J. Serb. Chem. Soc., 78, 1301 (2013); Matricardi, P., et al.: Carbohyd. Polym., 27, 215 (1995)<br></p>

<p>Applications 1,7-Dibromoheptane is a useful synthetic intermediate. 1,7-Dibromoheptane can be used in the synthesis of random thermotropic liquid crystalline copolyether and ternary copolyether. It can also be used in the synthesis of thermotropic liquid crystalline dendrimer exhibiting a nematic phase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Percec, V., et al.: J. Polym. Sci. A Polym. Chem., 25, 1943, 1987; Percec, V., et al.: Macromolecules 23, 5 (1990); Percec, V., et al.: Macromolecules, 25, 3843 (1992)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Bromoacetyl Bromide, is a builidng block used for various organic synthesis. It can be used for the synthesis of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Toshima, K., et al.: Yuki Gosei Kagaku Kyokaishi, 70, 1187 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Cyclopropanecarbonyl Chloride is a reagent used in the synthesis of orally bioavailable HCV NS5A inhibitor for the treatment of Hepatitis C virus.<br>References Kang, IJ. Med. Chem., 60, 228 (2017);<br></p>

<p>Applications 1,2-Dimethylisothiourea-HI (cas# 41306-45-0) is a useful research chemical.<br></p>

<p>Applications 4,5-Dimethyl-3-isoxazolamine is an isoxazole derivative used in the preparation of a varitey of biologically active compounds such as selective ETA receptor antagonists.<br>References Murugesan, N. et al.: J. Med. Chem., 46, 125 (2003);<br></p>

<p>Applications Insecticidal activity.<br>References Durden, J. et al.; J. Agr. Food Chem. 17, 94 (1969)<br></p>

<p>Applications N-METHYLETHYLENEDIAMINE (cas# 109-81-9) is a useful research chemical.<br></p>

<p>Applications (cas# 1993-11-08) is a useful research chemical.<br></p>

<p>Applications 2-Aminoimidazole Sulfate (cas# 1450-93-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent.<br>References Ferguson, C., et al.: Macromolecules, 35, 9243 (2002); Ferguson, C., et al.: Macromolecules, 38, 2191 (2005);<br></p>

<p>Applications 2-AMINO-4,6-DICHLOROPYRIMIDINE (cas# 56-05-3) is a useful research chemical.<br></p>

<p>Applications A regent used for the synthesis of HIV-1 protease inhibitors and antiplasmin drugs<br>References Isoda, S., et al.: Chem. Pharm. Bull., 28, 2329-36 (1980), Melnick, M., et al.: J. Med. Chem., 39, 2795 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications N-methyl-2-phenylpropan-1-amine (cas# 93-88-9) is a useful research chemical.<br></p>

<p>Applications N-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.<br>References Beak, P. et al.: J. Org. Chem., 58, 1109 (1993);<br></p>

<p>Applications 2-Formylphenylboronic acid (cas# 40138-16-7) is a useful research chemical.<br></p>

<p>Applications 1,4-Diidobenzene is used in single molecular bridging of Au nanogaps. It can also form copolymers with ethynylbenzenes in sponge to give elastic hydrophobic materials.<br>References Komoto, Yuki., et al.: J. Phys. Chem. C, 117(46), 24277-24282 (2013)<br></p>

<p>Applications 4-Chloro-2-fluoroaniline is a compound used in the synthesis of 4-Chloro-2-fluoro-3-iodobenzenamine (1000590-87-3).<br></p>

<p>Applications 1,1-dimethylguanidine Sulfate (cas# 598-65-2) is a useful research chemical.<br></p>

<p>Applications N-METHYLTHIOUREA (cas# 598-52-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Indole derivative<br></p>

<p>Applications Methoxyacetaldehyde Dimethyl Acetal is a reagent used in balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-1R inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zimmermann, K., et al.: Bioorg. Med. Chem. Lett., 18, 4075 (2008);<br></p>

<p>Applications Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level.<br>References Yin, L., et al.: PLoS One., 7, 48048 (2012); Rodriguez, J.D.,e t al.: Chem. Biochem. Engin. Quart., 20, 173 (2006);<br></p>

<p>Applications Diethyl 2-n-Butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications Diisopropyl Malonate is a disinfection byproduct of Isoprothiolane (I874300); a dithiolane pesticide commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.<br>References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988); Jinno, H., et al.: Arch. Toxicol., 71, 550 (1997)<br></p>

<p>Applications 4-Bromocinnamic Acid (cas# 1200-07-3) is a compound useful in organic synthesis.<br>References Patel, C., et al.: Bioorg. Med. Chem. Lett., 16, 4752 (2006), Ghorai, P., et al.: J. Med. Chem., 51, 7193 (2008),<br></p>

<p>Applications 2-Methyl-4-nitropyridine (cas# 13508-96-8) is a compound useful in organic synthesis.<br></p>

<p>3-Quinolinecarboxylic acid is a water-soluble drug that is soluble in both organic solvents and water. It is reactive, which limits its therapeutic use. 3-Quinolinecarboxylic acid is used to treat inflammatory disease by inhibiting the production of prostaglandins and leukotrienes in the body. 3-Quinolinecarboxylic acid has been shown to have genotoxic effects on primary cells, as well as an antiinflammatory effect. It also has been shown to be effective for treating rheumatoid arthritis in animal models, but not humans.</p>