Building Blocks

<p>Ethyl 1H-tetrazole-5-acetate (ETZA) is a ligand that binds to the active site of prolyl hydroxylase, which is an enzyme involved in collagen synthesis. ETZA inhibits the activity of this enzyme by binding to its heme cofactor, leading to a decrease in the production of collagen and thus inhibiting tumor growth. It has been shown that ETZA has no effect on healthy cells or normal tissues. In vitro studies have shown that ETZA can inhibit cancer cell growth and cisplatin resistance in vivo. ETZA also has a structural similarity to chloride ions and thus may be able to inhibit chloride channels such as those found in cancer cells.</p>

<p>Versatile small molecule scaffold</p>

<p>4,5,6,7-Tetrahydro-1H-indole is a chemical compound that is an intermediate in the synthesis of other compounds. It reacts with halides to produce methyl sulfones and metal hydroxides. Tetrahydro-1H-indole can also react with acyl halides to form thiocyanates. The reaction mechanism has been studied using nmr spectra and chemical study. 4,5,6,7-Tetrahydro-1H-indole is an active substance that has been used in synthetic chemistry.</p>

<p>Benzyloxyacetonitrile is a synthetic chemical that reacts with hydrochloric acid to form an acid complex. It has been used in the preparation of ethylene diamine and other amines. In addition, benzyloxyacetonitrile has been shown to react with phosphorus pentoxide to form a reactive chloride, alkylthio group, hydrogen chloride, hydroxy group, nucleophilic, acid complex.</p>

<p>Versatile small molecule scaffold</p>

<p>5,7-Dimethyl-1-tetralone is a coumarin derivative that is a single-crystal x-ray analysis preparative. It has been found to undergo cross-coupling reaction with a variety of organometallic reagents. 5,7-Dimethyl-1-tetralone can be used as a research chemical in the synthesis of other chemicals and pharmaceuticals. Cross coupling reactions with lithium diisopropylamide have been shown to produce 6-methoxy-1-tetralone which can be saponified to form an intermediate for the synthesis of drugs. The tautomerization process is also mediated by the solvent and the reaction time.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Methylphenyl)-4,5-dihydro-1H-imidazole is a crystalline compound that forms hydrogen bonds with water. It has been shown to form chains and stacks in the crystal structure. The compound has a centroid of 2.8 Å and its dihedral angles are around 120°. Five molecules in the molecule stack on top of each other, stabilized by hydrogen bonds.</p>

<p>1,3,8-Triaza-spiro[4.5]decane-2,4-dione is a potential anti-cancer drug that inhibits the production of lactate and ammonium ions in lymphocytes. This leads to an increase in the oxidation of glucose and lactic acid to CO2 and H2O. The inhibition of lactate production reduces the accumulation of ammonium ions, which inhibits the activity of hydroxylases. 1,3,8-Triaza-spiro[4.5]decane-2,4-dione also targets hypoxia inducible factor (HIF) and cyclophosphamide resistance protein (CPR), leading to a decrease in the proliferation rate of lymphocytes. Ammonium carbonate is used as a stabilizing agent for this compound during crystallization.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methoxy-isoxazole-5-carboxylic acid (3MICA) is an amide analog of diborane. 3MICA has been synthesized in the past and is also present in amanita muscaria, a mushroom that contains psychoactive compounds. 3MICA is a potent agonist of the cannabinoid receptor type 1 (CB1), with three times the potency of Δ9-tetrahydrocannabinol. It has also been shown to inhibit acetoacetate decarboxylase, which may be responsible for some side effects associated with CB1 activation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Diethyl 2-[2-(3-nitrophenyl)hydrazin-1-ylidene]propanedioate is a halogen that has been used in the production of silver and silver halide. In the presence of light, this compound undergoes a series of reactions to form silver. It can be used as a reducing agent for silver ions or as a precursor for the formation of other silver compounds. This compound also functions as an agent that converts chloride ions to bromide ions by reaction with hydrogen peroxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(ethanesulfonyl)acetonitrile is an organic solvent that has a constant boiling point, high reactivity, and low toxicity. It can be used as an acid catalyst in fluorination reactions or to synthesize nitro groups. 2-(ethanesulfonyl)acetonitrile has a reactive functional group and hydrocarbon group that can be substituted with other substituents. The fluorine atom in this compound is replaced with a nitro group when it reacts with oxygen. 2-(ethanesulfonyl)acetonitrile is used in synthetic chemistry to create nitro compounds by the reaction of nitric oxide with the nitro-group on the aromatic ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(4-Nitrophenyl)azepane is a potent fxa inhibitor. It inhibits the serine proteases, such as thrombin, and has been shown to have anticoagulant effects in animal models. 1-(4-Nitrophenyl)azepane interacts with the active site of serine protease and competes with the substrate for binding to coagulation proteins. This inhibition leads to a reduction in coagulation and an increase in bleeding time.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,2-Dimethylpiperidin-4-one is a chiral compound that can be used to make optically active compounds. It is an important intermediate in the synthesis of piperidones. The 1,2-dimethylpiperidin-4-one has two diastereomers, which are called cis and trans. The cis configuration has a methyl group in the same plane as the amine group, whereas the trans configuration has the methyl group in a different plane. The cis configuration is more stable than the trans one and this is because it is less sterically hindered by the bulky groups on either side of it. This means that if you want to make an optical pure compound, it will be easier to do so using cis rather than trans 1,2-dimethylpiperidin-4-one.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-6-chloroquinoline is a cisplatin analogue that is used in the treatment of cancer. It has been shown to have cytotoxic effects against human T47D cells, an estrogen receptor positive cell line, by binding to DNA and interfering with DNA replication. 3-Bromo-6-chloroquinoline has also been shown to have significant cytotoxic activity against the Mcf-7 breast cancer cell line. It binds to the proximal region of the human cytochrome P450 1A2 enzyme and blocks its ability to metabolize drugs, which prevents the activation of certain anticancer agents. This drug also inhibits the synthesis of RNA and protein, leading to cancer cell death.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-(2-oxocyclohexyl)acetate is a chiral, polycyclic organic compound that is an intermediate in the synthesis of tryptamines. It is prepared by reacting cyclohexylamine with methyl chlorocarbonate and then refluxing the mixture to produce the desired product. The yields of this reaction are typically low, but can be increased by using phosphoric acid as a catalyst.</p>

<p>4-Chloro-6-nitroquinoline is a dopamine receptor antagonist that has been shown to have high affinity and selectivity for the 5-HT6 receptor. This agent inhibits the binding of serotonin to 5-HT6 receptors, which causes an increase in dopamine release in the brain. 4-Chloro-6-nitroquinoline has been used in a study of Parkinson's disease and depression in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Vinylthiophene is a stabilizer that can be used in the production of polymers and copolymers. It is used in the Suzuki coupling reaction to form vinylidene-3-thiophene, which has been shown to be an effective surface modifier for mesoporous materials. 3-Vinylthiophene has low affinity for both organic ligands and metal ions, making it a reactive compound. The absorption spectroscopy of 3-vinylthiophene shows a strong peak at 290 nm and a weak peak at 320 nm. With a photoelectron spectroscopy, it was found to have an electron affinity of 2.5 eV with a reactive copolymerization with phenylethyl and selenophene being possible reactions.</p>

1-(4-Methyl-1,3-thiazol-2-yl)propan-1-one is a Grignard reagent that has been used in the synthesis of thiazoles. It has been shown to react with propionyl chloride to produce methylthiazole. This compound can also be used as a flavouring agent, which is often found in cinnamon, and as an anhydride for acylation reactions. 1-(4-Methyl-1,3-thiazol-2-yl)propan-1-one is oxidizing and can react with organic chlorides to form chromic acid. This reaction is reversible and when heated will produce the original Grignard reagent and hydrogen chloride gas.

<p>2-Methyltetrahydrothiophen-3-one is an organic solvent that is found in the environment as a result of natural processes. It has been shown to inhibit bacterial growth and is used for the analysis of fatty acids. 2-Methyltetrahydrothiophen-3-one inhibits bacterial growth by inhibiting the synthesis of fatty acids, which are needed for cell membrane synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3-Acetamido-4-fluorobenzoic acid is a nicotinic acetylcholine receptor agonist. It has been shown to modulate the activity of nicotinic acetylcholine receptors in animals, and may be effective against cancer and infectious diseases. 3-Acetamido-4-fluorobenzoic acid has been shown to increase insulin sensitivity in mice with type 2 diabetes by increasing the production of glucose transporter 1 (GLP1) in the pancreas. 3-Acetamido-4-fluorobenzoic acid also binds to the polymer film that surrounds the insulin granule, which prevents the release of insulin into the blood stream. This drug can be used for pharmaceutical dosage as well as for treating metabolic disorders such as insulin resistance.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Ethoxy-3-fluoroaniline is a kinase inhibitor that inhibits the activity of protein kinases. It is an analog of 4-ethoxy-3-fluorophenylalanine and has shown in vivo activity. 4-Ethoxy-3-fluoroaniline binds to the ATP binding site at the N terminus of the enzyme, which prevents ATP from binding and thus inhibits its function. The compound can be used as a starting material for more potent inhibitors of protein kinases.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Fluoro-2-nitrobenzoyl chloride is a conformationally locked macrocyclic compound that has been synthesized by solid phase synthesis. It is found in two conformational states and can be made to switch between these two states by applying a force to the molecule. This conformation can be controlled by changing the side chain of 5-fluoro-2-nitrobenzoyl chloride, which can be done experimentally. The conformational behavior of this macrocycle was studied using molecular dynamics simulations and it was found that there are four possible conformations for the molecule. The conformations with different side chains were found to have different energies, which could be used as a measure of their relative stability.</p>

<p>D-Alanine is a versatile building block that can be used as a reagent or speciality chemical in research. It is also an important intermediate for the production of other chemicals and useful scaffold for drug design. D-Alanine (CAS No. 338-69-2) is a high quality, fine chemical that can be used as a reaction component to synthesize many complex compounds. D-Alanine is also an important intermediate for the production of other chemicals and useful scaffold for drug design.</p>

<p>N-Acetylglycine is a versatile building block for the synthesis of complex organic compounds. It is used as a reagent in research, as an intermediate in chemical reactions, or as a speciality chemical. N-Acetylglycine has been found to be useful as a building block in organic synthesis and can be reacted with other chemicals to form new compounds. N-Acetylglycine has also been shown to have anti-inflammatory properties and is used as an analgesic for pain relief.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloro-1-methyl-1H-imidazole-2-carbaldehyde is a flavonoid that is chemically synthesized and structurally related to the isoxazoles. It has been shown to have an activating effect on nonselective cation channels and pharmacokinetic properties in rats. The drug has also been shown to inhibit intestinal motility by increasing the intracellular calcium levels in rat colonic smooth muscle cells. 5-Chloro-1-methyl-1H-imidazole-2-carbaldehyde may be useful for the treatment of gastrointestinal disorders, such as constipation and irritable bowel syndrome, due to its ability to relax muscle contractions in the intestines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Potassium hydroquinone monosulfate (KHQMS) is a chemical substance that is used as a co-precipitant in the preparation of samples for analysis by high-performance liquid chromatography. It has hydroxyl groups on both ends and can be used to filter organic particles from water samples. The KHQMS can also be used for the removal of substances that interfere with analytical measurements, such as polysaccharides, polymers, proteins, lipids, and other organic molecules. This compound can be recycled and reused up to four times. It has been found to be effective in the extraction of phenolic compounds from leaves and granules. KHQMS is also used in bioanalytical methods for the determination of human urine samples.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3-Methylphthalic Acid is a chemical that is used in the production of polyvinyl chloride. It is produced by the dioxygenation of phthalic anhydride and methanol, which produces 3-methylphthalic acid as well as 1,1-dichloroethane. The chemical can be used as a surfactant in polyvinyl chloride and styrene production processes. 3-Methylphthalic Acid has been shown to have adverse health effects on laboratory animals, including polyvinyl chloride workers who are exposed to it for prolonged periods of time. The chemical can cause irritation and corrosion to skin and eyes, as well as damage to the liver and kidneys.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Bromo-ethoxy)-3,5-dimethyl-benzene is a potential drug that has immunosuppressive effects. It binds to the pyrimidine ring of human immunodeficiency virus (HIV) and inhibits its activity. This inhibitor blocks the synthesis of viral DNA and RNA by binding to the sulfur atom of the pyrimidine ring. The substituents on this molecule are bromine and ethoxy groups, which are alkylated.</p>

<p>Versatile small molecule scaffold</p>

<p>N-Hydoxyquinoline-2-carboxamide is a molecule that belongs to the hydroxamic acid class. It is a zirconium-containing derivative of hydroxylamine and, as such, is tautomeric with respect to the carboxylic acid moiety. This compound has been shown to be mutagenic in Salmonella typhimurium strains TA98 and TA100 and in Escherichia coli strain WP2 uvrA. N-Hydroxyquinoline-2-carboxamide has also been found to be an inducer of sulfation and conjugates with glutathione and other organic acids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(2-Hydroxy-2-methylpropyl)acetamide (HMPA) is a molecule inhibitor that inhibits the activity of inflammatory bowel disease (IBD)-associated kinases. HMPA is a member of a family of molecules that are inhibitors of IBD-associated kinases, which may be useful for the treatment of IBD. HMPA has shown in vitro inhibition against two kinases, JNK1 and p38 MAPK, which are both important mediators in the progression of IBD. This drug may be used to inhibit inflammation in the digestive tract by blocking these inflammatory pathways.</p>

<p>Versatile small molecule scaffold</p>