Building Blocks

<p>Stability Volatile<br>Applications 3-Butyn-1-ol is an unsaturated alcohol that is used as a reagent to synthesize Kainic acid (K135000), a neuroexcitatory and neurotoxic analogue of glutamate that is utilized as a means to selectively lesion neuronal cell bodies. 3-Butyn-1-ol is also an important intermediate to prepare a variety of natural products in food and cosmetic industries.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anderson, J. &amp; Whiting, M.: J. Org. Chem., 68, 6160 (2003); Ben-Ari, Y., et al.: Brain Res., 165, 3362 (1979); Olney, J., et al.: Brain Res., 77, 507 (1974); Yu, X., et al.: Org. Prep. Proc. Int., 38, 467 (2006)<br></p>

<p>Applications Bromocyclohexane-d11 is used in the synthetic preparation and regioselective bromination of sp3 C-H bonds by organophotoredox catalysis.<br>References Kee, C.W., et al.: Asian. J. Org. Chem., 3, 536 (2014);<br></p>

<p>Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);<br></p>

<p>Applications DL-4-Hydroxyphenylalanine-3,3-d2 (CAS# 35693-18-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Applications An intermediate for the synthesis of many biologically active molecules including receptor ligands and enzyme inhibitors<br>References Chesworth, R., et al.: Bioorg. Med. Chem. Lett., 15, 5562 (2005), Gupta, A., et al.: Med. Chem., 3, 241 (2007), Ramajayam, R., et al.: Eur. J. Med. Chem., 43, 2004 (2008),<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications Bromoacetaldehyde Diethyl Acetal (cas# 2032-35-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Methoxy-2-propanone is used in the bio-amination of ketones in organic solvents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mutti, F. et al.: Adv. Synth. Catal.of Chem., 30, 2624 (2012); Mutti, F. et al.: Adv. Synth. Catal., 353, 3227 (2011);<br></p>

<p>Applications Intermediate in the production of ABT 737<br>References Kubota, D., et al.: Bioorg. Med. Chem., 14, 2089 (2006), Park, C., et al.: J. Med. Chem., 51, 6902 (2008),<br></p>

<p>Applications trans-2-Hexenal is an unsaturated aldehyde that has an apple odour. trans-2-Hexenal is produced by soybean plants, and is also a sex pheromone produced by the female polyphemus moth.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corbo, M., et al.: J. Agr. Food Chem., 48, 2401 (2000); De Lucca, A., et al.: J. Food Sci., 76, M381 (2011); Riddiford, L.: Science, 158, 139 (1967)<br></p>

<p>Applications 1-Bromo-4-nitrobenzene is part of a group of compounds that have the ability to stimulate the microbial degradation of polychlorinated biphenyls (PCBs), rendering them less harmful to the environment, animals and humans. 1-Bromo-4-nitrobenzene is also an electron-poor arene that has genotoxic effects on humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeWeerd, K. &amp; Bedard, D.: Env. Sci. Tech., 33, 2057 (1999); Huang, Q., et al.: J. Env. Sci., 8, 103 (1995); Imperato. G., et al.: Adv. Synth. Cat. 348, 2243 (2006)<br></p>

<p>Applications 1-Bromoeicosane-20,20,20-d3 (CAS# 202480-72-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl Oxalopropionate is a useful precursor in the synthesis of 2-Methylcitric Acid (M265080); a metabolite of Citric Acid (C521000) that can also be formed from condensation of propionoyl-CoA and oxaloacetic acid catalyzed by a citrate synthase enzyme.<br>References Allen, R. H., et al.: Metabolism, 42, 978 (1993)<br></p>

<p>Applications (±)-1-Phenylethanol-d10 (CAS# 219586-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Chlorobutyroyl Chloride is used in the preparation of mitosene and mitosane analogs of Mitomycin C (M371900), an antitumor antibiotic. .<br>References Verboom, W. et al.: Anti-Canc. Drug Des., 2, 271 (1987); Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),<br></p>

<p>Applications DL-4-Hydroxyphenyl-2,6-d2-alanine-2-d1 (CAS# 73036-42-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of NADPH oxidase 1 (NOX1).<br>References Gianni, Davide., et at.: ACS Chem. Biol., 5, 9(2010);.<br></p>

<p>Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.<br></p>

<p>Applications (±)-1-Phenylethan-1-d1-ol (CAS# 3101-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(3-aminopropyl-d6)amine (CAS# 1219805-55-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl carbamimidate sulfate (CAS# 29427-58-5) is a useful research chemical compound.<br></p>

<p>Applications 1-Hexadecane-d33-thiol (CAS# 218956-22-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 1-Bromo-2-methylpropane is a halogenated alkane used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Noller, C.R., et al.: Org. Syntheses., 13, (1933); Wang, Z.M., et al.: Lett. Org. Chem., 4, 72 (2007);<br></p>

<p>Applications A diester derivative in relation to aquatic toxicity to Tetrahymena.<br>References Konemann, H., et al.: Toxicology, 19, 209 (1981), Mekenyan, O., et al.: Arzneim.-Frosch., 24, 421 (1986), Bearden, A., et al.: Environ. Toxicol. Chem., 16, 1311 (1997),<br></p>

<p>Applications n-Butyl-d9-benzene (CAS# 65087-59-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Heptynoic Acid is used as a reagent in organic synthesis, inlcuding that of some novel triazole derivatives which display antiproliferative activity and also of acetylenic fatty acids and their esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pertino, M., et al.: Molecules, 19, 2523 (2014); Nakatani, M., et al.: B. Chem. Soc. Jpn., 59, 3535 (1986);<br></p>

<p>Applications 4-Hydroxy-5-Methoxy-2-Pyridinecarbaldehyde is used in the synthesis of N-substituted γ-pyridones<br>References Korenova, A., et al.: CHEM. PAP., 51, 383-389 (1997)<br></p>

<p>Applications N,N'-Diisopropylthiourea is a reagent for the improved synthesis of cefathiamidine. Studies on the chemical nature of the thyroid inhibiting actions of compounds. Design and testing of antithyroid agents with decreased antioxidant activity.<br>References Wang, H., et al.: Zhongguo Xiandai Yingyong Yaoxue, 27, 126 (2010); Astwood, E. B., et al.: Endocrinology, 37, 456 (1945); Abou-Shaaban, R. R. A., et al.: Pharm. Res., 13, 129 (1996)<br></p>

<p>Applications n-Butyl-4,4,4-d3-benzene (CAS# 109232-94-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5,5-Dimethylhydantoin is part of a group of hydantoin compounds that are being evaluated for their anticonvulsant and central nervous system antitumour properties.<br>References Rishipathak, D., et al.: Asian J. Chem., 19, 5450 (2007); Peng, G., et al.: J. Med. Chem., 18, 846 (1975)<br></p>

<p>Applications 1-Bromo-2,3-dimethyl-benzene is a useful synthetic intermediate. It is used as a reagent to synthesize vaniprevir. It can also be used to synthesize various piperidine derivatives, e.g., 4-arylpiperidines and cinnamoylpiperidine, which are 5-HT2C agonist and PAR1 antagonist, respectively.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, Z., et a;.: J. Org. Chem., 76, 9553 (2011); Conway, R., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012); Planty, B., et al.: Bioorg. Med. Chem. Lett., 20, 1735 (2010)<br></p>

<p>Applications 3-Fluoropropan-1-ol is used as a reagent to synthesize fluorinated amino acids (e.g. DL-erythro-4-Fluoroglutamine [F591630]). 3-Fluoropropan-1-ol is also used as a reagent to synthesize labelled N-desmethyl-loperamide analogues, compounds that have potential use as imaging radiotracers.<br>References Bao, X. &amp; Duliang, L.: Tetrahedron Lett., 54, 1412 (2013); Drouet, F., et al.: Eur. J. Org. Chem., 2014, 1195 (2014)<br></p>

<p>Applications 1,3-Propane-2,2-d2-diamine (CAS# 352438-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Moisture Sensitive<br>Applications A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.<br>References Perich, J.W., et al.: Synthesis, 142 (1988)<br></p>

<p>Applications (2Z)-2-Butenedioic Acid 1-Ethyl Ester is a phytochemical isolated from cranberries. (2Z)-2-Butenedioic Acid 1-Ethyl Ester was shown to exhibit potential antiproliferative and antioxidant activities.<br>References He, X.J., et al.: J. Agri. Food. Chem., 54, 7069 (2006); Dymicky, M., et al.: App. Environ. Microbiol., 53, 110 (1987);<br></p>