Building Blocks

<p>6-Hydroxyquinoline-2-carboxylic acid is a drug that has been shown to inhibit phospholipidosis, which is the accumulation of phospholipids in cells. It also inhibits naphthalene-induced hyperphosphorylation and histamine release from mast cells. 6-Hydroxyquinoline-2-carboxylic acid is an acceptor for the pharmacophore model and has been validated by molecular properties. The optimization process for this compound was monitored and validated. This lead compound is being considered as a potential therapeutic agent for the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus erythematosus.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitrothiophene-3-carbaldehyde (NTAC) is a tripodal that has been shown to be able to form aggregations with other molecules. It has been used in solar cells as a semiconductor material and can be used as a ligand for optical or x-ray sensors. NTAC also has the ability to absorb light and can be used as a dye in dye-sensitized solar cells. The electron affinity of NTAC is low, making it an effective electron acceptor for photocatalytic reactions. This compound is also useful for particle size measurements using microscopy techniques.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Imidazole is a highly polar aromatic compound with two annular nitrogen atoms. Imidazole is widely used in the affinity purification of proteins with polyhistidine tags (His-Tag). In the protein purification process, imidazole is used for the elution of His-Tag-fused recombinant proteins from a metal-immobilised resins. In the elution buffers, imidazole is typically used in the 50 – 500 mM concentration range (Bornhorst and Falke, 2000).</p>

<p>2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a synthetic chemical that has been shown to have antiviral activity against influenza virus and inhibit the synthesis of proteins in cancer cells. It inhibits the influenza virus from replicating by binding to the viral RNA polymerase and preventing it from transcribing viral RNA into proteins. 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane also binds to the boronic ester group of enzymes that are involved in plant metabolism and can be used as an herbicide. This chemical is synthesized by reacting boric acid with trimethoxysilane in an acidified water solution. The reaction produces hydrochloric acid which reacts with trimethoxysilane to form silanols. The silanols react with boric acid to produce 2</p>

<p>Versatile small molecule scaffold</p>

<p>4-Iodo-1-tritylimidazole is an organic molecule that has a chemical stability comparable to that of a nucleophile. It is a molecule with a heterocycle and accepts electrons from carbinol compounds, halides, and other functional groups. 4-Iodo-1-tritylimidazole can be synthesized by the palladium-catalyzed coupling reaction between organometallic reagents and histidine. This compound has been shown to have properties that are similar to those of biomimetic molecules, such as cross-coupling.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>