Building Blocks

(1-Methylpiperidin-4-yl)methanol is a potent inhibitor of the kinases vegfr-2 and vesicular glutamate transporter 2 (vglut2). It is also active against human tumor xenografts. The inhibitory activity was determined to be due to its ability to bind and covalently modify tyrosine residues in the kinase domain. The inhibitory potency of (1-Methylpiperidin-4-yl)methanol was found to be constant, regardless of oxygenation status. This suggests that the inhibition is not due to the binding of oxygenated metabolites. In vitro experiments showed that it inhibits cellular proliferation by blocking protein synthesis and arresting cells at G1 phase. This drug has potential as an antitumor agent because it inhibits tumor growth without affecting normal tissue or causing significant toxicity in animal models.

6-Methoxyindole-2-carboxylic acid methyl ester is a pyrroloquinoline alkaloid with cytotoxic and antiproliferative activities. It inhibits the growth of cancer cells in culture by inducing apoptosis and cell cycle arrest. 6-Methoxyindole-2-carboxylic acid methyl ester has been shown to be effective against breast cancer cell lines in vitro and to inhibit the proliferation of breast cancer cells in vivo. This compound also inhibits the growth of a number of other cancer cell lines such as prostate, colon, lung, liver, stomach, and leukemia. The mechanism of action for this compound is thought to be due to its ability to act as an intramolecular quencher of reactive oxygen species (ROS) or as an inhibitor of DNA synthesis through inhibition of ribonucleotide reductase activity.

6-Methoxyindole-2-carboxylic acid (6MI) is a potent inhibitor of the enzyme catechol-O-methyltransferase (COMT). This inhibition prevents the conversion of catecholamines, such as dopamine and norepinephrine, to their corresponding methylated products. COMT inhibitors are used clinically to treat Parkinson's disease and other diseases that result from excessive levels of these neurotransmitters. 6MI is also an effective inhibitor of tyrosinase activity in vitro. It has been shown to inhibit the synthesis of melanin by melanocytes and inhibits the production of eumelanin, which is responsible for black or brown skin pigments. The inhibitory potency of 6MI was found to be greater than that for kojic acid, arbutin, and hydroquinone. Optimization studies showed that 6MI was most potent at a concentration of 1 mM and had an IC50 value of 0.3 mM in

Used for antibody separation by hydrophobic charge induction chromatography

6-Methoxyindole is an acetate extract of the plant 5-methoxyindole. It has been shown to be a 5-HT1A receptor agonist in animals, and has been shown to have cardiac effects in rats. 6-Methoxyindole is also used as a precursor for the synthesis of diphenylacetylindoles. 6-Methoxyindole is one of the molecules that can be recombined to form a batcho-leimgruber indole (BLI).

Versatile small molecule scaffold