Ethers

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)benzeneethanamine is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.<br>References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),<br></p>

<p>Applications tert-Butylmethoxydimethylsilane is used as a reactant in the preparation of chlorosilanes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Masaoka, S., et al.: J. Organomet. Chem., 691, 174 (2006);<br></p>

<p>Applications 1-Nitro-2-[(1E)-2-nitroethenyl]-4-(phenylmethoxy)-benzene is an intermediate used in the synthesis of 5-Hydroxyindole-3-acetic acid (H953605), which is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications 2,2-DIMETHOXY-1-PROPANAMINE (cas# 131713-50-3) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Ethoxy-5-(ethoxysulfonyl)benzoate is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications (3R,4R)-Dihydro-3,4-bis(phenylmethoxy)-2,5-furandione is an intermediate in the synthesis of N-alkenylsuccinimide derivatives.<br>References Ohwada, J., et al.: Bull. Chem. Soc. Jap., 63, 287 (1990);<br></p>

<p>Applications Synthesis and receptor binding of 5-(amino[3H]2methyl)-3-isothiazolol ([3H]thiomuscimol), a specific GABAA agonist photoaffinity label.<br>References Frolund, B., et al.: J. Labelled Compounds Radiopharm., 36, 877 (1995),<br></p>

<p>Applications 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol (cas# 77544-60-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.<br>References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications [3-(3,4-dimethoxyphenyl)propyl](methyl)amine hydrochloride (cas# 83979-31-1) is a useful research chemical.<br></p>

<p>Applications Tetramethoxypropane is a useful synthetic intermediate. It can be used to synthesize various compounds such as diiodonoradamantane and Salicylates[e.g. Salsalate(S095700)].<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ioannou, S., et al.: Tetrahedron Lett., 51, 2671 (2010); Sher, M., et al.: J. Org. Chem., 72, 6284 (2007)<br></p>

<p>Applications 2,3-Dimethoxyphenol (cas# 5150-42-5) is a useful research chemical.<br></p>

<p>Applications 4-(Methoxycarbonyl)phenylboronic Acid is used in the synthesis and evaluation of several organic compounds including that of 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate which is a potent inhibitor of intracellular NAAA activity. Also used in the design and synthesis of BMS-955176 which is a potent, orally active second generation HIV-1 maturation inhibitor.<br>References Nuzzi, A., et al.: Eur. J. Med. Chem., 111, 138 (2016); Rogueiro-Ren, A., et al.: ACS Med. Chem. Lett., 7, 568 (2016);<br></p>

<p>Applications (2,3,4-Trimethoxyphenyl)boronic Acid is a reagent used in the synthesis of heteroaryl, mono and bicyclic compounds which may be used as inhibitors for EGF and PDGF receptor tyrosine kinases. Also used in the synthesis of non-steroidal CYP 17 inhibitors in the treatment of prostate cancer<br>References Hutschenreuter, T. et al.: J. Enz. Inhib. Med. Chem., 19, 17 (2004);<br></p>

<p>Applications 3,5-Dimethoxytoluene (cas# 4179-19-5) is a useful research chemical.<br></p>

<p>Applications N10-(Ethoxycarbonyl)tryptamine is an intermediate in the synthesis of N-Methyltryptamine-d3 (M331922), which is a labeled N-Methyltryptamine, a N-monomethylated derivative of tryptamine. N-Methyltryptamine, unlike its unmethylated counterpart, does not produce any psychoactive effects. High levels of N-Methyltryptamine have been found in cisternal cerebrospinal fluid of patients with acute paranoid schizophrenia.<br>References Schmid, C. et al.: J. Neurosci., 30, 13513 (2010); Uebelhack, R. et al.: Biomed. Biochim. Acta, 42, 1343 (1983);<br></p>

<p>Stability Light Sensitive<br>Applications Cis-1-Bromo-2-ethoxyethylene<br></p>

<p>Applications 3,4,5-Trimethoxyphenol is a useful synthetic intermediate in the synthesis of Thymonin (T413210); a flavonoid compound with potential antioxidant activity against peroxyl radicals.<br>References Dugas, A.J., et al.: J. Nat. Prod., 63, 327 (2000)<br></p>

<p>Applications (2R,​3S,​4S,​5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone was used in the synthetic preparation of N-substituted valiolamine derivatives.<br>References Fukase, H., et al.: J. Org. Chem., 57, 3642 (1992);<br></p>

<p>Applications trans-3,4,5,4'-Tetramethoxystilbene (cas# 134029-49-5) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-(2-(tert-Butoxy)-2-oxoethoxy)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 3-ETHOXY-2-CYCLOHEXEN-1-ONE (cas# 5323-87-5) is a useful research chemical.<br></p>

<p>Applications [4-(Difluoromethoxy)phenyl]hydrazine is used as a reagent in the synthesis of dihydropyrazolopyridinones as functionally selective benzodiazepine binding site ligands on the GABAA receptor.<br>References Mitchinson, A., et al.: Bioorg. Med. Chem. Lett., 14, 3441 (2004)<br></p>

<p>Applications 3-(2-Aminoethoxy)propionic Acid (cas# 144942-89-2) is a compound useful in organic synthesis.<br></p>

<p>Applications ETHYL 4-ETHOXYBENZOATE (cas# 23676-09-7) is a useful research chemical.<br></p>

<p>Applications Methoxy4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzenemethanol, is prepared synthetically from vanillin (V097500) with an intermediate of methoxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-benzaldehyde (M269710).<br>References Gowravarm, S. et al.: Adv. Synth. Catal., 343, 169 (2001)<br></p>

<p>Applications 1,4-Dimethoxybenzene is a useful chemical in organic synthesis.<br>References Digwal, Chander S., et al.: Asian J. of Org. Chem., 7(5), 865-869 (2018);Cai, Zhi-Bin, et al.: RSC Advances, 6(52), 46853-46863 (2016);Lin, Qi, et al.: Soft Matter, 13(39), 7222-7226 (2017)<br></p>

<p>Applications 4,4-Dimethoxy-2-butanone is a reactant in the synthesis of naphthalimide-naphthyridine derivatives as a fluorescent probe for the detection of hydroxyl radicals in living cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meng, L., et. al.: Chem. Commun., 50, 4843 (2014)<br></p>

<p>Applications 4,4'-Dimethoxydiphenylamine is a diphenylamine derivative used as a chemical additive for cured rubber. 4,4'-Dimethoxydiphenylamine is highly toxic and may potentially induce chromosome abberation.<br>References Kel'man, G.Y. et al.: Kauch. Rez., 26, 28 (1967); Sofuni, T. et al.: Mutat. res. Gen. Toxicol. Test., 24, 175 (1990);<br></p>

<p>Applications Intermediate in the production of modified guanine derivatives<br>References Kim, S., et al.: J. Med. Chem., 21, 883 (1978),<br></p>

<p>Applications Methyl 2-Acetamido-2-(Dimethoxyphosphoryl)Acetate (cas# 89524-99-2) is a useful research chemical.<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Applications Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is used in the preparation of dendronized polymers. Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine can be used in the synthesis of optically degradable dendrons for temporary adhesion of proteins to DNA. It is also used in the preparation of tricylic polyamide receptor for carbohydrate recognition.<br>References Calderon, M. et al.: Macromol. Sym., 258, 53 (2007); Kostiainen, M.A. et al.: Chem. Eur. J., 16, 6912 (2010); Klein, E. et al.: Angew. Chem. Int. Ed., 44, 298 (2005);<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Applications Methyl (1R,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Ester is used in the discovery of a potent, selective and orally bioavailable dual CCR2 and CCR5 antagonist.<br>References Zheng, C., et al.: Bioorg. Med. Chem. Lett., 21, 1442-1446 (2011)<br></p>

<p>Applications 2-(1,1-Dimethylethoxy)-1-propanol is a useful reagent for organic synthesis.<br></p>

<p>Applications 2-(4-Amino-2-ethoxyphenyl)pthalimide (cas# 106981-52-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-(Dimethoxyphosphoryl)acetic acid<br></p>

<p>Applications N-[[4-(Phenylmethoxy)phenyl]methyl]-2-[(3-thienylcarbonyl)amino]-4-thiazoleacetamide is derived from ethyl 2-amino-4-thiaxolacetate (E899330) which is used in the synthesis of various pharmaceutical and biologically active compounds including inhibitors and antibiotics.<br>References Inamoto, Y., et al.: J. Antibiot., 41, 828 (1988)<br></p>

<p>Applications 2-[2-(2-Propynyloxy)ethoxy]ethanol is a reactant used in the preparation of divalent ligands based on 3-deoxy-4-thiolactose as inhibitors of E. coli β-galactosidase.<br>References Cagnoni, A.J., et. al.: Org. Biomol. Chem., 11, 5500 (2013)<br></p>

<p>Applications N-(2-(1,3-Dioxoisoindolin-2-yl)ethoxy)benzamide is an intermediate in the synthesis of Fluvoxamine Maleate (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.<br>References Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977); Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996); Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997); Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)<br></p>

<p>Applications 2,5-Dimethoxybenzyl Alcohol can be used as a self-indicating standard for the determination of organolithium reagents<br>References Winkle, M.R. et al.: J. Chem. Soc. Chem. Comm., 3, 1980 (1980):<br></p>

<p>Applications Methyl 2-Amino-3,4,5-trimethoxybenzoate could be a constituent contributing to the aroma of green tea leaves.<br>References Hasegawa, T., et al.: J. Food Eng., 4, 10 (2014)<br></p>

<p>Applications 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.<br>References Ye, X. et al.: Zhong. Yao. Xuax. Zaz., 20, 106 (2010);<br></p>

<p>Applications 2,2-Diethoxy-N-ethylethanamine is used in the preparation of 1-substituted-2-mercaptoimidazoles with antithyroid activity.<br>References Jones, R.G.J. Am. Chem. Soc., 71, 4000 (1949)<br></p>

<p>Applications Ethoxybenzene is a reagent used in the synthesis of benzenesulphonylurea derivatives as anti-hyperglycaemic agents and various PTP1B inhibitors.<br>References Liu, P. et al.: Bioorg. Med. Chem., 23, 7079 (2015);<br></p>

<p>Applications Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1. Also used in the synthesis of benzobisoxazoles used in the preparation of organic semiconductors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kazmierski, W. et al.: J. Med. Chem., 54, 3756 (2011); Mike, J. et al.: Org. Lett., 10, 4915 (2008);<br></p>

<p>Applications 4,5-Dimethoxy-2-nitroaniline (cas# 7595-31-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications [3-(Ethoxycarbonyl)propyl]triphenylphosphonium Bromide is a reactant used in the preparation of maresin 1, a potent anti-inflammatory and pro-resolving lipid mediator.<br>References Tungen, J.E., et. al.: Tetrahedron Lett., 56, 1843 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications Ethyl 3,3-diethoxypropionate<br></p>

<p>Applications 5-Bromo-2-ethoxy-benzenesulfonyl chloride<br></p>

<p>Applications 2-(Ethoxymethyl)furan (cas# 6270-56-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)acetic acid (cas# 877140-09-5) is a useful research chemical.<br></p>

<p>Applications [(Methoxy)methyl]triphenylphosphonium Chloride is used in the synthesis of Cephalotaxine (C261050), an antiviral and antitumor agent. Also used in the synthesis of Taxol A fragment.<br>References Sells, M., et al.: J. Virol., 62, 2836 (1988), Kaneko, S., et al.: J. Clin. Microbiol., 27, 1930 (1989), Baba, Y., et al.: Bioorg. Med. Chem., 13, 5164 (2005), Romero, M., et al.: Antiviral Res., 68, 75 (2005); Hirai, S. et al.: Tetrahedron Lett., 54, 1888 (2013); Xing, P. et al.: Synth., 45, 596 (2013);<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.<br>References Wu, S., et al.: J. Agri. Food Chem., 61, 4035 (2013); Reynertson, K., et al.: J. Nat. Prod., 69, 1228 (2006)<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications 3,5-Dimethoxyaniline (cas# 10272-07-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethoxyacetic acid<br></p>

<p>Applications 5-[3-(Trifluoromethoxy)phenyl-2-Furancarboxylic Acid is the structural analogue of 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid (T790925), a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.<br>References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)<br></p>

<p>Applications N-[1-[3-(2-Ethoxyphenyl)-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl]acetamide is an intermediate in the synthesis of Vardenafil (V098001) related compounds.<br>References Olszewska, T., et al.: Tetahedron., 69, 474 (2013);<br></p>

<p>Applications tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.<br>References Poty, Sophie, et al.: Bioconjugate Chem., 27(3), 752-761 (2016)<br></p>

<p>Applications Methyl Methoxyacetate is a reagent used in the synthesis of diphenylamine-terepthalaldehyde resins which maybe be used as a catalyst for tetrahydropyranylation.<br>References Tanemura, K. et al.: Org. Prep. Proc. Int., 48, 72 (2016); By: Robiette, R. et al.: J. Am. Chem. Soc., 138, 737 (2016);<br></p>