Amides

<p>Impurity Albendazole Impurity 6 Calcium<br>Applications Cyanamide is used in the synthesis of H2 receptor histamine antagonists. Also use in the synthesis of oxadiazoles and 1,2,4-thiaziazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. (Albendazole Impurity 6)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, R. et al.: J. Med. CHem., 31, 656 (1988); Unangst, P. et al.: J. Med. CHem., 35, 3691 (1992);<br></p>

<p>Applications 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).<br>References Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);<br></p>

<p>Applications N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.<br>References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Applications N-4-Benzyloxyphenyl Isobutyrylacetamide (cas# 265989-30-8) is a compound useful in organic synthesis.<br></p>

<p>M06239 - Fmoc-D-isoGln-OH</p>

<p>Applications Intermediate in the production of Cyclophosphamide metabolites.<br>References Takamizawa, A., et al.: Chem. Pharm. Bull., 20, 1612 (1972),<br></p>