Amides

<p>Applications Benzamide is a compound that is widely used as a starting material for various organic syntheses and reactions. Benzamide derivatives are prevalent in the pharmaceutical industry, for example Raclopride (R070800), a Dopamine (D533780) D-2 agonist that is used to treat patients with Parkinson’s Disease. Benzamide derivatives are also used in chemistry, for example N-nitrophenyl benzamide derivatives are used as chromosensors to detect cyanide in aqueous environments.<br>References Ehrin, E., et al.: Int. J. Appl. Rad. Isot., 36, 269 (1985); Sun, Y., et al.: Tetrahedron, 65, 3480 (2009); Terai, M., et al.: Eur. J. Pharm., 173, 177 (1989)<br></p>

<p>Applications Hexacosanoic acid ((1S,2S,3R)-2,3-dihydroxy-1-hydroxymethyl-heptadecyl)-amide is a ceramide found in the moro blood orange (Citrus sinensis). It is a useful building block used in the preparation of 5-thio-α-GalCers as immunostimulators for IFN-​γ production stimulation in mouse NKT cells.<br>References Bi, J.; et al.: ACS Med. Chem. Lett., 6, 476 (2015); Valsecchi, M.; et al.: J. Agric. Food Chem., 60, 10103 (2012).<br></p>

<p>Applications N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.<br>References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Applications (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a part of the synthetic preparation of the synthesis and inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelets agents.<br>References Zhang, H., et al.: Bioorganic Med. Chem. Lett., 22, 3598 (2012).<br></p>

<p>Applications Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”.<br>References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. &amp; Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)<br></p>

<p>Impurity Iohexol USP Related Compound C<br>Applications N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.<br>References Haavaldsen, J. et al.: Acta Pharmac. Sue., 20, 219 (1983);<br></p>

<p>Applications CHLOROFLUOROACETAMIDE (cas# 431-09-4) is a useful research chemical.<br></p>