Carboxylic Acids

<p>Applications Tricosanoic Acid 1,2,3-Propanetriyl Ester, can be used for the manufacture of cosmetics, and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications DITHIOCARBONIC ACID S,S'-DIETHYL ESTER (cas# 623-80-3) is a useful research chemical.<br></p>

<p>Applications Cyclopentylacetic acid is a reagent the synthesis of Cyclopentamine (C988355), which is a vasoconstrictor that acts as a releasing agent of the neurotransmitters norepinephrine, epinephrine and dopamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, J.L. et al.: J. Pharmacol. Exp. Ther., 145, 83 (1964); Iversen, L.L.: J. Pharm. Pharmacol., 16, 435 (1964);<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Applications 1,2,4-Benzenetricarboxylic acid 1,2-Dihexyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Stability Air Sensitive<br>Applications (2S)-2-Mercaptopropanoic Acid is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).<br>References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications 7-Chloro-4-oxo-4H-chromene-2-carboxylic acid (cas# 114741-22-9) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 4-(2-Aminophenyl)-4-oxo-2-butenoic Acid is a novel human lens metabolite from normal and cataractous human lenses. A UV filter.<br>References Mizdrak, J., et al.: Tetrahedron, 63, 4990 (2007); Taylor, L. M., et al.: Exp. Eye Res., 75, 165 (2002)<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid<br></p>

<p>Applications Phenethyl Carbamate is an impurity in the synthesis of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>

<p>Applications Used in the synthesis of anti-tumor compounds comprising of hydroxyisovalerylshikonin analogs. Furthermore, the compound is a reagent in the synthesis of class II c-Met inhibitors, in the treatment of c-Met dependant tumors.<br>References Rao, Z. et al.: Eur. J. Med. Chem., 46, 3934 (2011); Liu, L. et al.: J. Med. Chem., 55, 1868 (2012);<br></p>

<p>Applications 2-Butyl-4,6-dihydroxybenzoic Acid is an intermediate in preparation of compounds for study in primin and miconidin biosynthesis routes in Primula obconica.<br>References Horper, W., et al.: Phytochem., 41, 451 (1996);<br></p>

<p>Applications Methyl 2-Bromo-1-cyclopentenecarboxylate is a versatile reactant that can be derived from Cyclopentanone (C988395), which is a compound used in the synthesis of various simple and complex organic compounds. Cyclopentanone is also used in the synthesis of peptidase IV inhibitors for the treatment of type 2 diabetes.<br>References Imamoto, T. et al.: J. Am. Chem. Soc., 112, 5244 (1990); Augeri, D. et al.: J. Med. Chem., 48, 5025 (2005);<br></p>

<p>Applications Ethyl 2-Ethylacetoacetate was a useful reagent in systematic investigation of saccharomyces cerevisiae enzymes catalyzing carbonyl reductions.<br>References Kaluzna, I., et al.: J. Am. Chem. Soc., 126, 12827 (2004);<br></p>

<p>Applications 5-Hydroxytoluene-2,4-disulfonic Acid acts as a synthetic reagent in the sulfonation of 2 and 3-Methylphenol.<br>References Strandlund, G., et al.: Acta Chem. Scand., 33, 261 (1979)<br></p>

<p>Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications (S)-2-[(Methylsulfonyl)oxy]propanoic Acid is used as a treatment to significantly improve the selectivity of optically active agent (S)-2-(4-Isobutylphenyl)propionic Acid during its synthesis.<br>References Garot, C., et al.: Bull. Soc. Chim. Belg., 105, 755-757 (1996)<br></p>

<p>Applications 4'-Hydroxybiphenyl-3-carboxylic Acid is a biaryl compound that can be prepared via palladium bis[(dipiperidinylphosphino)amino]phenyl-catalyzed Suzuki-Miyaura cross coupling reactions of organoboronic acids or trifluoroborates and aryl bromides and can also be synthesized by simultaneous hydroxylation and carboxylation of biphenyls. 4'-Hydroxybiphenyl-3-carboxylic Acid is a useful building block with applications in various syntheses.<br>References Shibahara, F., et al.: Org. Lett., 6, 2437 (2004); Bolliger, J., Frech, C.: Adv. Synth. Catal., 352, 1075 (2010);<br></p>

<p>Applications 4-Ethylsulfonylphenylboronic acid is used in the discovery of small molecular RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis.<br>References Harris, P. A,, et al.: ACS Med. Chem. Lett., 4, 1238 (2013)<br></p>

<p>Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.<br></p>

<p>Applications 4-Nitrobenzyl Acetoacetate acts as a reagent in the preparation of panipenem via esterification of nitrobenzyl alcohol followed by substitution, cyclizations and hydrogenation. Panipenem I is a new carbapenem antibiotic for the treatment of inflammation.<br>References Fang, H., et al.: hongguo Yaowu Huaxue Zazhi, 21, 216 (2011)<br></p>

<p>Applications Methyl Oxirane-2-carboxylate is an intermediate used in the synthesis of DL-Indole-3-lactic Acid-d5 (I627102), which is the isotope labelled analog of DL-Indole-3-lactic Acid (I627100); a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.<br>References Nguyen, S.T., et al.: Bioorg. Med. Chem. Lett., 20, 5739 (2010); Nakamura, K., et al.: Peptide Sci., 40, 61 (2003)<br></p>

<p>Stability Light, Temperature and Moisture sensitive<br>Applications trans-N-(1E)-1,3-Butadien-1-yl-carbamic Acid 2,2,2-Trichloroethyl Ester (cas# 77627-82-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Propylphosphonic Anhydride is used to prepare aryloxybenzylmorpholines as dual serotonin and noradrenaline reuptake inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fish, P., et al.: Bioorg. Med. Chem. Lett., 18, 2562 (2008)<br></p>

<p>Applications 6-Acrylamidohexanoic Acid is a useful research chemical for organic synthesis and other chemical processes.<br>References Yamada, K., et al.: Tetrahedron Lett., 36, 9493 (1995); Park, W. K. C., et al.: Methods Enzymol., 242, 294 (1994); Nishimura, S., et al.: Tetrahedron Lett., 35, 5657 (1994)<br></p>

<p>Applications A reactant used in the preparation of (-)-Amathaspiramide F.<br>References Sakaguchi, K. et al.: Tetrahedron, 65, 10355 (2009); Sakaguchi, K. et al.: Org. Lett., 10, 5449 (2008)<br></p>

<p>Applications 4-(2-Ethoxy-2-oxoethoxy)phenylboronic acid<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid Dimethyl Ester (cas# 35190-68-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloro-2-fluorobenzoic Acid (cas# 394-30-9) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-Ethynylphenyl)boronic acid<br></p>

<p>Applications γ-Isodurylic Acid is an intermediate in the synthesis of Ketoprofen (K200800) related compounds.<br>References Colomina, M., et al.: J. Chem. Thermodynamics., 19, 1139 (1987);<br></p>

<p>Applications 2-Hydroxyphenylboronic acid<br></p>

<p>Applications Androstenediol 17-Acetate is used in synthetic preparation for direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids. Androstenediol 17-Acetate is also obtained from Dehydro Epiandrosterone (D229585) which is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.<br>References Ebeling, P., et al.: Lancet, 343, 1479 (1994); Morales, A.J., et al.: J. Clin. Endocrinol. Metab., 78, 1360 (1994); Ramachary, D.B., et al.: RSC Advances, 3, 13497-13506 (2013); Yahara, M., et al.: J. Toxicol. Sci., 2, 161 (1977);<br></p>

<p>Applications Methyl (1R,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Ester is used in the discovery of a potent, selective and orally bioavailable dual CCR2 and CCR5 antagonist.<br>References Zheng, C., et al.: Bioorg. Med. Chem. Lett., 21, 1442-1446 (2011)<br></p>

<p>Applications Dimethyl cyclopentane-1,3-dicarboxylate (cas# 2435-36-1) is a useful research chemical.<br></p>

<p>Applications 4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid (cas# 202197-73-7) is a useful research chemical for organic synthesis and other chemical processes.<br>References Bogert, M. T., et al.: J. Am. Chem. Soc., 29, 82 (1907); Baker, B. R., et al.: J. Org. Chem., 17, 141 (1952)<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.<br>References Wu, S., et al.: J. Agri. Food Chem., 61, 4035 (2013); Reynertson, K., et al.: J. Nat. Prod., 69, 1228 (2006)<br></p>

<p>Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.<br>References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);<br></p>

<p>Applications DL-3-aminoisobutyric acid hydrate is a useful research chemical for organic synthesis and other chemical processes.<br>References Saito, N., et al.: Bunseki Kagaku, 63, 909 (2014)<br></p>

<p>Applications 2-benzylcyclopropane-1-carboxylic acid (cas# 103986-55-6) is a useful research chemical.<br></p>

<p>Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications 3-((E)-(2,4-Dimethylphenyl)diazenyl)-2,4-dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications 6-Fluoronicotinic acid<br></p>

<p>Applications tert-Butyl (3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)carbamate is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4 for potential cancer diagnosis.<br>References Poty, Sophie, et al.: Bioconjugate Chem., 27(3), 752-761 (2016)<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications Methyl 5-bromofuran-2-carboxylate<br></p>

<p>Applications tert-Butyl 3-Cyanomorpholine-4-carboxylate is used as a reactant for the synthesis of HIV integrase inhibitors.<br>References Gardelli, C., et. al.: J. Med. Chem., 50, 4953 (2007); Pace, P., et. al.: J. Med. Chem., 50, 2225 (2007); Summa, V., et. al.: J. Med. Chem., 49, 6646 (2006)<br></p>

<p>Applications 2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 4-(Methylamino)benzoic Acid (cas# 10541-83-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromo-2-chloronicotinic acid<br></p>

<p>Applications 2-Amino-4-hydroxybenzoic acid (cas# 38160-63-3) is a useful research chemical.<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications 3-Hydroxyhomophthalic acid (cas# 42421-12-5) is a useful research chemical.<br></p>

<p>Applications 1,2-Ethanedisulfonic Acid Diethyl Ester is used in the industrial manufacturing process for the synthesis of alkyl disulfonate.<br>References Wu, M., et al.: Faming Zhuanli Shenqing, 2012:1569603 (2012)<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Applications Methyl Methoxyacetate is a reagent used in the synthesis of diphenylamine-terepthalaldehyde resins which maybe be used as a catalyst for tetrahydropyranylation.<br>References Tanemura, K. et al.: Org. Prep. Proc. Int., 48, 72 (2016); By: Robiette, R. et al.: J. Am. Chem. Soc., 138, 737 (2016);<br></p>

<p>Applications Used for production of peptide thioester.<br>References Gaeta, A., et al.: Bioorg. Med. Chem. Lett., 20, 4649 (2010),<br></p>

<p>Applications Penta-2,4-dienoic acid (cas# 626-99-3) is a useful research chemical.<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>