Carboxylic Acids

<p>2-(2-Phenylacetamido)acetic acid (Phenyl-ac-Gly-OH) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.</p>

<p>H-D-cis-Hyp-OH (D-allo-Hydroxyproline) belongs to the class of organic compounds known as proline and derivatives.</p>

<p>L-Homoproline, an endogenous amino acid in animals, regulates testosterone and activates NMDA receptors.</p>

<p>Nicotinuric acid: a minor acyl glycine metabolite of fatty acids, synthesized by glycine N-acyltransferase.</p>

<p>N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).</p>

<p>D-Leucine stops seizures post-onset and lessens long-term potentiation without affecting basal synaptic transmission.</p>

<p>Beta-hydroxybutyrate aids in ketone body metabolism and is elevated in ketosis; it's a byproduct of valine from muscles.</p>

<p>4-Acetamidobutanoic acid, a GABA derivative in eukaryotes, found in blood, feces, urine, and human prostate.</p>

<p>2,2-Dihydroxyacetic acid (Formylformic acid) is an organic compound that is both an aldehyde and a carboxylic acid, is associated with primary hyperoxaluria.</p>

<p>DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen. </p>

<p>DL-Valine (H-DL-Val-OH) is 2-amino-3-methylbutanoic acid.It is synthesized in plants via several steps starting from pyruvic acid.</p>

<p>H-Gly-Pro-OH (Glycyl proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism</p>

<p>Methylmalonic acid (Isosuccinic acid) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A.</p>

<p>Applications n-Nonanoic Acid is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers.<br>References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009);<br></p>

<p>Applications A metabolite of Trimebutine (T795605(P)), which is an opioid receptor agonist and an antispasmodic.<br>References Dieks, H., et al.: J. Labelled Comp. Radiopharm., 28, 1093 (1990), Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>

<p>Applications Acetylpyruvic acid is a derivative of pyruvic acid (P998900) which is an intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications 5,6-dibromonicotinic acid (cas# 29241-64-3) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 2-Benzylacrylic Acid (cas# 5669-19-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Adamantanedicarboxylic acid, is a monomer that can be used in polymer science, self assembly and lithography.<br></p>

<p>Applications 4-n-Butoxybenzoic acid<br></p>

<p>Applications Reagent used to prepare Guanidine derivatives.<br>References Nozawa, D., et al.: Bioorg. Med. Chem. Lett., 11, 1481 (2001), Choudhury, A., et al.: Biochem., 46, 4066 (2007), Yuan, D., et al.: Bioorg. Med. Chem., 15, 265 (2007),<br></p>

<p>Applications Crotonic Acid is found in water extracts from carrot seeds (Daucus carota L.) and is shown to have strong herbicidal properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jasicka-Misiak, I., et al.: Phytochemistry, 66, 1485 (2005)<br></p>

<p>Applications A metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>

<p>Applications Repaglinide intermediate.<br>References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Carboxamidobenzoic acid<br></p>

<p>Applications 2,3-Dihydroxypropanoic acid(20% in water) (cas# 473-81-4) is a useful research chemical.<br></p>

<p>Applications Formic Acid-d is labelled Formic Acid (F692900). Formic Acid (F692900) is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents.<br>References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);<br></p>

<p>Applications 3-Azidopropionic Acid is a mutagenic substance.<br>References LaVelle, J. M., et al.: Mutat. Res., 177, 27 (1987); Carlsson, L., et al.: J. Chem. Inf. Model., 49, 2551 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications TAUROURSODEOXYCHOLIC ACID (cas# 14605-22-2) is a useful research chemical.<br></p>

<p>Applications Maleic Acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. Also is a reagent in the preparation of TiO2/carbon nanotube composites.<br>References Le, L. et al.: ChemMedChem., 8, 289 (2013); Yao, Y. et al.: Env. Sci. Tech., 42, 4952 (2008)l<br></p>

<p>Applications Hydrazine acetate (cas# 7335-65-1) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-Mercaptoacetate is an off-odor compound in white wine and an eye irritant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nikolantonaki, M., Darriet, P.: J. Agr. Food Chem., 59, 10191 (2011); Bagley, D.M., et. al.: Toxicol. in vitro, 13, 505 (1999)<br></p>

<p>Applications (S)-2-Acetamido-5-ureidopentanoic Acid (cas# 33965-42-3) is a useful research chemical.<br></p>

<p>Applications Polyphosphoric Acid is a ligand used as an analytical tool to image nanoparticles through photon emission topography. Used also in the synthesis of pharmaceuticals.<br>References Peng J. et al.: Biomat., 37, 9535 (2013);<br></p>

<p>Applications Tetradecanedioic acid (cas# 821-38-5) is a useful research chemical.<br></p>

<p>Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.<br></p>

<p>Applications A redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gough, J.D., et al.: JACS, 124 (15), 3885 (2002)<br></p>

<p>Applications Ethyl hydrazinoacetate, HCl<br></p>

<p>Applications A metabolite of aldehydes.<br>References Shiobara, Y., et al.: Xenobiotica, 9, 157 (1979),<br></p>

<p>Applications trans-3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is a reagent used in the synthesis of indanyl insecticides.<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.<br>References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);<br></p>

<p>Applications 2-Ethylhexanoic Acid is used in biological studies as flavor precursor extraction from different grape varieties and its effect on wine aroma during alcohol fermentation<br>References Loscos, N., et al.: J. Agric. Food Chem., 55, 6674 (2007)<br></p>

<p>Stability Light Sensitive<br>Applications TRANS-2-OCTENOIC ACID (cas# 1871-67-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Oxohexanoic Acid (cas# 2492-75-3) has been useful in a biological study that investigated the impact of glutathione on wines oxidative stability.<br>References Nikolantonaki, M., et al.: Front. Chem. (Lausanne, Switzerland), 6, 182 (2018)<br></p>

<p>Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)<br></p>

<p>Applications Veratric Acid is a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E., et al.: Eur. Food Res. Technol., 229, 365 (2009), Spaccini, R., et al.: Soil Biol. Biochem., 41, 1164 (2009), Narasimhan, B., et al.: Eur. J. Med. Chem., 44, 689 (2009), Pereira, L., et al.: J. Biotechnol., 139, 68 (2009),<br></p>

<p>Applications Tiglic acid is the stable isomer of angelic acid. Tiglic acid was found as glyceride in croton oil, as butyl ester in the oil of the Roman camomile, and as geranyl tiglate in oil of geranium. Tiglic acid is formed during the charcoaling of maple wood.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bueding, et al.: J. Biol. Chem., 202, 505 (1953),<br></p>

<p>Applications Octyl 3-Octyloxiraneoctanoic Acid (cas# 106-84-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Cis-Pinic Acid is used to develop an exposure system for the toxicological evaluation of particles derived from coal-fired power plants. It is formed from α-pinene (P466605) oxidation.<br>References Ruiz, P., et al.: Inhal. Toxicol., 19, 607 (2007); Kristensen, K., et al.: Atmos. Chem. Phy., 13, 3763 (2013)<br></p>

<p>Applications Used in the synthesis of substituted terphenyls.<br>References Strukelj, M., et al.: Science, 267, 1969 (1995), Burroughes, J., et al.: Nature, 347, 589 (1990),<br></p>

<p>Applications 4-ETHYL-3-NITROBENZOIC ACID (cas# 103440-95-5) is a useful research chemical.<br></p>

<p>Applications (1-acetyl-2,3-dihydro-1H-indol-5-yl)boronic acid (cas# 905971-97-3) is a useful research chemical.<br></p>

<p>Impurity Sertraline EP Impurity E<br>Applications (R)-(-)-Mandelic Acid (Sertraline EP Impurity E) is an antiseptic (urinary).<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),<br></p>

<p>Applications 2-(2-butoxyethoxy)acetic acid (cas# 82941-26-2) is a useful research chemical.<br></p>

<p>Applications 2,4-Dioxo-4-phenylbutanoic acid<br></p>

<p>Applications 2-Ethoxybenzoic Acid is a component of dental cement. Low concentrations of 2-Ethoxybenzoic Acid in combination with Eugenol (E938640), gives a stabilizing effect to liposomes to lower damages to cells.<br>References Fujisawa, S., et al.: J. Dent. Res., 82, 43(2003); Brauer, G.M., et al.: J. Dent. Res., 62, 366 (1983); Brauer, G.M., et al.: J. Dent. Res., 63, 137 (1984); Fujisawa, S., et al.: J. Biomed. Mater. Res., 21, 89 (1987)<br></p>

<p>Applications Bis(2,4,4-trimethylpentyl)phosphinic acid (cas# 83411-71-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications PERFLUORO-3,6-DIOXAHEPTANOIC ACID (cas# 151772-58-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Used in the manufacturing of L-tryptophan by enzymic reaction.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications ethyl 2-cyclopropyl-2-hydroxyacetate (cas# 1185387-66-9) is a useful research chemical.<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>

<p>Applications 2,2-dimethyl-4-oxo-4-(propan-2-yloxy)butanoic acid (cas# 1803601-41-3) is a useful research chemical.<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester is a diester derivative of Phthalic Acid (P384480) and can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications 1,2,3,4-Cyclobutanetetracarboxylic Acid 1,2,3,4-Tetramethyl Ester is product from the formation of a mixture of maleic anhydride and hexamethylbenzene when exposed to ultraviolet irradiation.<br>References Raciszewski, Z.: J. Chem. Soc., 12, 1147-1155 (1966);<br></p>

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Applications N-(2,6-Diisopropylphenylcarbamoylmethyl)iminodiacetic Acid (cas# 65717-97-7) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-2-Hydroxybutanoic acid (cas# 20016-85-7) is a useful research chemical.<br></p>

<p>Applications Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.<br> E0<br>References Zuckermann, R.N. et al.; J. Am. Chem. Soc., 115, 10646 (1992); Bull, R., et al.: Toxicol. Appl. Pharmacol., 182, 55 (2002), Mitch, W., et al.: Water Sci. Technol., 2, 191 (2002),<br></p>

<p>Applications ethyl 2-azidoacetate (cas# 637-81-0) is a useful research chemical.<br></p>

<p>Applications 1,4-dibutyl benzene-1,4-dicarboxylate (cas# 1962-75-0) is a useful research chemical.<br></p>

<p>Applications Hexanedioic Acid Mono(4-hydroxybutyl) Ester is an intermediate in the synthesis of aliphatic polyesters.<br>References McCabe, R. W., et al.: Tetrahedron., 60, 765 (2004);<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of trifluoroacylated compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References HugenBerg, V., J. Fluorine. Chem., 131, 942 (2010); Belyakova, Z.V., et al.: Russ. J. Gen. Chem., 79, 2634 (2009); Wu, J.L., et al.: Jingxi. Huagong. Zhongjianti., 40, 64 (2010);<br></p>

<p>Applications 4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.<br>References Eren, G., et al.: Bioorg. Med. Chem., 18, 6467 (2010); Weber, V., et al.: Bioorg. Med. Chem., 13, 4552 (2005)<br></p>

<p>Applications 1,11-Undecanedicarboxylic Acid is used in the synthesis of two Bis(tetrahydroisoquinoline) which were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans.<br>References Terent’eva, E. O., et al.: Chem. Nat. Compd., 53, 328-332 (2017)<br></p>

<p>Applications 17-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid is an intermediate used to prepare (11β,​17α)​-17-​[(Ethoxycarbonyl)​oxy]​-​11-​hydroxy-​3-​oxo-​androsta-​1,​4-​diene-​17-​carboxylic acid (E890570) which is a derivative of Loteprednol Etabonate (L471400), an ophthalmic corticosteroid.<br>References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)<br></p>

<p>Applications 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>

<p>Applications 3,4-Secocholest-5-ene-3,4-dioic Acid Dimethyl Ester is an intermediate used in the synthesis of 3,4-Seco-solanidine-3,4-dioic Acid (S682410), which is a derivative of Solanidine (S682410).<br></p>

<p>Applications 4-Sulfamoylbenzoic Acid is used as a reagent in the synthesis of carbonic anhydrase inhibitors anticonvulsant agents.<br>References Singh, S. et al.: J. Enz. Inhib. Med. Chem., 31, 417 (2016);<br></p>

<p>Applications (E)-Cyano(methoxyimino)-acetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.<br>References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);<br></p>

<p>Applications 2-(2-carbamoylphenyl)acetic acid (cas# 23362-56-3) is a useful research chemical.<br></p>

<p>Applications 4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.<br>References Phillips, R. et al.: Am. J. Physiol., 152, 523 (1948);<br></p>

<p>Applications 6-[(6-Aminohexyl)amino]-6-oxo-hexanoic acid is a nylon oligomer with flame retardant properties.<br>References Zahn, Helmut et al.: Chemische Berichte, 92, 1381 (1959)<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid is a compound useful in organic synthesis.<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid<br></p>

<p>Applications 11-MERCAPTOUNDECANOIC ACID (cas# 71310-21-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>