Carboxylic Acids

<p>NSC 90469 (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis and insulin resistance.</p>

<p>5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.</p>

<p>Methyl acetylacetate found in urine indicates propionyl-CoA carboxylase or 2-methylacetoacetyl-CoA thiolase deficiency.</p>

<p>(±)-Leucine (DL-2-Aminmo-4-methylvalerianic acid) can be found in Green bell peppers, Green zucchinis, Italian sweet red peppers, and Red bell peppers.</p>

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle.

<p>D-(+)-​Phenyllactic acid (D-3-Phenyllactic acid) is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits Gram-positive and Gram-negative bacteria.</p>

<p>DL-Selenomethionine (SeMet) is a selenium analog of methionine, substituting sulfur with selenium, and can replace methionine in proteins.</p>

<p>N-Methylsarcosine improves athletic performance, boosts immunity, treats autism/epilepsy, tracks COPD, and aids in ionic liquid development.</p>

<p>Hydrocinnamic acid: white, sweet-smelling crystalline solid; used in cosmetics, food, and pharma.</p>

<p>Mesoxalate sodium (monohydrate) is primarily located in the cytoplasm within the cell. Mesoxalic acid can be biosynthesized from malonic acid.</p>

<p>D-Proline, (R)-pyrrolidine-2-carboxylic acid, is L-Proline's isomer, found in human plasma/saliva, possibly from bacteria or racemase activity.</p>

<p>Dihydroxyfumaric acid produces superoxide anions, hydroxyl radicals, can inhibit insulin, and converts to hydroxypyruvate or oxaloglycolate.</p>

<p>N-Acetylornithine is found in human blood plasma (avg. 1.1±0.4 μmol/L) and urine (~1 μmol/day).</p>

<p>Applications Ethyl Nitroacetate is an ester of nitrocarboxylic acid used as an intermediate in the preparation of unsubstituted amino acids.<br>References Sidorin, G.I.: Gig. Aspe. Okhr. Zdor. Nasel., 144 (1977);<br></p>

<p>Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q. et al.: Carbon, 54, 36 (2013);<br></p>

<p>Applications 11-MERCAPTOUNDECANOIC ACID (cas# 71310-21-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.<br></p>

<p>Applications Parabanic acid appears to be an important marker of free radical reactions in vivo and may be used to monitor free radical activity and to evaluate pharmacological therapy with radical scavengers.<br>References Koumoto, Y., et al.: J. Biol. Chem., 276, 29688 (2001), Gibon, Y., et al.: Plant Cell, 16, 3304 (2004), Kaplan, F., et al.: Plant J., 44, 730 (2005), Ishii, N., et al.: Science, 316, 593 (2007),<br></p>

<p>Applications Ethacrynic Acid Epoxide is an intermediate in the synthesis of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965), Kim., et al.: Am. J. Cardiol., 27, 407 (1971), Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977),<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications Hydrazine acetate (cas# 7335-65-1) is a useful research chemical.<br></p>

<p>Applications Heptadecanedioic Acid (cas# 2424-90-0) is a useful research chemical.<br></p>

<p>Applications Phthalanilic acid is a compound that is useful in the production of fertilizers.<br>References Liang, S., et al.: Faming Zhuanli Shenqing.,4 (2019)<br></p>

<p>Applications 3,4,5-Trimethoxyphenylacetic Acid is a reagent in the preparation of 3-phenylcoumarins as antidepressant agents.<br>References Sashidhara, K.V., et al.: Bioorg. Med. Chem. Lett., 24, 4876 (2014);<br></p>

<p>Applications 2,2-Diphenylpentanoic Acid (cas# 841-32-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Cyclohexanecarboxylic acid<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid, Technical Grade (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3,5-DINITRO-4-HYDROXYBENZOIC ACID (cas# 1019-52-9) is a useful research chemical.<br></p>

<p>Applications A naturally occurring chelation agent.<br>References Boonme, P., et al.: J. Biomed. Nanotechnol., 5, 373 (2009), Noh, J., et al.: Bioorg. Med. Chem., Lett., 19, 5586 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.<br></p>

<p>Applications Perfluorohexanoic Acid is a perfluorinated compound (FPC) that can cause acute toxicity to humans and the environment. Perfluorohexanoic Acid is also used as a reagent in the synthesis of 3,3,4,4,5,5,6,6,7,7,7-Undecafluoro-2-heptanol (U787500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Latala, A., et al.: Environ. Toxicol. Phar., 28, 167 (2009); Mulkiewicz, E., et al.: Environ. Toxicol. Phar., 23, 279 (2007)<br></p>

<p>Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.<br></p>

<p>Applications ethyl 2-azidoacetate (cas# 637-81-0) is a useful research chemical.<br></p>

<p>Applications Boric Acid is a common chemical component in insecticides, specifically for flea erradication. Also has the properties of an effective flame retardant.<br>References Hinkle, N. et al.: J. Med. Entomol., 32, 424 (1995); Dogan, M. et al.: Polym. Degrad. Stab., 99, 12 (2014);<br></p>

<p>Applications A redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gough, J.D., et al.: JACS, 124 (15), 3885 (2002)<br></p>

<p>Applications 2-Tetrahydrofuroic acid is used as a reagent to synthesize Alfuzosin (HCl: A532000), an unselective alpha-1 blocker that is used to treat lower urinary tract symptoms and benign prostatic hyperplasia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Grasso, M., et al.: Arch. Esp. Urol., 48, 97 (1994); Roehrborn, C., et al.: BJU Int., 92, 257 (2003)<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.<br></p>

<p>Applications DL-3-Aminoisobutyric acid (cas# 144-90-1) is a useful research chemical.<br></p>

<p>Applications 3-Mercaptopropionic Acid (cas# 107-96-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-butoxyacetic acid (cas# 2516-93-0) is a useful research chemical.<br></p>

<p>Applications A benzoic acid derivative used in photolysis reactions and biomaterial studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wetzels, G.M. et al.: Biomaterials., 20, 1879 (1999); Mao, C. et al.: Adv. Coll. Int. Sci., 110, 5 (2004);<br></p>

<p>Stability Stench<br>Applications 2,2-Dimethylcyclopropylcarboxylic acid<br></p>

<p>Applications 4-(Benzyloxy)butanoic acid<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications 2,4-Dioxo-4-phenylbutanoic acid<br></p>

<p>Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid (cas# 16837-14-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dihydroxybenzoic acid is a useful synthetic intermediate. An organic building block for plastics and rubber products.<br>References Gautam, R., et al.: Cryst. Growth Des., 18, 1501 (2018); Shvedene, N. V., et al.: J. Anal. Chem., 72, 95 (2017);<br></p>

<p>Applications A solid phase organic linker for synthesis of tethering carboxylic acids to support.<br>References Backes, B.J. and Ellman, J. A.: J. Org. Chem., 64, 2322 (1999)<br></p>

<p>Applications 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic Acid is a reagent used in the preparation of hapten and immunogen for the production of polyclonal antibodies, specific to Cypermethrin (C989000).<br>References Lee, N. et al.: J. Agri. Food Chem., 46, 520 (1998); Hongsibsong, S. et al.: Int. J. Agri. Biol., 14, 246 (2012);<br></p>

<p>Applications Intermediate in the preparation of Camostat metabolites.<br>References Bodor, N., et al.: Pharm. Res., 3, 120 (1984), Han, L., et al.: Biochem., 46, 1432 (2007),<br></p>

<p>Applications 3-(methylamino)-3-oxopropanoic acid (cas# 42105-98-6) is a useful research chemical.<br></p>

<p>Applications Methyl-3-hydroxyisothiazole-5-carboxylate (cas# 100241-89-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Trimesinic Acid is used for multifunctional therapeutics. It shows inhibitory activity against Torpedo Californica acetylcholinesterase and prevented amyloid-β peptide aggregate formation.<br>References Peckels, C., et al.: Curr. Enz. Inhib., 9, 67 (2013)<br></p>

<p>Applications 2-(2-ethoxyethoxy)acetic acid (cas# 7743-94-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>

<p>Applications 4-Pyridylthioacetic Acid (cas# 10351-19-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Nonadecanedioic Acid (cas# 6250-70-0) is a useful research chemical.<br></p>

<p>Applications (±)-Jasmonic Acid can be used as reactant/reagent for synthetic preparation of fluorescent-labeled jasmonate and application to fluorescent imaging in cabbage seedlings.<br>References Liu, S., et al.: Tetrahedron Lett., 53, 4235-4239 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications Perfluorobutanesulfonic acid (PFBS) is a stable fluorosurfactant because of the strength of carbon–fluorine bonds. PFBS has served as a replacement for the persistent, toxic, and bioaccumulative perfluorooctanesulfonic acid (PFOS) in 3M's Scotchgard stain repellents. PFBS is neither toxic nor bioaccumulative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Renner R., et al.: Environ. Sci. Technol., 40, 12 (2006), Betts, K.S., et al.: Environ. Health Perspect., 115, 250 (2007),<br></p>

<p>Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.<br>References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)<br></p>

<p>Applications Crotonic Acid is found in water extracts from carrot seeds (Daucus carota L.) and is shown to have strong herbicidal properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jasicka-Misiak, I., et al.: Phytochemistry, 66, 1485 (2005)<br></p>

<p>Applications A metabolite of aldehydes.<br>References Shiobara, Y., et al.: Xenobiotica, 9, 157 (1979),<br></p>

<p>Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).<br>References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)<br></p>

<p>Applications Monohydrazide Adipic Acid is a synthetic reagent and a plant growth retarding agent.<br>References Ye, W-L., et al.: J. Pharm. Sci, 104, 2293-2303 (2015);<br></p>

<p>Applications Polyphosphoric Acid is a ligand used as an analytical tool to image nanoparticles through photon emission topography. Used also in the synthesis of pharmaceuticals.<br>References Peng J. et al.: Biomat., 37, 9535 (2013);<br></p>

<p>Applications o-Arsanilic Acid is an organoarsenic compound. o-Arsanilic Acid is a highly toxic contaminant and can be found in plants growing in contaminated soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, A.-C. et al.: Chemosphere, 73, 1781 (2008);<br></p>

<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>

<p>Applications (8Z,11Z,14Z)-8,11,14-Heptadecatrienoic Acid, is a naturally occurring hydroxylated fatty acid that is found in Acinetobacter species. It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro. It also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.<br>References Moss, C.W., et al.: J. Clin. Microbiol. 26(3), 484-492 (1988).; Kaspersen, M.H., et al.: Med. Chem. Commun. 8(6), 1360-1365 (2017).<br></p>

<p>Applications Fendizoic Acid is a reagent in the synthesis of fluorinated polyphthalazinone ethers containing perfluorophenylene moieties.<br>References Lu, Z., et al.: J. Polym. Sci. A1, 42, 925 (2004)<br></p>

<p>Applications Dihydroresorcylic Acid is a useful reagent in detecting proteins in living cells.<br>References Reddie, K., et al.: Mol. Biosys., 4, 521-531 (2008); Seo, Y., et al.: Bioorg. Med. Chem. Lett., 19, 356-359 (2009);<br></p>

<p>Applications 3,3-Dimethylbutyric Acid is used in the synthesis of imidazo[4,5-c]pyridine derivatives as anitmicrobial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jose. G., et. al.: Eur. J. Med. Chem., 77, 288 (2014)<br></p>

<p>Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.<br></p>

<p>Applications 3-(Phenylthio)acrylic Acid (cas# 63413-91-2) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.<br></p>

<p>Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.<br></p>

<p>Applications A metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>

<p>Stability Air Sensitive<br>Applications Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, T.R. et al.: Bull. Kor. Chem. Soc., 3, 162 (1982); Badr, M.Z.A. et al.: Bull. Chem. Soc. Jap., 56, 326 (1983); Langler, R.F. et al.: Can. J. Chem., 57, 3193 (1979);<br></p>

<p>Applications 7H-Dodecafluoroheptanoic Acid is a derivative of Heptanoic Acid (H998455) which can be used as an organic building blocks for the synthesis of variety of chemical compounds. Heptanoic Acid is used in the synthesis of 17-epi-Testosterone Enanthate (T155095). It is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. It is also one of many additives in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anneken, D. et al.: Fatty Acids, Ullmann's Encyclopedia of Industrial Chemistry (2006); Wudy, S., et al.: Steroids, 66, 759 (2001); Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007); Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009)<br></p>

<p>Applications tert-butyl N-[3-(chlorosulfonyl)propyl]carbamate (cas# 1196153-59-9) is a useful research chemical.<br></p>

<p>Applications 2-Amino-2-phenylbutyric acid 96% (cas# 5438-07-3) is a useful research chemical.<br></p>

<p>Applications Hexanedioic Acid Mono(4-hydroxybutyl) Ester is an intermediate in the synthesis of aliphatic polyesters.<br>References McCabe, R. W., et al.: Tetrahedron., 60, 765 (2004);<br></p>

<p>Applications (S)-2-Amino-4-[(3-aminopropyl)amino]-butanoic Acid is used in the reaction of carboxynorspermidine decarboxylase of Vibrio alginolyticus.<br>References Nakao, H., et al.: J. Gen. Microbiol. 136, 1699-704 (1990)<br></p>

<p>Applications PERFLUORO-3,6-DIOXAHEPTANOIC ACID (cas# 151772-58-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-DIAMINOPTERIDINE-6-CARBOXYLIC ACID (cas# 716-74-5) is a useful research chemical.<br></p>

<p>Applications 2-Oxohexanoic Acid (cas# 2492-75-3) has been useful in a biological study that investigated the impact of glutathione on wines oxidative stability.<br>References Nikolantonaki, M., et al.: Front. Chem. (Lausanne, Switzerland), 6, 182 (2018)<br></p>

<p>Applications tert-Butyl [(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate Oxalate is a starting material and useful building block of various pharmaceuticals.<br></p>

<p>Stability Volatile<br>Applications Methyl Acetate is used as an organic chemical solvent for a multitude of organic processes. Also used in the production of biodiesel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, Y. et al.: J. mol. Cat., 32, 241 (2005); Ogino, H. et al.: J. Biosci. Bioeng., 89, 451 (2000);<br></p>

<p>Applications trans-3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is a reagent used in the synthesis of indanyl insecticides.<br></p>