Carboxylic Acids

<p>Applications Magnesium Monoperoxyphthalic Acid Hexahydrate is used as an oxidant in various synthetic reactions. For example: it is a mild and efficient oxidant for the synthesis of selenones which are useful synthetic intermediates in the synthesis of different heterocyclic compounds.<br>References Temperini, A., et al.: Beilstein J. Org. Chem., 10, 1267 (2014); Salvador, J.A.R., et al.: Beilstein J. Org. Chem., 8, 164 (2012); Carvalho, J.F.S., et al.: Tetrahedron, 65, 2773 (2009)<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Isostearic Acid may be a useful reagent in the regioselective preparation of alkenes via photoredox/cobaloxime dual-catalytic decarboxylative elimination of carboxylic acids,<br>References Cartwright, K. C., et al.: Chem. Eur. J., 26, 12454 (2020)<br></p>

<p>Applications (S)-2-Acetamido-5-ureidopentanoic Acid (cas# 33965-42-3) is a useful research chemical.<br></p>

<p>Applications (S)-2-Amino-4-[(3-aminopropyl)amino]-butanoic Acid is used in the reaction of carboxynorspermidine decarboxylase of Vibrio alginolyticus.<br>References Nakao, H., et al.: J. Gen. Microbiol. 136, 1699-704 (1990)<br></p>

<p>Applications 2-Cyclopentyl-2-hydroxy-2-phenylacetic Acid is an impurity of Glycopyrrolate (G657000), a novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints. It is used in the synthesis of muscarinic M3 receptor antagonists.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995); Kumar, N. et al.: Bioorg. Med. Chem. Lett., 17, 5256 (2007);<br></p>

<p>Applications 2-Azidobenzoic Acid (cas# 31162-13-7) is a useful research chemical.<br></p>

<p>Applications Hydrazine acetate (cas# 7335-65-1) is a useful research chemical.<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>

<p>Applications (2E)-2,4-Pentadienoic Acid (cas# 21651-12-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A metabolite of Trimebutine (T795605(P)), which is an opioid receptor agonist and an antispasmodic.<br>References Dieks, H., et al.: J. Labelled Comp. Radiopharm., 28, 1093 (1990), Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>

<p>Applications ACETOACETIC ACID ISOAMYL ESTER (cas# 2308-18-1) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Cyano-2-oximinoacetate is an intermediate in synthesizing 2-Cyano-2-(methoxyimino)acetic Acid (C989423), which is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Impurity Sertraline EP Impurity E<br>Applications (R)-(-)-Mandelic Acid (Sertraline EP Impurity E) is an antiseptic (urinary).<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),<br></p>

<p>Applications 2-(4-Hydroxycyclohexyl)acetic acid (cas# 99799-09-4) is a useful research chemical.<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications 2-(Hydroxyimino)-3-phenylpropanoic acid (cas# 3682-17-5) is a useful research chemical.<br></p>

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Applications 2-hydroxyhexanoic acid (cas# 6064-63-7) is a useful research chemical.<br></p>

<p>Applications 2-aminobenzene-1,4-disulfonic acid (cas# 98-44-2) is a useful research chemical.<br></p>

<p>Applications Ethyl difluoroacetate<br></p>

<p>Applications 4-(Benzyloxy)butanoic acid<br></p>

<p>Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q. et al.: Carbon, 54, 36 (2013);<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>

<p>Applications 5-(3-hydroxyphenyl)pentanoic acid (cas# 31129-95-0) is a useful research chemical.<br></p>

<p>Applications (2E)-3-Phenyl-2-propenoic Acid is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.<br>References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);<br></p>

<p>Applications A metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>

<p>Stability Moisture Sensitive<br>Applications Perfluorobutanesulfonic acid (PFBS) is a stable fluorosurfactant because of the strength of carbon–fluorine bonds. PFBS has served as a replacement for the persistent, toxic, and bioaccumulative perfluorooctanesulfonic acid (PFOS) in 3M's Scotchgard stain repellents. PFBS is neither toxic nor bioaccumulative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Renner R., et al.: Environ. Sci. Technol., 40, 12 (2006), Betts, K.S., et al.: Environ. Health Perspect., 115, 250 (2007),<br></p>

<p>Applications p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.<br>References Karimi, F., et al.: J. Chem. Pharm. Res., 7, 1028 (2015); Zheng, F., et al.: Guangdong Huagong, 42, 27 (2015);<br></p>

<p>Stability Light Sensitive<br>Applications (2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic Acid, is a reagent used as an analytical standard.<br></p>

<p>Applications Hydrazine derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-(ETHOXYCARBONYL)BENZOIC ACID (cas# 713-57-5) is a useful research chemical.<br></p>

<p>Applications Parabanic acid appears to be an important marker of free radical reactions in vivo and may be used to monitor free radical activity and to evaluate pharmacological therapy with radical scavengers.<br>References Koumoto, Y., et al.: J. Biol. Chem., 276, 29688 (2001), Gibon, Y., et al.: Plant Cell, 16, 3304 (2004), Kaplan, F., et al.: Plant J., 44, 730 (2005), Ishii, N., et al.: Science, 316, 593 (2007),<br></p>

<p>Applications A solid phase organic linker for synthesis of tethering carboxylic acids to support.<br>References Backes, B.J. and Ellman, J. A.: J. Org. Chem., 64, 2322 (1999)<br></p>

<p>Applications 2-(carboxymethyldisulfanyl)acetic acid (cas# 505-73-7) is a useful research chemical.<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of Camostat metabolites.<br>References Bodor, N., et al.: Pharm. Res., 3, 120 (1984), Han, L., et al.: Biochem., 46, 1432 (2007),<br></p>

<p>Impurity Orlistat USP Related Compound B<br>Applications Orlistat USP Related Compound B<br></p>

<p>Applications 7-Benzothiazolecarboxylic Acid is an intermediate used in the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). It is also used to prepare aminofuro-pyridine derivatives as inhibitors of TAK1.<br>References Huynh, T., et al.: Bioorg. Med. Chem. Lett., 19, 2924 (2009); Horneberger, K., et al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications A phosphonic acid derivative for development of biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),<br></p>

<p>Applications (E)-Cyano(methoxyimino)-acetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Applications 3-(4-tert-Butylbenzene)propionic Acid (cas# 1208-64-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications Used for the preparation of bisphosphonic acid derivatives as anti-osteoporosis agents.<br>References Amin, D., et al.: Drug Res., 46, 759 (1996), Martin, M., et al.: J. Med. Chem., 45, 2904 (2002),<br></p>

<p>Applications DL-p-Hydroxyphenyllactic Acid is used as a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis.<br>References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)<br></p>

<p>Applications 3-(Phenylthio)acrylic Acid (cas# 63413-91-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications α-Aleuritic acid is a major ingredient of shellac and is also a starting reagent in the manufacture of perfumes.<br>References Jakubowska, M., et al.: Polimery ., 15, 295 (1970); Shamsuzzaman, L.A., et al.: Pakistan. J. Biol. Agri. Sci., 11, 68 (1968);<br></p>

<p>Applications Decanoic acid is used in manufacturing of esters for artificial fruit flavors and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications A redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gough, J.D., et al.: JACS, 124 (15), 3885 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications Methane disulfonic acid is used in esterification.<br></p>

<p>Applications Morpholin-​4-​yl Acetic Acid was used in preparation of pyrrolidine-fused fullerene multicarboxylates by photoreaction.<br>References Gan, L., et al.: J. Org. Chem., 63, 4240 (1998).<br></p>

<p>Applications 4-(Methoxymethyl)benzoic acid<br></p>

<p>Applications 6-Bromo-2-napthoic Acid is used in the preparation of Adapalene, a synthetic aromatic retinoid with specificity for RARβ and RARγ receptors.<br>References Milanese, A. et al.: Bioorg, Chem., 39, 151 (2011);<br></p>

<p>Applications Tiglic acid is the stable isomer of angelic acid. Tiglic acid was found as glyceride in croton oil, as butyl ester in the oil of the Roman camomile, and as geranyl tiglate in oil of geranium. Tiglic acid is formed during the charcoaling of maple wood.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bueding, et al.: J. Biol. Chem., 202, 505 (1953),<br></p>

<p>Applications 3-Amino-4-(carboxymethyl)benzoic acid<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid is a compound useful in organic synthesis.<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.<br></p>

<p>Applications Hexacosanoic acid ((1S,2S,3R)-2,3-dihydroxy-1-hydroxymethyl-heptadecyl)-amide is a ceramide found in the moro blood orange (Citrus sinensis). It is a useful building block used in the preparation of 5-thio-α-GalCers as immunostimulators for IFN-​γ production stimulation in mouse NKT cells.<br>References Bi, J.; et al.: ACS Med. Chem. Lett., 6, 476 (2015); Valsecchi, M.; et al.: J. Agric. Food Chem., 60, 10103 (2012).<br></p>

<p>Applications 2-​[(2-​Hydroxyethyl)​octadecylamino]​ethyl ester octadecanoic acid is used as a modifier to Polymer films of LDPE and ethylene-​vinyl acetate copolymers (EVA) to enhance antifog properties.<br>References Irusta, L., et al.: J. Appl. Polym. Sci., 111, 2299-2307 (2009);<br></p>

<p>Applications Diagnostic determination of Melamine and related compounds in kidney tissue.<br>References Mast, R., et al.: Food Chem. Toxicol., 21, 807 (1983), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000), Ehling, S., et al.: Food Addit. Contam., 24, 1319 (2007), Vail, T., et al.: J. Anal. Toxicol., 31, 304 (2007),<br></p>

<p>Applications (cas# 526-83-0) is a useful research chemical.<br></p>

<p>Applications Butylboronic Acid is a boronic acid derivative that can be used as a transport carriers in membrane-based sugar separations. Butylboronic Acid is used as an analytical reagent in the determination of serum glucose.<br>References Smith, B.D. et al.: ACS Symp. Ser., 642, 194 (1996); Prendergast, J.L. et al.: Anal. Bional. Chem., 397, 1779 (2010);<br></p>

<p>Applications 2-(2-butoxyethoxy)acetic acid (cas# 82941-26-2) is a useful research chemical.<br></p>

<p>Applications 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>

<p>Applications tert-Butyl [(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate Oxalate is a starting material and useful building block of various pharmaceuticals.<br></p>

<p>Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.<br></p>

<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>

<p>Applications 1,1-Cyclohexanediacetic Acid (cas# 4355-11-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(2-Amino-ethyl)-benzoic Acid is a useful reagent for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Applications 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid has been used in synthesis of; GdDOTAGA(C18)2: an efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes; bifunctional prochelators for coupling to bioactive peptides for radiometal labeling; DOTAGA-anhydride, building block for prepn. of DOTA-like chelating agents.<br>References Filippi M., et al., ChemComm., 51, 17455-17458 (2015); Eisenwiener K. P., et al., Bioorg. Med. Chem. Lett., 10, 2133-2135 (2000); Bernhard C., et al., Chem. Eur. J., 18, 7834-7841 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Carboxamidobenzoic acid<br></p>

<p>Applications Tetradecanedioic acid (cas# 821-38-5) is a useful research chemical.<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-[(6-Aminohexyl)amino]-6-oxo-hexanoic acid is a nylon oligomer with flame retardant properties.<br>References Zahn, Helmut et al.: Chemische Berichte, 92, 1381 (1959)<br></p>

<p>Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.<br>References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)<br></p>

<p>Applications ethyl 2-cyclopropyl-2-hydroxyacetate (cas# 1185387-66-9) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxymandelic Acid (cas# 17119-15-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>

<p>Applications 3-Hydroxysuberic Acid is a derivative of sebacic acid (S211410) a urinary metabolite that has been identified as an anti-fatigue biomarker.<br>References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)<br></p>

<p>Applications o-Arsanilic Acid is an organoarsenic compound. o-Arsanilic Acid is a highly toxic contaminant and can be found in plants growing in contaminated soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, A.-C. et al.: Chemosphere, 73, 1781 (2008);<br></p>

<p>Stability Moisture Sensitive<br>Applications Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2.This compound is a contaminant of emerging concern (CECs).<br>References Zubkova, N., et al.: Bull. Exp. Biol. Med., 155, 821 (2013); Lin, Y., et al.: Anal. Chem., 66, 1971(1994)<br></p>

<p>Applications Ethyl 4-Phenylacetoacetate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.<br>References Kimata, A., et al.: J. Med. Chem., 50, 5053 (2007); Palanki, M., et al.: Bioorg. Med. Chme. Lett., 12, 2573 (2002)<br></p>

<p>Applications Vinyl Acetate used in the preparation of bis(heterocycles) with pyrazoline, used in the preparation of anti-inflammatory and analgesic activities. Also used in the synthesis of antimalarial compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sreenivasa, S. et al.: Open. J. Med. Chem., 3, 50 (2013); Verbrugghen, T. et al.: J. Med. Chem., 56, 376 (2013);<br></p>

<p>Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.<br>References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>

<p>Applications 4-(2,2,3-Trimethylcyclopentyl)butanoic Acid is used in preparation of Alicyclic compounds as off-note masking agent in consumables.Is used in preparation of 4-(2,2,3-Trimethylcyclopentyl)butanoic Acid as an off-note masking agent in consumables.<br>References Slack, Jay P., et al.: U.S., (2013); Slack, Jay P., et al.: PCT Int. Appl., (2008);<br></p>

<p>Stability Volatile<br>Applications 2-Pentyl Acetate has a weak banana odor. 2-Pentyl Acetate is an irritant.Environmental contaminants; food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dong, T., et al.: J. Hortic. Sci. Biotechnol. 89, 441 (2014); Xu, Z., et al.: Food Bioprocess Tech 9, 407 (2016)<br></p>

<p>Applications 4-Dodecylbenzenesulfonic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>