Carboxylic Acids

<p>Applications Maleimidoacetic Acid (cas# 25021-08-3) is a compound useful in organic synthesis.<br>References Brownlee, J., et al.: Bioorg. Chem., 34, 424 (2006),<br></p>

<p>Applications 2,4-Diaminobenzenesulfonic acid (cas# 88-63-1) is a useful reagent for improving the chlorine resistance and water permeability of polyamide (PA) membrane in water treatment.<br>References Meng, Q. W., et al.: ACS Applied Mat., 12, 35393 (2020)<br></p>

<p>Applications (R)-2-(Tetrahydropyranyloxy)propionic Acid can be employed to synthesize lactic acid oligomers, depsides, and depsipeptides on solid phase.<br>References Kuisle, O., et al.: Tetrahedron Lett. 40, 1203 (1999); Kim, S. et al. tetrahedron asymmetry 22, 1499 (2011)<br></p>

<p>Applications 4-Formylbenzenesulfonic Acid is used in preparation method for 3-Phenyl-L-serine derivatives.<br>References Xu, W., et al.:PCT Int. Appl., (2020):<br></p>

<p>Applications 6-Bromohexanoic Acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosen, D. B., et al.: PCT Int. Appl. (2020), WO 2020254617 A1<br></p>

<p>Applications 2-amino-3-hydroxy-3-phenylpropanoic acid (cas# 7695-56-9) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.<br></p>

<p>Applications Ethoxyacetic acid<br></p>

<p>Applications 2-PHENOXYBENZOIC ACID (cas# 2243-42-7) is a useful research chemical.<br></p>

<p>Applications (6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)acetic acid (cas# 877140-09-5) is a useful research chemical.<br></p>

<p>Applications 5-[2-(Trifluoromethyl)phenyl]-2-furoic Acid is a chemical reagent used in the preparation of novel TRPV1 antagonists. Also used in the preparation of potent inhibitors of FeII and MnII E, coli Methionine Aminopeptidase as antibacterial agents.<br>References Huguet, F. et al.: ChemMedChem. 7, 1020 (2012); Kim, N. et al.: Chem. Asian J., 8, 400 (2013);<br></p>

<p>Applications 3-Hydroxy-4-phenylbenzoic Acid is a useful reagent for the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channel.<br>References Hadida Ruah, S. S., et al.: U.S. Pat. Appl. Publ. (2012), US 20120196869 A1<br></p>

<p>Applications 2-hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid (cas# 101949-49-9) is a useful research chemical.<br></p>

<p>Applications 2-(Methoxyimino)-3-oxo-butanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of Cefotaxime Bromoacetyl Analogue (C242940), which is an impurity of Cefotaxime (C242950), a broad spectrum third generation cephalosporin antibiotic.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),<br></p>

<p>Impurity Ketoprofen EP Impurity G<br>Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.<br>References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.<br></p>

<p>Applications methyl 3-formylcyclohexane-1-carboxylate (cas# 50738-62-0) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 4-(2-Aminophenyl)-4-oxo-2-butenoic Acid is a novel human lens metabolite from normal and cataractous human lenses. A UV filter.<br>References Mizdrak, J., et al.: Tetrahedron, 63, 4990 (2007); Taylor, L. M., et al.: Exp. Eye Res., 75, 165 (2002)<br></p>

<p>Applications 3-Oxohexanoic Acid is an enzymatic metabolite and a building block for bacterial autoinducers.<br>References Naef, R., et al.: J. Agric. Food Chem., 56, 517-527 (2008);<br></p>

<p>Applications 2-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid (cas# 13193-24-3) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications methyl 2-(2-formylphenyl)acetate (cas# 63969-83-5) is a useful research chemical.<br></p>

<p>Applications 5-carbamoylpentanoic acid (cas# 334-25-8) is a useful research chemical.<br></p>

<p>Applications Dibenzothiophene-2-boronic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Duncton, M. A. J., et al.: Org. Lett., 10, 3259 (2008)<br></p>

<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>

<p>Applications A benzoic acid derivative used in studies relating to Human UDP-glucuronosyltransferases as well as a reagent in acylation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiong, Y. et al.: Biochemistry, 45, 2322 (2006); Chaudhary, A.G. et al.: J. Am. Chem. Soc., 116, 4097 (1994);<br></p>

<p>Applications 3,5-Dinitro-o-toluic Acid is used to gather data for partition coefficients of solutes and vapors into anhydrous THF and 1,4-dioxane using Abraham model.<br>References Saifullah, M., et al.: J. Solution Chem., 40, 2082 (2011);<br></p>

<p>Applications Pentachlorophenyl Cyanoacetate is an intermediate used in the synthesis of Cefacetrile (C231500), which is a cephalosporin antibiotic. Antibacterial.<br>References Dajan, A., et al.: Vet. Microbiol., 35, 213 (1993), Becker, M., et al.: Anal. Chim. Acta, 520, 19 (2004), El-Shaboury, S., et al.: J. Pharm. Biomed. Anal., 45, 1 (2007),<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications Phenylmethyl ester N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-Carbamic acid is a useful chiral building block. It has been used in the synthesis of all-cis carbocyclic precursor of ticagrelor via oxidation/stereoselective reduction sequences.<br>References Wlodarczyk, J.; et al.: Tet. Lett., 56, 6093 (2015).<br></p>

<p>Applications 2-Cyclohexylvinylboronic Acid is used in the synthesis of vinylbenziodoxolones, a novel type of hypervalent iodine(III) reagents.<br>References Stridfeldt, E., et al.: Chem. Eur. J., 22, 16066-16070 (2016)<br></p>

<p>Applications Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.<br>References Qi, J.L., et al.: Euro. J. Medn. Chem., 46, 934 (2011); Schirlin, D., et al.: J. Enzymes. Inhibition., 1, 243 (1987);<br></p>

<p>Applications 2-Pyridylphosphonic Acid is used as ligand in the hydrothermal preparation of copper(II)-lanthanide(III) and zinc(II)-lanthanide(III) pyridylphosphonate coordination polymers.<br>References Ma, Y., et al.: Chem. Eur. J., 13, 4759 (2007);<br></p>

<p>Applications Isopropenylboronic Acid Pinacol Ester, can be used as an intermediate in the synthesis of variety of cyclic and acyclic organic compounds. It is also shown that the α-Substituted Allyl/Croty of this compound can be used for highly Diastereo- and Enantioselective allylboration of aldehydes.<br>References Salaun, J. et al.: Topics in Curr. Chem. 1, 144 (1988); Chen, J. et al.: J. Amer. Chem. Soci., 135, 5316 (2013);<br></p>

<p>Applications tert-Butyl (Trimethylsilyl)acetate is used to prepare lithium enolates, and is also a useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rathke, M. &amp; Elghanian, R. tert-Butyl Trimethylsilylacetate In Handbook of Reagents for Organic Synthesis: Reagents for Silicon-Mediated Organic Synthesis; Fuchs, P.; Wiley, 2011; 147-148<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications 6-Bromo-2-chloronicotinic acid<br></p>

<p>Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.<br>References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications 6-Fluoronicotinic acid<br></p>

<p>Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.<br>References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);<br></p>

<p>Applications DL-3-(Benzylthio)lactic Acid is used in the preparation of somatostatin analogs, affecting growth hormones.<br></p>

<p>Applications 3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, J., et al.: Acta Crystallogr. B., 66, 3281 (2010)<br></p>

<p>Applications (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic Acid (cas# 155-84-0) is a useful research chemical.<br></p>

<p>Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications tert-Butyl (((mesityl)sulfonyl)oxy)carbamate is a useful reagent for the enantioselective aziridination of α,β-unsaturated aldehydes.<br>References Arai, H., et l.: Tetrahedron Lett., 50, 3329(2009)<br></p>

<p>Applications Benzyl Acetoacetic Amide (cas# 882-36-0) is a compound useful in organic synthesis.<br>References Sakaki, J., et al.: Chem. Pharm. Bull., 37, 2952 (1989),<br></p>

<p>Applications 4-(Methylamino)benzoic Acid (cas# 10541-83-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloropentyl acetate is a Friedel-Crafts haloalkyl ester with antibacterial properties.<br></p>

<p>Applications 3-hydroxybutanoic acid (cas# 300-85-6) is a useful research chemical.<br></p>

<p>Applications N-M-Tolylphthalamic Acid is used to prevent premature drop an anti shock treatment for pants. On ingestion is hydrolyzed to produce m-toluidine<br>References Pawar, G., et al.: Synth. Comm., 32, 1929-1936 (2002)<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid (V850000); a lichen metabolite with anti-inflammatory properties.<br>References Shachak, M., et al.: Science, 236, 1098 (1987); Froberg, L., et al.: Lichenologist, 25, 83 (1993); Hesbacher, S., et al.: J. Chem. Ecology, 21, 233 (1995)<br></p>

<p>Applications 3-(Diethylphosphono)propanoic acid<br></p>

<p>Applications 2-(1,3-BENZOTHIAZOL-2-YLTHIO)SUCCINIC ACID (cas# 95154-01-1) is a useful research chemical.<br></p>

<p>Applications 2-Aminobenzeneboronic acid pinacol ester is a reagent used to synthesize regiospecific quinolines. It can also be used to synthesize (±)-Epimeloscine and (±)-Meloscine.<br>References Zhang, H., et al.: J. Am. Chem. Soc. 133, 10376 (2011); Horn, J., et al.: Org. Lett 10, 4117 (2008)<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 9-Ethyl-9H-carbazole-3-carboxylic Acid is a useful reagent for the preparation of an oxime ester photoinitiator.<br>References Hu, C., &amp; Yu, P.: Faming Zhuanli Shenqing (2020), CN 111320714 A<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications 5-(aminomethyl)-2-furoic acid hydrochloride (cas# 934-65-6) is a useful research chemical.<br></p>

<p>Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.<br>References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);<br></p>