Carboxylic Acids

<p>Applications (-)-DIBENZOYL-L-TARTARIC ACID MONOHYDRATE (cas# 62708-56-9) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxycyclohexane-1-carboxylic acid<br></p>

<p>Applications 3-(Cyclopropylaminocarbonyl)phenylboronic acid<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications (2S,2aR,2aS,8aR)-2a-(2-((Cyclopropylmethyl)(methyl)amino)ethyl)-2,4,8a-trihydroxy-2,2a,8a-tetrahydro-1H-indeno[1,7,6-bcd]benzo-2-carboxylic Acid is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium, Inner Salt (C176953), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).<br>References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)<br></p>

<p>Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.<br></p>

<p>Applications 1-Hydroxycyclopentanecarboxylic Acid is a reagent used in the preparation of pyridone-conjugated monobactam antibiotics showing gram-negative activity.<br>References Brown, M. et al.: J. Med. Chem., 56, 5541 (2013); Rozhko, E. et al.: ChemCatChem., 5, 1998 (2013);<br></p>

<p>Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.<br>References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)<br></p>

<p>Applications 3-(3-Furyl)acrylic Acid is a reactant in the preparation of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.<br>References Hornberger, K.R., et. al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications 3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, J., et al.: Acta Crystallogr. B., 66, 3281 (2010)<br></p>

<p>Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.<br></p>

<p>Applications Used for preparation of Terfenadine (T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications tert-Butyl (2-((4-Aminophenyl)amino)-2-oxoethyl)carbamate is an intermediate in the synthesis of (E)-2-Formamido-N-(4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)acetamide (F792100), a compound useful in organic synthesis.<br></p>

<p>Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.<br>References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);<br></p>

<p>Applications ethyl (4-aminophenyl)carbamate (cas# 57399-97-0) is a useful research chemical.<br></p>

<p>Applications 2-Phenylthio-5-propionylphenylacetic Acid is a useful synthetic intermediate in the synthesis of Zaltoprofen (Z146000); an inhibitor of Cox-1 and Cox-2. Zaltoprofen preferentially inhibits Cox-2.<br>References Chen, W., et al.: Faming Zhuanli Shenqing. CN 1986528 A 20070627. Jun 27, 2007; Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000)<br></p>

<p>Stability Store in Freezer<br>Applications A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br></p>

<p>Applications 4-Acetylbutyric Acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. Also used to prepare PARP inhibitors for the treatment of cancer as well.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Zhu, G. et al.: Bioorg. Med. Chem., 20, 4653 (2012);<br></p>

<p>Applications Methyl 5-Chloro-3-(Chlorosulfonyl)Thiophene-2-Carboxylate (cas# 126910-68-7) is a useful research chemical.<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Applications p-Cyanobenzoic Acid Trimer is used in the synthetic preparation of Terbium Triazinetribenzoate Formate Metal Organic Framework (MOF).<br>References Han, Y., et al.: J. Mater. Chem. A Mater. Energy Sustain., 3, 24525 (2015)<br></p>

<p>Applications (+)-Dibenzoyl-D-Tartaric Acid Monohydrate (cas# 80822-15-7) is a useful research chemical.<br></p>

<p>Applications 3-(Diethylphosphono)propanoic acid<br></p>

<p>Applications 4'-Hydroxybiphenyl-3-carboxylic Acid is a biaryl compound that can be prepared via palladium bis[(dipiperidinylphosphino)amino]phenyl-catalyzed Suzuki-Miyaura cross coupling reactions of organoboronic acids or trifluoroborates and aryl bromides and can also be synthesized by simultaneous hydroxylation and carboxylation of biphenyls. 4'-Hydroxybiphenyl-3-carboxylic Acid is a useful building block with applications in various syntheses.<br>References Shibahara, F., et al.: Org. Lett., 6, 2437 (2004); Bolliger, J., Frech, C.: Adv. Synth. Catal., 352, 1075 (2010);<br></p>

<p>Applications 2-Amino-4-hydroxybenzoic acid (cas# 38160-63-3) is a useful research chemical.<br></p>

<p>Applications cis-10-Pentadecenoic Acid is a monounsaturated fatty acid, that can inhibits IFN-γ-induced production of kynurenine in Thp-1 cells by 16%.<br>References Costabile M. et al.: Prostaglandins Leukot. Essent. Fatty Acids 122, 7-15 (2017).;<br></p>

<p>Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);<br></p>

<p>Applications 4-Carboxyphenylboronic acid is a reagent used in suzuki coupling reactions.<br>References Hu, Z., et al.: Wuji Huaxue Xuebao, 34, 387 (2018); Ibrahim, M., et al.: J. Organomet. Chem., 859, 44 (2018); Erami, R. S., et al.: Catalysts, 7, 76 (2017)<br></p>

<p>Applications 2,4,5-TRIMETHOXYBENZOIC ACID (cas# 490-64-2) is a useful research chemical.<br></p>

<p>Applications 2-PHENYLNICOTINIC ACID (cas# 33421-39-5) is a useful research chemical.<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications 2-Isopropoxy-2-phenylacetic acid<br></p>

<p>Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Ethenyl Ester (cas# 865860-80-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Acetamidomethyl)benzoic acid<br></p>

<p>Applications Useful in the preparation of substances with antiinflammatory activity.<br></p>

<p>Applications 3-Furoic Acid, is metabolized by Corynebacterium fascians from soil, limonoid metabolism based on a biological studies.<br>References Hasegawa, S., et al.: J. Arg. Food Chem., 31, 807 (1983)<br></p>

<p>Applications 4-(2,3-Dihydro-1H-indol-1-yl)-4-oxobutanoic Acid (cas# 105105-00-8) could be useful in biological studies. It has been used to screen and target LsrK kinase inhibitors.<br>References Medarametla, P., et al.: ChemMedChem, 13, 2400 (2018)<br></p>

<p>Stability Very Very Moisture sensitive<br>Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);<br></p>

<p>Applications 2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.<br>References Luo, J., et al.: Nat. Chem., 8, 1027 (2016)<br></p>

<p>Applications 4-(dimethylamino)-3-nitrobenzoic Acid (cas# 28096-56-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2,​2-​Bis(hydroxymethyl)​propionic Acid is a reagent used in the synthesis of disulfide monomers for cross-linked poly(urethane-urea) coatings.<br>References Nevejans, S. et al.: Polym., 166, 229 (2019);<br></p>

<p>Applications 4-Hydroxybut-2-ynoic Acid (cas# 7218-52-2) is a useful reagent for the green preparation of polyseleno-substituted enamines.<br>References Wang, Y. C., et al.: Green Chem., 20, 604 (2018)<br></p>

<p>Applications Phenylmethyl ester N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-Carbamic acid is a useful chiral building block. It has been used in the synthesis of all-cis carbocyclic precursor of ticagrelor via oxidation/stereoselective reduction sequences.<br>References Wlodarczyk, J.; et al.: Tet. Lett., 56, 6093 (2015).<br></p>

<p>Applications 1,2,4-Benzenetricarboxylic acid 1,2-Dihexyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid (cas# 189365-92-2) is a useful research chemical.<br></p>

<p>Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.<br>References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications 4-Thiazolecarboxylic Acid (cas# 3973-08-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Diphenylphosphoryl)acetic acid (cas# 1831-63-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Diphenylphosphinodithioic acid is used in the extraction of rhodium from nitrate media using phosphinic acids. It also functions as a new materials for microelectronic and molecular electronic devices.<br>References Samuels, A. C., et al.: Solvent Extraction and Ion Exchange, 33, 418 (2015)<br></p>

<p>Applications Methyl Diethylphosphonoacetate (cas# 1067-74-9) is a useful research chemical.<br></p>

<p>Applications Diethyl 1,1-Cyclopropanedicarboxylate (cas# 1559-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 2-Benzylacetoacetate (cas# 620-79-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.<br>References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);<br></p>

<p>Applications 4,5-Dimethoxy-2-nitrobenzoic Acid (cas# 4998-07-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY.<br>References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)<br></p>

<p>Stability Moisture Sensitive, Air Sensitive<br>Applications As-Methyl Arsonothioic Acid is used as a standard for arsenic inspection. It is used as an aid to help in determining the level of toxicity in humans. Metabolite in some mammals and microbiota.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naranmandura, H. et al.: Chem. Res. Toxicol., 24, 1586 (2011); Bu, N. et al.: Metallom., 3, 1064 (2011);<br></p>

<p>Applications 2-Phenoxypropionic Acid is used in organic chemistry reduction reactions. Used in the synthesis of PPAR (peroxisome proliferator-activated receptor (PPAR) ligands.<br>References Brown, P. et al.: Synthesis., 7, 778 (1997);<br></p>

<p>Applications (2E,​4E)​-2,​4-​Tetradecadienoic acid is used as a reactant in polymerization reactions such as the syntheses of monoacylglycerol and 1,​2-​diacyl-​sn-​glycerol.<br>References Matsumoto, A., et al.: Polym. J., 35, 652-61 (2003); Srisiri, W., et al.: J. Org. Chem. 61, 5911-15 (1996)<br></p>

<p>Applications A useful synthetic intermediate.<br>References Li, A., et al.: J. Med. Chem., 42, 706 (1999), Low, E., et al.: Bioorg. Med. Chem. Lett., 19, 196 (2009),<br></p>

<p>Applications Phenyl[2-phenylthio)phenyl]carbamate is an intermediate utilized for the synthesis of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Niphade, N.C., et al.: Org. Proc. Rsch. Dev., 13, 792 (2009); Stolarczyk, E.U., et al.: Pharm. Dev. Tech., 14, 27 (2009);<br></p>

<p>Applications 3-Hydroxyhomophthalic acid (cas# 42421-12-5) is a useful research chemical.<br></p>

<p>Applications 2-Cyclohexylideneacetic acid (cas# 1552-91-6) is a useful research chemical.<br></p>