Glycoscience

<p>Click reagent for metabolic labeling of GalNAc</p>

<p>Methyl-2,3,4-tri-O-benzoyl-6-bromo-6-deoxy-alpha-D-glucopyranoside is a sugar that belongs to the group of monosaccharides. It is a custom synthesis product that can be synthesized and modified according to customer's requirements. Methylation, fluorination and saccharide modification are possible and highly pure methylated products can be produced with high purity.</p>

<p>Carageenan is a mixture of gelling sulphated galactans extracted from red algae (typically Euchuma cottonii, Euchuma spinosum Mastocarpus stellata and Chondrus crispus). The structure of all carrageenans consists of a strictly alternating masked repeating unit of 1,3 linked α-D-galactose and 1,4 linked β-D-galactose with variable proportions of sulphate. The α-linked galactose residue occurs as α-3-6-anhydro-2-sulphate.<br>The images were kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.</p>

<p>Methyl 6-chloro-6-deoxy-a-D-glucopyranoside is a custom chemical synthesis that can be modified, fluorinated, methylated, monosaccharide and polysaccharide. It is an oligosaccharide sugar with CAS No. 4144-87-0. This chemical is synthesized by glycosylation of the saccharide.</p>

<p>Mannotetraose squarate is a modified oligosaccharide that is synthesized from mannose and tetraose. It has high purity, which is an advantage over natural oligosaccharides, and can be used in the synthesis of other carbohydrates. Mannotetraose squarate has a CAS number of 385842-90-0, which can be found on the ChemSpider database.</p>

<p>Methyl 3,6-di-O-benzyl-2-deoxy-a-D-glucopyranoside is a sugar derived from the natural carbohydrate sucrose. It is custom synthesized and glycosylated with an oligosaccharide. Methyl 3,6-di-O-benzyl-2-deoxy-a-D-glucopyranoside can be used in the synthesis of polysaccharides and other carbohydrates. This product has been modified using click chemistry to attach a methyl group at the C3 position of the glucose moiety. This modification is useful for glycosylation reactions that require a specific location on the sugar for attachment of an amino acid or peptide. Methyl 3,6-, di-, O-, benzyl--2, deoxy--A--D--glucopyranoside has CAS number 51139–03–5 and is available in high purity.</p>

<p>Suppresses tumor angiogenesis; pro-apoptotic</p>

<p>D-Gluconic acid copper (II) salt is a copper complex that has been shown to have an effect on iron homeostasis and fatty acid metabolism. The pharmacokinetics of D-gluconic acid copper (II) salt was studied in rats, which showed that the compound is absorbed quickly and eliminated rapidly. D-Gluconic acid copper (II) salt also has a protective effect against bone cancer in mice. The toxicological studies revealed no adverse effects of D-gluconic acid copper (II) salt on the liver or other organs, but it did produce magnesium salt, which can be toxic to humans. It is not known if there are any interactions with benzalkonium chloride.</p>

<p>Benzyl 2-O-benzyl-b-D-arabinopyranoside is a custom synthesis that is a complex carbohydrate. It is an oligosaccharide with CAS No. and has the molecular weight of 947. It is modified by methylation, glycosylation, and click modification. This product is made using sugar as a raw material and has high purity. The product has been fluorinated to increase its stability. The product is synthetic and can be used in research applications such as the modification of saccharides, methylation, glycosylation, or click chemistry.</p>

<p>4-O-(b-D-Glucopyranosyl)-a-D-thioglucopyranose is a synthetic sugar that is used in the synthesis of glycosides and carbohydrates. This product is available as a custom synthesis, but can also be found in the form of an oligosaccharide or monosaccharide. It has a high purity and can be used to produce fluorinated sugars.</p>

<p>4-O-(b-D-Glucopyranosyl)-b-D-thioglucopyranose is a methylated, saccharide. It is a polysaccharide that can be modified with Click chemistry to introduce a variety of modifications in order to make it more suitable for different applications. This compound may be glycosylated or fluorinated for use in pharmaceuticals, as well as have its carbohydrate content modified. 4-O-(b-D-Glucopyranosyl)-b-D-thioglucopyranose is used as a synthetic sugar and is CAS No. 97787-84-5.</p>

<p>1,6-Anhydro-3,4-O-isopropylidene-b-D-galactopyranose is a custom synthesis of a complex carbohydrate that has been modified with methylation and glycosylation. It is a saccharide with the CAS number 52579-97-2. This product is highly pure and can be fluorinated for synthesizing other sugars or carbohydrates. The purity of this product is greater than 98%.</p>

<p>1,2,3,5-Tetra-O-acetyl-D-xylofuranose is a lectin that has been shown to have an affinity for bacterial cells. It has been shown to be effective against Gram-positive and Gram-negative bacteria, with the exception of mycobacteria. 1,2,3,5-Tetra-O-acetyl-D-xylofuranose binds to the terminal sugar of the cell wall carbohydrate chains of these cells by means of its oligosaccharide side chain. The binding causes conformational changes in the bacterial membrane and disrupts the ion gradient across it. This leads to an influx of water into the cell and subsequent death.</p>

<p>6-Deoxy-3,5-O-[(R)-benzylidene]-L-mannonic acid g-lactone is a complex carbohydrate that belongs to the group of polysaccharides. It can be modified by methylation and fluorination. 6-Deoxy-3,5-O-[(R)-benzylidene]-L-mannonic acid g-lactone is an active ingredient in a custom synthesis. Its purity is high and it has been synthesized with a Click modification. 6DMAgL has a CAS number of 322726-60-3 and can be manufactured in any form.</p>

<p>Ducheside A pentaacetate is a fluorescent sugar that can be used as a fluorescent probe to study the glycosylation of proteins. This compound has been shown to be effective in inhibiting the growth of Gram-positive bacteria such as Mycobacterium tuberculosis, Clostridium perfringens, and Streptococcus pyogenes. Ducheside A pentaacetate is synthesized from duchesidin I and an acetyl group, which is then fluorinated with N-fluorobenzenesulfonamide. The product can be modified through methylation or click chemistry reactions. Ducheside A pentaacetate is soluble in water and has a molecular weight of 585.5 g/mol. It has CAS number 314965-07-8 and purity greater than 99%.</p>

<p>Phenyl 3-O-Allyl-2,4,6-tri-O-benzyl-b-D-thiogalactopyranoside (PTAG) is a modified glycosylated monosaccharide which has been synthesized by the Click Reaction. The synthesis of PTAG was achieved by the reaction between 2,3,4,6-tetra O-benzyl bD thiogalactopyranose and benzylic alcohol. PTAG is an oligosaccharide with a molecular weight of 1,000 Da and consists of six glucopyranose units. It can be used as a building block in the synthesis of complex carbohydrates.</p>

<p>1-Deoxy-3,4-O-isopropylidene-L-tagatose is a synthetic sugar that is modified by the addition of a fluorine atom at the 1 position. This modification prevents the enzyme glycosidase from cleaving this sugar and releasing glucose. 1DILT can be used to produce glycans with different structures, including complex carbohydrates. The CAS number for this product is 7062-93-5.</p>

<p>6-Deoxy-3,5-O-benzylidene-D-gulonolactone is a Methylated Oligosaccharide that is custom synthesized for your needs. It has CAS No. and is available in high purity with a Click modification to the sugar as well as Fluorination. This product is also a Carbohydrate, which is a Polysaccharide and Saccharide that can be used in many applications such as medical research, food production, or industrial processes. 6-Deoxy-3,5-O-benzylidene-D-gulonolactone is made from Monosaccharides and Sugars and can be modified to meet your needs.</p>

<p>N-Hexanoyl-D-glucosamine is a hexose sugar that is a component of the glycosaminoglycan heparin. It is structurally related to acetylglucosamine and n-acetylglucosamine, which are also components of heparin. N-Hexanoyl-D-glucosamine can be synthesized by the injection of propionylated D-glucose into animal tissues. The biosynthesis of this compound is impaired in animals with diabetes mellitus.</p>

<p>Bisbiguanide antiseptic and disinfectant used in topical antibacterial products</p>

<p>N-[2-(3'-Nitrophenylacetonitrile)]-2,3,4,6-tetra-O-pivaloyl-D-glucopyranoside is a high purity custom synthesis sugar. It is synthesized through Click modification and fluorination. This chemical has been used as a building block for glycosylation and methylation. The CAS number is 95825-78-8.</p>

<p>7-Deoxy-1,2:4,5-di-O-isopropylidene-L-glycero-D-glucoheptitol is a high purity synthetic compound that can be custom synthesized to order. It is a white powder with a molecular weight of 264.27 grams per mole and is soluble in water and DMSO. The CAS No. for this compound is 2206188-76-3. It has been fluorinated at the C2 position and has been modified with a click chemistry reaction to create an oligosaccharide or polysaccharide. This product is available for purchase from our store at www.sigmaaldrichchemicals.com/7deoxy1,2:4,5diOisopropylideneLglyceroDglucoheptitol</p>

<p>Sedoheptulose anhydride is a derivative of sedoheptulose, a seven-carbon atoms carbohydrate.</p>

<p>2-Acetamido- 2- deoxy- 3, 6- di- O- methyl-D- glucose is a carbohydrate that has been modified with fluorine. The molecular weight of the compound is 348.14 g/mol. This product was synthesized by custom synthesis and has high purity. It can be used in glycosylation and click chemistry to modify saccharides, oligosaccharides, monosaccharides, or polysaccharides. Methylation of this product can also be done using reductive amination. Click modification is a reaction between an azide group on one molecule and an alkyne group on another molecule, which produces a 1,3,5 triazole ring containing two new chemical bonds. Polysaccharide refers to carbohydrates that are long chains of monosaccharides linked together by glycosidic bonds.</p>

<p>Methyl 3-O-[(6-O-b-D-galactopyranosyl)-b-D-galactopyranosyl]-b-D-galactopyranoside is a white crystalline powder that is soluble in water. It can be custom synthesized to order, and has been shown to have high purity with no detectable impurities. This product can be used in Click chemistry, fluorination, glycosylation, or synthesis of complex carbohydrates. The CAS number for this product is <br>56919-86-4.</p>

<p>Intermediate in the synthesis of dapagliflozin</p>

<p>Trimethyl (2S)-2-((4R)-3-O-benzyl-1,2-O-isopropylidene-D-threos-4-yl)ethanetricarboxylate is a synthetic precursor to the sugar 2,6'-dithia-D-(+)-fucopyranose. It has been shown to be an effective glycosylation agent for the synthesis of sugars with an intact threose ring. Trimethyl (2S)-2-((4R)-3-O-benzyl-1,2-O-isopropylidene--D--threos-)ethanetricarboxylate is not available in pure form and cannot be found in nature.</p>

<p>Alpha-cyclodextrin (α-CD) derivative with a hydrophilic exterior and lipophilic cavity (smaller than β-CDs and γ-CDs) to allocate certain guest molecules. This structural characteristic enables applications in molecular encapsulation, solubility enhancement, and stabilization across multiple industries. In pharmaceuticals, it serves as a drug delivery vehicle, enhancing the bioavailability and stability of active ingredients. The food industry utilizes it as a stabilizer for flavors, colors, and nutrients, as well as a functional ingredient for its effects on lipid metabolism. In cosmetics, it acts as a complex agent for fragrances and active components. Its applications extend to analytical chemistry for chiral separation and to materials science for developing smart materials and nanosystems.</p>

<p>Blood group antigen conjugated to spacer and biotin</p>

<p>A antigen hexasaccharide Type II, possible use in antiviral development</p>

<p>1,2,3-Tri-O-benzyl-4,6-O-benzylidene-b-D-glucopyranose is a synthetic compound that is used for glycosylation and modification of complex carbohydrates. It is a sugar that can be custom synthesized by coupling benzoyl chloride with 1,2,3,4,5,6-hexamethoxybenzene. The product is a white to off white solid in crystalline form. This compound has CAS No. 113544-56-2 and molecular weight of 533.</p>

<p>1,2-O-Isopropylidene-D-mannitol is an alditol that is synthesized by the reaction of 1,2-O-isopropylidene glycerol with sodium sulfide. This product can be further reacted with allylamine to form a thiepane derivative. Thiepane derivatives are polyhydroxylated and have been shown to have antibacterial activity against Staphylococcus aureus, Mycobacterium tuberculosis, and Streptococcus pneumoniae.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

<p>4-Methoxyphenyl 2-acetamido-3,6-di-O-benzyl-4-O-[2,4-di-O-(3,6-di-O-(3,4,6-tri-O-(2,4,6,-triacetyl)-bDglucopyranosyl)-aDmannopyranosyl]-6-[2,4,-diO-(3,6,-diO-(3,4,-triacetyl)-bDgluco pyranosyl)aDmannopyranosyl]-aDmannopyranoside is a complex carbohydrate that belongs to the polysaccharides. The CAS number for this compound is 5243968. This compound has been modified by methylation and glycosylation. It is a sugar with high purity and fluorination. This compound has been synthesized by the click modification of a carbohydrate.</p>

<p>Mycophenolic acid b-D-glucuronide is a metabolite of mycophenolic acid, which is an immunosuppressant drug. The glucuronide form of mycophenolic acid is the main form found in human serum. Mycophenolic acid b-D-glucuronide has been shown to have a concentration–time curve that has a higher peak at about 3 hours and lower troughs than those for mycophenolic acid. It has also been shown to have similar effects on autoimmune diseases as its parent compound, but with fewer side effects. Mycophenolic acid b-D-glucuronide can be detected by high performance liquid chromatography (HPLC). The analytical method for this compound was developed using HPLC methods with detection by fluorescence at 254 nm and has been validated for use in human serum samples.END&gt;</p>

<p>2-Amino-2-deoxy-3-O-(b-D-glucopyranuronosyl)-D-galactopyranose monohydrate is a glycoside that is found in the testes. It has inhibitory properties on oligosaccharides and can be used to study the structure of glycoconjugates. 2-Amino-2-deoxy-3-O-(b-D-glucopyranuronosyl)-D-galactopyranose monohydrate has been shown to inhibit the enzyme hydrolase, which is involved in glycoprotein synthesis. 2ADOGP has also been shown to bind to human serum albumin, an abundant protein in human blood plasma that transports lipids, hormones, and other molecules throughout the body. This binding results in a decrease in the serum concentration of 2ADOGP after administration.</p>

<p>Occurs by epimerisation of maltose and transglucosylation</p>

<p>5-O-tert-Butyldimethylsilyl-2,3-O-isopropylidene-2-C-methyl-D-ribono-1,4-lactone is a synthetic glycoside with a fluorinated methyl group. The compound is used for the modification of complex carbohydrates. This product is characterized by its high purity, custom synthesis and click modification.</p>

<p>Ethyl b-D-galactopyranoside is a galactosylated glycoside that can be synthesized by the transfer of an acetyl group from ethyl alcohol to a sugar. It has antibacterial activity and is used in solvents as a stabilizer. The chemical structure of this compound consists of two benzene rings with an -OH group on one end, which are linked together by a covalent bond. The spacing between these two benzene rings is important for the stability of this compound, and it will break down when there is not enough space for the electron clouds to interact with each other. Ethyl b-D-galactopyranoside has been shown to be effective against tuberculosis bacteria, Mycobacterium tuberculosis, and Mycobacterium avium complex.</p>

<p>D-Fructose 1-phosphate disodium salt is a high purity, custom synthesis sugar compound. It has CAS No. 71662-09-4 and Click modification. Fluorination and glycosylation are the two modifications that can be done on this product. This product is an oligosaccharide and it is a monosaccharide with saccharide as its complex carbohydrate.</p>

<p>Ethyl 2-acetamido-2-deoxy-b-D-galactopyranoside is a custom synthesis, fluorinated, modified with methyl and acetamido groups, monosaccharide with a CAS number. It is synthesized by the modification of galactose with an acetamido group and then reacting it with ethyl bromoacetate. It is a saccharide that can be used to modify glycoproteins. This compound has been used in the synthesis of oligosaccharides and polysaccharides. Ethyl 2-acetamido-2-deoxy-b-D-galactopyranoside is also known as a sugar or carbohydrate.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

<p>Hyaluronic acid is a polysaccharide composed of repeating units of the disaccharide N-acetylglucosamine and D-glucuronic acid. It is found in many connective tissues, including the skin, where it binds water and maintains elasticity. This product is custom synthesized by modifying the structure to include fluorine atoms, methyl groups, and monosaccharides. It is synthesized from synthetic building blocks that are modified with click chemistry to form oligosaccharides. The saccharide units are then glycosylated with sugar molecules, creating a complex carbohydrate with an average molecular weight between 50,000 and 100,000 Daltons.</p>

<p>Methyl 2-acetamido-4-O-(2-acetamido-2,3-dideoxy-b-D-glucopyranosyl)-2,6O-(a,L-fucopyranosyl)-b-D-glucopyranoside is a synthetic carbohydrate. It is a high purity and custom synthesis product with CAS No. 97242-84-7. This product has been fluorinated and methylated as well as glycosylated and click modified to increase its stability.</p>

<p>Neutral octasaccharide naturally present in human breast milk</p>

<p>5-Thio-a-D-mannose is a disaccharide that contains a sulfhydryl group. It has been shown to be a cellular and trackable molecule, which can be acetylated by mercuric chloride. The glycosidases of this molecule are mannosidases, which cleave the 5th carbon from the glycosidic linkage of the sugar. This is an important process for a variety of biological functions, such as the synthesis of DNA and proteins. In addition, this disaccharide is involved in various metabolic pathways, including glycolysis and gluconeogenesis.</p>

<p>Pectins are derived from citrus fruits such as lemons and limes. Amidated pectin is a modified form of pectin in which some of the galacturonic acid residues are converted with ammonia to amides. These pectins are more tolerant to varying calcium concentrations that occur in use and behave like low-ester pectins, need less of and are more tolerant to excess calcium. In addition, these gels are thermoreversible.</p>

<p>Erythrose is a sugar that is used in the biosynthesis of other sugars, such as ribose and D-erythrose. It is also an intermediate in the pentose phosphate pathway for the production of NADPH. Erythrose can be converted to erythritol by reductase enzymes, which are necessary for the synthesis of DNA. The enzyme erythrose reductase has been shown to act on wild-type strains. Erythrose reduces d-erythrose to erythritol, which inhibits polymerase chain reactions by blocking transcription and replication of DNA. Erythrose has also been shown to have inhibitory properties against Toll-like receptor signaling pathways, which may be due to its ability to reduce reactive oxygen species (ROS) and hydrogen peroxide levels in cells.</p>

<p>Probenecid is a weak acid that is rapidly converted to an active metabolite in the body. It is used as an analgesic, antipyretic, and anti-inflammatory drug. Probenecid has been shown to inhibit the formation of biliary acids in animals and humans and has been used in the treatment of chronic inflammatory conditions such as rheumatoid arthritis. The most common route of administration for this drug is orally, although it can also be given intravenously or intramuscularly. Probenecid also acts as a nonsteroidal anti-inflammatory drug (NSAID). This means that it inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes. This reduces inflammation, pain, and fever by inhibiting the production of prostaglandins that play a role in these processes.</p>

<p>2-Acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-6-sulfo-D-glucopyranose sodium salt is a synthetic compound that is used in glycosylation reactions. It can be used for the production of oligosaccharides and complex carbohydrates, as well as for the modification of natural products. 2 Acetamido -2 deoxy -4 O-(b-D galactopyranosyl) -6 sulfo D glucopyranose sodium salt has a purity of 98% and was synthesized by fluorination. The CAS number is 145447 78 5.</p>