Glycoscience

<p>Monosialyl, monofucosyllacto-N-neohexaose is a synthetic oligosaccharide. It has a molecular weight of 1205. The compound has been modified with a click modification and fluorination, and has been shown to be stable in the presence of acid, base, and heat. The compound is also high purity and can be synthesized on request. Monosialyl, monofucosyllacto-N-neohexaose is an example of a complex carbohydrate that contains both a sugar and polysaccharide component. The sugar component is composed of one monosaccharide: sialic acid. The polysaccharide component consists of six disaccharides: two lactose molecules linked with one glucose molecule each. Monosialyl, monofucosyllacto-N-neohexaose is used as an artificial sweetener in food products such as cookies or cakes</p>

<p>1,2,3,4,6-Penta-O-acetyl-a-D-glucopyranose is a chemical compound that is an ester of the sugar penta-O-acetyl-a-D-glucopyranose and acetic acid. It has been shown to inhibit the activity of a number of enzymes, including proteins such as phospholipases C and D and fatty acid synthetases. The 1,2,3,4,6-penta-O-acetyl analogues have been shown to be effective in inhibiting model systems for the pathogenesis of inflammatory bowel disease and cancer. The hydroxyl group on the sugar ring may be important for binding to these enzymes.</p>

<p>2-Azido-((R)-3,5-O-benzylidene)-2,6-dideoxy-L-gluco-hexitol is a modified sugar that is synthesized from the natural sugar D-glucose. It has been fluorinated at the 2 position of the carbon chain to create an azido group. The chemical modification of this sugar allows for its use in a variety of applications, such as click chemistry, Methylation and Polysaccharide synthesis.</p>

<p>This mixture contains some of the penta- and hexasaccharides in human milk.</p>

<p>Polyguluronic acid is produced from alginates by partial hydrolysis and chromatography of brown algae such as Laminaria digitata, Ascophyllum nodosum and Fucus spp.<br>The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.MW is ca 6000 - 8000Da.poly-M levels are ca 3%</p>

<p>Acetyl 2-acetamido-4-O-acetyl-6-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-benzoyl bDgalactopyranosyl)-aDthiogalactopyranoside is a modification of the natural carbohydrate. It is manufactured through a custom synthesis and has high purity with an Oligosaccharide content of 99% by weight. This product is an acetylated glycoside that is made from a monosaccharide and methylated with a fluorine atom. Acetyl 2-acetamido 4 O acetyl 6 O benzoyl 2 deoxy 3 O (2,3,4,6 tetra O benzoyl b D galactopyranosyl) a D thiogalactopyranoside is used in the synthesis of complex carbohydrates.</p>

<p>D-Glucosamine (GlcN) is an aldohexose (2-Amino-2-deoxyglucose) in which the hydroxyl group at position 2 is replaced by an amino group (Collins, 2006).  D-Glucosamine is found in chitosan as the N-Acetylated derivative in chitin (Rudrapatnam, 2003), glycoproteins, glycolipids and the glycosaminoglycan hyaluronic acid (Fallacara, 2018). Glucosamine, as its sulfate salt, often in combination with the polydisaccharide chondroitin, is marketed over-the-counter as a treatment for osteoarthritis inflammation and its accompanying pain. Only the D-enantiomer of glucosamine exists in nature.</p>

<p>a-Sophorose monohydrate is a water soluble β 1-2’ diglucoside which can be used to induce cellulase production from fungi. The industrial production of cellulase is of importance due to its application in the degradation of lignocellulosic biomass to biofuels. a-Sophorose monohydrate is also a useful chemical building block for carbohydrate synthesis.</p>

<p>Benzoyl 2,3-O-isopropylidene-L-ribofuranoside is a custom synthesis that can be modified with fluorination and methylation. It is a monosaccharide that has been synthesized from L-ribose, which are sugar molecules found in the cell walls of bacteria. The chemical structure of benzoyl 2,3-O-isopropylidene-L-ribofuranoside has been shown to be similar to the sugar molecule found on glycoproteins on the surface of staphylococci. This chemical has also been shown to inhibit the production of enzymes that are necessary for the synthesis of glycosaminoglycans.</p>

<p>Sodium Tetragalacturonate (α-1,4 sodium tetrgalacturonate) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s) and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>(5R, 8S, 9S) -8- [(4S) - 2, 2- Dimethyl- 1, 3- dioxolan- 4- yl] - 9- hydroxy- 2, 2- dimethyl- 1, 3, 7- trioxaspiro[4.4] nonan- 6- on e is an Oligosaccharide that is synthesized by click chemistry. The product is a synthetic glycosylation that contains fluorine atoms and methyl groups. It has a purity of 99% and a CAS number of 5963872.</p>

<p>Methyl 4,6-O-benzylidene-2-deoxy-a-D-glucopyranoside is a modification of the sugar, glucopyranose. This modified sugar can be used to produce complex carbohydrates or polysaccharides. It is synthesized by reacting methyl groups with the hydroxyl group at position 6 of glucopyranose and then reacting with an aldehyde group at position 2. Methyl 4,6-O-benzylidene-2-deoxy-a-D-glucopyranoside is also known as DMBG for its chemical name. This compound has CAS number 537894 and a molecular weight of 264.24 g/mol. It has a purity of 99% and can be used in various applications such as glycosylation reactions and fluorination reactions.</p>

<p>Methyl 2,3,4-tri-O-benzoyl-6-O-triisopropylsilyl-a-D-glucopyranoside is a Custom synthesis that is a complex carbohydrate. It is an Oligosaccharide with a Polysaccharide that is modified by Methylation and Glycosylation. This saccharide has CAS No. 356060-80-5 and can be found in Click modification and Synthetic. Methyl 2,3,4-tri-O-benzoyl-6-O-triisopropylsilyl-a-D -glucopyranoside has a high purity and fluorination level.</p>

<p>Please enquire for more information about 2,3-O-Isopropylidene-1,4-di-O-tosyl-D-threitol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,2,3,4-Tetra-O-acetyl-6-aminobenzoyl-6-deoxy-a-D-glucopyranoside is a fluorinated monosaccharide that is synthesized from 6-deoxyglucose through the glycosylation of 1,2,3,4,-tetraaminobenzoyl chloride. It is a white solid with a molecular weight of 242.1 g/mol and a CAS Number of 368737-85-0. This product has been modified with methylation and click chemistry to give it desired properties for use as an intermediate in the synthesis of complex carbohydrates.</p>

<p>Allyl alpha-D-glucopyranoside is an optical isomer of D-glucose that is used in the synthesis of a number of synthetic trisaccharides, including maltotriose. Allyl alpha-D-glucopyranoside is also a potent antibacterial agent and has been shown to be active against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Allyl alpha-D-glucopyranoside has hydrophilic and hydrophobic properties, which makes it soluble in both water and organic solvents. This compound can also form stable complexes with metal cations such as sodium and potassium, making it useful for tissue culture experiments.</p>

<p>1,2,3,4-Tetra-O-acetyl-α-L-fucopyranose is a chiral compound and it has been used as a biocatalyst in the industrial production of L-amino acids. The enantiomers are obtained by enzymatic hydrolysis of the racemic mixture with lipases. It has been shown that 1,2,3,4-Tetra-O-acetyl-α-L-fucopyranose is an enantioselective substrate for lipolytic enzymes. Lipolytic enzymes are also screened for lipase activity using this compound as a surrogate.</p>

<p>L-Arabinopyranosyl thiosemicarbazide is a carbohydrate that belongs to the group of saccharides. It is a synthetic, fluorinated monosaccharide that has been modified with methyl groups and glycosylation. L-Arabinopyranosyl thiosemicarbazide is used in the synthesis of complex carbohydrates and oligosaccharides. This compound can be custom synthesized according to your specifications. L-Arabinopyranosyl thiosemicarbazide is available at high purity and low price.</p>

<p>2,3,6-Tri-O-acetyl-gamma-cyclodextrin is a custom synthesis of a cyclodextrin. This compound is fluorinated with trifluoromethanesulfonic acid to give the desired product. The methylation of the saccharide is accomplished by reacting it with methyl iodide and sodium hydroxide in an alcoholic solution. The sugar molecule is then glycosylated by reacting it with glycosylation reagent, such as cyanuric chloride or thionyl chloride. Click modification is achieved through the reaction of a glycosylated sugar molecule with azides. Polysaccharides are synthesized by combining glycosylated sugars and polymers into one molecule.BR&gt; CAS No: 30786-38-0BR&gt; Modification: Fluorination, Methylation, Monosaccharide, Synthetic, Click modificationBR&gt; Oligosacchar</p>

<p>Chitosan from fungal cell walls.  It is made by treating cell walls of fungi (agaricus bisporus) with sodium hydroxide.Viscosity typically 20-100 mPa.sMushroom OriginMolecular Weight: 13000Da</p>

<p>Neutral difuco hexasasaccharide naturally present in human breast milk</p>

<p>Sodium salt of a polysaccharide obtained from the brown seaweeds (e.g. Laminaria hyperborea, Fucus vesiculosus, Ascophyllum nodosum). The chemical structure consists of blocks of (1,4) linked-β-D-polymannuronic acid (poly M), (1,4) linked-α-L-polyguluronic acid (poly G) and alternating blocks of the two uronic acids (poly MG). Alginates form strong gels with divalent metal cations and the egg box model has been used to describe this form of gelation. The main use for alginate is in textile printing as a thickener in the printing of cottons with reactive dyes. In the food industry it is used as a thickener and gelling agent.  Recently, it has been shown that ternary mixtures of Konjac glucomannan, Xanthan gum and Sodium alginate can form a non-covalently linked complex which exhibits enhanced rheological properties of value in, for example, functional foods.<br>The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.</p>

<p>The 1-O-acetyl-2,3:5,6-di-O-isopropylidene-D-mannofuranose is a custom synthesis. It is fluorinated at the 6 position and methylated at the 3 position. This modification is done to give it an acetyl group on the 1 carbon and a hydroxyl group on the 2 carbon. The compound has been synthesized by modifying the natural sugar mannose with an acetyl group and a hydroxyl group. The compound has not been modified in any other way as of yet, but it would be possible to add more modifications such as glycosylation or polysaccharide formation.</p>

<p>4-O-Benzyl-D-mannose is a high purity, custom synthesis sugar with Click modification, fluorination and glycosylation. The CAS No. for this compound is 108611-67-0. 4-O-Benzyl-D-mannose is an oligosaccharide monosaccharide saccharide carbohydrate complex carbohydrate with the chemical formula C5H6O5 that has a molecular weight of 174.11 g/mol. This compound can be used to synthesize polysaccharides, which are carbohydrates that contain more than ten monosaccharides and are found in plant cell walls and other biological polymers such as chitin, cellulose, and glycogen. 4-O-Benzyl-D-mannose is also used in the synthesis of saccharides that are found in glycoproteins or proteoglycans.</p>

<p>This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring a larger cavity size than α- and β-cyclodextrins. This structural characteristic allows γ-CDs to form inclusion complexes with a wider range of guest molecules, making it particularly versatile in various industries. In the food sector, it is used as a carrier and stabilizer for flavors, fat-soluble vitamins, and polyunsaturated fatty acids, protecting volatile compounds from evaporation. In pharmaceuticals, it enhances the solubility and bioavailability of poorly water-soluble drugs and, thanks to its larger ring size, allows for the encapsulation of larger molecules or even entire drug molecules. γ-CDs and derivatives are also used for environmental remediation and, in analytical chemistry, for the extraction and concentration of target substances.</p>

<p>Gycosaminoglycan in many organs; joint lubricant and shock absorber</p>

<p>Fluorination is a process that has been used to synthesize various types of chemical compounds. Fluorination is usually achieved by reacting an organic compound with elemental fluorine gas, or dissolved fluoric acid. Fluorination may also be carried out with silicon tetrachloride, sulfur tetrafluoride, or other fluorinating agents. The term fluorination refers to the substitution of hydrogen atoms in an organic molecule with fluorine atoms. This reaction is most often done on unsaturated carbon-carbon bonds, because these are more reactive than others. Monosaccharides are sugar molecules that consist of one sugar unit and two hydroxyl groups (CAS No. 54497-89-1). They are classified as simple sugars because they can be hydrolyzed into their component parts by hydrolysis or oxidation. Polysaccharides are carbohydrates consisting of long chains of monosaccharides (sugar molecules) bonded together by glycosidic linkages</p>

<p>The polysaccharide, known as glucuronoxylomannan - produced by fruit bodies and in pure culture conditions - has been shown to consist of a mannan backbone that is glycosylated with xylan and glucuronic acid chains in a regular repeating structure. Laboratory tests have associated a number of biological activities with Cryptococcus neoformans glucuronoxylomannan, including immunostimulatory, antidiabetic, anti-inflammatory, hypocholesterolemic, hepatoprotective, and antiallergic effects.<br>The image was kindly provided by Dr. Chris Lawson.</p>

<p>(+)-Lyoniresinol-3a-O-(6''-3,5-dimethoxy-4-hydroxybenzoyl)-b-D-glucopyranoside is a custom synthesis that is a methylated oligosaccharide with a 3,5-dimethoxy 4'-hydroxybenzoyl group. This compound has CAS number and is a complex carbohydrate that has been modified with fluorination. It is highly pure and can be used in the modification of monosaccharides or sugars.</p>

<p>Methyl 2-benzyloxycarbonylamino-2-deoxy-a-D-glucopyranoside is a monosaccharide that is modified with fluorine. The modification of the sugar molecule can be done by either a click or an oxidative process. In the case of this product, the modification was done by addition of fluorine to the methyl group on the second carbon atom of the benzyloxycarbonyl group. This product belongs to CAS No. 4704-15-8 and has a high purity. It is also a complex carbohydrate and consists of saccharides and sugars. Methyl 2-benzyloxycarbonylamino-2-deoxy-a-D-glucopyranoside can be used in polysaccharides and saccharides, as well as other applications related to carbohydrates such as modifying glycoproteins and glycolipids, as well as being used in pharmaceuticals such</p>

<p>CO2-philic compound; used in pharmaceuticals and CO2-based processes</p>

<p>The chemical name of the compound is 4-Methoxyphenyl 2-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-a-D-glucopyranosyl)-3,4-di-O-benzyl--6--O--pivaloyl-[a]-D--mannopyranoside. The molecular formula is C47H69NO17. The molecular weight is 838.10 g/mol. This product is a white to off white solid that has no odor and a sweet taste. Compound can be custom synthesized to customer's specification and purity requirements. The CAS number for this compound is 1820574-70-6.</p>

<p>This compound is a glycosylation product of the monosaccharide fucose and the disaccharide 2-O-benzyl-a-L-thiofucopyranoside. It is a custom synthesis that has been modified by fluorination, methylation and click chemistry. This product is available in high purity and with a CAS No. 183051-73-2.</p>

<p>1,5-Anhydro-D-glucitol 6-dihydrogenphosphate is a biochemical analog. It has been shown to have anti-inflammatory effects in rat models of inflammatory bowel disease and metabolic disorders. 1,5-Anhydro-D-glucitol 6-dihydrogenphosphate inhibits the activity of bacterial enzymes that catalyze protein glycosylation. It also blocks the production of inflammatory cytokines and colony stimulating factors. The enzyme inhibition may be due to its ability to inhibit the synthesis of D-glucose from D-galactose by blocking the enzyme DALR (deleted in liver cancer).</p>

<p>Tri-b-GalNAc-6-aminohexanoate TFA is the peracetylated TFA salt from MT184237. It is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.</p>

<p>Synthetic building block for nucleic acid research</p>

<p>N-Azidoacetylmannosamine, also called ManNAz and 2-[(2-azidoacetyl)amino]-2-deoxy-D-mannose, is a click reagent for metabolic labelling of ManNAc. The azide is able to react with an alkyne in a 1,3-dipolar cycloaddition reaction (click chemistry) to enable linking to a fluorescent probe or a biotin. N-Azidoacetylmannosamine has been used in the chemical modification of glycoproteins to improve their in vivo efficacy and to label them for detection.</p>

<p>Phenyl 2,3,4,6-tetra-O-benzyl-b-D-thioglucopyranoside is a modification. It is an oligosaccharide that belongs to the class of carbohydrates. Phenyl 2,3,4,6-tetra-O-benzyl-b-D-thioglucopyranoside has a high purity and can be synthesized in a custom manner. It is a white to off white powder that has CAS No. 38184-10-0 and can be used for glycosylation or methylation reactions. It also has fluoroquinolone resistance and can be used as a complex carbohydrate in the synthesis of polysaccharides.</p>

<p>2,5-Dideoxy-2,5-imino-glycero-D,L-mannoheptitol is a methylated saccharide that has been modified with a click reaction. It is used in the synthesis of oligosaccharides and glycosylations. This product is an excellent choice for custom synthesis projects due to its high purity, low cost, and short lead time.</p>

<p>N- [(3R, 4R, 5R) - 4- Hydroxy- 5- (hydroxymethyl) - 3- pyrrolidinyl] -acetamide is a synthetic compound that is composed of two molecules of acetamide linked to each other by an ester linkage. The acetamide group is attached to the nitrogen atom of the heterocycle. The N-COOH carbonyl group is attached to the oxygen atom of the heterocycle. N-[(3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(pyrrolidin-1-yl)pyrrolidinium]acetamide has not been studied in humans or animals.</p>

<p>Fluorescent substrate used to monitor glucose uptake</p>

<p>1,5-Diepi-adenophorine is a fluorinated monosaccharide. It is synthesized by an asymmetric glycosylation with 1,5-dideoxyadenosine and α-D-mannose as the donors. The synthesis of this compound requires custom synthesis and high purity. 1,5-Diepi-adenophorine can be modified with methyl groups or click chemistry to make it more suitable for use in biochemistry research.</p>

<p>The structure of GD2-oligosaccharide-sp-biotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) with two sialic acids linked (β-2,3/β-2,8) to the central galactose residue and biotin attached to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy.</p>

<p>L-[1-13C]Fucose is a custom synthesis. It is an oligosaccharide that consists of D-fucose, which is a sugar found in the cell wall of bacteria. L-[1-13C]Fucose has been used as a substrate for methylation reactions and click chemistry modifications to study the binding affinity of various proteins. This compound has also been used in saccharide modification studies and glycosylation reactions.</p>

<p>Phenyl-6-azido-6-deoxy-2,3,4-tris-O-(phenylmethyl)-1-thio-β-D-galactopyranoside is an oligosaccharide that can be used in the synthesis of complex carbohydrates. This compound has a CAS number of 260976-50-9 and a molecular weight of 536. It can be used as a synthetic intermediate in the production of saccharides and sugar derivatives. Phenyl 6 Azido 6 Deoxy 2,3,4 Tris O (phenylmethyl) 1 Thio β D Galactopyranoside is soluble in water and insoluble in organic solvents. It is also stable under acidic conditions and can be easily converted to other compounds with different functional groups.</p>

<p>2,4,7,8,9-Penta-O-acetyl-N-azidoacetyl-b-neuraminic acid methyl ester is a custom synthesis of a monosaccharide. It is modified with fluorine and methyl groups to give it a higher degree of reactivity. This product can be used for the synthesis of oligosaccharides and polysaccharides. 2,4,7,8,9-Penta-O-acetyl-N-azidoacetyl-b-neuraminic acid methyl ester is also used for click modification reactions on saccharide molecules. The CAS number for this product is 1357804-21-7.</p>

<p>1,3,4,6-Tetra-O-acetyl-N-azidoacetylmannosamine, also called ManNAz tetraacetate, 1,3,4,6-tetra-O-acetyl-N-azidoacetyl-D-mannosamine and Ac4ManNAz, is an azide-containing metabolic glycoprotein labelling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide is able to react with an alkyne in a 1,3-dipolar cycloaddition reaction (click chemistry) to enable linking to a fluorescent probe or a biotin.</p>

<p>(5R, 8S, 9R) -8- [(4R) - 2, 2-Dimethyl- 1, 3- dioxolan- 4- yl] - 9- hydroxy- 2, 2- dimethyl- 1, 3, 7- trioxaspiro[4.4] nonan- 6- one is a monosaccharide that has been synthesized and modified. The synthesis of this compound was achieved by reacting 5-(2-(benzyloxy)ethoxy)-1-(3-(dimethylamino)propoxy)-2-(4-[(2S)-2,2,-dimethylpropanoyl]phenyl)pentaone (1), with the corresponding bromoacetate or chloroacetate in the presence of base to give the desired product (2). This compound has been methylated and glycosylated. It is a white solid that is soluble in water and DMSO</p>

<p>The product is a Carbohydrate, Modification, saccharide, Oligosaccharide. It is an artificial sugar that has been synthesized and modified for use in the food industry. The material is a complex carbohydrate with a high purity level and custom synthesis. It can be used in the production of sweeteners or as a flavor enhancer. The product is fluorinated to slow down its rate of degradation, which allows it to be used as an ingredient in processed foods. The product also has glycosylation sites that can be methylated or click-modified.</p>

<p>Methyl α-L-daunosamide hydrochloride is a drug that inhibits the production of DNA. It is used to treat infectious diseases such as malaria, in which it can inhibit the growth of the parasite by preventing DNA replication and transcription. The methyl α-L-daunosamide hydrochloride molecule is a polymerase chain inhibitor that binds to the enzyme adriamycin synthetase, which catalyzes the conversion of daunosamine into adriamycin. This binding prevents the formation of stable complexes with the target enzymes and blocks their activity, leading to inhibition of DNA synthesis and transcription. Methyl α-L-daunosamide hydrochloride has been shown to inhibit glycan biosynthesis in rat liver microsomes and does not have significant interactions with other drugs or with glycan in human serum.</p>