Antivirals

Applications 3,4-Difluoroaniline-2,6-d2 (CAS# 1061566-62-8) can be used in its derivative form as an antiviral agent for Hepatitis B.
References Qiu, Y.L., et.al., U.S. Pat. Appl. Publ., 187,(2019);

Impurity Atazanavir Impurity B
Applications An intermediate for the preparation of antiviral protease inhibitors. Atazanavir Impurity B
References Fassler, A., et al.: J. Med. Chem., 39, 3203 (1996), Bold, G., et al.: J. Med. Chem., 41, 3387 (1998).

Applications Darunavir intermediate.
References Ghosh, A., et al.: J. Med. Chem., 39, 3278 (1996), Ghosh, A., et al.: Bioorg. Med. Chem. Lett., 1998, 8, 687 (1998), Richman, D., et al.: Nature, 410, 995 (2001), Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003),

Applications Darunavir intermediate.
References Ghosh, A., et al.: J. Med. Chem., 39, 3278 (1996), Ghosh, A., et al.: Bioorg. Med. Chem. Lett., 1998, 8, 687 (1998), Richman, D., et al.: Nature, 410, 995 (2001), Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003),

Impurity Atazanavir Impurity (Pyridinyl Benzaldehyde)
Applications Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity
References F. Li et al., Drug Metabolism and Disposition 39, 294 (2011)

Stability Hygroscopic
Applications (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

Applications 2-Fluoro-3-methoxyaniline is a reagent that is used in the structure-activity relationship studies on a series of cyclopentane-containing macrocyclic inhibitors of hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Raboisson, R., et al.: Bioorg. Med. Chem. Lett., 18, 4853 (2008)

Applications An intermediate used in the preparation of Zanamivir derivatives.
References Andrews, D., et al.: Eur. J. Med. Chem., 34, 563 (1999), Altamore, T., et al.: Bioorg. Med. Chem., 14, 1126 (2006),

Applications An intermediate in the synthesis of Ritonavir.
References Sham, H., et al.: Bioorg. Med. Chem. Lett., 12, 3101 (2002),

Sofosbuvir is an antiviral agent that is used for the treatment of hepatitis C infections and is used in combination with other antiviral agents. This drug is an inhibitor of viral RNA polymerase called non-structural protein 5B (NS5B). As a result, it inhibits viral RNA replication.

Lobucavir is an antiviral compound with a mode of action that inhibits viral DNA polymerase. It is used for treating infections caused by herpesviruses and hepatitis B virus.

Foscarnet sodium is a pyrophosphate analog antiviral agent with action on viral DNA polymerase and is used for treating cytomegalovirus and herpes simplex virus infections.

Vicriviroc is an investigational pharmaceutical compound, specifically classified as an HIV entry inhibitor. It originates from a synthetic source, designed to target the CCR5 co-receptor on human immune cells. The mode of action involves blocking this co-receptor, thereby preventing the HIV virus from binding and fusing with the host cell membrane. This inhibition effectively obstructs the virus's ability to enter and infect the host cells, particularly those within the chemokine receptor family.

Selective and potent inhibitor of sialidases (neuraminidases) in influenza A and B viruses. The compound binds tightly to the viral neuraminidase active site in late stages of viral life-cycle. It inhibits shedding sialic acids from host cell surface glycans, which interact with viral hemagglutinin, and consequently prevents release of new viral particles from the host cell surface.

RNA polymerase (RdRp) inhibitor

SARS-CoV-2 nsp13-IN-1 (C1) inhibits nsp13 ssDNA+ATPase (IC50: 6 μM), not ssDNA-ATPase; useful for COVID-19 research.

YM-53403: Antiviral that combats both RSV subgroup A/B, treats respiratory infections.

Epetirimod (S-30563) is a small molecule immunomodulator with antitumor and anti-infective activity for the study of papillomavirus infections.

Rociclovir has antiviral activity and is used to treat viral infections.