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Antiparasitics

Antiparasitics

Antiparasitics are compounds designed to treat and prevent parasitic infections by inhibiting the growth and survival of parasites. This category includes a range of antiparasitic agents intended exclusively for laboratory use and not for human consumption. These products are essential for research purposes, allowing scientists to study parasitic life cycles, mechanisms of action, and the development of resistance. The use of antiparasitics in laboratory settings aids in the discovery and optimization of new treatments for parasitic diseases, contributing to advancements in medical and veterinary parasitology. Researchers rely on these products to enhance their understanding of parasitic infections and to develop more effective therapies.

Found 704 products of "Antiparasitics"

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  • PFK-IN-1
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    PFK-IN-1

    CAS:
    <p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>
    Formula:C18H15Cl2N3O4S
    Color and Shape:Solid
    Molecular weight:440.3

    Ref: TM-T204311

  • Ipronidazole
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    Ipronidazole

    CAS:
    <p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>
    Formula:C7H11N3O2
    Color and Shape:Solid
    Molecular weight:169.18

    Ref: TM-T200810

  • Arohynapene B
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    Arohynapene B

    CAS:
    <p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>
    Formula:C18H22O3
    Color and Shape:Solid
    Molecular weight:286.366

    Ref: TM-T205296

  • NEU-1017
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    NEU-1017

    CAS:
    <p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>
    Formula:C33H31ClFN5O3S
    Color and Shape:Solid
    Molecular weight:632.147

    Ref: TM-T205599

  • SLU-10906
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    SLU-10906

    CAS:
    <p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>
    Formula:C22H21BFN5O2
    Color and Shape:Solid
    Molecular weight:417.244

    Ref: TM-T205063

  • SPB07935
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    SPB07935

    CAS:
    <p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>
    Formula:C22H15N5O4S2
    Color and Shape:Solid
    Molecular weight:477.516

    Ref: TM-T205133

  • Menoctone
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    Menoctone

    CAS:
    <p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>
    Formula:C24H32O3
    Color and Shape:Solid
    Molecular weight:368.51

    Ref: TM-T201004

  • Insecticidal agent 16
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    Insecticidal agent 16

    CAS:
    <p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>
    Formula:C21H13Cl2F6N5O2S
    Color and Shape:Solid
    Molecular weight:584.32

    Ref: TM-T201261

  • Antimalarial agent 48
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    Antimalarial agent 48

    CAS:
    <p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>
    Formula:C19H14F3N11
    Color and Shape:Solid
    Molecular weight:453.383

    Ref: TM-T205719

  • MMV03
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    MMV03

    CAS:
    <p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>
    Formula:C19H14N4OS
    Color and Shape:Solid
    Molecular weight:346.406

    Ref: TM-T204698

  • Antimalarial agent 44
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    Antimalarial agent 44

    <p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>
    Formula:C37H37N5O7
    Color and Shape:Solid
    Molecular weight:663.72

    Ref: TM-T201453

  • MED6-189
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    MED6-189

    CAS:
    <p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 &lt; 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>
    Formula:C17H26N2O
    Color and Shape:Solid
    Molecular weight:274.40

    Ref: TM-T201291

  • Isazofos
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    Isazofos

    CAS:
    <p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>
    Formula:C9H17ClN3O3PS
    Color and Shape:Solid
    Molecular weight:313.74

    Ref: TM-T201803

  • PfCLK3-IN-1
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    PfCLK3-IN-1

    <p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>
    Formula:C28H27ClN4O4
    Color and Shape:Solid
    Molecular weight:518.99

    Ref: TM-T201861

  • PIQ-2
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    PIQ-2

    CAS:
    <p>PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.</p>
    Formula:C23H21F3N4O3
    Color and Shape:Solid
    Molecular weight:458.43

    Ref: TM-T200981

  • Ferrocene
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    Ferrocene

    CAS:
    <p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>
    Formula:C10H10Fe
    Color and Shape:Solid
    Molecular weight:186.03

    Ref: TM-T201646

  • Erythromycin B
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    Erythromycin B

    CAS:
    <p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>
    Formula:C37H67NO12
    Color and Shape:Solid
    Molecular weight:717.93

    Ref: TM-T201497

  • SAL-0010042
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    SAL-0010042

    CAS:
    <p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>
    Formula:C15H15FN4O
    Color and Shape:Solid
    Molecular weight:286.304

    Ref: TM-T204533

  • DNA crosslinker 6
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    DNA crosslinker 6

    CAS:
    <p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>
    Formula:C19H21N7O
    Color and Shape:Solid
    Molecular weight:363.42

    Ref: TM-T201475

  • Etofamide
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    Etofamide

    CAS:
    <p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>
    Formula:C19H20Cl2N2O5
    Color and Shape:Solid
    Molecular weight:427.28

    Ref: TM-T200359