DNA Cross Linkers
Found 617 products of "DNA Cross Linkers"
Eptaplatin
CAS:Platinum-based anti-tumor drugFormula:C11H20N2O6PtPurity:Min. 95%Color and Shape:PowderMolecular weight:471.37 g/molPNU 159682
CAS:DNA alkylating agent; highly potent metabolite of nemorubicinFormula:C32H35NO13Purity:Min. 90 Area-%Color and Shape:Red PowderMolecular weight:641.62 g/molIdarubicin hydrochloride
CAS:Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline
Formula:C26H28ClNO9Purity:Min. 95%Color and Shape:PowderMolecular weight:533.95 g/molSatraplatin
CAS:Platinum-based chemotherapeutic agentFormula:C10H22Cl2N2O4PtPurity:Min. 95%Color and Shape:Slightly Yellow PowderMolecular weight:500.28 g/molMitoxantrone hydrochloride
CAS:Inhibits DNA topoisomerase II; antineoplastic; immunomodulatory; antimicrobialFormula:C22H30Cl2N4O6Purity:Min. 97 Area-%Color and Shape:Dark Blue SolidMolecular weight:517.4 g/molCarboplatin - Bio-X ™
CAS:Carboplatin is an antineoplastic alkylating agent that is used in the treatment of ovarian cancer. This drug attaches alkyl groups to nucleotides leading to the formation of monoadducts. Carboplatin’s main mechanism of action is preventing DNA strands from separating for synthesis and transcription.Formula:C6H12N2O4PtPurity:Min. 95%Color and Shape:PowderMolecular weight:371.25 g/mol2-[2-[2-[2-[6-(Biotinylaminohexanoyl]aminoethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid N-Hydroxysuccinimide Ester
CAS:Controlled ProductStability Light and Moisture Sensitive
Applications A cross-linking, biotin-labelled compound.
References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)Formula:C35H46F3N7O10SColor and Shape:NeatMolecular weight:813.843,4-Bis-(methanethiosulfonylmethyl)-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxy Radical
CAS:Controlled ProductApplications A highly reactive thiol-specific cross-linking spin-label.
Formula:C12H22NO5S4Color and Shape:NeatMolecular weight:388.57Temozolomide
CAS:Temozolomide is a cancer drug that belongs to the class of alkylating agents. It has been shown to have anticancer activity against human tumor cells in vitro. Temozolomide induces cell death by activating the apoptotic pathway. This drug also inhibits the cell cycle and blocks the G2-M phase, resulting in accumulation of cells at this point in the cell cycle. Temozolomide has been studied for its effects for cancer treatment in certain research approaches.Formula:C6H6N6O2Purity:Min. 98 Area-%Color and Shape:Off-White PowderMolecular weight:194.15 g/molPolyethylene Glycol Bis(3-aminopropyl) Ether
CAS:Color and Shape:White to Light yellow to Dark green powder to lumpPalifosfamide
CAS:Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplasticFormula:C4H11Cl2N2O2PPurity:Min. 95%Color and Shape:SolidMolecular weight:221.02 g/molMal-PEG3-Acid
CAS:Formula:C13H19NO7Purity:>95.0%(T)(HPLC)Color and Shape:Colorless to Almost colorless clear liquidMolecular weight:301.30N-Succinimidyl Maleimidoacetate
CAS:Formula:C10H8N2O6Purity:>95.0%(qNMR)Color and Shape:White to Almost white powder to crystalMolecular weight:252.183-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt
CAS:Formula:C16H17N2NaO9SPurity:>97.0%(qNMR)Color and Shape:White to Almost white powder to crystalMolecular weight:436.37N-Succinimidyl 4-Maleimidobutyrate [Cross-linking Reagent]
CAS:Formula:C12H12N2O6Purity:>98.0%(HPLC)(N)Color and Shape:White to Light yellow to Light red powder to crystalMolecular weight:280.242-(Trihexylammonium)ethyl Methanethiosulfonate Bromide
Controlled ProductApplications A water soluble, bulkier analogue of the charged MTS reagent MTSET. Charged MTS reagents have been used successfully with SCAM (substituted cysteine accessibility method) to probe the topology and function of a number of ligand-gated ion channels and transporter proteins.
Formula:C21H46BrNO2S2Color and Shape:NeatMolecular weight:488.632-[2-[2-(2-t-Boc-aminoethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid Methyl Ester
CAS:Controlled ProductStability Light and Moisture Sensitive
Applications A cross-linking reagent.
References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)Formula:C21H28F3N3O7Color and Shape:NeatMolecular weight:491.4581[5-(Trimethylammonium)pentyl] Methanethiosulfonate Bromide
Controlled ProductStability Moisture Sensitive
Applications Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABAA receptor channel and of lactose permease.
References Duhten, R.L., et al.: Biochemistry, 32, 3139 (1993), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996), Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Vedantham, V. and Cannon, C.C.: J. Gen. Physiol., 111, 83 (1998), Lin, C.-W. and Tsung-Yu, C.: J. Gen. Physiol., 116, 535 (2000), Sullivan, D.A. and Cohen, J.B.: J. B.C., 275, 17, 12651 (2000)Formula:C9H22BrNO2S2Color and Shape:NeatMolecular weight:320.313-(Triethylammonium)propyl Methanthiosulfonate Bromide
CAS:Controlled ProductStability Hygroscopic; Store at -20°C and Desiccate
Applications A water soluble, analogue of the charged MTS reagent MTSET. Charged MTS reagents have been used successfully with SCAM (substituted cysteine accessibility method) to probe the topology and function of a number of ligand-gated ion channels and transporter proteins.
References Duhten, R.L., et al.: Biochemistry, 32, 3139 (1993), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996), Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Vedantham, V. and Cannon, C.C.: J. Gen. Physiol., 111, 83 (1998)Formula:C10H24NO2S2·BrColor and Shape:NeatMolecular weight:334.34Tetraethoxy-d20-silane
CAS:Controlled ProductApplications Tetraethoxy-d20-silane (CAS# 272778-10-6) is a useful isotopically labeled research compound.
Formula:C8D20O4SiColor and Shape:NeatMolecular weight:228.45
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