Nucleosides

<p>8-Azidoadenosine 3',5'-cyclic monophosphosphate is used for nucleotide labelling via a click reaction involving the azide moiety and a terminal alkyne conjugated to a label. The reaction generates a stable nucleotide labelled adduct containing a triazole link.</p>

<p>2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt is a nucleoside phosphoramidite that is used to synthesize oligonucleotides for use in research, diagnostics, and other applications. 2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt has antiviral properties, anticancer effects, and can be used for synthesis of modified DNA and RNA. This product has high purity, high quality, and is free from hazardous impurities.</p>

<p>P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate sodium salt is an intermediate in the biosynthesis of ATP. It is also a cofactor for adenylate kinase and pyruvate kinase. The synthesis of this compound takes place in human serum and requires the enzyme synthetase as well as sephadex g-100. Synthetase catalyzes the condensation of ATP with 5-AMP to yield P1-(5'-adenosyl) P3-(5'-adenosyl) triphosphate sodium salt. This reaction is reversible, and can be catalyzed by phosphohydrolases that hydrolyze ATP to AMP and inorganic phosphate. The physiological function of this compound is not yet clear, but it has been shown to increase intracellular Ca2+ levels in cardiac cells, leading to congestive heart failure. This compound has low potency, so it does not have any</p>

<p>1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil is an antiviral agent that is a modified monophosphate ribonucleoside. It has shown anticancer activity and can be used as an activator for diphosphate nucleosides. 1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil can also be used in the synthesis of deoxyribonucleosides and phosphoramidites. This product is high purity, high quality, and synthesized using synthetic methods.</p>

<p>4-C-Hydroxymethyl-1,2-O-isopropylidine-3-O-(4-methoxybenzyl)-a-D-ribofuranose is a novel antiviral drug with an IC50 of 0.01 μM. It inhibits the replication of viruses such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). The synthesis of 4C hydroxymethyl ribofuranoside starts from 2,4,6 trimethoxybenzaldehyde. The first step is the condensation reaction between 4C hydroxymethyl benzaldehyde and diethyl malonate in presence of pyridinium chlorochromate to yield 1,2,3,4 tetrahydroxy methylbenzene. In the next step, 1,2,3,4 tetrahydroxy methylbenzene is converted to 1,2,3 trihydroxy methylben</p>

<p>Please enquire for more information about 5-(Ferrocene-1-yl-ethynyl)-2'-deoxyuridinetriphosphate sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.</p>

<p>Deoxyadenosine analog resistant to adenosine deaminase</p>

<p>Please enquire for more information about Adenylyl-(3'-5')-guanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>Inhibitor of reverse transcriptase</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase (RT) inhibitor with anti-retroviral activity against HIV. Good oral bioavailability, high aqueous solubility and good cerebrospinal fluid penetrance. Synergistic with other nucleoside RT inhibitors such as AZT.</p>

<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>N-Acetyl-5'-O-DMT-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-adenosine 3'-CE phosphoramidite is a modified nucleoside with antiviral and antitumor activity. It is synthesized by modifying the ribonucleotide to an acetylated ribonucleotide. This compound is used in the synthesis of oligodeoxyribonucleotides as a synthetic DNA activator, antiretroviral agent, and anticancer agent. N-[5'-O-DMT-2'-O-[(tris(1-methylethyl)silyl]oxy]-methyl]-adenosine 3'-CE phosphoramidite has been shown to be effective against various types of human cancer cells in vitro, including prostate cancer cells.</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-Sp-oxazaphospholidine is a modified nucleoside that is synthesized from the amino acid phenylalanine. It has anticancer activity and is an activator of ribonucleosides. This compound also has novel properties, including high purity and high quality. N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-Sp-oxazaphospholidine can be used as a phosphoramidite to synthesize DNA or deoxyribonucleosides and diphosphates.</p>

<p>Anti-viral; anti-neoplastic</p>

<p>Ribonuclesides are a class of modified nucleosides that have been shown to be effective against cancer cells. Oleoyl CoA potassium salt is a Ribonucleoside that inhibits the growth of cancer cells by inhibiting DNA synthesis and RNA synthesis. The Ribonucleosides inhibit the formation of DNA by preventing the conversion of ribose-5-phosphate to deoxyribose-5-phosphate, which is required for DNA synthesis. Oleoyl CoA potassium salt also binds to the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides, thereby inhibiting DNA synthesis. This drug has been studied in preclinical animal trials.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>