Nucleosides

Natural glycoside

Natural glycoside

4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a nucleoside monophosphate that is used as an antiviral agent. It inhibits the synthesis of viral DNA and RNA by inhibiting the activity of enzymes needed for nucleotide synthesis. 4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine has shown anticancer properties in vitro against human colon cancer cells. This drug has been shown to inhibit the growth of tumor cells with high expression levels of cyclin D1 and low levels of p27 (a cell cycle regulatory protein).

Anti-viral agent; iodinated analog of deoxycytidine

N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.

2'- Deoxy- 1, 6- dihydro- 1- methyladenosine is a novel nucleoside activator. It is a modified form of adenosine and has shown anticancer activity in vivo. This compound also has antiviral activity against herpes simplex virus type 2 (HSV-2) and human cytomegalovirus (CMV). The antiviral effect of this drug is due to its ability to penetrate the cell membrane and inhibit viral DNA synthesis by inhibiting deoxyribonucleoside triphosphate (dNTP) incorporation into the viral DNA strand.

8-Azidoadenosine 5'-monophosphate sodium salt is an azido-conjugated adenosine monophosphate derivative used to introduce a label on oligonucleotides. A click reaction between the azide-functionalised nucleotide and a terminal alkyne-functionalised labelled moiety (with either a fluorophore or biotin) generates a stable conjugate containing a triazole link.

2,6-Diamino-9-(2'-deoxy-2'-fluoro-β-D-ribofuranosyl)purine is a modified purine nucleoside analog. This compound has modification that have the potential to influence its ability to interfere with nucleic acid synthesis, such as DNA or RNA.

Cytidyl-3'-5'-guanosine ammonium salt is a modified nucleoside that has antiviral and anticancer properties. It is synthetically made by modifying the phosphate groups of cytidine and guanosine with phosphoramidites. Cytidyl-3'-5'-guanosine ammonium salt has been shown to activate protein kinase C, which may be related to its anticancer activity.

2'-O-Methyl-N6-phenoxyacetyladenosine is a phosphoramidite nucleoside that is used in the synthesis of DNA and RNA. It has antiviral, anticancer, and antiribonucleases properties. The chemical structure of 2'-O-Methyl-N6-phenoxyacetyladenosine is similar to that of adenosine, but contains a methyl group on C2' position and an oxyalkyl group on N6. This compound can be used as a novel anticancer agent and has been shown to have high affinity for the purine receptor, inhibiting cancer cell proliferation by activating the p53 tumor suppressor pathway.

2'-O-tert-Butyldimethylsilyl-5'-O-MMT-uridine 3'-CE phosphoramidite is a monophosphate that is synthesized by reacting 2'-O-tert-butyldimethylsilyl-5'-O-methylguanosine 3'-CE with uridine 3'-CE. This nucleoside has been shown to be an activator of the immune system and to inhibit cancer cell growth in vitro. It also inhibits the synthesis of DNA and RNA, as well as ribonucleosides and deoxyribonucleosides. The purity of this product is high, with no detectable impurities or toxic substances known to the manufacturer. It is also stable at room temperature for at least six months. This product does not contain any phosphate groups or other reactive functional groups that could interfere with downstream reactions. 2'-O-tert-Butyldimethylsily