Nucleosides
Nucleosides are fundamental building blocks of nucleic acids, composed of a nitrogenous base attached to a sugar molecule. In this section, you can find a wide variety of nucleosides essential for research in molecular biology, biochemistry, and pharmacology. These compounds play crucial roles in the synthesis of DNA and RNA, and are also vital in various metabolic processes. Nucleosides are used in studying genetic material, developing antiviral and anticancer therapies, and understanding cellular mechanisms. At CymitQuimica, we provide high-quality nucleosides to support your research and development needs, ensuring purity and reliability for your experimental applications.
Found 3569 products of "Nucleosides"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Adenosine-5'-O-(1-thiotriphosphate) lithium salt - 100 mM aqueous solution
CAS:Adenosine-5'-O-(1-thiotriphosphate) lithium salt is an inhibitor of the guanine nucleotide-binding protein that is reversibly inhibited by adenosine triphosphate. It has been shown to inhibit HIV infection by binding to the Ryanodine receptor and blocking the release of calcium ions from intracellular stores. This prevents the activation of caspases, which are enzymes that cause cell lysis. Adenosine-5'-O-(1-thiotriphosphate) lithium salt also blocks transcription and polymerase chain reactions, and may inhibit the growth of cancer cells by inhibiting epidermal growth factor receptors on the cell surface.Formula:C10H12Li4N5O12P3SPurity:Min. 95%Color and Shape:PowderMolecular weight:546.98 g/molN6-Carbamoylthreonyladenosine sodium salt
CAS:N6-Carbamoylthreonyladenosine sodium salt is a fatty acid that is found in the bacterial cell wall. It has been shown to be an essential component of the cell wall for Gram-positive and Gram-negative bacteria. N6-Carbamoylthreonyladenosine sodium salt has been used to study the mechanism of protein synthesis in bacteria, especially how enzymes are involved in this process. Chemical biology studies have shown that this molecule can bind to DNA and inhibit bacterial growth. The crystal structure of N6-Carbamoylthreonyladenosine sodium salt has also been determined using x-ray diffraction data. This molecule inhibits the binding of proteins to DNA, which prevents transcription and replication. The reaction mechanism involves hydrogen bonding between the oxygen atoms on N6-Carbamoylthreonyladenosine sodium salt and divalent metal ions such as magnesium or zinc, which are required for protein synthesis.Formula:C15H19N6O8·NaPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:434.34 g/mol1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is an Activator for the synthesis of DNA and RNA. It is a novel synthetic nucleoside that has anticancer activity. 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil 5'-triphosphate triethylammonium salt is used as an antiviral agent, inhibiting viral replication by blocking the RNA polymerase enzyme.Formula:C9H13FN2O14P3·C6H16NPurity:Min. 95%Molecular weight:587.32 g/mol8-Chloro-2'-deoxyguanosine
CAS:8-Chloro-2'-deoxyguanosine is a reactive oxygen species that can cause oxidative damage to DNA. This compound is generated by the hypochlorous acid (HOCl) in cells and can be found in human tissues. 8-Chloro-2'-deoxyguanosine can also be generated by the HOCl in diabetic patients, where it has been shown to cause oxidative damage to DNA. 8-Chloro-2'-deoxyguanosine is a product of the reaction between hydrogen peroxide and catalase, and it is activated by HOCl. It has been shown to be carcinogenic in animal models, where it causes DNA damage that leads to cancer.Formula:C10H12ClN5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:301.69 g/mol4-Hydroxy-6-methylpyrimidine
CAS:4-Hydroxy-6-methylpyrimidine (4-OHMP) is a metabolite of trimethyltin. It is formed in the liver by methylation of 4,6-dimethylpyrimidine (4,6-DMPU). The levels of 4-OHMP in urine samples are used to monitor exposure to this agent. The median values for urinary concentrations of 4-OHMP are typically 10 times higher than those found in blood samples. The metabolite can be detected in urine up to 2 weeks after an individual’s last contact with trimethyltin. This compound has been shown to inhibit the synthesis of glycol dimethyl ethers and carbamates.
Formula:C5H6N2OPurity:Min. 95%Molecular weight:110.11 g/mol3'-O-Allylguanosine
3'-O-Allylguanosine is a antiviral agent that belongs to the group of synthetic nucleosides. It is a monophosphate analog of guanosine and an activator of ribonucleotide reductase. 3'-O-Allylguanosine has been shown to be effective against cancer cells in vitro. It has also been shown to inhibit DNA synthesis and promote DNA degradation in human leukemia cells, suggesting its potential use for the treatment of leukemia.
Formula:C13H17N5O5Purity:Min. 95%Molecular weight:323.3 g/mol5'-O-DMT-uridine 3'-CE phosphoramidite
CAS:5'-O-DMT-uridine 3'-CE phosphoramidite is a novel, modified and activator nucleoside. It can be used as an antiviral agent or in the synthesis of DNA. 5'-O-DMT-uridine 3'-CE phosphoramidite has been shown to be cytotoxic in vitro to cancer cells.Formula:C39H47N4O9PPurity:Min. 95%Molecular weight:746.79 g/molN6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite
N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite is a novel nucleoside that has antiviral and anticancer properties. It is an analog of adenosine and inhibits the action of ribonucleotide reductase, which is an enzyme that converts ribonucleotides to deoxyribonucleotides. N6-Benzoyl-2'-deoxy-2'-fluoroadenosine 3'-CE phosphoramidite also inhibits the synthesis of DNA, which may be due to its inhibition of DNA polymerase. This compound has been shown to inhibit the growth of leukemia cells in culture and induce apoptosis in human tumor cells.
Formula:C47H51FN7O7PPurity:Min. 95%Molecular weight:875.92 g/mol2'-Deoxy-5'-O-DMT-5-iodouridine
CAS:2'-Deoxy-5'-O-DMT-5-iodouridine is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.Formula:C30H29IN2O7Purity:Min. 95%Color and Shape:PowderMolecular weight:656.48 g/mol5'-Amino-5'-deoxyguanosine
CAS:5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.Formula:C10H14N6O4Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:282.26 g/molN6-Benzoyl-2’-chloro-2’-deoxy-5’-O-DMT-adenosine
N6-Benzoyl-2’-chloro-2’-deoxy-5’-O-DMT-adenosine is a novel nucleoside that has been shown to have anti-cancer, antiviral, and antiinflammatory activities. It is structurally related to 2’,3’,5’triphosphate adenine (TPAD) and inhibits the synthesis of DNA by competitive inhibition of ribonucleotide reductase. TPAD also induces apoptosis in tumor cells. N6BzCdA has an IC50 value of 0.5 μM for TPAD synthetase from Escherichia coli and rat liver, indicating that it is a potent inhibitor of this enzyme. The purity level of this product is greater than 98%, with a CAS number of 67972-83-1.Purity:Min. 95%Uridine-5-oxyacetic acid methyl ester
CAS:Uridine-5-oxyacetic acid methyl ester is a modified nucleotide that is an intermediate in the biosynthesis of uridine. This molecule can be synthesized from 5-hydroxymethyluridine and malonic acid by a methyltransferase. Uridine-5-oxyacetic acid methyl ester can also be obtained from the metabolism of deoxyribose. Analysis of this molecule is possible with spectrometric, mass spectrometric, and chemical structures methods. It has been shown to have a function in translation and protein synthesis. The chemical structure of uridine-5-oxyacetic acid methyl ester has been determined to be guanosine-3',5'-bis(2'-carboxyethyl)phosphate, which is different from that found in DNA or RNA.Formula:C12H16N2O9Purity:Min. 95%Color and Shape:PowderMolecular weight:332.26 g/mol5-Methylcytidine-5'-monophosphate
CAS:5-Methylcytidine-5'-monophosphate is a nucleotide that is an intermediate in the synthesis of DNA. It is a neutral form and has been sequenced. 5-Methylcytidine-5'-monophosphate is found in cellular components, such as mitochondria and nuclei. The biochemical properties of this molecule are dependent on its methylation state. This molecule also plays a role in mitochondrial functions and nuclear DNA modifications.
Formula:C10H16N3O8PPurity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:337.22 g/mol2',3'-Dideoxy-5-methylcytidine
CAS:2',3'-Dideoxy-5-methylcytidine is a synthetic nucleoside analog based on cytidine, a natural building block of DNA and RNA. This molecule is chemically modified to interfere with nucleic acid synthesis, making it a potential tool in antiviral or anticancer therapy, or for studying epigenetics.Formula:C10H15N3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:225.25 g/mol2,2'-Anhydrothymidine
CAS:2,2'-Anhydrothymidine is an anhydro version of thymidine. As 2,2'-Anhydrothymidine is a modified version of thymidine it can help researchers understand what happens when DNA is changed or damaged. Other possible uses as in research related to antiviral drug creation.Formula:C10H12N2O5Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:240.21 g/mol8-Allyloxy-9-(b-D-xylofuranosyl)guanine
8-Allyloxy-9-(b-D-xylofuranosyl)guanine is a novel nucleoside that is an activator of ribonucleotide reductase. It is a deoxyribonucleoside and monophosphate, and it has been shown to be active against cancer cells and viruses. 8-Allyloxy-9-(b-D-xylofuranosyl)guanine inhibits the growth of cancer cells by inhibiting DNA synthesis and protein synthesis, which may be due to its inhibition of ribonucleotide reductase. This drug also has antiviral activity against HIV, herpes simplex virus type 1 (HSV1), and herpes simplex virus type 2 (HSV2).Purity:Min. 95%N6-Succinyl adenosine
CAS:N6-Succinyl adenosine is a biochemical that is involved in the transfer of fatty acids across membranes. It has been shown to be effective in transfection experiments, where it can be used to increase the expression of genes. N6-Succinyl adenosine has also been shown to be an important substrate for various dehydrogenases. Deficiency of these enzymes leads to orotic aciduria, which is characterized by elevated levels of orotic acid in blood and urine and may lead to mental retardation. A linear calibration curve was generated for diagnosis purposes, with the enzyme activities being determined using a logistic regression model.Formula:C14H17N5O8Purity:Min. 95%Color and Shape:White PowderMolecular weight:383.31 g/mol2',3'-Di-O-acetyl-D-uridine
CAS:2',3'-Di-O-acetyl-D-uridine is a nucleoside for use in research applicationsFormula:C13H16N2O8Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:328.27 g/mol1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-N3-(2S)-(2-amino-3-carbonyl]propyluracil
CAS:1-(2’-Deoxy-2’-fluoro-β-D-arabinofuranosyl)-N3-(2S)-(2-amino-3-carbonyl]propyluracil is a novel, anticancer drug. It is active against both RNA and DNA viruses, such as HIV, influenza virus and herpes virus. 1-(2’-Deoxy-2’-fluoro-β-D-arabinofuranosyl)-N3-(2S)-(2-amino-3-carbonyl]propyluracil has been shown to be an activator for phosphoramidites in aqueous solution. This compound is of high purity with CAS No. 2072145–25–4. It is also a synthesized, monophosphate nucleoside that can be used in the production of modified nucleosides for therapeutic purposes or as antiviral agentsPurity:Min. 95%7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine
CAS:7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine is a novel modified ribonucleoside. It has the ability to activate DNA at the monophosphate level and can be used as a substrate for DNA polymerase and in the synthesis of deoxyribonucleosides. 7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine also has antiviral properties, which may be due to its inhibition of viral RNA synthesis. The compound is also used in anticancer treatment as it inhibits cellular proliferation by inhibiting DNA synthesis.
Purity:Min. 95%2'-Deoxy-5-ethyluridine
CAS:2'-Deoxy-5-ethyluridine is a nucleoside analog that is used in cancer gene therapy. It is an analog of the natural pyrimidine base uracil and inhibits RNA synthesis by competing with natural nucleosides for incorporation into the growing RNA chain. 2'-Deoxy-5-ethyluridine is cytotoxic to cervical cancer cells, inhibiting cell growth and proliferation at inhibitory doses of 0.1 μM. This drug has also been shown to have synergistic effects with other drugs such as trifluoroacetic acid, monoclonal antibody, tissue culture, glycosidic bond, biological properties, cancer tissues, and polymerase chain reaction (PCR).Formula:C11H16N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:256.26 g/mol2'-O-Methyl-5-propynylcytidine
CAS:2'-O-Methyl-5-propynylcytidine is an antiviral drug that inhibits the replication of retroviruses by competitive inhibition of the viral RNA polymerase. It has been shown to be effective against HIV, HSV and CMV. This drug also has shown anticancer activity in vitro and in vivo. 2'-O-Methyl-5-propynylcytidine has a novel mechanism of action and is used as a building block for oligonucleotide synthesis because it is resistant to degradation by nucleases.Formula:C13H17N3O5Purity:Min. 95%Color and Shape:PowderMolecular weight:295.29 g/molGuanosine 3', 5'- bisdiphosphate lithium salt
CAS:Regulates gene transcription; inhibits the synthesis of tRNA and rRNAFormula:C10H17N5O17P4·xLiPurity:Min. 95%Molecular weight:603.16 g/mol2'-Deoxy-6-methylthioguanosine
CAS:2'-Deoxy-6-methylthioguanosine is a novel nucleoside and nucleotide analog with antiviral and anticancer activities. It has been shown to inhibit the replication of DNA by inhibiting the activity of DNA polymerase. The target of this drug is not related to any virus or bacterial species, but it inhibits the growth of cancer cells in vitro. The synthesis of 2'-deoxy-6-methylthioguanosine can be achieved by modifying commercially available phosphoramidites.Formula:C11H15N5O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:297.33 g/mol2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid
CAS:2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid is a benzoic acid derivative for use in researchFormula:C16H11NO3SPurity:Min. 95%Color and Shape:PowderMolecular weight:297.33 g/moltrans-Zeatin-o-glucoside riboside
CAS:Trans-Zeatin-o-glucoside riboside is a nucleotide that is found in protonemata and is involved in the regulation of cell division, cytokinin production, and responses to light. It is a cytokinin that regulates the pathways of nitrogen metabolism and other metabolic pathways. Trans-Zeatin-o-glucoside riboside has been detected at detectable levels in cells, tissues, and fluids. It has been shown to be involved in the evolution of plants. It has been shown to regulate cell division by inhibiting the phosphorylation of fibrillarin protein kinase, which leads to an increase in cyclins D1/D2 with no change in cyclin E1/E2. This nucleotide may also play a role in regulating cytokinin production by binding to DNA and influencing gene transcription.Formula:C21H31N5O10Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:513.5 g/mol6-Mercapto-9-(2'-deoxy-β-D-ribofuranosyl)purine
CAS:6-Mercapto-9-(2'-deoxy-b-D-ribofuranosyl)purine (6MPD) is a purine nucleoside that is used in the preparation of glycosidic bonds. It forms a glycosidic bond with the terminal residue of an oligosaccharide, which leads to the formation of an oligodeoxynucleotide. 6MPD also has binding properties to DNA binding proteins, and it can be used as a growth factor. 6MPD is obtained by reacting 3-chloroperoxybenzoic acid with sodium trifluoroacetate in the presence of mercaptoethanol and sodium hydroxide. This reaction yields 6MPD as a white solid with a melting point of 179°C.Formula:C10H12N4O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:268.29 g/mol3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-2'-ketouridine
CAS:Used as a protected 2'-ketouridine nucleoside in the synthesis of modified RNA oligonucleotides. The 1,1,3,3-tetraisopropyldisiloxane-1,3-diyl (TIPDS or TBDPSi2) group protects the 3' and 5' hydroxyl groups, while the 2'-keto (or 2'-oxo) modification introduces a specific functional group at the 2' position of the ribose sugar.Formula:C21H36N2O7Si2Purity:Min. 95%Color and Shape:White PowderMolecular weight:484.69 g/molN4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine
CAS:N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a synthetic nucleoside that is used as an activator for DNA synthesis. It is also used in the preparation of diphosphate derivatives for use as antiviral and anticancer agents or as probes for DNA and RNA research. N4-Benzoyl-3'-deoxy-5'-O-DMT-cytidine is a novel, high purity, and high quality chemical with CAS No. 86234-45-9.
Formula:C37H35N3O7Purity:Min. 95%Molecular weight:633.69 g/mol2'-Deoxyguanosine 3'-O-L-valinyl ester
2'-Deoxyguanosine 3'-O-L-valinyl ester is a synthetic nucleoside obtained from 2'-deoxyguanosine and valine. It has antiviral activity against DNA viruses, such as herpes simplex virus and vaccinia virus, and anticancer activity. 2'-Deoxyguanosine 3'-O-L-valinyl ester is an analog of guanosine that has been modified to contain an L-valyl group at the 3' position. This modification increases the stability of this nucleoside in aqueous solutions and provides potent antiviral and anticancer activity.Purity:Min. 95%Polyinosinic acid-polycytidylic acid, homopolymer (1:1)
CAS:Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products. For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'Formula:(C10H13N4O8P)x•(C9H14N3O8P)xColor and Shape:PowderN4-Acetyl-5'-O-DMT-cytidine
CAS:N4-Acetyl-5'-O-DMT-cytidine is an antiviral drug that inhibits the viral DNA polymerase. It is a modified nucleoside, which is activated by phosphorylation. N4-Acetyl-5'-O-DMT-cytidine is used in research for its anticancer properties and has shown to inhibit the growth of cancer cells in vitro. The compound was found to be more potent than cytidine and other modified nucleosides.Formula:C32H33N3O8Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:587.63 g/mol2'-O-Benzoyl-5'-O-DMT-4-thiouridine
2'-O-Benzoyl-5'-O-DMT-4-thiouridine is a phosphoramidite monophosphate nucleoside analog. It has antiviral and anticancer properties, and has been shown to activate the immune system in mice. 2'-O-Benzoyl-5'-O-DMT-4-thiouridine is also novel because it is structurally different from all other nucleosides that have been studied for antiviral and anticancer activity. This drug can be used as an activator of DNA synthesis in vitro.Formula:C37H34N2O8SPurity:Min. 95%Color and Shape:Yellow SolidMolecular weight:666.76 g/mol2'-C-Methylcytidine
CAS:Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymeraseFormula:C10H15N3O5Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:257.25 g/mol8-Chloroadenosine
CAS:8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.Formula:C10H12ClN5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:301.69 g/mol2'-O-Methyladenosine
CAS:2'-O-Methyladenosine (2'-OMeA) is a nucleoside that is a low-energy analog of adenosine. It has been shown to be an effective inhibitor of protein synthesis in vitro, by inhibiting RNA polymerase in the process of transcription. 2'-OMeA has also been shown to inhibit virus replication in vitro and to have potent inhibitory activity against human immunodeficiency virus type 1 (HIV-1). 2'-OMeA inhibits viral replication by binding to the viral ribonucleotide reductase enzyme and blocking the conversion of ribonucleotides into deoxyribonucleotides. The chemical structures of 2'-OMeA are similar to those found in fatty acids and can be detected using chemical ionization mass spectroscopy. The sequence for 2'-OMeA was determined through sequencing methods including NMR spectroscopy and nuclear magnetic resonance data analysis.Formula:C11H15N5O4Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:281.27 g/mol8-Hydrazinoadenosine
CAS:8-Hydrazinoadenosine is an inhibitor of phosphodiesterase, which is a key enzyme in the regulation of cellular processes. 8-Hydrazinoadenosine binds to the active site of the enzyme and inhibits its function. This binding prevents hydrolysis of the phosphate bond between two nucleotides and so prevents the formation of a new nucleotide from a nucleoside and a phosphate molecule. 8-Hydrazinoadenosine has been shown to inhibit phosphodiesterases in vitro and in animals, including rat brain and mouse lung. Strategies for 8-hydrazinoadenosine commercialization have been investigated, including attaching it to other molecules that are more easily absorbed by cells or using irradiation to produce 8-aminoadenosine, which can be converted into 8-hydrazinoadenosine.Purity:Min. 95%5-Amino-2’-deoxy-2’-O-methyluridine HCl
5-Amino-2’-deoxy-2’-O-methyluridine HCl is a novel nucleoside analog that has been modified with an O-methyl group at the 5′ position of the ribose moiety. This modification inhibits phosphorylation by inhibiting DNA polymerase and thus, preventing DNA synthesis. 5-Amino-2’-deoxy-2’-O-methyluridine HCl has also been shown to inhibit viral replication by inhibiting viral RNA and protein synthesis, while not affecting human RNA and protein synthesis. 5AADMUT is an activator of diphosphate metabolism in cells which may be due to its ability to inhibit enzymes involved in nucleotide metabolism (e.g., adenosine kinase).Purity:Min. 95%2'-Deoxypseudoisocytidine
CAS:2'-Deoxypseudoisocytidine is a synthetic nucleoside that is structurally similar to pseudoisocytidine. It is used as an anti-cancer agent in labeling studies. The compound exhibits cytotoxic activity against tumor cells and inhibits the growth of cultured human cancer cell lines. 2'-Deoxypseudoisocytidine has been shown to be effective in preventing the growth of brain tumors in mice by targeting DNA synthesis, which may be due to its ability to act as an analog of cytosine and bind to DNA. This drug also has potential for use as a chemotherapeutic agent for leukemia and other cancers.Formula:C9H13N3O4Purity:Min. 95%Color and Shape:PowderMolecular weight:227.22 g/molDenufosol tetrasodium
CAS:A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance. The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.
Formula:C18H23N5Na4O21P4Purity:Min. 90 Area-%Color and Shape:PowderMolecular weight:861.25 g/molN6-Benzoyl-3’-deoxy-5'-O-DMT-3’- fluoroadenosine 2’-CE-phosphoramidite
N6-Benzoyl-3’-deoxy-5'-O-DMT-3’- fluoroadenosine 2’-CE-phosphoramidite is a novel and activator ribonucleoside with deoxyribonucleosides, diphosphate and phosphoramidites. It is an anti-cancer, antiviral, and antiinflammatory agent. N6-Benzoyl-3’-deoxy-5'-O-DMT-3’ -fluoro adenosine 2’ -CE phosphoramidite has a CAS no.Purity:Min. 95%Fmoc morpholino uridine monomer
Fmoc morpholino uridine monomer is a novel anticancer drug. It can inhibit the proliferation of cancer cells and induce cell apoptosis by interfering with the synthesis of DNA, RNA and protein. Fmoc morpholino uridine monomer has been shown to be active against viruses, such as human immunodeficiency virus (HIV), herpes simplex virus (HSV) and influenza A virus. This compound is also reported to have antiviral activity against HIV-1 in vitro and HSV-2 in vivo.Formula:C26H28ClN4O7PPurity:Min. 95%Molecular weight:574.13841[1,2-13C2, 2-15N]-Glycinamide ribonucleotide
Glycinamide ribonucleotide (GAR) is a nucleoside that is structurally similar to the natural nucleosides cytidine and adenosine. GAR has antiviral activity against HIV and HSV-1, and it inhibits the growth of cancer cells in culture. GAR has been shown to have novel anticancer properties, which may be due to its ability to inhibit DNA synthesis through a diphosphate or monophosphate mechanism. GAR can also be used as a precursor for the synthesis of other nucleosides.Purity:Min. 95%5’(R)-C-Methyl-5-methyluridine
CAS:5’(R)-C-Methyl-5-methyluridine is an nucleoside and a ribonucleoside. It has antiviral, anticancer, and DNA modifying properties. This product is used in research to make phosphoramidites, diphosphates, and deoxyribonucleosides. 5’(R)-C-Methyl-5-methyluridine is also used in the production of modified oligonucleotides as well as other novel DNA compounds.
Purity:Min. 95%2'-O-Acetyl-3'-deoxy-3'-fluoro-5'-O-toluoyluridine
2′-O-Acetyl-3′-deoxy-3′-fluoro-5′-O-toluoyluridine is a novel, activator ribonucleoside. It is synthesized by the phosphoramidite method and modified with an acetyl group at the 2′ position and a toluoyl group at the 3′ position. This compound has been shown to be active against cancer cells in vitro and in vivo.Formula:C19H19FN2O7Purity:Min. 95%Molecular weight:406.36 g/mol1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-docosanoyl)-cytosine
1-(4’-Azido-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)N4-(n-docosanoyl)-cytosine is a deoxyribonucleoside monophosphate with antiviral effects. It is a novel nucleotide analogue that contains an azido group and a 2,4,6-trifluorobenzene moiety. The 4′ position of the sugar is modified with an n-docosanoyl group. 1-(4’Azo-2′deoxy-2′fluoro-bDara)ribonucleosides are synthetic nucleotides that can be used to inhibit viral replication by inhibiting DNA polymerase and RNA polymerase.Purity:Min. 95%Adenine
CAS:Adenine is a nucleobase found in DNA and RNA. It is an essential component of the human body and is used in the production of phosphoramidites, which are chemical compounds that can be converted into phosphodiester bonds. Adenine has been shown to have anticancer properties, and it may function as a novel activator for other anticancer drugs. Adenine is also used as a monophosphate in some cases. The purity of this compound exceeds 99% and the molecular weight ranges from 162 to 166.5 Daltons.
Formula:C5H5N5Purity:Min. 98.0 Area-%Molecular weight:135.13 g/molN4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite
CAS:Nucleoside phosphoramidites are widely used as building blocks in the chemical synthesis of oligonucleotides. The use of a chemical synthesis rather than an enzymatic one allows bespoke oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with the 5’ hydroxyl of the next nucleoside in the desired sequence. The reaction is usually catalysed by 1H-tetrazole or 4,5-dicyanoimidazole in acetonitrile. N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite, also called N4-Bz-5'-DMT-5-Me-dC phosphoramidite, is used in the synthesis of 2’-deoxy-5-methylcytidine-containing oligonucleotides as antisense drugs.Formula:C47H54N5O8PPurity:Min. 95%Color and Shape:White PowderMolecular weight:847.93 g/mol2'-Deoxy-N2-DMF-5'-O-tritylguanosine
CAS:2'-Deoxy-N2-DMF-5'-O-tritylguanosine is a nucleoside that is used as a building block in the synthesis of oligonucleotides and other DNA analogues. It is a novel, synthetic nucleoside. The compound has antiviral and anticancer properties. It has been evaluated for use as an activator in antibody production and in the treatment of HIV infection and certain types of cancer. 2'-Deoxy-N2-DMF-5'-O-tritylguanosine is a phosphoramidite, which can be used to synthesize DNA or RNA. This product is available in high purity, diphosphate form and can be used to prepare Anticancer (CAS No. 40094-22-2) Novel Nucleosides (CAS No. 40094-22-2) Phosphoramidites (CAS No. 40094-22Formula:C32H32N6O4Purity:Min. 95%Molecular weight:564.65 g/molRibavirin 5'-triphosphate tetrasodium salt - 10mM aqueous solution
CAS:Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.Formula:C8H15N4O14P3·Na4Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:576.1 g/mol
![1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-N3-(2S)-(2-amino-3-carbonyl]propyluracil](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FND162854.webp&w=3840&q=75)
![7-b-D-Ribofuranosyl-7H- tetrazolo[5,1i]purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNR163016.webp&w=3840&q=75)
![2-[(Benzo[b]thien-2-ylcarbonyl)amino]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNB181580.webp&w=3840&q=75)
![[1,2-13C2, 2-15N]-Glycinamide ribonucleotide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNG170881.webp&w=3840&q=75)
