Membrane Transport Protein
Found 68 products for "Membrane Transport Protein".
Elacridar - Bio-X ™
CAS:Elacridar is an inhibitor of ATP-dependent transport, which is mediated by P-glycoprotein (P-gp). Functioning as an oral bioenhancer, Elacridar addresses multiple drug resistance in tumors, a common challenge in cancer treatment often linked to changes in the expression of protein inhibitors. Inhibition of P-gp by Elacridar is a key mechanism behind its effectiveness. P-glycoprotein, a well-characterized human ABC transporter of the MDR/TAP subfamily, acts as an ATP-dependent efflux pump with broad substrate specificity. Its increased expression in the intestines can hinder drug absorption, leading to reduced bioavailability and inadequate therapeutic plasma concentrations. Elacridar addresses this challenge by inhibiting P-gp, thereby increasing the bioavailability of coadministered drugs. Overall, Elacridar emerges as a promising option for the treatment of solid tumors, offering a strategic approach to overcoming multidrug resistance in cancer therapy.
Formula:C34H33N3O5Purity:Min. 95%Color and Shape:PowderMolecular weight:563.64 g/molRevaprazan HCl - Bio-X ™
CAS:Revaprazan is a proton pump inhibitor drug that is used for the treatment of GERD and other conditions related to an excess in stomach acid production. This drug works by inhibiting the proton pump in the stomach lining known as the H+/K+-ATPase, resulting in a reduction of stomach acid and relief of symptoms.Formula:C22H24ClFN4Purity:Min. 95%Color and Shape:PowderMolecular weight:398.9 g/molDuloxetine HCl - Bio-X ™
CAS:Controlled ProductDuloxetine is a serotonin and norepinephrine reuptake inhibitor drug that is used to treat anxiety, pain, osteoarthritis and stress incontinence. This drug inhibits the reuptake of the neurotransmitters serotonin and norepinephrine so that there are increased levels of them in the synaptic cleft.Formula:C18H19NOS·HClPurity:Min. 95%Color and Shape:PowderMolecular weight:333.88 g/molProbenecid - Bio-X ™
CAS:Controlled ProductProbenecid is a uricosuric agent that is used to treat gout and hyperuricemia. This drug works by inhibiting the reabsorption of uric acid in the renal tubes which results in more uric acid being passed out in the urine. By lowering uric acid levels, Probenecid helps prevent the formation of uric acid crystals in joints, reducing the risk of gout attacks. This drug can also be used as an adjunct to antibacterial therapy.Formula:C13H19NO4SPurity:Min. 95%Color and Shape:PowderMolecular weight:285.36 g/molTolazamide
CAS:Inhibitor of sulphonylurea receptor SUR1; hypoglycemic agent
Formula:C14H21N3O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:311.4 g/molEpiblastin A
CAS:Inhibits CK1 α, δ and ε isoforms (IC50 values = 8.9, 0.5, and 4.7 μM, respectively). Induces reprogramming of epiblast-derived stem cells (EpiSCs) to embryonic stem cells (ESCs). If the latter express Oct4-GFP, the compound can be used as a tool to study this signaling pathway.Formula:C12H10ClN7Purity:Min. 95%Molecular weight:287.71 g/molDoxepin HCl - Bio-X ™
CAS:Controlled ProductDoxepin is a psychotropic agent that is used in the treatment of depression, anxiety and insomnia. This drug has antidepressant and anxiolytic properties. This mechanism of action for this drug is not clear however it is known to be a histamine receptor antagonist.Formula:C19H21NO•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:315.84 g/molFasentin
CAS:Inhibitor of glucose uptake via GLUT1 and GLUT4 transporters, promoting intracellular glucose deprivation. The compound is a chemical sensitizer to the FAS cell death receptor and is able to break down the resistance of caspase activation. It has potential for anti-cancer therapy as it modulates the Warburg effect in cancer cell lines.Formula:C11H9ClF3NO2Purity:Min. 95%Color and Shape:SolidMolecular weight:279.64 g/molIpragliflozin
CAS:Inhibitor of sodium-glucose cotransporter SGLT2
Formula:C21H21FO5SPurity:Min. 95%Color and Shape:PowderMolecular weight:404.45 g/molDCAC 50
CAS:Inhibitor of the intracellular copper chaperones ATOX1 and CCSFormula:C17H12BrF2N3OSPurity:Min. 95%Color and Shape:SolidMolecular weight:424.26 g/mol(S)-Lansoprazole
CAS:Gastric proton pump inhibitorFormula:C16H14F3N3O2SPurity:Min. 95%Color and Shape:White PowderMolecular weight:369.36 g/molRabeprazole sodium salt - Bio-X ™
CAS:Rabeprazole is a proton pump inhibitor drug that is used to treat symptoms of GERD, heal gastrointestinal ulcers and eradicate Helicobacter pylori. This antiulcer drug suppresses gastric acid by inhibiting the gastric H+/K+ ATPase at the parietal cell.
Formula:C18H20N3O3SNaPurity:Min. 95%Color and Shape:PowderMolecular weight:381.43 g/molPantoprazole sodium hydrate - Bio-X ™
CAS:Pantoprazole is a proton pump inhibitor drug that is used to treat erosive esophagitis and promotes healing of tissue damage caused by gastric acid. It is used for the management of GERD. Through the proton pump inhibition, the formation of hydrochloric acid is inhibited thus inhibiting gastric secretion.Formula:(C16H14F2N3NaO4S)2•(H2O)3Purity:Min. 95%Color and Shape:PowderMolecular weight:864.75 g/molAnacetrapib
CAS:A potent inhibitor of CETP that inhibits transfer of cholesteryl esters and triglycerides. Raises HDL cholesterol levels whilst lowering LDL cholesterol. Reduces cardiovascular events in patients with atherosclerotic vascular disease that receive statin treatment.
Formula:C30H25F10NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:637.51 g/molAZD 3965
CAS:AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with binding affinity of 1.6 nM, 6-fold selective for MTC1 over MCT2.
Formula:C21H24F3N5O5SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:515.51 g/molN-Methyl paroxetine
CAS:Inhibitor of serotonin reuptakeFormula:C20H22FNO3Purity:Min. 95%Color and Shape:PowderMolecular weight:343.39 g/molTetrabenazine - Bio-X ™
CAS:Controlled ProductTetrabenazine is a drug that has been used for the treatment of Parkinson's disease. It acts by inhibiting dopamine release and reducing the activity of nerve cells in the brain. Tetrabenazine Bio-X is used to treat dyskinesias, that are abnormal and involuntary muscle movements by inhibiting the monoamine transporter (VMAT2). Tetrabenazine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use."Formula:C19H27NO3Purity:Min. 99 Area-%Color and Shape:White PowderMolecular weight:317.42 g/molZimeldine
CAS:Serotonin uptake inhibitor; anti-depressant
Formula:C16H17BrN2Purity:Min. 95%Color and Shape:Yellow To Light Brown LiquidMolecular weight:317.22 g/molDL-Venlafaxine HCl - Bio-X ™
CAS:Controlled ProductVenlafaxine is an antidepressant drug used in the treatment of major depression, anxiety disorder and panic disorder. It is classed as an SNRI drug meaning it inhibits the reuptake of serotonin and norepinephrine so that there is an increased level of the neurotransmitters in the synaptic cleft.Formula:C17H27NO2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:313.86 g/molOrg 24598
CAS:A selective inhibitor of glial glycine transporter type 1 (GlyT-1b). It has no considerable affinity for noradrenaline, dopamine, serotonin and GABA receptors. Increases amplitude of electronically evoked NMDA receptor-mediated glutamatergic excitatory postsynaptic current (eEPSCs). This raises glycine levels in spinal cord slides and extends the duration of current at glycinergic synapses.Formula:C19H20F3NO3Purity:Min. 95%Molecular weight:367.36 g/mol
