Aminoacids and derivatives

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Carbocisteine Lactam is an impurity of the mucolytic agent Carbocisteine (C178760).<br>References Anonymous., et al.: Biochem. J., 219, 345 (1984); Sanger, F., et al.: Biochem. J., 59, 509 (1955); Hekman, C., et al.: J. Pharm. Biomed. Anal., 20, 763 (1999);<br></p>

<p>Stability Hygroscopic, moisture sensitive<br>Applications Stearoyl L-α-Lysolecithin is an bioactive lysophosphatidylcholine derived compound found to be released by bronchial epithelial cells. Stearoyl L-α-Lysolecithin have also been utilized in the development of liposomes and michelles by drug transdermal delivery devices.<br>References Zhuge, Y., et al.: Allergy Asthma Immunol Res., 6, 66 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004),<br></p>

<p>Applications L-Kynurenine-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of L-Kynurenine. L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid, an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Stability Very Very Hygroscopic<br>Applications A metabolic intermediate of L-Carnitine.<br>References Huffman, K. et al.: Diab. Care, 32, 1678 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications sym-Homospermidine is an analogue of Spermidine. sym-Homospermidine is used as antineoplastic.<br>References Pegg, A., et al.: Cancer Res., 48, 759 (1988), Bergeron, R., et al.: J. Med. Chem., 37, 3464 (1994), Bergeron, R., et al.: Drug Metab. Dispos., 23, 1117 (1995),<br></p>

<p>Applications Dioxindolyl-L-alanine is used in the synthesis of peptides containing 5-Hydroxytryptophan, Oxindolylalanine, N-Formylkynurenine and Kynurenine.<br>References Berlett, B., et al.: J. Biol. Chem., 272, 20313 (1997), Chang, T., et al.: J. Biomed. Sci., 7, 357 (2000); Frolov, A., et al.: J. Pept. Sci., 13, 862 (2007);<br></p>

<p>Impurity Baclofen EP Impurity A<br>Applications 4-(4-Chlorophenyl)-2-pyrrolidinone is used in the preparation of potential and selective antagonists of the α1A adrenergic receptor (1,2). It is an impurity of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br>References (1) Whitlock, G. et al.: Bioorg. med. Chem. Lett., 19, 3118 (2009)(2) Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications 2-Hydroxy L-Tryptophan is a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from Tryptophan.<br>References Southan, M.D., et al.: Med. Chem. Res., 6, 343 (1996);<br></p>

<p>Applications Essential amino acid.<br>References Goze, C., et al.: Eur. J. Pharmacol., 643, 153 (2010), Bhandare, P., et al.: J. Chem. Pharm. Res., 2, 372 (2010),<br></p>

<p>Applications An important metabolite of Benzene.<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>