Aminoacids and derivatives

<p>Applications Minor Cisapride (C496400) metabolite.<br>References Meuldermans, W., et al.; Drug Metab. Disposition, 16, 410 (1988), Lowry J., et al.; Clin. pharmacol. ther., 73, 209 (2003), Shao L., et al.: Bioorg. Med. Chem. Lett., 19, 5679 (2009),<br></p>

<p>Applications Glycine 6-Ethylchenodeoxycholate-d5 is the labelled version of Glycine 6-Ethylchenodeoxycholate (G625250) which can be used as reactant/reagent in synthetic preparation of bile acid analogs as FXR/TGR5 agonists.<br>References Or, Y., et al.: PCT Int. Appl., WO 2016073767 A1 20160512 (2016)<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications α-Methyldopa Methyl Ester is an impurity in the synthesis of L-α-Methyl DOPA Methyl Ester Hydrochloride which is a Methyldopa angiotensin II analog.<br>References Karle, I., et al.: Biochemistry, 29, 6747 (1990), Biron, E., et al.: Bioorg. Med. Chem., 12, 1279 (2004),<br></p>

<p>Applications Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications L-Carnitine-d3 Chloride is the isotope labelled analog of L-Carnitine (C184110); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid (K660500) and an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications Isotope labelled L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications N-Methyl-p-tyramineúHCl (cas# 370-98-9) is a useful research chemical.<br></p>

<p>Applications A labelled metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>