Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10433 products of "Benzimidazole and Imidazole Derivatives"
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Albendazole sulfoxide
CAS:<p>Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.</p>Formula:C12H15N3O3SPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:281.33 g/molPantoprazole N-oxide sodium
CAS:<p>Pantoprazole N-oxide sodium is a custom synthesis drug product that is being developed as an impurity standard in the synthesis of Pantoprazole. The compound is also used as a pharmacopoeia analytical standard and a HPLC standard.</p>Formula:C16H15F2N3O5S·NaPurity:Min. 95%Color and Shape:PowderMolecular weight:422.36 g/mol2-Hydroxybenzimidazole
CAS:<p>2-Hydroxybenzimidazole is a benzimidazole compound that is used in the treatment of nervous system diseases. It has been shown to have anti-inflammatory properties and can be used in the treatment of syncytial virus infection. 2-Hydroxybenzimidazole inhibits the production of reactive oxygen species and nitric oxide, which are involved in neurodegenerative disorders. The mechanism of action for 2-Hydroxybenzimidazole involves the formation of hydrogen bonds with hydroxyl groups on proteins. It also has been shown to reduce locomotor activity and increase sleep time in mice, which may be due to inhibition of acetylcholine release from cholinergic neurons.</p>Formula:C7H6N2OPurity:Min. 97.5 Area-%Color and Shape:Off-White PowderMolecular weight:134.14 g/mol2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt
<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt is a white to off-white crystalline powder. It is soluble in water and sparingly soluble in alcohol. This product is used as an analytical standard and has been found to be a metabolite of the drug clozapine. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt has also been found to be an impurity in the drug product lamotrigine.</p>Formula:C24H29NO5•NaPurity:Min. 95%Molecular weight:434.49 g/mol2,3-Dichlorobenzoic acid
CAS:<p>2,3-Dichlorobenzoic acid is an organic compound that belongs to the class of carboxylates. It is used as a drug substance in the treatment of mycobacterial infections. 2,3-Dichlorobenzoic acid has been shown to have antimicrobial activity against Mycobacterium tuberculosis and other mycobacteria. The sensitivity index for this compound was determined using a chromatographic method with human erythrocytes as the test organism. 2,3-Dichlorobenzoic acid displays its antibacterial activity by inhibiting protein synthesis and cell division. This drug also forms crystalline solids that are soluble in organic solvents such as chloroform or benzene.</p>Formula:C7H4Cl2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:191.01 g/molN-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]-2,3-dichlorobenzamide
CAS:<p>N-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]-2,3-dichlorobenzamide is a pharmaceutical dosage form that is titrated to achieve the desired therapeutic effect. It is used to treat epilepsy and bipolar disorder. Lamotrigine binds to sodium channels in nerve cells and blocks their opening. This prevents the influx of sodium ions that are necessary for neuronal transmission. Lamotrigine has been shown to have an anticonvulsant effect by reducing the frequency of seizures in patients with epilepsy.</p>Formula:C16H9Cl4N5OPurity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:429.09 g/mol3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one
CAS:<p>3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.</p>Formula:C9H6Cl2N4OPurity:Min. 95 Area-%Color and Shape:PowderMolecular weight:257.08 g/molCarbendazim
CAS:<p>Carbendazim is a fungicide that inhibits the growth of fungi and bacteria. It has been shown to be potent inducers of polymerase chain reaction (PCR) amplification, with a rate constant of 0.0103 per minute. Carbendazim also has a significant effect on electrochemical impedance spectroscopy (EIS). The EIS analysis was used to compare carbendazim-treated cells with untreated cells, which showed that carbendazim causes an increase in the resistance across the cell membrane. This research suggests that carbendazim may be genotoxic, as it increased the amount of DNA damage observed in wild-type strains and altered the optical properties of DNA. Carbendazim is also an effective inhibitor of nitrite ion oxidation and colloidal gold deposition, which has led to its use as a water vapor control agent for plants.</p>Formula:C9H9N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:191.19 g/mol5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole N-oxide
CAS:<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole N-oxide is an ammonium salt of a sulfoxide with a chloride. It is also known as esomeprazole magnesium. This drug is used in the preparation of pharmaceutical preparations and is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and other conditions. The magnesium salt form is a polymorphic substance that has a crystalline form that occurs in nature, called alpha form, and a synthetic form that occurs in laboratory experiments and has been designated beta form. The alpha form exhibits enantioselectivity when it binds to the enzyme pepsin, which causes the drug to have an antiulcer effect.</p>Formula:C17H19N3O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:361.42 g/mol(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS:<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>Formula:C15H15NPurity:Min. 95%Color and Shape:White PowderMolecular weight:209.29 g/mol4-Desmethoxy omeprazole sulfide
CAS:<p>4-Desmethoxy omeprazole sulfide is a metabolite of omeprazole, a drug that is used to treat ulcers and gastroesophageal reflux disease. 4-Desmethoxy omeprazole sulfide is not an impurity in the production of omeprazole, but is present as a natural component of omeprazole. This compound has been shown to be an impurity standard for HPLC analysis. The pharmacopoeia defines 4-desmethoxy omeprazole sulfide as an API impurity in drug products. It is also being studied for its potential use in drug development and research and development.</p>Formula:C16H17N3OSPurity:Min. 95%Color and Shape:White to off-white solid.Molecular weight:299.39 g/molMethyl 2,2-dithienylglycolate
CAS:<p>Intermediate for tiotropium bromide synthesis</p>Formula:C11H10O3S2Purity:Min. 95%Color and Shape:White PowderMolecular weight:254.33 g/molRabeprazole
CAS:<p>Rabeprazole is a proton pump inhibitor that suppresses the production of stomach acid by blocking the H+/K+ ATPase enzyme. It is used for the treatment of gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole has been shown to be more effective than omeprazole in reducing gastric acid secretion in two-way crossover studies. Rabeprazole also has been shown to inhibit the growth of antibiotic-resistant strains of bacteria. In addition, rabeprazole binds to metal ions like iron and copper, which may affect its pharmacokinetics and efficacy. This drug is currently being investigated as an analytical method for determination of proton pump inhibitors in human serum and urine samples by electrochemical impedance spectroscopy (EIS).</p>Formula:C18H21N3O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:359.44 g/mol2-Mercaptobenzimidazole
CAS:<p>2-Mercaptobenzimidazole is a chemical compound that can be used for the treatment of infectious diseases. It has been shown to have antioxidative properties and inhibit the growth of bacteria. 2-Mercaptobenzimidazole also has an effect on human serum, which may be due to its ability to bind with proteins in serum and form hydrogen bonds. 2-Mercaptobenzimidazole is stable at high temperatures and has been shown as an effective antimicrobial agent against gram positive and gram negative bacteria.</p>Formula:C7H6N2SPurity:Min. 99 Area-%Color and Shape:White/Off-White SolidMolecular weight:150.19 g/molVarenicline
CAS:Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.Formula:C13H13N3Purity:99.76%Color and Shape:SolidMolecular weight:211.265-Methyl-6-nitro-1H-indazole
CAS:Formula:C8H7N3O2Purity:98%Color and Shape:SolidMolecular weight:177.0546-Bromo-3-chloro-1H-indazole
CAS:Formula:C7H4BrClN2Purity:98%Color and Shape:Solid, Yellow solidMolecular weight:229.9252-Amino-5-bromobenzimidazole
CAS:Formula:C7H6BrN3Purity:95%Color and Shape:SolidMolecular weight:212.052-(1H-2-Benzoimidazolyl)-ethylamine
CAS:Formula:C9H11N3Purity:95%Color and Shape:SolidMolecular weight:161.208[3-(1-methyl-1H-imidazol-2-yl)phenyl]amine dihydrochloride
Formula:C10H13Cl2N3Purity:98%Molecular weight:246.14(2-((1R,3S,4S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[2.2.1]HEPTAN-3-YL)-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER
CAS:Purity:98%Molecular weight:439.35998544-Methyl-1H-benzimidazole-2-carboxylic acid
CAS:Formula:C9H8N2O2Purity:95%Color and Shape:SolidMolecular weight:176.1752-Chloromethylbenzimidazole
CAS:Formula:C8H7ClN2Purity:95%Color and Shape:Tan powderMolecular weight:166.612-Amino-4-methyloxazole
CAS:Formula:C4H6N2OPurity:95%Color and Shape:Liquid, OilMolecular weight:98.105(R)-methyl 5-(6-(hydroxymethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS:Purity:95%Molecular weight:476.47000121,3-Bis(2,6-di(pentan-3-yl)phenyl)-1H-imidazol-3-ium chloride
CAS:Purity:97%Molecular weight:537.27001952-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
CAS:Formula:C16H14F3N3OSPurity:98%Molecular weight:353.365-Methoxy-1H-indazole-3-carbaldehyde
CAS:Formula:C9H8N2O2Purity:98%Color and Shape:SolidMolecular weight:176.1752-(1H-IMIDAZOL-1-YL)-N-(3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)ACETAMIDE
CAS:Purity:98%Molecular weight:327.1900024
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