Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65644 products of "Quinazoline and Quinoline Derivatives"
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N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine Methyl Ester
CAS:Controlled Product<p>Applications N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine Methyl Ester is an impurity of the drug Valsartan (V095750), which is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C25H30N2O3Color and Shape:Colourless OilyMolecular weight:406.52Olanzapine N-Oxide
CAS:<p>Impurity Olanzapine EP Impurity D/ Olanzepine USP Related Compound C<br>Applications A metabolite of Olanzapine (Olanzapine EP Impurity D).<br>References Jacobsen, E., et al.: Acta Pharmacol. Toxacol., 11, 135 (1955), Chakrabarti, J.K., et al.: J. Med. Chem., 23, 878 (1980), Luo, H., et al.: J. Pharm. Sci., 11, 1079 (1992), Moore, N.A., et al.: Curr. Opin. Invest. Drugs, 2, 281 (1993),<br></p>Formula:C17H20N4OSColor and Shape:YellowMolecular weight:328.432-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine
CAS:Purity:99.0%Color and Shape:SolidMolecular weight:321.3760070800781N-Deshydroxyethyl Dasatinib
CAS:Controlled ProductFormula:C20H22ClN7OSColor and Shape:Off-WhiteMolecular weight:443.95N-Desmethyl Imatinib Dimesylate
Controlled Product<p>Stability Hygroscopic<br>Applications N-Desmethyl Imatinib Dimesylate is a by-product of the synthesis of N-Desmethyl Imatinib Mesylate (D292345), a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formula:C28H29N7O•C3H8O2SColor and Shape:NeatMolecular weight:479.58210816Desmethyl Amisulpride Hydrobromide
CAS:Controlled ProductFormula:C16H26BrN3O4SColor and Shape:NeatMolecular weight:436.36(2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]
CAS:<p>Applications (2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formula:C30H43NO8Color and Shape:White SolidMolecular weight:545.66cis-Montelukast
CAS:Controlled Product<p>Impurity Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast Cis-Isomer<br>Stability Light Sensitive<br>Applications cis-Montelukast (Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast cis Isomer) is a cis geometric isomer of Montelukast. An impurity of Montelukast.<br>References Schoors, D., et al.: Br. J. Clin. Pharmacol., 40, 277 (1995), Amin, R., et al.: J. Pharm. Biomed. Anal., 13, 155 (1995), Reiss, T., et al.: J. Allergy Clin. Immunol., 98, 528 (1996),<br></p>Formula:C35H36ClNO3SColor and Shape:Light YellowMolecular weight:586.18D-Tryptophan Methyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Intermediate for the synthesis of Tryptophan derivatives.<br>References Deveau, A., et al.: Bioorg. Med. Chem. Lett., 18, 3522 (2008),<br></p>Formula:C12H14N2O2·ClHColor and Shape:White To Off-WhiteMolecular weight:254.71(AlphaR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride
CAS:Controlled Product<p>Applications (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet (C441800), which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels).<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Formula:C22H25NColor and Shape:NeatMolecular weight:303.443-Bromo-5-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-pyridine
Purity:95.0%Molecular weight:266.09799194335944’-Bromomethyl-2-cyanobiphenyl
CAS:Controlled Product<p>Impurity Irbesartan Bromo Nitrile Impurity<br>Applications Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References KIm, Y.S., et al.: Bioorg. Med. Chem., 3, 2667 (1993),<br></p>Formula:C14H10BrNColor and Shape:NeatMolecular weight:272.14Mosapride N-Oxide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Mosapride (M731000).<br>References Chen, H., et al.: J. Pharm. Biomed. Anal., 40, 142 (2006), Pedraglio, S., et al.: J. Pharm. Biomed. Anal., 44, 665 (2007), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008), Curran, M., et al.: Drugs, 68, 981 (2008),<br></p>Formula:C21H25ClFN3O4Color and Shape:NeatMolecular weight:437.89N-Demethyl Ivabradine Hydrochloride
CAS:Controlled ProductFormula:C26H34N2O5·ClHColor and Shape:NeatMolecular weight:491.02Reserpine
CAS:Controlled Product<p>Applications An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.<br>References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),<br></p>Formula:C33H40N2O9Color and Shape:Off-WhiteMolecular weight:608.68rac-Monepantel Sulfone
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications rac-Monepantel Sulfone is a derivative of Monepantel (M515800), a recently discovered anthelmitic used in the treatment of parasitic nematodes via stun or kill without damaging the host entity.<br>References Baur, R. et al.: Mol. Pharm., 87, 96 (2015); Stuchlikova, L. et al.: Chemico. Biol. Interact., 227, 63 (2015);<br></p>Formula:C20H13F6N3O4SColor and Shape:NeatMolecular weight:505.39Captopril
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Formula:C9H15NO3SColor and Shape:NeatMolecular weight:217.29Fluazuron
CAS:Controlled Product<p>Applications A pesticide, like other BPUs it interferes with chitin synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamada, R., et al.: Biosci., Biotechnol., Biochem., 70, 54 (2006), Kryger, U., et al.: Vet. Parasitol., 143, 380 (2007), Arakawa, T., et al.: App. Entomol. Zool., 43, 167 (2008),<br></p>Formula:C20H10Cl2F5N3O3Color and Shape:White To Off-WhiteMolecular weight:506.21Quizalofop
CAS:<p> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C17H13ClN2O4Color and Shape:Off-White To Light YellowMolecular weight:344.75Rivastigmine N-Oxide (Technical Grade)
CAS:Controlled Product<p>Applications Rivastigmine N-Oxide is an impurity of Rivastigmine (R541000, Tartrate Salt) which is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C14H22N2O3Color and Shape:Light Yellow LiquidMolecular weight:266.34Dronedarone Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H44N2O5S·ClHColor and Shape:NeatMolecular weight:593.22N-Nitrosodiethylamine (1 mg/mL in Methanol)
CAS:Formula:C4H10N2OColor and Shape:Single SolutionMolecular weight:102.14endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
CAS:Controlled Product<p>Impurity Granisetron EP Impurity E<br>Applications Granisetron impurity E. An intermediate of Granisetron.<br>References McCallum, R., et al.: Drugs, 36, 652 (1988), Kaumann, A., et al.: Br. J. Pharmacol., 100, 879 (1990), Mohr, K., et al.: Pharmacol. Toxicol., 70, 198 (1992), Van, W.A., et al.: Nucl. Med. Biol., 21, 41 (1994), Mize, A., et al.: Brain Res., 836, 229 (1999),<br></p>Formula:C9H18N2Color and Shape:NeatMolecular weight:154.253Levofloxacin Hemihydrate
CAS:<p>Applications Levofloxacin Hemihydrate is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992); North, D.S., et al.: Pharmacotherapy, 18, 915 (1998); Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003);<br></p>Formula:C18H20FN3O4·H2OColor and Shape:Light YellowMolecular weight:740.75(R)-1-(2-Bromopyridin-4-yl)ethanamine dihydrochloride
CAS:Purity:97.0%Molecular weight:273.98001098632812-De(dimethylamino)-2-vinyl Dimetindene
CAS:<p>Applications Dimetindene derivative, a histaminic H1 receptor antagonist.<br></p>Formula:C18H17NColor and Shape:Light YellowMolecular weight:247.3343Benzarone
CAS:Controlled Product<p>Applications Benzarone is an EYA (Eyes Absents), multifunctional protein involved in organogenesis, inhibitor which makes it a potent anticancer agent. EYA’s are over expressed in ovarian and breast cancers. As well it is involved in the synthesis of Human Uric Acid Transporter 1 inhibitors which may be used to treat kidney diseases.<br>References Tadjuidje, E. et al.: PLoS One., 7, 34806 (2012); M, Wempe, et al.: J. Med. Chem., 54, 2701 (2011);<br></p>Formula:C17H14O3Color and Shape:NeatMolecular weight:266.29METHYL-1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE
CAS:Purity:95.0%Molecular weight:391.8299865722656aR-Brivaracetam
CAS:Controlled Product<p>Applications αR-Brivaracetam acts as a reagent for the preparation of 2-Oxo-1-pyrrolidine derivatives and their anticonvulsants activity. Also, is an impurity of Brivaracetam (B677645), a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Differding, E., et al.: PCT Int. Appl. (2001), WO 2001062726 A2 20010830; Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Formula:C11H20N2O2Color and Shape:NeatMolecular weight:212.29Robenidine-d8
CAS:Controlled Product<p>Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.<br>References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)<br></p>Formula:C15H5D8Cl2N5Color and Shape:YellowMolecular weight:342.25Sitagliptin Triazecine Analog
CAS:Controlled Product<p>Impurity Sitagliptin Tablets EP Impurity FP-B<br>Applications Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.<br>References Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H13F6N5O2Color and Shape:NeatMolecular weight:421.30Riociguat
CAS:Controlled Product<p>Applications Riociguat is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formula:C20H19FN8O2Color and Shape:NeatMolecular weight:422.4157Acrivastine
CAS:Controlled Product<p>Applications Acrivastine is an allergy medication that is histamine H2 antagonists.<br>References Manna, V.K., et al.: J. Int. Med. Res., 20, 106 (1992);<br></p>Formula:C22H24N2O2Color and Shape:Off White PowderMolecular weight:348.44N-Boc-Sitagliptin
CAS:Controlled Product<p>Applications N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.<br>References Aschner, P., et al.: Diabetes Care, 29, 2632 (2006); Charbonnel, B., et al.: Diabetes Care, 29, 2638 (2006)<br></p>Formula:C21H23F6N5O3Color and Shape:NeatMolecular weight:507.43N-Phenoxycarbonylparoxetine
CAS:Controlled Product<p>Applications N-Phenoxycarbonylparoxetine is an impurity of Paroxetine (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>Formula:C26H24FNO5Color and Shape:NeatMolecular weight:449.47Anastrozole Mono Acid
CAS:<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C17H20N4O2Color and Shape:Off-WhiteMolecular weight:312.374'-Ethoxyacetophenone
CAS:<p>Applications 4'-Ethoxyacetophenone, is an acetophenone derivative that can be used as an antibacterial agent. It is a reagent for plymerization. It can also be used as a flavoring agent in fabricating cigarettes with flavored filter tips.<br>References Sivakumar, P., et al.: Chem. Bio. Drug Design, 72, 303 (2008); Mathis, D. E., Beitraege zur Tabakforschung Int., 12, 1 (1983);<br></p>Formula:C10H12O2Color and Shape:White To Off-WhiteMolecular weight:164.205,5-Diphenyl Hydantoin
CAS:<p>Applications Diphenyl Hydantoin is an anticonvulsant agent that suppresses abnormal brain activity associated with seizure. It is used to treat ulcers, epidermolysis bullosa, chorea, Parkinson’s syndrome, trigeminal neuralgia, acute alcoholism, and inflammatory conditions (1,2).<br>References (1) Kim, S. H., et al.: Birth Defects Res B Dev Reprod Toxicol. 95, 337 (2012)(2) Younes, N., et al.: Dermatol Online J. 12, 5 (2006)<br></p>Formula:C15H12N2O2Color and Shape:WhiteMolecular weight:252.27Pyrimethamine-d3
CAS:Controlled Product<p>Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.<br>References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),<br></p>Formula:C12H10D3ClN4Color and Shape:Off-WhiteMolecular weight:251.733-Nitrophthalic Acid
CAS:<p>Applications 3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.<br>References Zhang, Xu, et al.: Chinese J. of Structural Chem., 35(5), 765-773 (2016);Cheng, Xiao-Yue, et al.: Inorg. Chem. Comm., 86, 192-199 (2017)<br></p>Formula:C8H5NO6Color and Shape:BeigeMolecular weight:211.132',6'-Picolinoxylidide
CAS:Controlled ProductFormula:C14H14N2OColor and Shape:NeatMolecular weight:226.27(5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone [Aprepit
CAS:Controlled Product<p>Applications Aprepitant-M3 is an active metabolite of Aprepitant.<br>References Ballard, T., et al.: Eur. J. Pharmacol., 412, 255 (2001), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Severini, C., et al.: Pharmacol. Rev., 54, 285 (2002),<br></p>Formula:C20H16F7NO3Color and Shape:NeatMolecular weight:451.33Dolutegravir intermediate-1
CAS:Controlled ProductFormula:C13H17NO8Color and Shape:Light YellowMolecular weight:315.28Celecoxib-d4
CAS:Controlled Product<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H10D4F3N3O2SColor and Shape:White To Light YellowMolecular weight:385.4rac-5-Bromo Naproxen
CAS:Controlled ProductFormula:C14H13BrO3Color and Shape:NeatMolecular weight:309.16Valsartan-d9 (Major)
CAS:Controlled Product<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C24H20D9N5O3Color and Shape:Off WhiteMolecular weight:444.572-(2-Aminoethoxy)anisole
CAS:Controlled Product<p>Applications 2-(2-Aminoethoxy)anisole is used as an additive to vinylphosphonic acid esters and acrylonitrile forming compounds displaying hypotensive activity. An impurity from the process of Carvedilol (C184625)<br>References Reznik, V. et al.: Russ. Chem. Bull., 48, 979, (1999); Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Formula:C9H13NO2Color and Shape:NeatMolecular weight:167.20Lisinopril (S,S,R)-Diketopiperazine (~90%)
CAS:<p>Impurity Lisinopril EP Impurity D<br>Stability Hygroscopic<br>Applications Lisinopril (S,S,R)-Diketopiperazine (Lisinopril EP Impurity D) is an impurity of Lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor (1).<br>References 1. Goa, K. et al.: Drugs. 1996 Oct;52(4):564-88.<br></p>Formula:C21H29N3O4Purity:~90%Color and Shape:White To Off-WhiteMolecular weight:387.47N-Butyl-N-methylnitrosamine (1 mg/mL in Methanol)
CAS:Formula:C5H12N2OColor and Shape:Single SolutionMolecular weight:116.16Chloropretadalafil
CAS:<p>Applications An intermediate in the synthesis of Tadalafil (T004500), which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003),<br></p>Formula:C22H19ClN2O5Color and Shape:White To Light Orange ColourMolecular weight:426.85Clozapine N-Oxide
CAS:Controlled Product<p>Impurity CLOZAPINE N-OXIDE IMPURITY<br>Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major metabolite of clozapine (C587500) that can be monitored by HPLC.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baldessarini, E., et al.: Neuropsychopharmacol., 9, 117 (1993); Lin, G., et al.: J. Pharm. Sci, 83, 1412 (1994); Roth, B.L., et al.: J. Pharmacol. Exp. Ther., 268, 1403 (1994)<br></p>Formula:C18H19ClN4OColor and Shape:Light Yellow To YellowMolecular weight:342.82Bis(2-aminoethylthio)methane Dihydrochloride
CAS:Controlled Product<p>Applications Bis(2-aminoethylthio)methane is a potential inhibitor of γ-glutamylcysteine synthetase, the first enzyme in the glutathione biosynthesis pathway.<br>References Sweetman, B.J., et al.: J. Med. Chem., 12, 888 (1969); Seelig, G.F., et al.: J. Biol. Chem., 259, 3534 (1984);<br></p>Formula:C5H14N2S2·2(HCl)Color and Shape:NeatMolecular weight:239.22Agomelatine Dimer Urea
CAS:<p>Impurity Agomelatine Impurity 4<br>Applications Agomelatine Dimer Urea is an impurity of Agomelatine (A430020). Agomelatine Impurity 4<br>References Depreux, P., et al.: J. Med. Chem., 37, 3231 (1994); Wregget, K., et al.: J. Biol. Chem., 270, 22488 (1995); Ying, S., et al.: Eur. J. Pharmacol., 296, 33 (1996);<br></p>Formula:C27H28N2O3Color and Shape:NeatMolecular weight:428.52Ethosuximide-d3
CAS:Controlled ProductFormula:C7H8D3NO2Color and Shape:White To Light YellowMolecular weight:144.19Ribociclib nitroso impurity 1
Controlled ProductFormula:C23H29N9O2Color and Shape:NeatMolecular weight:419.4954-Defluoro-2-fluoro Haloperidol
CAS:<p>Applications 4-Defluoro-2-fluoro Haloperidol is a positional isomer and impurity of the antipsychotic agent Haloperidol (H103700).<br></p>Formula:C21H23ClFNO2Color and Shape:NeatMolecular weight:375.862-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
CAS:<p>Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.<br>References Francesco, C., et al.: Eur. J. Org. Chem., 27, 6011 (2015)<br></p>Formula:C11H13F3O5SColor and Shape:NeatMolecular weight:314.278Gabapentin-d10
CAS:Controlled Product<p>Applications Gabapentin-d10 is the labelled analogue of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C92H10H7NO2Color and Shape:White To Off-WhiteMolecular weight:181.308(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one (Mixture of Regioisomers)
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity F+Omeprazole EP Impurity G<br>Stability Sample unstable under MS condition<br>Applications 8(9)-Methoxy-1,3-dimethyl-12-thioxopyrido[1’,2’:3,4]imidazo[1,2-a]benzimidazol-2-(12H)-one(Mixture of Regioisomers) (Omeprazole EP Impurity F+Omeprazole EP Impurity G) is a mixture of regioisomers of Omeprazole Impurity.<br>References Rackur, G., et al.: Biochem. Biophys. Res. Commmun., 128, 477 (1985),<br></p>Formula:C16H13N3O2SColor and Shape:NeatMolecular weight:311.36Omeprazole Sulfone N-Oxide
CAS:<p>Impurity Omeprazole EP Impurity I<br>Applications Omeprazole Sulfone N-Oxide (Omeprazole EP Impurity I) is a metabolite of Omeprazole. Impurity I.<br>References Stevens, C.M., et al.: J. Biol. Chem., 75, 182 (1950), Okamoto, S., et al.: Biochem. Biophys. Res. Commun., 101, 440 (1981)<br></p>Formula:C17H19N3O5SColor and Shape:NeatMolecular weight:377.41trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol(Ambroxol Impurity C)
CAS:Controlled Product<p>Impurity Ambroxol EP Impurity C Hydrochloride<br>Stability Light Sensitive<br>Applications trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug and the metabolite of Bromhexine (B678600). Ambroxol EP Impurity C<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C13H16Br2N2OColor and Shape:NeatMolecular weight:376.093,6-Diiodo-1H-indazole
CAS:Controlled Product<p>Applications 3,6-Diiodo-1H-indazole is used to prepare aryl-substituted indazole derivatives as modulators and inhibitors of protein kinases in the treatment of tumor growth, cellular proliferation, and angiogenesis.<br>References Kania, R., et al.: PCT Int. Appl., WO 2001002369 A2 20010111 (2001)<br></p>Formula:C7H4I2N2Color and Shape:NeatMolecular weight:369.931-CYCLOPROPYL-6,7,8-TRIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:283.20599365234375Mirabegron O-Glucuronide Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Mirabegron O-Glucuronide Sodium Salt is the is related to the compound Mirabegron O-Glucuronide (M364905) whcich is a metabolite of Mirabegron (M364900).<br>References van Teijilingen, R., et al.: J. Chromat. B., 887, 102 (2012)<br></p>Formula:C27H31N4O8S·xNaColor and Shape:NeatMolecular weight:572.63(S)-2-(((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)(nitroso)amino)-3-methylbutanoic Acid
CAS:Controlled ProductFormula:C19H20N6O3Color and Shape:Light YellowMolecular weight:380.4(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
CAS:Controlled Product<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate used to prepare trans-2-arylcyclopropylamines as potent and selective dipeptidyl peptidase IV inhibitors.<br>References Tsai, T., et al.: Bioorg. Med. Chem., 17, 2388 (2009)<br></p>Formula:C9H9F2N·HClColor and Shape:Off White SolidMolecular weight:205.6321-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine (~10% inorganics)
CAS:Controlled Product<p>Impurity Apremilast EP Impurity H<br>Applications 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine is used in the enantioselective synthesis of Apremilast (A729700) aminosulfone using catalytic asymetric hydrogenation. Apremilast EP Impurity H<br>References Ruchelman, A., et al.: Tetrahedron Asymmetr., 26, 553-559 (2015);<br></p>Formula:C12H19NO4SColor and Shape:NeatMolecular weight:273.352-(3-hydroxyphenyl)-6-methylquinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:279.2950134277344N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine
CAS:Purity:95.0%Molecular weight:461.8800048828125Sulindac-d6
CAS:Controlled Product<p>Applications Labelled analogue of Sulindac is a non-steroidal anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bjorkman. et al.: Am. J. Med., 105, 17S (1998); Thakur, et al.: Am. J. Hypertens., 12, 925 (1999);<br></p>Formula:C20H11D6FO3SColor and Shape:NeatMolecular weight:362.454-Dehydroxy-5-hydroxy Ritonavir
CAS:Controlled Product<p>Impurity Ritonavir EP Impurity N<br>Applications 4-Dehydroxy-5-Hydroxy Ritonavir (Ritonavir EP Impurity N) is an impurity of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Kempf, D.J. et al.: J. Med. Chem., 41, 602 (1998); Mekapati, S.B. et al.: J. Enzyme Inhib., 16, 185 (2001);<br></p>Formula:C37H48N6O5S2Color and Shape:NeatMolecular weight:720.942-(Methoxymethyl)-5-(phenylthio)-1H-benzimidazole
CAS:Controlled Product<p>Applications Febantel (F227000) impurity. Anthelmintic.<br>References Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>Formula:C15H14N2OSColor and Shape:NeatMolecular weight:270.352'-Hydroxy-3'-methoxyacetophenone
CAS:Controlled Product<p>Applications 2'-Hydroxy-3'-methoxyacetophenone, is an intermediate used for he synthesis of various chemical compounds. It can be used for the synthesis of 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.<br>References Nadine, d. M., et al.: J. Med. Chem., 34, 736 (1991);<br></p>Formula:C9H10O3Color and Shape:NeatMolecular weight:166.18(S)-Isotimolol
CAS:Controlled Product<p>Applications An isomer of the antiarrhythmic, antiglaucoma agent Timolol (T443700).<br>References Marini, R.D. et al.: Anal. Chim. Acta, 531, 131 (2005);<br></p>Formula:C13H24N4O3SColor and Shape:WhiteMolecular weight:316.42N-(2,6-Dichlorophenyl)-carbonimidic Dichloride
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications N-(2,6-dichlorophenyl)-carbonimidic Dichloride is an impurity of clonidine (C587130). Chlonidine is α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Formula:C7H3Cl4NColor and Shape:NeatMolecular weight:242.92Atazanavir-d6
CAS:Controlled Product<p>Applications Atazanavir-d6 is the isotope labelled analog of Atazanavir (A790051); an azapeptide HIV protease inhibitor. Atazanavir has also been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004); Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004)<br></p>Formula:C38H46D6N6O7Color and Shape:NeatMolecular weight:710.89N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine Impurity)
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity H<br>Applications N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine EP Impurity H) is an impurity of Cimetidine (C441650), an H2-receptor antagonist that is used for the treatment and prevention of stress-induced gastroduodenal lesions.<br>References Burland, W., et al.: Brit. J. Clin. Pharm., 2, 481 (1975); Kauffman, G. & Morton, I.: Gastroenterology, 75, 1099 (1978); Peura, D. & Johnson, L.: Ann. Int. Med., 103, 173 (1985)<br></p>Formula:C10H18N8S2Color and Shape:Off-WhiteMolecular weight:314.43(E/Z)-Tamoxifen-d5
CAS:Controlled Product<p>Applications Mixture of labelled Tamoxifen and its (E)-isomer.<br></p>Formula:C26H24D5NOColor and Shape:Off White SolidMolecular weight:376.55Diclazuril
CAS:<p>Applications Nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988);<br></p>Formula:C17H9Cl3N4O2Color and Shape:Off-WhiteMolecular weight:407.64Resiquimod-d5
CAS:Controlled Product<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Formula:C17H17D5N4O2Color and Shape:NeatMolecular weight:319.415,6-Dihydro Tofacitinib
CAS:Controlled Product<p>Applications 5,6-Dihydro CP-690550 is an impurity of CP-690550 (C781350), a pyrrolo[2,3-d]pyrimidine derivative, as Janus kinase inhibitor for treatment of rheumatoid arthritis.<br>References Sheiner, L., et al.: Clin. Pharmacol. Ther., 25, 358 (1979); Dayneka, N., et al.: J. Pharmacokin. Biopharm., 21, 457 (1993); Changelian, P., et al.: Science, 302, 875 (2003); Lee, H., et al.: Clin. Pharmacol. Ther., 73, 348 (2003); Hutmacher, M., et al.: J. Clin. Pharmacol., 47, 238 (2007)<br></p>Formula:C16H22N6OColor and Shape:NeatMolecular weight:314.39Pimozide N-Oxide
CAS:<p>Applications Pimozide N-Oxide is an impurity of Pimozide (P447800) with hERG inhibitory activity. Pimozide impurity E.<br></p>Formula:C28H29F2N3O2Color and Shape:Off White PowderMolecular weight:477.543-(4-Fluoro-phenyl)-1-methyl-1H-pyrazole-4-carbaldehyde
CAS:Formula:C11H9FN2OPurity:95.0%Color and Shape:Solid, Light yellow powderMolecular weight:204.204
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