Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65615 products of "Quinazoline and Quinoline Derivatives"
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Reduced Haloperidol-d4
CAS:Controlled Product<p>Applications Labelled Haloperidol Metabolite II<br>References Cutroneo, P., et al.: J. Pharm. Biomed. Anal., 41, 333 (2006), Sheridan, R., et al.: J. Med. Chem., 50, 3173 (2007), Lee, I., et al.: Eur. J. Pharmacol., 578(2, 123 (2008), Entrena, J., et al.: Psychopharmacol., 205, 21 (2009),<br></p>Formula:C21H21D4ClFNO2Color and Shape:White To Light YellowMolecular weight:381.9Saccharin N-(2-Acetic Acid Isopropyl Ester)(Piroxicam Impurity F)
CAS:Controlled Product<p>Impurity Piroxicam EP Impurity F<br>Applications Piroxicam impurity F.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Formula:C12H13NO5SColor and Shape:NeatMolecular weight:283.30Mirabegron O-Glucuronide Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Mirabegron O-Glucuronide Sodium Salt is the is related to the compound Mirabegron O-Glucuronide (M364905) whcich is a metabolite of Mirabegron (M364900).<br>References van Teijilingen, R., et al.: J. Chromat. B., 887, 102 (2012)<br></p>Formula:C27H31N4O8S·xNaColor and Shape:NeatMolecular weight:572.63Mephenoxalone
CAS:Controlled Product<p>Applications Muscle relaxant, also used as a mild tranquilizer.<br>References Erk N., et al.: J. Pharm. Biomed. Anal., 21, 429(1999), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Vilar, S., et al.: J. Med. Chem., 49, 1118 (2006),<br></p>Formula:C11H13NO4Color and Shape:NeatMolecular weight:223.23Dehydro Felodipine-d3
CAS:Controlled ProductFormula:C18H14D3Cl2NO4Color and Shape:NeatMolecular weight:385.26Eltrombopag Ethyl Ester
Controlled Product<p>Applications Eltrombopag Ethyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C27H26N4O4Color and Shape:NeatMolecular weight:470.52Ethyl 1-(4-nitrophenyl)-1H-pyrazole-3-carboxylate
CAS:Purity:95.0%Molecular weight:261.23699951171875Ibrutinib-d4 (Major)
CAS:Controlled Product<p>Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Formula:C25H20D4N6O2Color and Shape:NeatMolecular weight:444.525-Amino-3-methyl-1-quinolin-5-yl-1H-pyrazole-4-carbonitrile
Purity:95.0%Molecular weight:249.276992797851566-chloro-2-(4-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:297.73999023437510-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one
CAS:Purity:98%Molecular weight:318.3760070800781p-Chlonixin
CAS:<p>Applications p-Chlonixin may be used in pharmaceutical tablet dosage formulations.<br>References Kumar, M. N., et al.: I. J. Pharm., 5, 170-179 (2015)<br></p>Formula:C13H11ClN2O2Color and Shape:NeatMolecular weight:262.69Teneligliptin
CAS:<p>Teneligliptin (MP-513), potent DPP-4 inhibitor, IC50 ~1 nM, blocks DPP-4 in human/rat plasma and recombinant forms.</p>Formula:C22H30N6OSPurity:99.73%Color and Shape:SolidMolecular weight:426.58(S)-Lisinopril-d5 Sodium
CAS:Controlled ProductFormula:C21H26D5N3NaO5Color and Shape:NeatMolecular weight:433.51(S)-2-(((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)(nitroso)amino)-3-methylbutanoic Acid
CAS:Controlled ProductFormula:C19H20N6O3Color and Shape:Light YellowMolecular weight:380.4rac trans-Loxoprofen Alcohol
CAS:<p>Applications The cis-alcohol metabolite of Loxoprofen (L472900).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Terada, A., et al.: J. Med. Chem., 27, 212 (1984), Sugimoto, M., et al.: Biochem. Pharmacol., 42, 2363 (1991), Riendeau, D., et al.: Bioorg. Med. Chem. Lett., 14, 1201 (2004),<br></p>Formula:C15H20O3Color and Shape:NeatMolecular weight:248.32O-Ethyl Albuterol
CAS:Controlled Product<p>Impurity Levalbuterol USP Related Compound E<br>Applications O-Ethyl Albuterol is an analog of Albuterol (A514500). A β2-adrenoceptor agonist. Bronchodilator; tocolytic. Levalbuterol USP Related Compound E.<br>References Han, et al.: Bioorg. Med. Chem., 14, 6043 (2006), Liyou, H., et al.: Biochem., 46, 1432 (2007), Agrawal, D., et al.: J. Allergy Clin. Immunol., 113, 503 (2004),<br></p>Formula:C15H25NO3Color and Shape:NeatMolecular weight:267.36DL-Norepinephrine-d6 Hydrochloride, 85%
CAS:Controlled Product<p>Applications Antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),<br></p>Formula:C82H6H5NO3·ClHPurity:85%Color and Shape:NeatMolecular weight:211.68N-nitroso-Ritalinic Acid
CAS:Controlled ProductFormula:C13H16N2O3Color and Shape:NeatMolecular weight:248.283-Hydroxy Nevirapine
CAS:Controlled Product<p>Applications A metabolite of Nevirapine (N391275).<br>References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),<br></p>Formula:C15H14N4O2Color and Shape:NeatMolecular weight:282.303,6-Diiodo-1H-indazole
CAS:Controlled Product<p>Applications 3,6-Diiodo-1H-indazole is used to prepare aryl-substituted indazole derivatives as modulators and inhibitors of protein kinases in the treatment of tumor growth, cellular proliferation, and angiogenesis.<br>References Kania, R., et al.: PCT Int. Appl., WO 2001002369 A2 20010111 (2001)<br></p>Formula:C7H4I2N2Color and Shape:NeatMolecular weight:369.93Carisoprodol
CAS:Controlled Product<p>Applications Muscle relaxant (skeletal).<br>References Musso, D., et al.: J. Med. Chem. 46, 399 (2003), Newman, P., et al.: Eur. J. Clin. Pharm., 23, 31 (1982).<br></p>Formula:C12H24N2O4Color and Shape:White To Off-WhiteMolecular weight:260.33Nizatidine Sulfoxide
CAS:Controlled ProductFormula:C12H21N5O3S2Color and Shape:NeatMolecular weight:347.46Ethosuximide-d3
CAS:Controlled ProductFormula:C7H8D3NO2Color and Shape:White To Light YellowMolecular weight:144.1912-Hydroxy Irinotecan (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Irinotecan (I767500) found in human bile and urine.<br>References Lokeic, F. et al.: Clin. Cancer Res., 2, 1943 (1996); Dodds, H.M. et al.: Anti-cancer Drug Des., 16, 239 (2001); Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987); Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993);<br></p>Formula:C33H38N4O7Color and Shape:Off-WhiteMolecular weight:602.68Didesmethyl Cariprazine
CAS:Controlled Product<p>Applications Didesmethyl Cariprazine, s a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.<br>References Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)<br></p>Formula:C19H28Cl2N4OColor and Shape:NeatMolecular weight:399.36Hydroxy Dehydro Nifedipine Lactone
CAS:Controlled ProductFormula:C16H12N2O6Color and Shape:NeatMolecular weight:328.28Diclazuril 6-Carboxamide
CAS:Controlled Product<p>Applications Diclazuril 6-Carboxamide is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br></p>Formula:C18H10Cl3N5O3Color and Shape:NeatMolecular weight:450.66rac-5-Bromo Naproxen
CAS:Controlled ProductFormula:C14H13BrO3Color and Shape:NeatMolecular weight:309.16cis-ent-Tadalafil
CAS:Controlled Product<p>Impurity Tadalafil EP Impurity C<br>Applications The (6S)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6S,12aR)<br>References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),<br></p>Formula:C22H19N3O4Color and Shape:White To Off-WhiteMolecular weight:389.40ethyl 2-morpholin-4-yl-4-(trifluoromethyl)pyrimidine-5-carboxylate
Molecular weight:305.25698852539065-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
CAS:Controlled Product<p>Applications 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.<br>References Marsilje, T. H., et al.: J. Med. Chem., 56, 5675 (2013);<br></p>Formula:C28H36ClN5O3SColor and Shape:NeatMolecular weight:558.14Celecoxib-d4
CAS:Controlled Product<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H10D4F3N3O2SColor and Shape:White To Light YellowMolecular weight:385.4Valsartan-d9 (Major)
CAS:Controlled Product<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C24H20D9N5O3Color and Shape:Off WhiteMolecular weight:444.57(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS:<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists such as Ticagrelor (T437700)for the prevention of thrombosis.<br>References Springthorpe, B. et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007);<br></p>Formula:C9H9F2N·C8H8O3Color and Shape:NeatMolecular weight:321.324-Chloro Bupropion Fumarate
CAS:Controlled Product<p>Applications A 4-chloro substituted analogue of Bupropion (B689625) used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.<br>References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009);<br></p>Formula:C13H17Cl2NO·C4H4O4Color and Shape:NeatMolecular weight:390.26N-pyridin-3-yl-2-(tetrahydro-2H-pyran-4-ylcarbonyl)hydrazinecarbothioamide
Molecular weight:280.3500061035156Rivastigmine N-Oxide (Technical Grade)
CAS:Controlled Product<p>Applications Rivastigmine N-Oxide is an impurity of Rivastigmine (R541000, Tartrate Salt) which is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C14H22N2O3Color and Shape:Light Yellow LiquidMolecular weight:266.34Dronedarone Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H44N2O5S·ClHColor and Shape:NeatMolecular weight:593.22endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
CAS:Controlled Product<p>Impurity Granisetron EP Impurity E<br>Applications Granisetron impurity E. An intermediate of Granisetron.<br>References McCallum, R., et al.: Drugs, 36, 652 (1988), Kaumann, A., et al.: Br. J. Pharmacol., 100, 879 (1990), Mohr, K., et al.: Pharmacol. Toxicol., 70, 198 (1992), Van, W.A., et al.: Nucl. Med. Biol., 21, 41 (1994), Mize, A., et al.: Brain Res., 836, 229 (1999),<br></p>Formula:C9H18N2Color and Shape:NeatMolecular weight:154.253(AlphaR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride
CAS:Controlled Product<p>Applications (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet (C441800), which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels).<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Formula:C22H25NColor and Shape:NeatMolecular weight:303.443-Bromo-5-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-pyridine
Purity:95.0%Molecular weight:266.0979919433594Levofloxacin Carboxylic Acid (Levofloxacin Difluoro Impurity)
CAS:Controlled Product<p>Impurity Levofloxacin USP Related Compound B<br>Applications Levofloxacin intermediate.<br>References Liu, Bo; Y., et al.: Bioorg. Med. Chem., 13, 2451 (2005), Lalitha D., et al.: J. Pharm. Biomed. Anal., 50, 710 (2009),<br></p>Formula:C13H9F2NO4Color and Shape:NeatMolecular weight:281.21
![10-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF759966.webp&w=3840&q=75)
![(S)-2-(((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)(nitroso)amino)-3-methylbutanoic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FT310923.webp&w=3840&q=75)
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![(AlphaR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM322070.webp&w=3840&q=75)
![3-Bromo-5-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-pyridine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF545461.webp&w=3840&q=75)
