Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65541 products of "Quinazoline and Quinoline Derivatives"
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Nifedipine
CAS:Controlled Product<p>Applications Used as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker.<br>References Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989), Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991), Brown, M.J., et al.: Lancet, 356, 366 (2000),<br></p>Formula:C17H18N2O6Color and Shape:Light YellowMolecular weight:346.33Acetylclonidine
CAS:<p>Impurity Clonidine EP Impurity B<br>Applications Acetylcholidine (Clonidine EP Impurity B) is an impurity in the synthesis of Clonidine (C587120) an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Formula:C11H11Cl2N3OColor and Shape:NeatMolecular weight:272.138-methyl-2-(4-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:90.0%Molecular weight:277.322998046875N-Des(4-Fluorophenyl)-N-(3-fluorophenyl) Ezetimibe
CAS:Formula:C24H21F2NO3Color and Shape:Off White SolidMolecular weight:409.432-Methyl-Celecoxib
CAS:Controlled Product<p>Impurity 2,4-Dimethyl Celecoxib Impurity<br>Applications 2-Methyl-Celecoxib is an analog of the anti-inflammatory drug Celecoxib (C251000). Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C18H16F3N3O2SColor and Shape:Off-White To BeigeMolecular weight:395.41-Cyclopropylmethyl-1H-pyrazole-4-carboxylic acid
CAS:Color and Shape:Solid, White solidMolecular weight:166.179992675781252-Amino-3,4-dimethylpyridine
CAS:Formula:C7H10N2Purity:98%Color and Shape:SolidMolecular weight:122.171N-Nitrosometoprolol
CAS:<p>Applications N-Nitrosometoprolol is an N-nitroso derivative of rac Metoprolol(M338815), which is a β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. N-Nitrosometoprolol can be used to assess human and rat hepatocytes.<br>References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985); Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986); Martelli, A., In Vivo, 11, 189-194, (1997);<br></p>Formula:C15H24N2O4Color and Shape:Colourless To Light YellowMolecular weight:296.362,6-Dichloro-N-methyl-3-nitropyridin-4-amine
CAS:Purity:98%Color and Shape:SolidMolecular weight:222.02999883-Methylisoquinoline
CAS:Formula:C10H9NPurity:95.0%Color and Shape:Chunks,Crystalline PowderMolecular weight:143.1896,6’-Methylenebis[(3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one(Ondansetron Impurity B)
CAS:<p>Impurity Ondansetron EP Impurity B<br>Applications Ondansetron EP Impurity B.<br></p>Formula:C37H38N6O2Color and Shape:NeatMolecular weight:598.742-[5-fluoro-2-(pyridin-3-yl)-1H-indol-3-yl]ethan-1-amine hydrochloride
CAS:Purity:95.0%Molecular weight:291.75cis-Hydroxy Perhexiline-d11 (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A labelled metabolite of Perhexiline.<br>References Shah, R., et al.: Br. Med. J., 284, 295 (1982), Gould, B., et al.: Xenobiotica, 16, 491 (1986), Marquet, P., et al.: Ther. Drug Monit., 24, 255 (2002), Sallustio, B., et al.: Br. J. Clin. Pharmacol., 54, 107 (2002),<br></p>Formula:C19D11H24NOColor and Shape:NeatMolecular weight:304.56O-Desmethyl Indomethacin
CAS:Controlled Product<p>Applications The major metabolite of Indomethacin.<br>References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),<br></p>Formula:C18H14ClNO4Color and Shape:NeatMolecular weight:343.76R-(+)-Norketamine hydrochloride
CAS:Controlled Product<p>Applications R-(+)-Norketamine is the main metabolite of ketamine (K165300) and is also a non-competitive NMDA receptor antagonist found in the rat cortex and spinal cord models.<br>References Ebert, B., et al.: Eur. J. Pharmacol., 333, 99 (1997); Stephen, R., et al.: Life. Sci., 69, 2051 (2001)<br></p>Formula:C12H14ClNO•(HCl)Color and Shape:NeatMolecular weight:260.165-Desmethyl-3-methyl Leflunomide
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity E<br>Applications 5-Desmethyl-3-methyl Leflunomide (Leflunomide EP Impurity E) is the 3-methyl-isomer of Leflunomide (L322750), as a poisonous impurity.<br></p>Formula:C12H9F3N2O2Color and Shape:NeatMolecular weight:270.21Fingolimod-d4 Hydrochloride
CAS:Controlled Product<p>Applications A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C19H30D4ClNO2Color and Shape:NeatMolecular weight:347.964-(5-methylthiophen-2-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purity:95.0%Molecular weight:273.36999511718754-(pyridine-3-carbonyl)-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid
CAS:Purity:95.0%Molecular weight:290.31900024414061-(3,4-Dichlorophenyl)piperazine
CAS:Controlled ProductFormula:C10H12Cl2N2Color and Shape:NeatMolecular weight:231.12Desbutyl Dronedarone Hydrochloride
CAS:<p>Impurity Dronedarone USP Related Compound A<br>Applications A metabolite of Dronedarone (D679445). Dronedarone impurity D. Dronedarone USP Related Compound A.<br>References Bolderman, R.W. et al.: J Chrom. B:Anal. Tech. Biomed. Life Sci., 887, 1727 (2009); Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009);<br></p>Formula:C27H36N2O5S·ClHColor and Shape:NeatMolecular weight:537.115-Hydroxypyrazine-2-carboxylic Acid
CAS:<p>Applications A versatile building block for the synthesis of new antituberculous agents. A metabolite of Pyrazinamide (P840600).<br>References Wieser, M. et al.: Appl. Microbiol. Biotech., 48, 174 (1997); Lacroix, C. et al.: Eur. J. Clin. Pharmacol., 36, 395 (1989);<br></p>Formula:C5H4N2O3Color and Shape:Light YellowMolecular weight:140.102-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
CAS:Purity:95.0%Molecular weight:389.38000488281255-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
CAS:Purity:97.0%Molecular weight:473.8900146484375Axitinib Tetrahydro-2H-pyran
CAS:Controlled ProductFormula:C27H26N4O2SColor and Shape:NeatMolecular weight:470.586Axitinib
CAS:Controlled ProductFormula:C22H18N4OSColor and Shape:Off-White To BeigeMolecular weight:386.47Thioridazine Hydrochloride
CAS:Controlled Product<p>Applications Thioridazine HCl is a dopamine receptor blocker and antipsychotic. It is the parent compound of sulforidazine and mesoridazine. This compound has been reported to bind strongly to dopamine receptors on cancer stem cells and cause differentiation leaving normal cells alone (see Can. Chem. News 12 July/August 2012).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, E.I., Toxicol. Appl. Pharmacol., 18, 185 (1971), Abdel-Moety, E.M., et al.: Anal. Profile Drug Subs., 18, 459 (1989),<br></p>Formula:C21H26N2S2·ClHColor and Shape:Light YellowMolecular weight:407.0417α-Dutasteride
CAS:Controlled Product<p>Impurity Dutateride EP Impurity E<br>Applications 17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).<br></p>Formula:C27H30F6N2O2Color and Shape:Dark Orange Colour SolidMolecular weight:528.53N-Demethyl Olanzapine
CAS:Controlled Product<p>Applications A metabolite of Olanzapine.<br></p>Formula:C16H18N4SColor and Shape:BrownMolecular weight:298.413-(1,3-benzodioxol-5-yl)-1-methyl-1{H}-pyrazole-5-carboxylic acid
CAS:Purity:95.0%Molecular weight:246.2220001220703(+/-)-Epinephrine Hydrochloride
CAS:Controlled Product<p>Applications (+/-)-Epinephrine hydrochloride is an adrenergic receptor agonist; Neurotransmitter; Causes suppression of efferent activity of the adrenal nerve.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirano, T., et al.: J. Auton. Nerv. Syst., 1, 283-290 (1980)<br></p>Formula:C9H13NO3·ClHColor and Shape:Off-WhiteMolecular weight:219.67Captopril
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Formula:C9H15NO3SColor and Shape:NeatMolecular weight:217.29Omeprazole Sulfide
CAS:Controlled ProductFormula:C17H19N3O2SColor and Shape:White To Light BrownMolecular weight:329.427-Hydroxy Quetiapine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.<br>References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Tanaka, E., et al.: J. Clin. Pharm. Ther., 24, 7 (1999)<br></p>Formula:C21H25N3O3SColor and Shape:WhiteMolecular weight:399.51Meloxicam-d3
CAS:Controlled Product<p>Applications Labelled form of Meloxicam. Preferential cyclooxygenase (COX-2) inhibitor. Used as an anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hawkey, C., et al.: Br. J. Rheumatol., 35, Suppl. 1, 1 (1996), Fleischmann, R., et al.: Expert Opin. Pharmacother., 3, 1501 (2002),<br></p>Formula:C142H3H10N3O4S2Color and Shape:Light Yellow To YellowMolecular weight:354.425-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile
CAS:Controlled Product<p>Impurity Olanzapine EP Impurity A/ Olanzapene USP Related Compound A<br>Applications 5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (Olanzapine EP Impurity A) is an impurity of Olanzapine (O253750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon., et al.: Fed. Regist., 65, 83041 (2000), Yu, L., et al.: J. Phys. Chem., 106, 544 (2002),<br></p>Formula:C12H9N3O2SColor and Shape:NeatMolecular weight:259.28Desisopropyl Atrazine-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Atrazine (ATR) (A794600).<br>References Compton, D., et al.: Eur. J. Pharmacol., 110, 157 (1985), Das, P., et al.: Toxicol. Sci., 59, 127 (2001), Das, P., et al.: Life Sci., 73, 3123 (2003), Coban, A., et al.: J. Neurochem., 100, 1177 (2007),<br></p>Formula:C52H5H3ClN5Color and Shape:Off-WhiteMolecular weight:178.636-O-Desmethyl Moxonidine
CAS:Controlled Product<p>Stability Hygroscopic and Light Sensitive<br>Applications 6-O-Desmethyl Moxonidine is an impurity of the antihypertensive agent, Moxonidine (M745800).<br>References Milovanovic, S. et al.: J. Pharmac. Biomed. Anal., 59, 151 (2012);<br></p>Formula:C8H10ClN5OColor and Shape:NeatMolecular weight:227.65Riluzole 5-Trifluoromethoxy Isomer
CAS:Controlled Product<p>Stability Toxic<br>Applications Riluzole 5-Trifluoromethoxy Isomer is an impurity of Riluzole (R510000); a neuroprotective agent. Riluzole modulates glutamatergic transmission. It is a glutamate release inhibitor and an anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gunakkunru, A., et al.: Asian J. Chem., 19, 2843 (2007); Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985); Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993); Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H5F3N2OSColor and Shape:NeatMolecular weight:234.22-(3-Chloro-thiophen-2-yl)-1H-benzoimidazole-5-carboxylic acid
CAS:Color and Shape:SolidMolecular weight:278.7099914550781
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