Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65580 products of "Quinazoline and Quinoline Derivatives"
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N-Desmethyl Sildenafil Hemicitrate
CAS:Controlled Product<p>Applications N-Desmethyl Sildenafil Hemicitrate is an impurity of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998)<br></p>Formula:C48H64N12O15S2Color and Shape:NeatMolecular weight:1113.22Sulindac Sulfone-d6
CAS:Controlled Product<p>Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.<br>References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);<br></p>Formula:C20H11D6FO4SColor and Shape:NeatMolecular weight:378.45N-Cyano-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-carbamimidic Acid Methyl Ester
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity B<br>Applications N-Cyano-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-carbamimidic Acid Methyl Ester which is an impurity of Cimetidine (C441650), which acts as a competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output (1).<br>References 1. Brimblecombe, R. et al.: J. Int. Med. Res. 1975 Mar:3(2) 86-92<br></p>Formula:C10H15N5OSColor and Shape:White To Off-WhiteMolecular weight:253.32Aripiprazole
CAS:Controlled Product<p>Applications Aripiprazole is an agonist at the dopamine autoreceptor and an antagonist at the postsynaptic D2 receptor (1,2,3,4). Aripiprazole is an antipsychotic and a potential drug candidate for treating psychoses such as schizophrenia.<br>References (1) Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998)(2) Shiokawa, M., et al.: Eur.J.Pharmacol. 570, 108 (2007)(3) Oshiro, Y., et al.: J. Med. Chem. 41, 658 (1998)(4) Ozdemir, V., et al.: Curr Opin Investig Drugs. 3, 113 (2002)<br></p>Formula:C23H27Cl2N3O2Color and Shape:NeatMolecular weight:448.39ent-Montelukast Sodium Salt
CAS:<p>Impurity Montelukast EP Impurity A<br>Applications ent-Montelukast Sodium Salt (Montelukast EP Impurity A) is the S-enantiomer of Montelukast. Results indicate that there is no apparent bioinversion of Montelukast to its S-enantiomer in humans.<br>References Cheng, H., et al.: Pharm. Res., 11, 824 (1994), Amin, R., et al.: J. Pharm. Biomed. Anal., 13, 155 (1995), Jones, T., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995), Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995),<br></p>Formula:C35H35ClNO3S·NaColor and Shape:Off-White To Light YellowMolecular weight:608.172-(2-(2-morpholinothiazol-4-yl)ethyl)isoindoline-1,3-dione hydrochloride
CAS:Purity:95.0%Molecular weight:379.8599853515625Apalutamide
CAS:Controlled Product<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formula:C21H15F4N5O2SColor and Shape:White To Off-WhiteMolecular weight:477.43471-(3-Hydroxypropyl)theobromine
CAS:Controlled ProductFormula:C10H14N4O3Color and Shape:White To Off-WhiteMolecular weight:238.243Nimodipine-d7
CAS:Controlled Product<p>Applications A labelled dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral).<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Formula:C21H19D7N2O7Color and Shape:NeatMolecular weight:425.482-Deschloro Aripiprazole
CAS:<p>Impurity Aripiprazole EP Impurity D<br>Applications 2-Deschloro Aripiprazole (Aripiprazole EP Impurity D) is an impurity of the antipsychotic agent Aripiprazole (A771000). Aripiprazole impurity B.<br>References Akaike, A., et al.: Brain Res., 418, 262 (1987); Kikuchi, K., et al.: Life Sci., 42, 343 (1988); Caprathe, B., et al.: J. Med. Chem., 34, 2736 (1991); Yamada, S., et al.: J. Pharm. Pharmacol., 49, 206 (1997);<br></p>Formula:C23H28ClN3O2Color and Shape:WhiteMolecular weight:413.94ABT 199 (Venetoclax)
CAS:Controlled Product<p>Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>Formula:C45H50ClN7O7SColor and Shape:Light Yellow To YellowMolecular weight:868.44Deacetyl Ketoconazole
CAS:Controlled Product<p>Impurity Ketoconazole EP Impurity D<br>Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C24H26Cl2N4O3Color and Shape:Off-WhiteMolecular weight:489.39Tadalafil
CAS:Controlled Product<p>Stability Unstable in Methanol<br>Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003); Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005); Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005);<br></p>Formula:C22H19N3O4Color and Shape:White To Off-WhiteMolecular weight:389.401-Methoxy Empagliflozin
CAS:Controlled Product<p>Applications 1-Methoxy Empagliflozin is an impurity in the synthesis of Empagliflozin drug (E521510), which is potent and selective inhibitor of sodium glucose co-transporter-2 (SGLT-2).<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>Formula:C24H29ClO8Color and Shape:White To Off-WhiteMolecular weight:480.94Febantel
CAS:Controlled Product<p>Applications Used as an anthelmintic.<br>References Thomas, H.: Res. Vet. Sci., 25, 290 (1978), Shmidl, J.A.: Vet. Med. Small Anim. Clin., 73, 775 (1978)<br></p>Formula:C20H22N4O6SColor and Shape:NeatMolecular weight:446.481-Chloroadamantane
CAS:<p>Impurity Adamantane EP Impurity A<br>Stability Light Sensitive<br>Applications 1-Chloroadamantane, an adamantane derivative shown to exhibit virucidal activity against the Newcastle disease virus in chick embryo fibroblasts. (Adamantane EP Impurity A)<br>References Aigami, K., et al.: J. Med. Chem., 18, 713 (1975)<br></p>Formula:C10H15ClColor and Shape:NeatMolecular weight:170.68Vadadustat
CAS:<p>Applications Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.<br>References Pergola, P., et al.: Kidney Int., 90, 1115 (2016);<br></p>Formula:C14H11ClN2O4Color and Shape:BeigeMolecular weight:306.702-(Diphenylmethoxy)-N-methylethylamine
CAS:Controlled Product<p>Applications 2-(Diphenylmethoxy)-N-methylethylamine is used in the pereparation of H1 and H2 receptor antagonists containing Diphenhydramine (D486900) derivatives. Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine (D486900) is categorized as an antihistaminic; sedative, hypnotic.<br>References Wolf, C. et al.: Archiv. de Pharm., 329, 87 (1996); Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),<br></p>Formula:C16H19NOColor and Shape:Light Yellow To YellowMolecular weight:241.336-chloro-2-(3-hydroxyphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:299.7099914550781(3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-(2,3,5,6-tetradeuterio-4-fluorophenyl)azetidin-2-one
CAS:Controlled Product<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C242H4H17F2NO3Color and Shape:NeatMolecular weight:413.45Paliperidone E-oxime
CAS:Controlled Product<p>Applications Paliperidone E-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent.<br>References Rao, J., et al.: Pharmacia Lettre, 3, 240 (2011);<br></p>Formula:C23H28F2N4O3Color and Shape:NeatMolecular weight:446.49Des-4-fluorobenzyl Mosapride
CAS:Controlled Product<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>Formula:C14H20ClN3O3Color and Shape:NeatMolecular weight:313.78Ranitidine N-Oxide
CAS:Controlled Product<p>Impurity Ranitidine EP Impurity E<br>Stability Very Hygroscopic<br>Applications Ranitidine N-Oxide (Ranitidine EP Impurity E) is a metabolite of Ranitidine (R120000).<br></p>Formula:C13H22N4O4SColor and Shape:BeigeMolecular weight:330.40(S)-Linagliptin
CAS:<p>Applications (S)-Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Formula:C25H28N8O2Color and Shape:NeatMolecular weight:472.54(1,3-benzodioxol-5-ylmethyl)(2-pyridinylmethyl)amine dihydrobromide
CAS:Purity:95.0%Molecular weight:404.10198974609375Ethyl 2-phenyl-3-(trifluoromethyl)pyrazole-4-carboxylate
CAS:Formula:C13H11F3N2O2Purity:95.0%Color and Shape:LiquidMolecular weight:284.238AMOZ-d5
CAS:Controlled Product<p>Applications A labelled metabolite of Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),<br></p>Formula:C82H5H10N3O3Color and Shape:NeatMolecular weight:206.25p-Nicorandil
CAS:<p>Applications A positional isomeric impurity of the antianginal Nicorandil (N398500).<br>References Fedorov, B.S. et al.: Pharmac. Chem. J., 43, 134 (2009); Tatyanenko, L.V. et al.: Biomed. Khim., 52, 174 (2006);<br></p>Formula:C8H9N3O4Color and Shape:BeigeMolecular weight:211.17((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
CAS:Controlled Product<p>Applications ((3s,4r)-4-(4-Fluorophenyl)Piperidin-3-Yl)Methanol (cas# 125224-43-3) is a useful research chemical.<br></p>Formula:C12H16FNOColor and Shape:Light YellowMolecular weight:209.26Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
CAS:Purity:95.0%Molecular weight:367.3999938964844Nilotinib-d3
CAS:Controlled Product<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formula:C282H3H19F3N7OColor and Shape:Off-White To Light YellowMolecular weight:532.533-Dehydroxy Salbutamol
CAS:Controlled Product<p>Impurity Levalbuterol USP Related Compound B; Salbutamol EP Impurity C<br>Applications 3-Dehydroxy Salbutamol (Levalbuterol USP Related Compound B; Salbutamol EP Impurity C) is an isoprenaline based selective stimulants of β-adrenergic receptors in bronchial muscles.<br>References Hartley, D., et al.: Nature., 219, 5156 (1968);<br></p>Formula:C13H21NO2Color and Shape:NeatMolecular weight:223.31N-Nitrosoephedrine
CAS:Controlled ProductFormula:C10H14N2O2Color and Shape:NeatMolecular weight:194.23Norneo Vardenafil
CAS:Controlled Product<p>Applications Norneo Vardenafil is a related compound of Vardenafil (V098001) as phosphodiesterase inhibitor.<br></p>Formula:C18H20N4O4Color and Shape:Off White SolidMolecular weight:356.381-(4-Pyridyl)-1,2,3,4-tetrahydro isoquinoline
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:210.27999877929688Acetyl Isoniazid-d4
CAS:Controlled Product<p>Applications A labelled metabolite of Isoniazid (I821450) in plasma.<br>References Peloquin, C., et al.: Antimicrob. Agents Chemother., 41, 2670 (1997), Peloquin, C., et al.: Drugs, 62, 2169 (2002),<br></p>Formula:C8H5D4N3O2Color and Shape:Off-WhiteMolecular weight:183.24-Dechloro-4-hydroxy Diclazuril
CAS:<p>Applications 4-Dechloro-4-hydroxy Diclazuril is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Formula:C17H10Cl2N4O3Color and Shape:NeatMolecular weight:389.19(3-Cyclohexyl)propyl 5-(1,3-dioxolan-2-yl)-2-thienyl ketone
CAS:Purity:97.0%Molecular weight:308.440002441406254,4',4''-(2,4,6-Trimethylbenzene-1,3,5-triyl)tripyridine
CAS:Purity:97%Molecular weight:351.45300292968754-(Benzo[d]thiazol-2-ylthio)morpholine
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:252.350006103515624-[3-(methoxycarbonyl)-5-(thiophen-2-yl)-1H-pyrazol-1-yl]benzoic acid
CAS:Purity:95.0%Molecular weight:328.3399963378906N-Mesyldronedarone
CAS:Controlled Product<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formula:C32H46N2O7S2Color and Shape:NeatMolecular weight:634.853-Ethyl-2-imine Meloxicam
CAS:Controlled Product<p>Applications Meloxicam (M216100) impurity.<br></p>Formula:C16H17N3O4S2Color and Shape:Light YellowMolecular weight:379.45
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