Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65580 products of "Quinazoline and Quinoline Derivatives"
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Lacidipine
CAS:Controlled Product<p>Applications A dihydropyridine calcium channel blocker. Antihypertensive.<br>References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),<br></p>Formula:C26H33NO6Color and Shape:Light YellowMolecular weight:455.54Ethyl 5-{[1,1'-biphenyl]-4-yl}-1H-pyrazole-3-carboxylate
CAS:Purity:95.0%Molecular weight:292.3380126953125Irbesartan-d4
CAS:Controlled Product<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals<br></p>Formula:C25H24D4N6OColor and Shape:NeatMolecular weight:432.55Ranitidine N-Oxide
CAS:Controlled Product<p>Impurity Ranitidine EP Impurity E<br>Stability Very Hygroscopic<br>Applications Ranitidine N-Oxide (Ranitidine EP Impurity E) is a metabolite of Ranitidine (R120000).<br></p>Formula:C13H22N4O4SColor and Shape:BeigeMolecular weight:330.40Des-4-fluorobenzyl Mosapride
CAS:Controlled Product<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>Formula:C14H20ClN3O3Color and Shape:NeatMolecular weight:313.78Paliperidone E-oxime
CAS:Controlled Product<p>Applications Paliperidone E-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent.<br>References Rao, J., et al.: Pharmacia Lettre, 3, 240 (2011);<br></p>Formula:C23H28F2N4O3Color and Shape:NeatMolecular weight:446.497-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 7-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone is used in the synthesis of aripiprazole, an antipsychotic oral drug used in the treatment of Schizophrenia.<br>References Bonacorsi, S. et al.: J. Label. Comp. Radiopharm., 49, 1 (2006); Morita, Seiji; K. et al.: Tetrahedron, 54, 4811 (1998);<br></p>Formula:C13H16ClNO2Color and Shape:Off-WhiteMolecular weight:253.722-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
CAS:Purity:97.0%Color and Shape:LiquidMolecular weight:370.8299865722656Felbamate-d4
CAS:Controlled Product<p>Applications Antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>Formula:C11H10D4N2O4Color and Shape:NeatMolecular weight:242.2672-Pyridin-2-yl-benzofuran-5-carboxylic acid methyl ester
Purity:95.0%Molecular weight:253.25700378417975-Chloro-Vortioxetine Hydrobromide
CAS:Controlled Product<p>Applications 5-Chloro-Vortioxetine is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C18H22BrClN2SColor and Shape:NeatMolecular weight:413.8Vildagliptin Amide
CAS:Controlled Product<p>Impurity Vildagliptin Amide Impurity<br>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H27N3O3Color and Shape:Off-WhiteMolecular weight:321.41Nifursol (~90%)
CAS:Controlled Product<p>Applications A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Formula:C12H7N5O9Purity:~90%Color and Shape:NeatMolecular weight:365.21Methyl 4’-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-ca
CAS:Formula:C34H32N4O2Color and Shape:YellowMolecular weight:528.64Maraviroc
CAS:Controlled ProductFormula:C29H41F2N5OColor and Shape:White To Off-WhiteMolecular weight:513.67Teneligliptin
CAS:<p>Teneligliptin (MP-513), potent DPP-4 inhibitor, IC50 ~1 nM, blocks DPP-4 in human/rat plasma and recombinant forms.</p>Formula:C22H30N6OSPurity:99.73%Color and Shape:SolidMolecular weight:426.582,6-Dichloroformanilide
CAS:Controlled Product<p>Applications 2,6-Dichloroformanilide is an intermediate in the synthesis of N-(2,6-Dichlorophenyl)-carbonimidic Dichloride (D436565). N-(2,6-dichlorophenyl)-carbonimidic Dichloride is an impurity of clonidine (C587130). Chlonidine is α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Formula:C7H5Cl2NOColor and Shape:NeatMolecular weight:190.034-Anilino-4-oxobutanoic Acid
CAS:Controlled Product<p>Applications The metabolite (MII) of Suberoylanilide Hydroxamic Acid (S688700).<br>References Sun, W.S., et al.: J. Med. Chem., 46, 5619 (2003)<br></p>Formula:C10H11NO3Color and Shape:NeatMolecular weight:193.206-chloro-2-(3-hydroxyphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:299.7099914550781Haloperidol-d4
CAS:Controlled Product<p>Applications Antidyskinetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980), Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formula:C212H4H19ClFNO2Color and Shape:WhiteMolecular weight:379.89Aripiprazole N4-Oxide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 9<br>Applications Aripiprazole N4-Oxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000). Aripiprazole Impurity 9<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Formula:C23H27Cl2N3O3Color and Shape:NeatMolecular weight:464.38(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid
CAS:Controlled Product<p>Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.<br>References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)<br></p>Formula:C15H18F3NO4Color and Shape:NeatMolecular weight:333.30Piperazin-1-yl(quinoxalin-6-yl)methanone hydrochloride
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:278.7399902343756-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline
CAS:Controlled Product<p>Impurity Efavirenz USP Related Compound C/ Efavirenz Quinoline Impurity<br>Applications 6-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Jiang, B., et al.: Euro. J. Org. Chem., 16, 2693 (2008); Ribeiro, J.A., et al.: J. Pharma. Biomed. Anal., 43, 298 (2007);<br></p>Formula:C13H9ClF3NColor and Shape:NeatMolecular weight:271.67N-Demethyl Olanzapine
CAS:Controlled Product<p>Applications A metabolite of Olanzapine.<br></p>Formula:C16H18N4SColor and Shape:BrownMolecular weight:298.4117α-Dutasteride
CAS:Controlled Product<p>Impurity Dutateride EP Impurity E<br>Applications 17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).<br></p>Formula:C27H30F6N2O2Color and Shape:Dark Orange Colour SolidMolecular weight:528.53Regorafenib (Pyridine)-N-oxide
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>Formula:C21H15ClF4N4O4Color and Shape:NeatMolecular weight:498.812-(5-amino-3-methyl-1H-pyrazol-1-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
CAS:Purity:95.0%Molecular weight:245.28599548339844Sulindac
CAS:Controlled Product<p>Applications Sulindac is a non-steroidal anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bjorkman., et al.: Am. J. Med., 105, 17S (1998), Thakur, et al.: Am. J. Hypertens., 12, 925 (1999),<br></p>Formula:C20H17FO3SColor and Shape:Yellow To Dark OrangeMolecular weight:356.412'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]methanol
CAS:Controlled Product<p>Applications Losartan (L470500) impurity.<br>References Huskey, S., et al.: Drug Metab. Dispos., 22, 651 (1994), Herr, R., et al.: Bioorg. Med. Chem., 10, 3379 (2002),<br></p>Formula:C14H12N4OColor and Shape:NeatMolecular weight:252.27N-Nitroso Nitrofurantoin impurity R
Controlled ProductFormula:C7H6N4O6Color and Shape:NeatMolecular weight:242.145742,7-Bis(pyridin-4-ylmethyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
CAS:Purity:95%Molecular weight:448.43798828125Ezetimibe Diol Impurity
CAS:Controlled ProductFormula:C24H25F2NO3Color and Shape:NeatMolecular weight:413.462,6-Diamino-5-ethyl-5-phenyl-4(5H)-Pyrimidinone
CAS:Controlled ProductFormula:C12H14N4OColor and Shape:NeatMolecular weight:230.272,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
CAS:Controlled Product<p>Impurity Flecainide EP Impurity D<br>Applications Flecainide Acetate Impurity D.<br>References Banitt, E., et al.: J. Med. Chem., 18, 1130 (1975),<br></p>Formula:C11H8F6O4Color and Shape:White To Off-WhiteMolecular weight:318.176-Methoxy-2-naphthol
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.<br>References Mahajan, S.S., et. al.: J. Med. Chem., 57, 3283 (2014)<br></p>Formula:C11H10O2Color and Shape:NeatMolecular weight:174.20cis Lacidipine
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Z-Isomer of Lacidipine; a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),<br></p>Formula:C26H33NO6Color and Shape:NeatMolecular weight:455.54Ezetimibe-d4 β-D-Glucuronide, >85%
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Phase-II labelled metabolite of Ezetimibe, an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C30H25D4F2NO9Purity:>85%Color and Shape:NeatMolecular weight:589.575-(4'-Methyl-2-biphenyl)tetrazole
CAS:<p>Impurity Irbesartan EP Impurity E / Irbesartan Methyl Impurity/ Losartan Impurity E<br>Applications Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Formula:C14H12N4Color and Shape:NeatMolecular weight:236.27[3-[[[2-(Diaminomethyleneamino)-4-thiazolyl]methyl]thio]propionyl]sulfamide Hydrochloride
CAS:Controlled Product<p>Impurity Famotidine EP Impurity C<br>Applications An intermediate in the synthesis of the metabolite of the drug Famotidine.<br>References Yanagisawa, I., et al.: J. Med. Chem., 30, 1787 (1987), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),<br></p>Formula:C8H14N6O3S3·ClHColor and Shape:Off-WhiteMolecular weight:374.89Perphenazine Sulfoxide
CAS:Controlled Product<p>Impurity Perphenazine EP Impurity A<br>Applications Perphenazine Sulfoxide (Perphenazine EP Impurity A) acts as a D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.<br>References Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975), O Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formula:C21H26ClN3O2SColor and Shape:NeatMolecular weight:419.97Dasatinib Carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Protected Dasatinib Carboxylic Acid (D193605). An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C24H28ClN7O3SColor and Shape:NeatMolecular weight:530.041-(2,3-dimethyl-1H-indol-1-yl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-2-ol
CAS:Purity:95.0%Molecular weight:297.4020080566406Epinephrine Sulfonic Acid-d3
CAS:Controlled Product<p>Applications A labelled Epinephrine (E588585) derivative formed in injection solutions and eye drops during sterilization and storage of L-Epinephrine Bitartrate.<br>References De Mol, N.J. et al.: Pharmac. Week., 117, 1 (1982); Liu, C. et al.: Yao. Fen. Zaz., 2, 200 (1982);<br></p>Formula:C9H10D3NO5SColor and Shape:Light BrownMolecular weight:250.29Hydroxy Nefazodone Dihydrochloride
CAS:Controlled Product<p>Applications A metabolite of Nefazodone (N389100), an antidepressant.<br>References Barbhaiya, R., et al.: Eur. J. Clin. Pharmacol., 49, 221 (1995), Greene, D., et al.: Clin. Pharmacokinet., 33, 260 (1997), Kalgutkar, A., et al.: Drug Metab. Dispos., 33, 243 (2005),<br></p>Formula:C25H34Cl3N5O3Color and Shape:NeatMolecular weight:558.93
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