Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
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Found 65580 products of "Quinazoline and Quinoline Derivatives"
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(5,5’-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6’-dichloro-3-hydroxy-3,3’-biindoline-2,2’-dione)
CAS:<p>Impurity Ziprasidone EP Impurity D<br>Applications (5,5’-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6’-dichloro-3-hydroxy-3,3’-biindoline-2,2’-dione) (Ziprasidone EP Impurity D) is a compound related to Ziprasidone (Z485000), which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.<br>References Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995)<br></p>Formula:C42H40Cl2N8O3S2Color and Shape:NeatMolecular weight:839.854-Phenyl-2-(pyrazin-2-yl)-1,3-thiazole-5-carboxylic acid
CAS:Color and Shape:SolidMolecular weight:283.309997558593752(R,S)-Hydroxy-4[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxo-butanoic Acid
CAS:Controlled ProductFormula:C13H17NO6Color and Shape:NeatMolecular weight:283.28Menbutone
CAS:<p>Applications Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Symonds, H., et al.: Vet. Rec., 110, 423 (1982); Kumri, K., et al.: Indian Vet. J., 75, 1124 (1998);<br></p>Formula:C15H14O4Color and Shape:Off White SolidMolecular weight:258.27Hydroxythiovardenafil
CAS:Controlled Product<p>Applications Hydroxythiovardenafil is a hydroxylated thiol analogue of the PDE 5 inhibitor Vardenafil (H995300).<br></p>Formula:C23H32N6O4S2Color and Shape:Light Yellow SolidMolecular weight:520.67Atipamezole
CAS:<p>Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.</p>Formula:C14H16N2Purity:99.88%Color and Shape:Off-White To Light Yellow Crystal PowderMolecular weight:212.295-Methyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-ylamine
CAS:Formula:C10H8Cl3N3Purity:97.0%Molecular weight:276.55Cilostazol
CAS:Controlled Product<p>Applications A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo. Neuroprotective & Neuroresearch product.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Formula:C20H27N5O2Color and Shape:NeatMolecular weight:369.462-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:357.42999267578125Ethyl 4-Acetamidobenzoate
CAS:Controlled Product<p>Applications Ethyl 4-acetamidobenzoate is a reagent that is used in the synthesis of DAMPA-d3, which is a labeleld antitumor agent.<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formula:C11H13NO3Color and Shape:Off-WhiteMolecular weight:207.232-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4,6-diphenyl-1,3,5-triazine
CAS:Purity:95%Molecular weight:419.91000366210945-Nitro-2-furfuraldazine
CAS:Controlled Product<p>Impurity Nitrofurazone USP Related Compound A<br>Applications 5-Nitro-2-furfuraldazine is an impurity in the synthesis of Nitrofurazone (N493880), anti-infective (topical). Antimicrobial. Nitrofurazone USP Related Compound A<br>References Morris, et al.: Cancer Res., 29, 2145 (1969), Sanderson, H., et al.: Toxicol. Lett., 144, 383 (2003),<br></p>Formula:C10H6N4O6Color and Shape:NeatMolecular weight:278.1782-Oxo-ivabradine Hydrochloride
CAS:Controlled ProductFormula:C27H34N2O6·ClHColor and Shape:NeatMolecular weight:519.03(3’S)-ent-Ezetimibe
CAS:<p>Applications An enantiomeric impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and cholesterol absorption inhibitor.<br></p>Formula:C24H21F2NO3Color and Shape:WhiteMolecular weight:409.43Diaveridine
CAS:Controlled Product<p>Applications Diaveridine is a dihydrofolate reductase inhibitor. It is used in veterinary medicine as a drug for its anticoccidial properties and its function as an antibacterial synergist.<br>References Wang, H., et al.: J. Chromatogr. B., 965, 91 (2014); Wang, X., et al.: Regul. Toxicol. Pharm., 73, 232 (2015); Sporri, S., et al.: Food. Addit. Contam. A., 31, 806 (2014)<br></p>Formula:C13H16N4O2Color and Shape:NeatMolecular weight:260.296-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Lornoxicam)
CAS:Purity:97.0%Molecular weight:371.809997558593752-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE
CAS:Purity:95.0%Molecular weight:337.37899780273443-[6-(Trifluoromethyl)pyridin-3-yl]propanoic acid
CAS:Formula:C9H8F3NO2Purity:95.0%Color and Shape:SolidMolecular weight:219.1638-methyl-2-(2-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:277.3229980468756-Bromo-2-chloro-4-phenyl-quinazoline
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:319.5899963378906(R)-(+)-5’-Hydroxyphenyl Carvedilol
CAS:<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.472-(2-Isopropylamino-thiazol-4-yl)-7-methoxy-quinolin-4-ol
CAS:Purity:97.0%Molecular weight:315.3900146484375Tianeptine Metabolite MC5 Sodium Salt
CAS:Controlled Product<p>Applications Primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Formula:C19H20ClN2O4S·NaColor and Shape:NeatMolecular weight:430.88[3-(3-pyridin-4-yl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]amine
CAS:Purity:95.0%Molecular weight:288.3139953613281rac Epinephrine-d3
CAS:Controlled ProductFormula:C92H3H10NO3Color and Shape:NeatMolecular weight:186.22N,N'-Dicyclohexylurea
CAS:Controlled Product<p>Impurity Lomustine USP Related Compound C<br>Applications N,N'-Dicyclohexylurea,is a substituted Urea (U822500) compound, which has shown to be a potent inhibitor of juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm M. sexta. Lomustine USP Related Compound C.<br>References Garriga, M., et al.: Chemosphere, 82, 1604 (2011)<br></p>Formula:C13H24N2OColor and Shape:Light YellowMolecular weight:224.344-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
CAS:Controlled Product<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>Formula:C11H8F3N3O2Color and Shape:Light YellowMolecular weight:271.20Bisdionin C
CAS:Controlled Product<p>Applications Bisdionin C is the derivative of Theobromine (T343800), which is a metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004)<br></p>Formula:C17H20N8O4Color and Shape:NeatMolecular weight:400.39Droperidol
CAS:Controlled Product<p>Applications A D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic. Neuroprotective agent.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Formula:C22H22FN3O2Color and Shape:NeatMolecular weight:379.43Everolimus-d4 (>85%)
CAS:Controlled Product<p>Applications Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Formula:C532H4H79NO14Purity:>85%Color and Shape:White To Light YellowMolecular weight:962.25Omeprazole-d3 Sulfone
CAS:Controlled ProductFormula:C17H16D3N3O4SColor and Shape:NeatMolecular weight:364.43Bupivacaine Hydrochloride
CAS:Controlled Product<p>Applications Bupivacaine HCl (cas# 18010-40-7) is a useful research chemical.<br></p>Formula:C18H28N2O·ClHColor and Shape:NeatMolecular weight:324.89(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde
CAS:Purity:95%Molecular weight:317.36300659179694-((3-Chloro-2,4-difluorophenyl)amino)-7-methoxyquinazolin-6-ol
CAS:Purity:97.0%Molecular weight:337.7099914550781Doravirine
CAS:<p>Applications Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus.<br>References Feng, M., et al.: Antimicrob Agents Chemother, 60, 2241-7 (2016); Lai, M.T., et al.: Antimicrob Agents Chemother, 58, 1652-63 (2014); Anderson, M.S., et al.: Antivir Ther., 20, 397-405 (2015);<br></p>Formula:C17H11ClF3N5O3Color and Shape:NeatMolecular weight:425.75(R)-O-Desmethyl Naproxen
CAS:Controlled Product<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>Formula:C13H12O3Color and Shape:NeatMolecular weight:216.2310-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one
CAS:Purity:98%Molecular weight:318.3760070800781AR-C133913XX
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formula:C14H22N6O4SColor and Shape:NeatMolecular weight:370.43Ethylenediamine P-Toluenesulfonate
CAS:Controlled Product<p>Impurity Xylometazoline EP Impurity E<br>Stability Hygroscopic<br>Applications Ethylenediamine P-Toluenesulfonate is a reactant used in the synthesis of antitumor agents. Also is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the ability to shift energy metabolism from mitochondrial to glycolysis (2).<br>References 1. Fliri, A. et al.: J. Med. Chem. 2009 Dec 24;52(24):8038-46.2. Gohil, V. et al.: Nat Biotechnol. 2010 Mar;28(3):249-55.<br></p>Formula:C7H8O3S·C2H8N2Color and Shape:NeatMolecular weight:232.2999Apremilast-d5
CAS:Controlled ProductFormula:C22D5H19N2O7SColor and Shape:NeatMolecular weight:465.531
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