
Steroids and Derivatives
Found 4962 products of "Steroids and Derivatives"
Palovarotene
CAS:Controlled ProductApplications Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.
References Hind, M., et al.: Curr. Opinion Invest. Drugs, 10(11), 1243 (2009); Stolk, J., et al.: Therap. advances Respi. dise., 4, 319 (2010);Formula:C27H30N2O2Color and Shape:NeatMolecular weight:414.54(Z)-Guggulsterone
CAS:Controlled ProductApplications (Z)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.
References Yang, D. et al.: J. Lipid Res., 53, 529 (2012); El-Mekkawy, S. et al.: Nat. Prod. Res., 27, 146 (2013);Formula:C21H28O2Color and Shape:NeatMolecular weight:312.45(16β)-17,21-Dihydroxy-16β-methyl-pregna-1,4,9(11)-triene-3,20-dione
CAS:Controlled ProductImpurity Betamethasone EP Impurity C
Applications (16β)-17,21-Dihydroxy-16β-methyl-pregna-1,4,9(11)-triene-3,20-dione (Betamethasone EP Impurity C) is used in biological studies to perform preclinical characterization of VBP15, a novel anti-inflammatory delta 9,11 steroid. This compound is also used in analytical studies to determine the stability from reversed-phase high performance liquid chromatography (RP-HPLC) to separate low levels of dexamethasone and other related compounds from betametasone, which is an active pharmaceutical ingredient.
References Reeves, E.K.M., et al.: Bioorg., Med. Chem., 21, 2241 (2013), Xiong, Y., et al.: J. Pharm. Biomed. Anal., 49, 646 (2009)Formula:C22H28O4Color and Shape:NeatMolecular weight:356.46Latanoprost
CAS:Applications Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.
References Rhee, D.J., et al.: Clinic. Ophthalmol., 2, 313 (2008), Hernandez, M., et al.: Exp. Eye Res., 86, 798 (2008), Nagata, T., et al.: J. Pharmacol. Sci., 106, 423 (2008), Ikeda, Y., et al.: J. Ocular Pharmacol. Ther., 24, 230 (2008),Formula:C26H40O5Color and Shape:Light YellowMolecular weight:432.595,6-trans-Vitamin D3
CAS:5,6-trans-Vitamin D3(5,6-trans-Cholecalciferol) is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.Formula:C27H44OPurity:98.23%Color and Shape:SolidMolecular weight:384.6416a-Methyl Prednisolone
CAS:Controlled ProductApplications 16α-Methylprednisolone is the 16α-Methyl analogue of Prednisolone (P703740). 16α-Methylprednisolone is an anti-inflammatory corticosteroid.
References Biju, P. et al.: Bioorg. Med. Chem. Lett., 22, 1086 (2012); Dausse, J.P. et al.: Mol. Pharmacol., 13, 948 (1977):Formula:C22H30O5Color and Shape:NeatMolecular weight:374.47Dienestrol
CAS:Applications Dienestrol is a metabolite of Diethylstilbestrol, a non-steroidal synthetic estrogen derivative.
References Liehr, J.G., et al.: Steroids, 40, 713 (1982); Yearley, E. et al.: J. Mol. Struct., 890, 240 (2008);Formula:C18H18O2Color and Shape:NeatMolecular weight:266.3317α-Progesterone
CAS:Applications 17α-Progesterone is a testosterone precursror generated from cholesterol. Also used as a diagnostic agent in the identification and study of ovarian Leydig cell tumor disease.
References Vesely, D. et al.: Proc. Natl. Acad. Sci. USA., 76, 3491 (1979); Arhan, E. et al.: J. Pediatric Endocrinol. Metab., 21, 181 (2008);Formula:C21H30O2Color and Shape:NeatMolecular weight:314.4611b-Hydroxy Etiocholanolone
CAS:Controlled ProductApplications A metabolite of Etiocholanolone.
References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),Formula:C19H30O3Color and Shape:White To Off-WhiteMolecular weight:306.44Estradiol 17-Valerate
CAS:Controlled ProductApplications Estradiol (E888000) derivative. An estrogen.
References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),Formula:C23H32O3Color and Shape:White To Off-WhiteMolecular weight:356.5(3a)-Allopregnanolone
CAS:Controlled ProductApplications (3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain. In 2019, the US Food and Drug Administration approved (3α)-Allopregnanolone as an intravenous infusion for treating postpartum depression.
References Puja, G. et al.: Neuron, 4, 759 (1990); Belelli, D. et ael. Neurosteroid, 6, 565 (2006); Viapiano, M. et al.: Neurochem. Res., 23, 155 (1998);Formula:C21H34O2Color and Shape:White To Off-WhiteMolecular weight:318.49(3b)-Allopregnanolone Sulfate Sodium Salt
CAS:Controlled ProductApplications (3β)-Allopregnanolone Sulfate is the sulfate conjugate of (3β)-Allopregnanolone, a metabolite of progesterone and a potent inhibitory modulator of GABAA receptors.
References Li, P. et al.: Mol. Pharmacol., 77, 539 (2010); El-Etr, M. et al.: Brain Res., 790, 334 (1998); Park-Chung, M. et al.: Brain Res., 830, 72 (1999);Formula:C21H33NaO5SColor and Shape:NeatMolecular weight:420.54δ7-Avenasterol (E/Z mixture)
CAS:Applications Δ7-Avenasterol is an analog of Stigmasterol (S686750); a plant sterol that is used as a precursor in the synthesis of progesterone.
References Han, P., et al.: Biotechnol. App. Biochem., 54, 105 (2009); Matsunaga, I., et al.: Anal. Biochem., 393, 222 (2009); Huang, C., et al.: Plant Physiol., 150, 1192 (2009)Formula:C29H48OColor and Shape:White To Off-WhiteMolecular weight:412.6924(R/S)-Hydroxycholesterol-d7
CAS:Controlled ProductApplications 24(R/S)-Hydroxycholesterol-d7 is used in the study of biochemical methods for quantitative detection of steroids containing quantitative charge tags and oxidizing agents and using mass spectroscopy for detection.
References Groffoths, Williams., US 20150233953, (2015)Formula:C272H7H39O2Color and Shape:NeatMolecular weight:409.7Dexamethasone Phenylpropionate
CAS:Controlled ProductFormula:C31H37FO6Color and Shape:NeatMolecular weight:524.626β-Hydroxy-11-deoxycortisol
CAS:Controlled ProductApplications 6β-Hydroxy-11-deoxycortisol is a corticosteroid which is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),Formula:C21H30O5Color and Shape:NeatMolecular weight:362.467α-Hydroxy-4-cholesten-3-one
CAS:Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),Formula:C27H44O2Color and Shape:NeatMolecular weight:400.64Betamethasone 21-Valerate
CAS:Impurity Betamethasone Valerate EP Impurity E
Applications Betamethasone 21-Valerate (Betamethasone Valerate EP Impurity E) is an isomeric impurity of Betamethasone 17-Valerate (B327075), as an corticosteroid. Betamethasone 21-Valerate was generated in the stress study of the active drug Betamethasone 17-Valerate (B327075).
References Caron, J.C., et al.: J. Pharmaceut. Sci., 73, 1703 (1984); Stouch, T.R., et al.: J. Med. Chem., 29, 2125 (1986);Formula:C27H37FO6Color and Shape:WhiteMolecular weight:476.58trans-Latanoprost Acid
CAS:Controlled ProductApplications The trans metabolite of Latanoprost (L177280), Prostaglandin analog.
References Botchkareva, N., et al.: FASEB J., 115, 645 (2001),Formula:C23H34O5Color and Shape:NeatMolecular weight:390.5136beta-Hydroxy Progesterone (Contains up to 20% 17alpha-Hydroxy Progesterone)
CAS:Formula:C21H30O3Purity:>80%Color and Shape:NeatMolecular weight:330.46Desmosterol
CAS:Applications A metabolite of Cholesterol (C432501).
References Marx, J., et al.: Science, 294, 508 (2001), Plosch, T., et al.: J. Biol. Chem., 277, 33870 (2002), Lund, E., et al.: J .Biol. Chem., 278, 22980 (2003),Formula:C27H44OColor and Shape:White To Off-WhiteMolecular weight:384.643-epi-25-Hydroxy Vitamin D3
CAS:Stability Light Sensitive, Temperature Sensitive
Applications The epimer metabolite of Calcifediol or 25-hydroxyvitamin D3 (C125700).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sakaki, T., et al.: Eur. J. Biochem., 267, 6158 (2000), Kamao, M., et al.: J. Biol. Chem., 278, 1463 (2003),Formula:C27H44O2Color and Shape:NeatMolecular weight:400.6425-Hydroxy Cholesterol
CAS:Applications An oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.
References Aupeix, K. et al.: Immunobiology, 194, 415 (1995); Moog, C. et al.: Antivir. Chem, Chemother., 9, 491 (1998); Ayala-Torres, S. et al.: Exp. Cell Res., 246, 193 (1999);Formula:C27H46O2Color and Shape:NeatMolecular weight:402.65Testosterone 17-Decanoate
CAS:Controlled ProductApplications Testosterone 17-Decanoate, is an ester of Testosterone (T155000). Testosterone 17-Decanoate, can be used as a potential long-acting male contraceptive, with the combination of subcutaneous etonogestrel implants .
References Brady, B. M., et al.: Human Reproduction, 21 (1), 285 (2006); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000);Formula:C29H46O3Color and Shape:NeatMolecular weight:442.67S-deacetyl spironolactone
CAS:Applications A metabolite of Spironolactone.
References Morris, R., et al.: Eur. J. Clin. Pharmacol., 34, 233 (1988), Dasgupta, A., et al.: Am. J. Clin. Pathol., 111, 406 (1999)Formula:C22H30O3SColor and Shape:NeatMolecular weight:374.545α-Pregnane-3β,20(S)-diol
CAS:Controlled ProductApplications 5α-Pregnane-3β,20(S)-diol, is a metabolite of Progesterone (P755900).
References Beall, et al.: Biochem. J., 31, 35 (1937), Okuda, A., et al.: J. Biol. Chem., 259, 7519 (1984), Russell, D., et al.: Biochemistry, 31, 4737 (1992), Kondo, K., et al.: Eur. J. Biochem., 219, 357 (1994), Westerbacka, J., et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003),Formula:C21H36O2Color and Shape:NeatMolecular weight:320.5117-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid
Controlled ProductApplications 17-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid is an intermediate used to prepare (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid (E890570) which is a derivative of Loteprednol Etabonate (L471400), an ophthalmic corticosteroid.
References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)Formula:C20H24O5Color and Shape:NeatMolecular weight:344.417-Hydroxy Pregnenolone
CAS:Controlled ProductApplications 17-Hydroxy Pregnenolone, is a metabolite of Pregnenolone (P712200).
References Kramer, R., et al.: J. Steroid Biochemi., 18, 715 (1983), Hiwatashi, A., et al.: J. Biochem., 98, 619 (1985), Eiichi, T., et al.: J. Pharmacol. Sci., 95, 140 (2004),Formula:C21H32O3Color and Shape:White To Off-WhiteMolecular weight:332.486b-Chloro-17-acetoxy Progesterone
CAS:Controlled ProductApplications Progesterone (P755900) impurity.
References Liang, T., et al.: Biol. Chem., 256, 7998 (1981), Bratoeff, E., et al.: J. Steroid Biochem. Mol. Biol., 111, 275 (2008),Formula:C23H31ClO4Color and Shape:NeatMolecular weight:406.943O,O-Dimethyl Methylphosphonate
CAS:Controlled ProductApplications O,O-Dimethyl Methylphosphonate is a commercially used preignition additive for gasoline, anti-foaming agent, plasticizer, stabilizer and antistatic agents.
References Jang, S.H., et al.: J. Korean. Phy. Soc., 55, 294 (2009); Schneider, B.B., et al.: Int. J. Mass. Spectro., 298, 45 (2010);Formula:C3H9O3PColor and Shape:NeatMolecular weight:124.076Corticosterone
CAS:Controlled ProductApplications Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.
References Schmidt, M., et al.: Endocrinol., 150, 2709 (2009), Bailey, M., et al.: J. Immunol., 182, 7888 (2009), Brunton, P., et al.: J. Neurosci., 29, 6449 (2009), Pruett, S., et al.: Toxicol. Sci., 109, 265 (2009),Formula:C21H30O4Color and Shape:NeatMolecular weight:346.46∆1-Testosterone
CAS:Controlled ProductApplications Testosterone (T155000) derivative. It is a potent androgen with anabolic properties. Since the begining of the year 2005, the use of steroid precursors (prohormones) is illegal in the United States. Controlled substance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liao, S., et al.: J. Biol. Chem., 248, 6154 (1973), Saartok, T., et al.: Endocrinology, 114, 2100 (1984), Sugawara, T., et al.: J. Biol. Chem., 278, 42487 (2003),Formula:C19H28O2Color and Shape:White To Off-WhiteMolecular weight:288.42Equilin
CAS:Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity used in the study of hypertension.Formula:C18H20O2Purity:98.57% - 99.72%Molecular weight:268.35(E)-Betamethasone-∆17,20 21-Aldehyde
CAS:Formula:C22H27FO4Color and Shape:NeatMolecular weight:374.45Testosterone Laurate
CAS:Controlled ProductFormula:C31H50O3Color and Shape:White To Off-WhiteMolecular weight:470.73(11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS:Applications (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, can be used for the synthesis of Calicoferol E, a vitamin D3 analogues.
References Vir Singh, T., et al.: ARKAT USA, INc., (2002);Formula:C22H28O5Color and Shape:White To Light RedMolecular weight:372.4517a-Dihydro Equilenin
CAS:Controlled ProductApplications The 17α-metabolite of Equilin (E592800).
References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),Formula:C18H20O2Color and Shape:NeatMolecular weight:268.359-Dehydroestrone
CAS:Controlled ProductFormula:C18H20O2Color and Shape:White To Off-WhiteMolecular weight:268.35Medroxy Progesterone
CAS:Controlled ProductImpurity Medroxyprogesterone Acetate USP Related Compound B
Applications An orally active progestogen used in hormone replacement therepy (HRT), in the past has been used as a component of oral contraceptives.SMedroxyprogesterone Acetate USP Related Compound B.
References Pan, Q., et al.: Mol. Hum. Reprod., 13, 797 (2007), Matsson, P., et al.: J. Pharmacol. Exp. Ther., 323, 19 (2007), Jukosky, J.A., et al.: Bull. Environ. Contam. Toxicol., 81, 230 (2008), Cherkasov, A., et al.: J. Med. Chem., 51, 2047 (2008),Formula:C22H32O3Color and Shape:NeatMolecular weight:344.4920b-Dihydroprogesterone
CAS:Controlled ProductImpurity Progesterone EP Impurity C
Applications 20β-Dihydroprogesterone (Progesterone EP Impurity C) is an impurity of Progesterone (P755900), a steroid hormone secreted by the corpus luteum. Progesterone have various significant physiological roles, such as inducing the maturation and secretory activities of the uterine endothelium and the suppression of ovulation. Progesterone is also implicated in the etiology of breast cancer.
References Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),Formula:C21H32O2Color and Shape:White To Off-WhiteMolecular weight:316.485-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
CAS:Controlled ProductApplications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750).
References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);Formula:C33H33FN2O5Color and Shape:NeatMolecular weight:556.62Tibolone
CAS:Controlled ProductApplications A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
References de Visser, J., et al.: Arzneim.-Forsch., 34, 1010 (1984), Geusens, P., et al.: Maturitas Suppl, 1, 1 (1987)Formula:C21H28O2Color and Shape:WhiteMolecular weight:312.4517β-Estradiol
CAS:Controlled ProductImpurity Ethinylestradiol EP Impurity D
Applications 17b-Estradiol is the major estrogen (1) secreted by the premenopausal ovary (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.Formula:C18H24O2Color and Shape:NeatMolecular weight:272.381,2-Dihydro Prednicarbate
CAS:Impurity Prednicarbate USP Related Compound A
Applications 1,2-Dihydro Prednicarbate is a related compound of Prednicarbate (P703700). Prednicarbate related compound A. Prednicarbate USP Related Compound A.
References Conolly, et al.: J. Chem. Soc., 828 (1937),Formula:C27H38O8Color and Shape:NeatMolecular weight:490.59Pregnenolone Carbonitrile
CAS:Controlled ProductApplications Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).
References Kliewer, S.A., et. al.: Cell, 92, 73 (1998); Savas, U., et. al.: Drug Metab. Dispos., 28, 529 (2000)Formula:C22H31NO2Color and Shape:NeatMolecular weight:341.49

