Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Found 79450 products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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4’-Hydroxy Diclofenac-D4
CAS:Controlled ProductFormula:C142H4H7Cl2NO3Color and Shape:NeatMolecular weight:316.1728-Oxo Ivermectin B1a (Impurity)
CAS:<p>Impurity Ivermectin EP Impurity D<br>Applications 28-Oxo Ivermectin B1a is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H72O15Color and Shape:NeatMolecular weight:889.08(5E)-Bimatoprost
CAS:<p>Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).<br></p>Formula:C25H37NO4Color and Shape:NeatMolecular weight:415.565,6-trans Travoprost
CAS:<p>Applications An 5,6-trans isomeric impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600).<br></p>Formula:C26H35F3O6Color and Shape:NeatMolecular weight:500.55trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Formula:C26H40O5Color and Shape:ColourlessMolecular weight:432.59E,E-Farnesylacetone
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications E,E-Farnesylacetone, is a natural organic compound which is present in many essential oils. It has been shown that, Farnesylacetone inhibits electron transport in isolated rat liver mitochondria.<br>References Dupont, J. et al.: Biology of the Cell, 67(2), 141-146 (1989); Gaviria, M. et al.: Chem. & Biodiversity 8, 532 (2011)<br></p>Formula:C18H30OColor and Shape:NeatMolecular weight:262.43(4-Carboxy-3-ethoxy)phenyl Acetic Acid
CAS:Controlled Product<p>Impurity Repaglinide EP Impurity A<br>Applications (4-Carboxy-3-ethoxy)phenyl Acetic Acid (Repaglinide EP Impurity A) is a Repaglinide impurity.<br>References Owens, D., et al.: Eur. J. Clin. Invest., 29, 30 (1999), Wolffenbuttel, B., et al.: Neth. J. Med., 55, 229 (1999),<br></p>Formula:C11H12O5Color and Shape:NeatMolecular weight:224.21Ivermectin B1a (>85%)
CAS:Controlled Product<p>Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H74O14Purity:>85%Color and Shape:NeatMolecular weight:875.09Δ23-FK-506(>90%)
CAS:Controlled Product<p>Impurity Tacrolimus Diene Impurity (USP)<br>Applications Δ23-FK 506 is an impurity of FK-506 (Tacrolimus) (F370000), an immunosuppressant macrolactam.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Namiki, Y., et al.: J. Antibiot 1993, 46, 1149,,Akashi, T; J Pharm Biomed Anal 1996, 14, 339,,,,Wiedeman, P; J Med Chem 1999, 42, 4456,,,<br></p>Formula:C44H67NO11Purity:>90%Color and Shape:NeatMolecular weight:786.00N-Despropyl-macitentan
CAS:Controlled Product<p>Applications N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)<br>References Atsmon, J., et al.: Clin. Pharmacokinet., 525, 685 (2013); Sidharta, P.N., et al.: Clin. Drug Invest. (2014)<br></p>Formula:C16H14Br2N6O4SColor and Shape:NeatMolecular weight:546.19Levosimendan Cyanoacetate Hydrazone Impurity
Controlled Product<p>Applications Levosimendan Cyanoacetate Hydrazone is an impurity of Levosimendan (L378000); a positive inotropic agent with vasodilating activity. Also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C16H17N5O3Color and Shape:NeatMolecular weight:327.34Cyclosporin H
CAS:<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C62H111N11O12Color and Shape:NeatMolecular weight:1202.614-Chlorobenzal Chloride
CAS:<p>Applications 4-Chlorobenzal Chloride is an impurity that is formed in the synthesis of Benoxaprofen (B165300); a non-steroidal anti-inflammatory ophthalmic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cockerill, A.F., et al.: J. Chromatogr., 129, 339 (1976); Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003); Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007); Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009)<br></p>Formula:C7H5Cl3Color and Shape:NeatMolecular weight:195.471,2-Bismethylphenidate (Mixture of Diastereomers)
Controlled Product<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Formula:C23H27NO4Color and Shape:NeatMolecular weight:381.462-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac impurity)
CAS:<p>Impurity Diclofenac EP Impurity B<br>Applications 2-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac EP Impurity B) is an impurity of Diclofenac (D436450).<br>References Brogden, R., et al.: Drugs, 20, 24 (1980), Orienti, I., et al.: Eur. J. Pharm. Biopharm., 37, 110 (1991), Sagara, K., et al.: Chem. Pharm. Bull., 40, 3303 (1992), Connors, K., et al.: J. Pharm. Sci., 84, 843 (1995),<br></p>Formula:C13H9Cl2NOColor and Shape:YellowMolecular weight:266.12N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide
CAS:Controlled Product<p>Applications N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C16H19N3O5Color and Shape:NeatMolecular weight:333.34Oxindole (2-Indolone)
CAS:Controlled Product<p>Applications Indole analogue; shows pharmacological activity.<br>References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),<br></p>Formula:C8H7NOColor and Shape:Light RedMolecular weight:133.15Desisobutyl Febuxostat
CAS:Controlled ProductFormula:C12H8N2O3SColor and Shape:Light Yellow SolidMolecular weight:260.27Apixaban Dimer
CAS:Controlled Product<p>Applications Apixaban Dimer is an impurity compound of Apixaban (A726700). Apixaban is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C40H34N10O6Color and Shape:NeatMolecular weight:750.783-Descyano-3-((hydroxyimino)methyl) Febuxostat
CAS:Controlled ProductFormula:C16H18N2O4SColor and Shape:NeatMolecular weight:334.394a-Hydroxy Ivermectin
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4a-Hydroxy Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C48H74O15Color and Shape:NeatMolecular weight:891.09(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C12H14N4O4Color and Shape:NeatMolecular weight:278.27(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity (>90%)
CAS:Formula:C44H69NO12Color and Shape:White To Light YellowMolecular weight:804.02Ivermectin B1b
CAS:Controlled ProductFormula:C47H72O14Color and Shape:Off WhiteMolecular weight:861.0665-Desbromo, 5-Chloro Brimonidine
CAS:Controlled Product<p>Impurity Brimonidine EP Impurity H<br>Applications UK 14819 is a quinoxalinyl imidazolidine α2-adrenoceptor agonist and is structurally related to Brimonidine (B677520).<br>References Thaina, P., et al.: J. Auton. Pharmacol., 19, 185 (1999)<br></p>Formula:C11H10ClN5Color and Shape:Light Yellow To YellowMolecular weight:247.68363-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Impurity Allopurinol EP Impurity E / Allopurinol USP Related Compound E<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxylic Acid Ethyl Ester (Allopurinol EP Impurity E) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975)<br></p>Formula:C7H9N3O3Color and Shape:WhiteMolecular weight:183.16Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
CAS:<p>Applications Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.<br>References Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005);<br></p>Formula:C18H21NO4SColor and Shape:NeatMolecular weight:347.434-(4-Nitrophenyl)-3-morpholinone
CAS:Controlled ProductFormula:C10H10N2O4Color and Shape:NeatMolecular weight:222.20(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS:<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists such as Ticagrelor (T437700)for the prevention of thrombosis.<br>References Springthorpe, B. et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007);<br></p>Formula:C9H9F2N·C8H8O3Color and Shape:NeatMolecular weight:321.329-Hydroxy Ramipril Diketopiperazine
CAS:Formula:C23H30N2O5Color and Shape:NeatMolecular weight:414.49N-Formyl Apixaban
CAS:Controlled Product<p>Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C26H25N5O5Color and Shape:NeatMolecular weight:487.51L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
CAS:Formula:C9H15NO2Color and Shape:White To Off-WhiteMolecular weight:169.22AR-C133913XX
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formula:C14H22N6O4SColor and Shape:NeatMolecular weight:370.43(S)-Repaglinide Ethyl Ester (Repaglinide Impurity)
CAS:Controlled Product<p>Applications Repaglinide impurity.<br>References Grell, W., et al.: J. Med. Chem., 41, 5219 (1998),<br></p>Formula:C29H40N2O4Color and Shape:NeatMolecular weight:480.64Simendan
CAS:Controlled Product<p>Applications Simendan is the racemic mixture of Levosimendan (L378000) which is a positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C14H12N6OColor and Shape:Yellow SolidMolecular weight:280.28(2S,3aR,7aS)-Octahydroindole-2-carboxylic Acid (~90%, contains cis)
CAS:Controlled ProductFormula:C9H15NO2Color and Shape:NeatMolecular weight:169.22
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