Sulfonamides and Derivatives

Impurity Etodolac EP Impurity B
Applications 8-Methyl Etodolac (Etodolac EP Impurity B) is an impurity of Etodolac (E933100) which was examined for mutagenicity in reverse mutation tests on bacteria. Etodolac impurity B.
References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),

Applications Sulfadiazine Sodium Salt can be used as reactant/reagent in preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride and hydrobromide cocrystals with iodine.
References Pan, F., et al.: CrystEngComm, 17, 6641 (2015)

Applications Aceclofenac is an anti-inflammatory and analgesic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yscla, A., et al.: Drugs Exp. Clin. Res., 14, 491 (1988), Ballesteros, R., et al.: Clin. Trials J., 27, 12 (1990)

Applications 3-(p-Chlorophenyl)-3-hydroxyphthalimidine is an analog of Chlorthalidone (C427500) and has potential antidiuretic and hyperglycemic activities.
References Wales, J.K., et al.: P. Soc. Exp. Biol. Med., 128, 581 (1968)

Applications Acetaminophen Glutathione Disodium Salt is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3,4).
References (1) Chen, C., et al.: Xenobiotica, 30, 1019 (2000) (2) Ikeda, H., et al.: Biochem. J., 364, 563 (2002) (3) Aleksunes, L., et al.: Toxicol. Sci., 83, 44 (2005) (4) Elsby, R., et al.: J. Biol. Chem., 278, 22243 (2003)

Applications Labelled Indapamide. Used as an antihypertensive. Diuretic.
References Leary, et al.: Curr. Ther. Res., 15, 571 (1973), Kyncl, J., et al.: Arzneim.-Forsch., 25, 1491 (1975), DiFeo, T.J., et al.: Anal. Profiles Drug Subs. Excip., 23, 229 (1994),

Applications Bumetanide (B689550) analogue as diuretic and antihypertensive. Bumetanide impurity.
References Feit, P.W., et al.: J. Med. Chem., 14, 432 (1971),

Impurity Gliclazide EP Impurity C
Applications Tosylurethane (Gliclazide EP Impurity C) is an intermediate in the synthesis of Gliclazide (G409877), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.
References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)

Applications 4-Phenylsulfonylaniline is used in the preparation of novel Flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.
References Kemppainen, J., et al.: J. Biol. Chem., 267, 968 (1992), Amler, L., et al.: Cancer Res., 60, 6134 (2000), Klotz, L., et al.: Clin. Prostate Cancer, 3, 215 (2005),

Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications Ibuprofen Piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen (I140000), which is a selective cyclooxygenase inhibitor.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998); Xiang, L., et al.: Huaxi Yaoxue Zazhi, 21, 178 (2006); Chem. and Eng. News p9, July 4 (2016);

Impurity Mefeneic Acid EP Impurity B
Applications N-(2,3-Dimethylphenyl) Mefenamic Acid Carboxamide is a derivative of Mefenamic Acid (M205050); an anti-inflammatory agent and analgesic.
References Winder, C.V., J. Pharmacol. Exp. Ther., 138, 405 (1962)

Applications Used as an antihypertensive. Diuretic.
References Leary, et al.: Curr. Ther. Res., 15, 571 (1973), Kyncl, J., et al.: Arzneim.-Forsch., 25, 1491 (1975), DiFeo, T.J., et al.: Anal. Profiles Drug Subs. Excip., 23, 229 (1994),