Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
At CymitQuimica, we offer high-purity sulphonamides and their derivatives for research in microbiology and pharmaceutical development.
Found 2595 products of "Sulfonamides and Derivatives"
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4-Chlorobenzoic Acid
CAS:Controlled Product<p>Impurity Acemetacin EP Impurity A / Bezafibrate EP Impurity B<br>Applications A benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioassays. It is used as a preservative.<br>References Rep, M., et al.: J. Biol. Chem., 275, 8290 (2000), Jaeger, T., et al.: Biofactors, 27, 109 (2006), Kim, J., et al.: Fungal Biology, 114, 817 (2010),<br></p>Formula:C7H5ClO2Color and Shape:White To Off-WhiteMolecular weight:156.573-Anilino-2-(3,4,5-trimethoxybenzyl)acrylonitrile, (Mixture of cis/trans isomers)
CAS:<p>Applications Used as a reference standard for the drug Trimethoprim.Note this compound is a cis / trans mixture.<br></p>Formula:C19H20N2O3Color and Shape:WhiteMolecular weight:324.371-Hydroxy Ibuprofen (Ibuprofen Impurity L) (Mixture of Diastereomers)
CAS:<p>Impurity Ibuprofen EP Impurity L<br>Applications 1-Hydroxy Ibuprofen (Ibuprofen EP Impurity L) is a degradation product of Ibuprofen.<br>References Forrest, J., et al.: Clin. Pharmacokinet., 7(2), 93 (1982), Shockcor, J., et al.: Xenobiotica, 26, 189 (1996), Nicholls, A., et al.: Chem. Res. Toxicol., 14, 975 (2001), Holmes, E., et al.: Toxicol. Sci., 87, 1 (2005),<br></p>Formula:C13H18O3Color and Shape:Off-WhiteMolecular weight:222.28N-Acetyl Dapsone
CAS:Controlled Product<p>Applications A metabolite of Dapsone (D193250).<br>References Shin, I., et al.: J. App. Pharmacol., 10, 193 (2002), Bhaiya, P., et al.: Toxicol. App. Pharmacol., 215, 158 (2006), Paixao, P., et al.: Eur. J. Pharm. Sci., 36, 544 (2009),<br></p>Formula:C14H14N2O3SColor and Shape:NeatMolecular weight:290.34Zonisamide
CAS:<p>Applications Sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant. Neuroprotective & Neuroresearch Product.<br>References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980), Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987), Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993), Sorkin, E.M., et al.: Drugs, 45, 760 (1993),<br></p>Formula:C8H8N2O3SColor and Shape:White To Off-WhiteMolecular weight:212.23trans-Carboxy Glimepiride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An active metabolite of Glimepiride (G410150).<br>References Groop, L., et al.: Diabetes Care, 15, 737 (1992), Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),<br></p>Formula:C24H32N4O7SColor and Shape:NeatMolecular weight:520.6Acetaminophen Mercapurate Disodium
CAS:<p>Applications Acetaminophen Mercapurate Disodium Salt is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Potter, D.W. et al.: Mol. Pharmacol., 29, 155 (1986)<br></p>Formula:C13H14N2O5S·2NaColor and Shape:NeatMolecular weight:356.311-Amino-2-methylindoline
CAS:Controlled ProductFormula:C9H12N2Color and Shape:NeatMolecular weight:148.20Ibuprofen-d3 Acyl-β-D-glucuronide (mixture of diastereomers)
CAS:Controlled Product<p>Applications Ibuprofen-d3 Acyl-β-D-glucuronide (mixture of diastereomers) is a compound useful in organic synthesis.<br></p>Formula:C19D3H23O8Color and Shape:NeatMolecular weight:385.42p-Phenetidine-d5 Hydrochloride
CAS:Controlled Product<p>Applications Labelled p-Phenetidine (P296300). A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.<br>References Green, C., et al.: Br. Med. J., 1, 162 (1969), Nelson, S., et al.: J. Med. Chem., 25, 753 (1982), Nicholls, A., et al.: Xenobiotica, 27, 1175 (1997),<br></p>Formula:C8H7D5ClNOColor and Shape:NeatMolecular weight:178.67Sulfasalazine-d4
CAS:Controlled Product<p>Applications Labelled Sulfasalazine (S699084). An anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.<br>References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972), McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976), Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985),<br></p>Formula:C18H10D4N4O5SColor and Shape:Yellow To OrangeMolecular weight:402.42O-Desmethyl Brinzolamide
CAS:Controlled Product<p>Impurity Brinzolamide O-Desmethyl Impurity<br>Applications O-Desmethyl Brinzolamide is a derivative of Brinzolamide (B677601), a carbonic anhydrase inhibitor that is used as an ocular topical treatment for patients experiencing intraocular pressure. Brinzolamide reduces pressure by reducing the rate of aqueous humour formation.<br>References Cvetkovic, R. & Perry, C.: Drugs & Aging, 20, 919 (2003); Ermis, S., et al.: Eye, 19, 303 (2005); Silver, L., et al.: Surv. Ophthalmol., 44, S147 (2000)<br></p>Formula:C11H19N3O5S3Color and Shape:NeatMolecular weight:369.4807Trimethoprim
CAS:<p>Applications Antibacterial. This compound is a contaminant of emerging concern (CECs).<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>Formula:C14H18N4O3Color and Shape:Off-WhiteMolecular weight:290.32N-Acetyl Sulfapyridine
CAS:Controlled Product<p>Applications A major active metabolite related to the adverse effects of Sulfasalazine in human serum.<br>References Stenson, W., et al.: J. Clin. Invest., 69, 494 (1982), Bissonnette, E., et al.: J. Immunol., 156, 218 (1996), Hirohata, S., et al.: J. Neurol. Sci., 67, 115 (1985), Pullar, T., et al.: Br. Med. J., 290, 1535 (1985), Ireland, A., et al.: Clin. Sci., 78, 119 (1990),<br></p>Formula:C13H13N3O3SColor and Shape:NeatMolecular weight:291.331-(4-Acetylphenyl)-2-methyl-1-propanone
CAS:<p>Applications A potential impurity in Ibuprofen (I140000). A degradation product of Ibuprofen arising from oxidative and thermal treatments.<br>References Heikkinen, L., et al.: Acta Pharm. Fenn., 92, 275 (1983), Kepp, D., et al.: Pharm Res., 5, 676 (1997),<br></p>Formula:C12H14O2Color and Shape:NeatMolecular weight:190.24O-Methyl Chlorthalidone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications O-Methyl Chlorthalidone is an impurity of Chlorthalidone (C427500), a diuretic and antihypertensive agent.<br>References Quaglia, M.G., et al.: J. Chromatograph., 456, 435 (1988);<br></p>Formula:C15H13ClN2O4SColor and Shape:Off-WhiteMolecular weight:352.7932-Methylindoline
CAS:Controlled Product<p>Applications 2-Methylindoline is an intermediate in the production of various indole derivatives<br>References Severino, B., et al.: Bioorg. Med. Chem., 16, 6009 (2008); Zlotos, D., et al.: J. Med. Chem., 52, 826 (2009);<br></p>Formula:C9H11NColor and Shape:Light Yellow LiquidMolecular weight:133.191,1-Bis(p-isobutylphenyl)ethane
CAS:Controlled ProductFormula:C22H30Color and Shape:NeatMolecular weight:294.47S-Methyl-d3-thioacetaminophen
CAS:Controlled Product<p>Applications S-Methyl-d3-thioacetaminophen is deuterium labeled S-Methyl-3-thioacetaminophen (M330610), a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Formula:C92H3H8NO2SColor and Shape:NeatMolecular weight:200.27Hydrochlorothiazide-13C,d2
CAS:Controlled ProductFormula:CC62H2H6ClN3O4S2Color and Shape:WhiteMolecular weight:300.74
