Sulfonamides and Derivatives

<p>Applications Hydrochlorothiazide-d2 is the labeled analogue of Hydrochlorothiazide (H714560), a carbonic anhydrase inhibitor as a diuretic.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961); Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981)<br></p>

<p>Impurity Ibuprofen EP Impurity D<br>Applications 2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.<br>References Jia, C., et al.: Science, 287, 1992 (2000), Yu, J., et al.: Org. Biomol. Chem., 4, 4041 (2006),<br></p>

<p>Impurity Acetazolamide EP Impurity A<br>Applications N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide is an impurity of Acetazolamide (A161500). Acetazolamide EP Impurity A<br>References Zarghi, A., et al.: J. Pharm. Biomed. Anal., 28, 169 (2002), Subbarao, D., et al.: J. Chromatogr., 67, 841 (2008),<br></p>

<p>Impurity Glipizide EP Impurity D<br>Applications 4-[β-(6-Methylpyrazinyl-2-carboxamido)ethyl]benzene Sulfonamide (Glipizide EP Impurity D) is an intermediate in the synthesis of the impurity 5-Desmethyl-6-methyl Glipizide (D292550).<br></p>

<p>Applications Carbonic anhydrase inhibitor. Diuretic.<br>References Parasrampuria, J., et al.: Anal. Profiles Drug Subs. Excip. 22, 1 (1993),<br></p>

<p>Applications Acetaminophen-d3 is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Acetaminophen-d4 (major) is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)(3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications rac-Acetaminophen Mercapturate-d5 (Major), is a labeled analogue and free acid of 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References van der Hooft, J.,et al.: Metabolomics, 12, 1 (2016)<br></p>

<p>Impurity Etodolac EP Impurity B<br>Applications 8-Methyl Etodolac (Etodolac EP Impurity B) is an impurity of Etodolac (E933100) which was examined for mutagenicity in reverse mutation tests on bacteria. Etodolac impurity B.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications Sulfadiazine Sodium Salt can be used as reactant/reagent in preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride and hydrobromide cocrystals with iodine.<br>References Pan, F., et al.: CrystEngComm, 17, 6641 (2015)<br></p>

<p>Applications 3-(p-Chlorophenyl)-3-hydroxyphthalimidine is an analog of Chlorthalidone (C427500) and has potential antidiuretic and hyperglycemic activities.<br>References Wales, J.K., et al.: P. Soc. Exp. Biol. Med., 128, 581 (1968)<br></p>

Methyl 2-disazobenzoate hydrochloride is a drug product that is used as an HPLC standard and as a metabolite in the development of drugs. It has been found to be naturally occurring and is a research and development metabolite. Methyl 2-disazobenzoate hydrochloride is also an impurity of API, which can be quantified in analytical studies. It is a synthetic compound with CAS No. 35358-78-2 and it can be used to manufacture high purity pharmaceuticals. Methyl 2-disazobenzoate hydrochloride has been shown to have niche pharmacological effects, such as anti-inflammatory activities.

<p>3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid is a chemical compound that is an impurity standard for HPLC. It is also used as a pharmacopoeia, drug development, and analytical reference standard. The CAS number for this compound is 66364-71-4. This compound has been shown to be metabolized by microsomal oxidation, glucuronidation, or sulfation pathways in humans. 3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid can also be found in natural sources such as plants and animals.</p>

<p>Aceclofenac methyl ester is an analgesic that belongs to the arylpropionic acid derivatives. It has been developed for the treatment of acute pain. Aceclofenac methyl ester has a structural formula of CH3CO-O-CH3 and a molecular weight of 164.2 g/mol. Aceclofenac is metabolized by CYP450 enzymes, which are located in the liver and other organs, to form acetic acid and 5-hydroxyaceclofenac. The reaction time is approximately 1 hour and tetrahydrofuranyl (THF) is used as a nucleophile in this reaction. This product can be synthesized by reacting ethyl acetate with acetonitrile in high yield, making it stable and anhydrous. The analgesic effects of aceclofenac methyl ester are due to its ability to block the transmission of pain signals from nerves to the brain at the spinal cord level</p>

<p>2-[4-(2-Methylpropanoyl)phenyl] propanoic acid is a pharmaceutical intermediate that is used for the production of carprofen. It has been found to be an analytical method for the determination of 4-hydroxybenzoic acid and 4-isobutylacetophenone. The compound is analyzed by chromatographic methods and electrophoresis methods. The optimization of the solvent composition, flow rate, and impurities during the synthesis process are also studied in this research. 2-[4-(2-Methylpropanoyl)phenyl] propanoic acid has been found to be a meaningful validation of analytical methods for medicines, with an impurity limit of 0.1%.</p>

<p>3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is an impurity in the synthesis of a drug. It is not active and has no known therapeutic value. 3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is used as a reference standard for HPLC and has been shown to be metabolized by cytochrome P450 enzymes.</p>

Methyl 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-carboxylate-1,1-dioxide is a centrosymmetric molecule with an aspergillus flavus conformation. It is an acetanilide derivative that has been shown to be an effective antioxidant and medicine for the treatment of cancer. This product is also used in the production of hydrogen bonds and linkers in organic synthesis. The yields are high and it can be oriented during irradiation.

<p>Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the group of carboxylic acid esters. It has been approved for the treatment of pain and inflammation caused by osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other conditions. Piroxicam is available in tablets, capsules, injectable solutions, and topical creams. The pharmacokinetics of piroxicam have been studied using intravenous and oral administration in healthy volunteers. Tolerability and side effects are minimal with piroxicam.</p>