TCM Compound Library

<p>Stability Light Sensitive<br>Applications Isotope labelled N-Nitrosodiethylamine (N525465) (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Farber, E. et al.: Cancer Res. 1984 Oct;44(10):4217-23.2. el-Demerdash, E. et al.: Anticancer Res. 2002 Mar-Apr;22(2A):977-84.3. Kweon, S. et al.: Life Sci. 2003 Sep 26;73(19):2515-26.<br></p>

<p>Applications N-Nitroso-N-methylaniline is used in the preparation of resin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miura, K., et al.: Jpn. Kokai Tokkyo Koho (2020), JP 2020029543 A<br></p>

<p>Applications N-Nitrosopyrrolidine-d8 (CAS# 1219802-09-1) is a useful isotopically labeled research compound.<br>References Persichetti, R. A., et al.: From PCT Int. Appl. (2010), WO 2010132810 A1 20101118<br></p>

<p>Applications A carcinogenic nitrosocompound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bos, J., et al.: Cancer Res., 49, 4682 (1989), Wong, H., et al.: Carcinogenesis, 24, 291 (2003), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 601 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications N-Ethyl-N-nitroso-2-propanamine is a building block used in synthesis of amino acids, peptides, and proteins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piotrowska, K., et al.: Synthetic Communications, Vol. 9, Issue 8 (1979);<br></p>

<p>Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications N-Nitrosodibenzylamine (NDBzA) is mutagenic to Salmonella typhimurium and induces DNA strand breaks in isolated rat hepatocytes.<br>References Dunn, W., et al.: Bioorg. Chem., 10, 29 (1981), Rose, S., et al.: J. Med. Chem., 25, 769 (1982), Basak, S., et al.: J. Pharm. Sci., 73, 429 (1984), Zielenska, M., et al.: Mutation Res., 180, 11 (1987),<br></p>

<p>Applications N-Nitrosodiisobutylamine is a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Stability Light Sensitive<br>Applications N-Methyl-N’-nitrosopiperazine was used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);<br></p>

<p>Applications N-Methyl-N’-nitrosopiperazine-d4 is the isotope labelled analog of N-Methyl-N’-nitrosopiperazine (M325800), which is used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);<br></p>

<p>Stability Light Sensitive<br>Applications N-Nitroso-di-n-butylamine (cas# 924-16-3) is a compound useful in organic synthesis.<br></p>

<p>Applications One of the N-nitrosamines found in the water sources and water treatment process. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raska, I., et al.: Bioorg. Med. Chem., 13, 6830 (2005), Puzyn, T., et al.: Environ. Sci. Technol., 42, 5189 (2008),<br></p>

<p>Applications Labelled NEMA (N525950). One of the N-nitrosamines found in the water sources and water treatment process. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raska, I., et al.: Bioorg. Med. Chem., 13, 6830 (2005), Puzyn, T., et al.: Environ. Sci. Technol., 42, 5189 (2008),<br></p>

<p>Applications N-Nitrosodimethylamine-d6 (1.0 mg/mL in Methanol) is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References Chem. and Eng. News, p.5, Feb. 25, 2019<br></p>

<p>Stability Light Sensitive<br>Applications A carcinogenic nitrosocompound.<br>References Wong, H., et al.: Carcinogenesis, 24, 291<br></p>

<p>Applications Labelled N-Nitrosodiisobutylamine (N525610). N-Nitrosodiisobutylamine is a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Applications A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.<br>References Nagasawa, H.T., et al.: J. Med. Chem., 16 (5), 583-585 (1973)<br></p>

<p>Applications A carcinogenic compound.<br>References Lu, S., et al.: Cancer Res., 46, 1485 (1986), Tricker, A., et al.: Eur. J. Cancer Prev., 6, 226 (1997),<br></p>

<p>Applications N-tert-Butyl-N-ethylnitrosamine is a tyrosinase inhibitor and a possible carcinogen.<br>References Yuan, Jintao, et al.: Chem. Res. in Toxic., 24(12), 2269-2279 (2011);Ponce, Yovani M., et al.: QSAR &amp; Combi. Sci., 26(4), 469-487 (2007)<br></p>

<p>Applications N-Nitrosodiphenylamine is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211<br></p>

<p>Applications A novel anti-androgenic compound. A carcinogenic agent.<br>References Singer, G., et al.: Chem-Biol. Interact.,19, 133 (1977), Chou, J., et al.: J. Med. Chem., 22, 792 (1979), Dunn, W., et al.: Bioorg. Chem., 10, 29 (1981), Basak, S., et al.: J. Pharm. Sci., 73, 429 (1984),<br></p>

<p>Applications A chiral N-nitroso compound formed in smoke food (smoked bacon, smoked Swiss cheese, smoke flavoring). A carcinogenic compound.<br>References Lu, S, et al.: Cancer Res., 46, 1485 (1986), Ikins, W.G., et al.: Food Chem. Toxicol., 26, 15 (1988), Kodama, M., et al.: Anticancer Res. 12, 1671 (1992), Ferguson, L., et al.: Mutat Res., 443, 1 (1999),<br></p>