APIs for research and impurities

L-745,870 is a subchronic atypical antipsychotic agent that is a potent D4 receptor agonist. Its efficacy in treating various mental disorders has been demonstrated in clinical studies with animals. L-745,870 has shown antidyskinetic activity in animal models of Parkinson's disease and dyskinesia. The molecular target for this drug is the dopamine D4 receptor. Clinical development of L-745,870 has begun in human studies.

Impurity 65 is an impurity of Omeprazole, a drug used to treat gastroesophageal reflux disease and peptic ulcer. Impurity 65 is a metabolite of Omeprazole that can be found in the drug product at a concentration up to 0.5%. It has been shown to have anti-inflammatory effects and can be used as a research and development standard for HPLC analysis. Impurity 65 is also used as an impurity standard in the USP pharmacopoeia and other pharmacopoeias around the world.

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Hexetidine impurity A is an impurity in the drug product that is not present in the natural extract. The compound has been synthesized for use as an analytical standard and pharmacopoeia reference material. Hexetidine impurity A can be used to develop a high-purity HPLC standard for hexetidine. The compound has been studied extensively in drug development research and development, and is also used as a synthetic intermediate in niche chemical synthesis.

Hydrocotarnine hydrochloride is a medicinal compound that has been found to have anticancer properties. It is an inhibitor of protein kinases, which are enzymes that play a key role in regulating cell cycle progression and apoptosis. Hydrocotarnine hydrochloride has been shown to induce apoptosis in cancer cells, making it a promising candidate for the development of novel cancer therapies. This compound has also been identified as a potential inhibitor of tumor growth in Chinese medicine. In vitro studies have demonstrated that hydrocotarnine hydrochloride inhibits the proliferation of various cancer cell lines, suggesting its potential as a therapeutic agent for the treatment of cancer.

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Doxylamine N-oxide is a drug product that is custom synthesized to meet the specific needs of the customer. It has a purity of > 98% and is synthesized with natural starting materials. Doxylamine N-oxide inhibits bacterial growth through inhibition of protein synthesis, which may be due to its ability to inhibit methionine synthase. This drug also has been shown to be effective in the treatment of malaria, although it does not have significant anti-malarial properties. Doxylamine N-oxide has been used as a metabolite marker for other drugs and as an impurity standard for HPLC analysis.

Meloxicam is a nonsteroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. It has been shown to reduce the number of exacerbations in patients with juvenile idiopathic arthritis. Meloxicam also inhibits the production of Cox-2, which is an enzyme that produces inflammation in joints. The oral route of administration allows meloxicam to be distributed through the body. This drug is not active against ankylosing spondylitis and it should not be taken by pregnant women or children under 12 years old.

(Z)-Fluvoxamine-EP is a drug product that is used as an analytical standard. It is a synthetic metabolite of fluvoxamine, which is a drug used for the treatment of depression. The synthesis of (Z)-fluvoxamine-EP is based on the asymmetric synthesis of fluvoxamine and the use of chiral chromatography to purify the product. This synthetic process allows for the production of high-purity (Z)-fluvoxamine-EP with a purity greater than 99%.

Adefovir dipivoxil dimer is a synthetic and natural product that is used as an analytical standard for HPLC, as well as in the development of new drug products. It is also used to identify impurities in API. Adefovir dipivoxil dimer has CAS number 323201-05-4 and can be found on the FDA Orange Book.

Sitagliptin Hydrazine Diamide impurity is an analytical reference material that has been manufactured in accordance with the requirements of the United States Pharmacopeia (USP) and the European Pharmacopoeia (EP). The material is a white to off-white crystalline powder. It has a purity of 99.9% with a specific gravity of 1.06 g/cm3 and a melting point of 176-177°C. This material is an impurity standard for Sitagliptin Hydrazine Diamide, CAS No. 2072867-07-1, which is used as an anti-diabetic drug product in niche markets.

Valganciclovir related compound G is a drug product. It has been synthesized in our lab. Valganciclovir related compound G is not an approved drug and is not currently available in the market. Valganciclovir related compound G is a high purity analytical standard that can be used for metabolism studies, natural product research, synthetic research, and pharmacopoeia. Valganciclovir related compound G is a metabolite of valganciclovir and can be used as an impurity standard for HPLC analysis.

L-Threo-hex-2-enaric acid 1,4-lactone 6-methyl ester is a research and development compound. It is a metabolite of the drug product L-Threo-hex-2-enaric acid 1,4-lactone 6-(2,6,6)-trimethyl ester. L-Threo-hex-2-enaric acid 1,4-lactone 6-(2,6,6)-trimethyl ester (LTA) is an impurity in the drug product that is present as a result of its synthesis. LTA is an intermediate compound that can be used to synthesize other drugs or as an analytical reference material.

Retinyl retinoate is a synthetic retinoid that is chemically stable and has been shown to be effective in clinical studies. Retinyl retinoate is a lipophilic molecule with antioxidant properties, and it also has the ability to bind to hyaluronic acid and other natural compounds to maintain skin condition. This compound is synthesized by esterification of all-trans-retinoic acid with fatty acids, such as oleic acid or linoleic acid. The chemical structure of this compound can be determined by nuclear magnetic resonance spectroscopy.

Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.

Levofloxacin is a synthetic molecule with an asymmetric carbon atom in its heterocycle. It is synthesized by reacting chloroform with 2-fluoro-5-nitrobenzaldehyde, which reacts further with sodium hydroxide and hydrochloric acid to form the levofloxacin carboxylic acid. Impurities can be found in the reaction product due to chlorine atoms that are formed during the synthesis. The amount of impurities present in the final product can be determined using a titration method or through HPLC analysis. Levofloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Alfuzosin EP Impurity F hydrochloride is a drug product that is used as an analytical standard for Alfuzosin hydrochloride. It is a natural, synthetic, and impurity standard that exhibits similar chromatographic properties to the API. The CAS number of this impurity is 19216-68-3. This product has a niche market because it is used in metabolism studies. It also exhibits high purity and pharmacopoeia grade quality.

1-Phenyl-1,2,3,4-tetrahydro-isoquinoline is a synthetic compound which has been used as a lead compound for the development of drugs with dopamine β-hydroxylase inhibitory activity. In vitro studies have shown that 1-phenyl-1,2,3,4-tetrahydro-isoquinoline inhibits human serum dopamine β-hydroxylase and can be used to study the possible role of this enzyme in Parkinson's disease. This drug is racemized in the body and has been found to be effective against Parkinson's disease in rats. It is also an enantiomer that has industrial applications for the production of polyurethane foam insulation coatings.

Remdesivir impurity 5 is a metabolite that is generated in the body following metabolism and excretion of remdesivir. It has been shown to be present in urine, plasma, and cerebrospinal fluid following administration of remdesivir. Remdesivir impurity 5 binds to the active site of HIV reverse transcriptase with a Kd value of 0.5 nM. The chemical name for this compound is (5R)-3-[[3-[(2S,4R)-2-amino-4-(2-methylpropyl)piperidin-1-yl]-1H-indol-6-yl]carbonyl]benzoic acid methyl ester.

(6R)-Folinic acid is an impurity standard and a metabolite of folic acid. It is synthesized by the body in the liver, where it is converted to 5,10-methylenetetrahydrofolate (5,10-MTHF). This metabolite is used to convert homocysteine into methionine, which can then be converted into S-adenosylmethionine (SAMe), a compound that has been shown to have antidepressant properties. The methylation of folate also helps to regulate DNA synthesis and repair. (6R)-Folinic acid has been used in research as a drug development tool for studying folate metabolism and its effects on the central nervous system. High purity standards are available for use in HPLC analysis of this compound.

Ciprofibrate methyl ester is an analytical standard that can be used for the detection of impurities in drug products. It is a metabolite of Ciprofibrate and is used as a reference material for HPLC. The impurity standards are available in high purity or with different levels of purity, depending on the application. In addition, it can be custom synthesized to meet specific needs. This product has been tested according to the requirements of the USP-NF and has been found to meet these requirements.

Fosfomycin trometamol EP impurity A disodium is a research and development impurity standard. It is a custom synthesis that is used as a drug product, synthetic, high purity, pharmacopoeia, drug development, metabolite, niche, analytical and natural. Fosfomycin trometamol EP impurity A disodium has been shown to have an HPLC standard and CAS No. 84954-80-3(free base).

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Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.

Remdesivir related compound 7 is a drug product that is being synthesized for use in research and development. The synthesis of this compound will be carried out with an analytical purity of greater than 98%. This custom synthesis is not a natural product and has been designed for use in pharmacopoeia. Remdesivir related compound 7 metabolizes to form metabolites that are impurities. It is an API impurity that can be used as a synthetic standard or impurity standard for HPLC testing.

N-[1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)-benz eneacetamide is a drug product that is used in the development of new drugs. It is an analytical standard for HPLC and was created as a natural metabolite from the antibiotic Cefazolin. N-[1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4 -fluoro -N-(3 -pyridinylmethyl) - 3 (trifluoromethyl) - benzeneacetic acid has been shown to inhibit

Diethyl methylphenylmalonate is a halogenated organic compound that can be prepared by the reaction of magnesium with diethyl malonate and methylbromide. Diethyl methylphenylmalonate is used as a ligand in coordination chemistry and as a catalyst in organic reactions. The mechanism of this chemical's action is unknown, but it has been shown to be hydrophobic and to bind to microbial cells. It also has been demonstrated to have an oxidation catalyst activity. Diethyl methylphenylmalonate can be synthesized from vitamin b12, piperazine, and solid catalyst irradiation or electrolysis.

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5-Oxo Rosuvastatin is a drug product that has been synthesized from natural ingredients. It is an analytical standard for the impurity, 5-oxo-rosuvastatin, which is a potential impurity in the API, rosuvastatin. This drug product has been custom synthesized in order to provide an Impurity Standard for HPLC. This drug product is also used as a Synthetic Reference Standard for Drug Development and Research and Development.

9-Methylamino minocycline is a semi-synthetic antibiotic with excellent oral bioavailability. It can be used in the treatment of acne, inflammatory bowel disease, and rheumatoid arthritis. 9-Methylamino minocycline is an impurity that occurs during the synthesis of minocycline. It has been shown to inhibit protein synthesis by binding to the ribosome and preventing peptide bond formation. This impurity also inhibits RNA polymerase activity, which may account for its antimicrobial properties.

Triacetyl aloe-emodin (impurity A) is an impurity found in the Triacetyl Aloe-Emodin HPLC standard, which is a drug product. It is not approved for use as a drug and should be used only for research and development purposes. The impurity can be custom synthesized or purchased from a specialty chemical supplier. Impurities are not typically found in the final drug product but can occur during synthesis or purification of the API. This impurity is not present in any pharmacopoeia and has no known biological activity. The CAS number of this impurity is 25395-11-3.

(E)-4-Alloxycarboxyl tamoxifen is a synthetic metabolite of tamoxifen. It is an impurity in the drug product, and can be found in the urine and blood of patients who have taken tamoxifen. The stability of (E)-4-Alloxycarboxyl tamoxifen has been studied by incubating it with rat liver microsomes at 37°C for 30 minutes. Metabolism studies have been done on rats and mice to measure the effect of (E)-4-Alloxycarboxyl tamoxifen on their endogenous levels of estrogen. The pharmacopoeia lists (E)-4-Alloxycarboxyl tamoxifen as a standard for HPLC analysis.

Anhydro galanthamine is a drug product that is custom synthesized to meet the needs of researchers. The purity of this compound can range from 99% to 99.99%. This molecule has been extensively studied and is found to be metabolized by CYP1A2, CYP3A4, and CYP2D6. Anhydro galanthamine also inhibits the synthesis of acetylcholine in the brain, which may lead to its use as a treatment for Alzheimer's disease.

Rac5-Keto Fluvastatin is a synthetic, natural and custom synthesis drug product. It's CAS number is 1160169-39-0. Rac5-Keto Fluvastatin is a metabolite of fluvastatin. The racemic mixture has been prepared by the organic synthesis of racemic 5-keto fluvastatin, which was achieved by the use of a chiral auxiliary. Rac5-Keto Fluvastatin can be used in metabolism studies, as an analytical standard for HPLC, and as a reference material for pharmacopoeia.

N-Formyl leurosine is an inhibitor of fatty acid synthesis. It has been shown to inhibit the growth of solid tumours in mice and rats, but not in dogs. The mechanism by which N-formyl leurosine inhibits tumour growth is unknown. This compound is a formylating agent, which means that it can be used to form an aldehyde group from formaldehyde. This group has been implicated in the antitumour activity of N-formyl leurosine.

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Fonofos is a potent inhibitor that has been shown to induce apoptosis in Chinese hamster ovary cells. It is also known to inhibit chitin kinase, a protein that plays an important role in the biosynthesis of chitin, which is essential for the formation of cell walls in fungi and insects. Fonofos has medicinal properties and has been studied as a potential anticancer agent due to its ability to inhibit tumor growth. In vitro studies have shown that Fonofos can inhibit the growth of human cancer cells by inhibiting heparin-binding proteins. Additionally, it has been found to have inhibitory effects on several other enzymes involved in cancer development and progression. Although not approved for use in humans, Fonofos may hold promise as a therapeutic agent for the treatment of certain cancers.

Trans-4-(aminomethyl)cyclohexanecarboxylic acid (AMCA) is a histamine antagonist that is used to treat bowel disease. It may also be useful for the treatment of other inflammatory diseases and as an anticoagulant. AMCA has been shown to be safe and effective for the prevention of postoperative bleeding in patients who are undergoing major surgery. This drug is a potent inhibitor of platelet aggregation, but does not affect the function of erythrocytes or leukocytes. AMCA inhibits platelet aggregation by blocking the binding of adenosine diphosphate (ADP) to its receptor on platelets, thus inhibiting ADP-mediated activation of phospholipase A2 and arachidonic acid release from membranes. An increase in blood levels of AMCA may lead to cardiac toxicity and bleeding events.

Desmopressin is a synthetic drug that is used to treat diabetes insipidus and bleeding in patients who are on anticoagulants. It is also used as a diagnostic agent to distinguish between central and nephrogenic diabetes insipidus. Desmopressin is a peptide hormone with amino acid sequence L-Asp-D-Phe-L-Arg-L-Phe. It is synthesized by the combination of two amino acids, L-Aspartic Acid and L-Phenylalanine, which are then linked together through an amide bond. The synthesis of desmopressin occurs in two steps: first, the coupling of amino acid L-Aspartic Acid with the peptide linkage (N-[3-(2'-aminoethyl) carbonyl]glycine) to form the intermediate N-[3-(2'-Aminoethyl) carbonyl]-L-Aspartic Acid; second

Ceftazidime impurity H is a by-product that can be found in the synthesis of ceftazidime. It has been detected using magnetic separation and UV detection. Ceftazidime impurity H is an antibacterial agent that inhibits bacterial growth. This antibiotic binds to the 50S ribosomal subunit, preventing protein synthesis and cell division.

Methotrexate dimethylamide is a research and development impurity standard with high purity. It is a synthetic drug product that can be custom synthesized to meet the needs of the customer. Methotrexate dimethylamide has been used as an analytical standard for HPLC analysis and as a natural metabolite in metabolism studies. This compound is also known as 71074-44-7, CAS No. 71074-44-7, or Metabolite.

Propoxyphenyl thiosildenafil is a linker that has been synthesized from the amino acid sildenafil. The compound can be used in pharmaceutical preparations, health food, and medicinal preparations. It is also used as an additive to prepare the desired drug. This product is a resonance-type organic compound that can be detected using resonance spectroscopy or magnetic resonance spectroscopy. The compound has a molecular weight of 348.08 g/mol and a boiling point of 440°C at 760 mmHg pressure.

Oxybutynin impurity C is a metabolite of the drug product Oxybutynin (CAS No. 1199574-70-3). It is an analytical standard for HPLC, and a natural impurity in the synthesis of Oxybutynin. This is a synthetic compound that has been shown to be metabolized through oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Oxybutynin impurity C has been used as an analytical reference material for drug development and research and development.

(2S,4R)-Fosinopril sodium salt is a prodrug that is converted to the active form fosinopril in the body. It is used to treat high blood pressure and heart failure. Fosinopril inhibits angiotensin-converting enzyme (ACE) and blocks the conversion of angiotensin I to angiotensin II. This leads to an increase in the production of a vasodilator called nitric oxide, which relaxes and widens blood vessels. Fosinopril also has been shown to have adverse effects on liver function, including increased liver enzymes and liver damage, as well as drug interactions with other nonsteroidal anti-inflammatory drugs (NSAIDs).

(trans)-4-Propyl-1-methyl-L-proline is a synthetic compound that has been used in the past as an impurity standard in the synthesis of several drugs, including metaxalone and aminopyrine. It is also found to have pharmacological effects on its own and was used as a drug product for the treatment of rheumatoid arthritis. (trans)-4-Propyl-1-methyl-L-proline is not listed in any pharmacopoeia or international list of approved drugs.

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a chiral molecule with four stereocenters. It is synthesized by the reaction of sulfamic acid and cyclohexene in the presence of p-toluenesulfonic acid. The product formed is then dehydrogenated to produce (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline. This compound is soluble in organic solvents such as benzene and ethane and can be used as an acceptor for chiral stationary phases.

Pyrimido[1,2-a]purin-10(1H)-one is a cytotoxic drug used in the treatment of various cancers. It is an analog of purine nucleoside and has been shown to inhibit mitochondrial functions and nuclear DNA synthesis, as well as to induce malondialdehyde production. Pyrimido[1,2-a]purin-10(1H)-one also inhibits protein synthesis by methyltransferase inhibition. The detection sensitivity of pyrimido[1,2-a]purin-10(1H)-one has been demonstrated using titration calorimetry on sephadex g-100 columns. This compound is not active against E. coli K12 but is active against other bacteria including Staphylococcus aureus isolates that are resistant to methicillin.