APIs for research and impurities

<p>Pf 3084014 hydrobromide is a pluripotent, non-tumorigenic, and self-renewing cell line that can differentiate into cells of all three germ layers. It is generated from the pancreatic tissue of a male donor aged 25 years who died from an unknown cause. The Pf 3084014 cell line is characterized by the expression of pluripotency markers, such as Oct4 and Nanog, and has been shown to have the potential to differentiate into neurons. This cell line has also been used in vitro methods for cancer research as well as for studying human pluripotent stem cells.</p>

<p>Finasteride 2-(2-methylpropanol)amide β-D-glucuronide is an inhibitor that has been shown to induce apoptosis in cancer cells. It is a metabolite of Finasteride, a medicinal drug used to treat benign prostatic hyperplasia and male pattern hair loss. This compound has been found in urine samples of patients who have taken Finasteride, suggesting its potential anticancer properties. Finasteride 2-(2-methylpropanol)amide β-D-glucuronide has been studied for its ability to inhibit protein kinases, specifically Chinese hamster ovary cell kinase and human tumor-associated kinases. This analog may have therapeutic potential as a novel class of kinase inhibitors for the treatment of cancer.</p>

<p>Please enquire for more information about 2-Bromo-N-(4-chlorophenethyl)propan-1-amine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Levofloxacin is a synthetic fluoroquinolone antibiotic. The diamine impurity of levofloxacin is the major metabolite of levofloxacin and is classified as a pharmacopoeia impurity. Research has shown that the diamine impurity may be formed from levofloxacin through oxidation, hydrolysis, or transamination reactions. Hydrolysis by esterases is the most likely mechanism for the formation of this compound and it has been shown to be excreted in urine. The HPLC standard for the diamine impurity of levofloxacin is available upon request.</p>

<p>Fluorometholone impurity 5 is a drug product that has been custom synthesized. It has not yet been assigned to a CAS number. This compound exhibits high purity and is an analytical grade. Metabolism studies have been conducted on this substance, which is natural and can be found in the drug development phase. This impurity standard is for HPLC analysis and research and development purposes only.</p>

<p>(-)-N,N-Bisdesmethyl tramadol is a potent inhibitor of apoptosis, which plays a key role in the development and progression of cancer. It is an analog of tramadol and has been shown to inhibit the growth of human cancer cells by blocking protein kinase activity. This drug has also been found to be effective against tumors in animal models. (-)-N,N-Bisdesmethyl tramadol is excreted in urine and has been identified as a potential biomarker for anticancer therapy. Studies have shown that this compound can enhance the therapeutic effects of polysaccharides and adenosine inhibitors in Chinese medicine, making it a promising candidate for future cancer treatment research.</p>

<p>2'-(2,3-Epoxypropoxy)-3-phenylpropiophenone is a research and development impurity standard. It is used as an impurity standard for HPLC analysis of the drug product, in pharmacopoeia, and in drug development. This compound has been shown to be metabolized by cytochrome P450 enzymes into unidentified metabolites. 2'-(2,3-Epoxypropoxy)-3-phenylpropiophenone may also act as a substrate for human epoxide hydrolase or for erythrocyte esterases.</p>

<p>4-Hydroxy mepivacaine is a drug product that belongs to the group of local anesthetics. It is a synthetic, non-proprietary compound that has been synthesized for research purposes. 4-Hydroxy mepivacaine has been shown to have analgesic effects in animals and humans. The metabolite profile of this agent has been studied in detail, and it includes metabolites such as piperidine, 4-hydroxypiperidine, 1-(4'-hydroxyphenyl)piperazine, and 4-hydroxymepivacaine. Metabolism studies show that the drug is metabolized by the liver and excreted through the kidneys. This drug product is not approved for use in humans or animals by any regulatory agencies.</p>

<p>2-[(4-Chlorophenyl)methylene]-N-phenylhydrazinecarbothioamide is a potent Chinese medicinal compound that has been shown to be an effective inhibitor of cancer cell growth. This compound is an analog of other inhibitors of kinases, which play an important role in the regulation of cell division and apoptosis. It has been found to be particularly effective against tumors and has shown promising anticancer activity in human urine samples. The protein kinase inhibitory activity of 2-[(4-Chlorophenyl)methylene]-N-phenylhydrazinecarbothioamide may be due to its ability to induce apoptosis in cancer cells. This makes it a valuable tool for the development of new cancer therapies.</p>

<p>Midostaurin Impurity 2 is a drug product that has been custom synthesized by our scientists. It is of high purity, and is used in analytical studies to understand its metabolism. This impurity also plays a role in drug development and pharmacopoeia. It can be found under CAS No. 155848-20-7, and has the molecular formula C10H16N4O2S. This compound has an analytical standard at HPLC, which can be used to make sure that it's purity meets FDA standards for research and development purposes.</p>

<p>MSC2360844 is a Chinese medicinal analog that has shown potent anticancer activity against various types of tumors. It functions as an inhibitor of kinases, which are proteins involved in cell signaling and growth regulation. MSC2360844 induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of specific kinases. This inhibitor has been shown to be effective against multiple cancer cell lines and has potential therapeutic applications for the treatment of cancer. MSC2360844 is excreted through urine after administration and shows promising results in preclinical studies as a potential anticancer agent.</p>

<p>Ethyl 2-(6-amino-2,3-dichlorobenzyl)glycine is a drug product with a CAS number of 70406-92-7. It has an analytical purity of greater than 98% and is supplied as a white powder. This product is metabolized in the human body to form an active metabolite. The chemical name for this drug product is ethyl 2-(6-amino-2,3-dichlorobenzyl)glycine, which can be found in the pharmacopoeia under the name of 6′ amino 2,3′ dichlorobenzyl glycine.</p>

<p>Racemic Enterodiol-d6 is a high purity synthetic racemic compound that is used as an impurity standard for use in HPLC. The CAS number for Racemic Enterodiol-d6 is 104411-12-3. Racemic Enterodiol-d6 has a melting point of 232°C and a boiling point of 464°C at atmospheric pressure. This product can be customized to meet the needs of your research, development, or drug production needs.</p>

<p>Gimatecan is a cycle-specific inhibitor that targets kinases and proteins involved in cancer cell growth. It is a medicinal compound that has been shown to be effective against various types of human cancers. Gimatecan works by inhibiting the activity of protein kinases, which are enzymes that promote cell division and proliferation. This inhibition leads to apoptosis, or programmed cell death, in tumor cells. Gimatecan has been tested extensively in Chinese hamster ovary cells and has demonstrated potent anticancer activity. The compound is excreted primarily through urine and has shown promising results as an anticancer agent in preclinical studies.</p>

<p>Lisinopril is a drug product that is used to treat high blood pressure, heart failure and other conditions. It belongs to the class of angiotensin-converting enzyme inhibitors and has been shown to inhibit the activity of angiotensin I converting enzyme (ACE) in the body, which leads to increased levels of bradykinin, an important peptide in inflammation. Lisinopril is a metabolite of cilazapril and lisinoprilat, both of which are prodrugs. Lisinopril has been shown to be effective in reducing blood pressure and improving survival rates in patients with heart failure.</p>

<p>Please enquire for more information about Benz[A]anthracene-7-acetic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>MDM2 inhibitors are a class of cancer drugs that inhibit the activity of MDM2, which is an oncoprotein that prevents the degradation of p53. This inhibition leads to increased levels of p53 and the activation of its tumor-suppressing functions. The anti-cancer activity of this drug has been shown in a number of cancer cells, including human colon cancer cells, human prostate cancer cells, and murine leukemia cells. Furthermore, this drug has been shown to have synergistic effects when combined with other chemotherapeutic agents such as cisplatin and vincristine.</p>

<p>Descarboxymethyl treprostinil is a synthetic compound that has been researched for use as a drug product. It is currently in the development stage and is not yet approved for sale to the public. Descarboxymethyl treprostinil is not found in nature and was synthesized from para-chloro-benzoic acid and 1,2,3,4-tetrahydroisoquinoline. This compound is an impurity standard with a purity greater than 98%. Descarboxymethyl treprostinil has been used in pharmacopoeia research as well as drug development studies. It has also been studied for metabolism and analytical properties.</p>

<p>2-[[2-(Acetyloxy)benzoyl]oxy]benzoic acid 2-carboxyphenyl ester is a synthetic compound that has anti-inflammatory and anti-cancer properties. It inhibits the production of prostaglandins by inhibiting phospholipase A2, which leads to an increase in cyclooxygenase levels. This may be due to the inhibition of the enzyme's activity or its induction by other compounds. The drug also has cytostatic and cytotoxic effects on cancer cells. It is used for the treatment of muscle spasms, hepatitis, cancer, skin cancers and autoimmune diseases. 2-[[2-(Acetyloxy)benzoyl]oxy]benzoic acid 2-carboxyphenyl ester is administered transdermally or systemically.</p>

<p>L-733,060 Hydrochloride is a drug product that was custom synthesized for the purpose of research and development. It is a white to off-white crystalline powder with a melting point of 178.5°C. The purity of L-733,060 Hydrochloride is greater than or equal to 98% by analytical HPLC. L-733,060 Hydrochloride has been studied in metabolism studies and has been shown to be metabolized by cytochrome P450 enzymes, oxidative metabolites, hydrolysis by esterases, glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>Hexadecanedioic acid mono-L-carnitine ester chloride is an analog of a naturally occurring compound that has been found to have medicinal properties. This compound has shown potential as an anticancer agent due to its ability to inhibit cancer cell replication and induce apoptosis. It has been studied extensively in human tumor cells, where it has been shown to inhibit kinase activity and protein synthesis. This inhibitor may also have potential as a urinary biomarker for cancer diagnosis. Additionally, this compound has been tested in Chinese hamster ovary cells, where it showed potent inhibitory effects on the growth of these cells. Overall, Hexadecanedioic acid mono-L-carnitine ester chloride is a promising candidate for further research into its potential therapeutic uses in cancer treatment.</p>

<p>4-aminobenzenesulfonyl sulfamethoxazole N-acetate is a drug product that has been approved for use in humans. It is an impurity standard of the API sulfamethoxazole, which is used to treat bacterial infections. 4-Aminobenzenesulfonyl sulfamethoxazole N-acetate is a metabolite and impurity of the synthesis process. It has been shown to be active against methicillin resistant Staphylococcus aureus (MRSA) and other bacteria, as well as being effective for the treatment of urinary tract infections. This product has niche applications in the pharmaceutical field and can be used for research and development or analytical purposes. 4-Aminobenzenesulfonyl sulfamethoxazole N-acetate is a white solid with high purity, making it suitable for pharmacopoeia applications.</p>

<p>Mesalamine impurity S is a mesalamine metabolite that has been identified as an impurity in the drug product. Mesalamine impurity S is an analytical standard that is used for HPLC analysis and can be used as a reference material for the pharmacopoeia. Mesalamine impurity S can also be synthesized from natural or synthetic sources.</p>

<p>Please enquire for more information about 5-Amino-2-(phenylmethoxy)benzoic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Deacetyl-N,o-didemethyldiltiazem is a drug product that is used for the treatment of hypertension. It is a synthetic compound and has not been found in nature. The impurity standard for this product is an analytical chemical that can be used to identify the presence of impurities in a sample. Deacetyl-N,o-didemethyldiltiazem can be synthesized from commercially available starting materials using custom synthesis methods. It is an API impurity and can be developed into a drug by researching and developing it as a niche therapy for hypertension. This compound has high purity and can be used as an HPLC standard.</p>

<p>Despropoxy ethoxy udenafil is a synthetic drug product with high purity. It is an impurity standard for HPLC and the natural metabolite of despropoxyphene. Despropoxy ethoxy udenafil has been shown to be pharmacologically active in animal models, but it is not yet known whether it possesses any therapeutic value.</p>

<p>Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid derivative group. It is used in the treatment of mild to moderate pain and inflammation, such as arthritis. Aceclofenac is rapidly hydrolyzed by esterases in the small intestine, resulting in the release of aceclofenac acid. Aceclofenac benzyl ester is a chemical intermediate that has been shown to be an efficient method for producing aceclofenac acid. It can be obtained by reacting bromoacetic anhydride with methyl alcohol and then hydrolyzing the product with strong acids. This compound may contain impurities, such as nucleophilic impurities, which can lead to side effects.</p>

<p>Montelukast impurity I is an impurity found in the drug product, Montelukast. It is a natural substance and is produced as a result of metabolism studies. The chemical name for this impurity is 3-hydroxy-4-(2-methylpropyl)-5-(4-methoxyphenyl)pentanoic acid. This impurity can be used as an analytical standard and can be synthesized for use in pharmacopoeia. This compound has not been shown to have any therapeutic effects on humans or animals. This impurity has been shown to cause nausea, vomiting, and diarrhea in some patients.</p>

<p>1-Glycoloyl-L-prolinamide is a drug product that is an analytical standard for the impurity 1-glycoloyl-L-proline (CAS No. 96166-39-1) in the API 1,4,5,6-tetrahydrobenzothiazole (CAS No. 86687-93-0). It has been synthesized to be used as an impurity standard and is provided at a purity of 98.0% or greater by weight. This chemical compound can be used in research and development for the production of drugs as well as in pharmaceutical manufacturing.</p>

<p>Sceptrin dihydrochloride is a natural product that is the first asymmetric synthesis of the sceptrin molecule. It has been shown to have anti-inflammatory properties and can be used for the treatment of inflammatory bowel disease. Sceptrin dihydrochloride inhibits the activity of leukotriene A4 hydrolase, which is an enzyme that controls the production of leukotrienes. This inhibition leads to decreased levels of leukotrienes and reduced inflammation in the gastrointestinal tract. Sceptrin dihydrochloride has also been shown to have an effect on skeleton cells, where it can inhibit bone resorption by activating osteoclasts and inhibiting osteoblasts.<br>Sceptrin dihydrochloride belongs to a group of compounds called fatty acid esters and has a chemical structure consisting of nitrogen atoms with two chiral centers. The synthesis was carried out using an asymmetric synthesis method that involved reaction with a chiral catalyst and</p>

<p>Propylthiouracil-d5 is a drug product that is used in the development of drugs. Propylthiouracil-d5 is a synthetic compound, which is also known as propylthiouracil (PTU). It has been used as an antithyroid drug and has been shown to have anti-inflammatory properties. PTU is metabolized by oxidation, hydrolysis, or conjugation with glucuronic acid. The major metabolites are 4′-hydroxypropylthiouracil and the 2′-glucuronide conjugate. The metabolite 4′-hydroxypropylthiouracil has been detected in urine at concentrations of up to 600 ng/mL following oral administration of PTU.</p>

<p>Isodiospyrin is a synthetic compound that is used in the synthesis of other compounds. It has been shown to inhibit cell growth in a number of different types of cells, including human leukemia cells and colon cancer cells. Isodiospyrin has also been shown to have potent inhibitory activity against the fatty acid synthase enzyme and the redox potentials it generates. This compound was found to be synthesized from two natural compounds, namely the plant families, quinone and dihydrobenzoquinone. The synthesis process involves an aldol cyclization reaction between these two compounds.</p>

<p>2-Oxo ticlopidine oxalic acid is a synthetic compound that has been used as an impurity standard in the synthesis of other compounds. The CAS number for this compound is 89481-79-8. 2-Oxo ticlopidine oxalic acid can be custom synthesized to meet specific requirements. It is typically used as a drug product or pharmacopoeia and can be used for research and development purposes. Metabolism studies have been conducted on 2-oxo ticlopidine oxalic acid, which has shown it to be metabolized through oxidation and conjugation with glutathione, glucuronide, or sulphate. HPLC standards for this compound are available at Sigma Aldrich.</p>

<p>N-Desethyl-E-clomiphene hydrochloride is a synthetic drug product that has been custom synthesized to meet the needs of our customer. It has been shown to be metabolized in vivo, with metabolites identified and characterized. This drug product is a synthetic, natural, and impurity standard. Metabolites have also been identified and characterized, so this compound may be used as an analytical reference material for HPLC methods.</p>

<p>Diclofenac isopropyl ester is a synthetic, non-natural drug product. It has been shown to be metabolized by the liver to produce diclofenac acid and sulfate conjugates. The drug product can be used as an analytical standard or impurity control in HPLC measurements of drug products that contain diclofenac. Diclofenac isopropyl ester is also used for research and development purposes and has niche applications for pharmacopoeia purposes.</p>

<p>Please enquire for more information about N-Desformyl N-acetyl (S,S,R,S)-orlistat (orlistat impurity) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Dihydrexidine hydrochloride is a phosphate ion transport inhibitor that binds to the acetylcholine transporter, and inhibits the uptake of acetylcholine in the brain. It is used as an opioid analgesic, as well as to treat depression, cognitive disorders, and Parkinson's disease. Dihydrexidine hydrochloride binds to the catechol-O-methyltransferase (COMT) enzyme and prevents it from breaking down dopamine. This leads to increased levels of dopamine in the synapse and enhanced transmission of nerve impulses between neurons. Dihydrexidine hydrochloride also has been shown to bind to antigen molecules on cells, which may be important for its antiviral properties.</p>

<p>2,2',4,4',5,6'-Hexachlorobiphenyl (PCB-153) is a potent inhibitor of kinases and has been shown to induce apoptosis in tumor cells. It is an analog of medicinal inhibitors used for the treatment of cancer. PCB-153 has been tested on both Chinese hamster ovary cells and human cancer cell lines and has demonstrated its anticancer properties by inhibiting protein kinase activity. In addition, it has been found in urine samples from individuals with cancer, suggesting that it may play a role in the development or progression of this disease. The potential therapeutic benefits of PCB-153 as an anticancer agent are currently being investigated.</p>

<p>(S)-5-Chloronaproxen is a synthetic drug product with a purity of 99.9%. It has been synthesized from natural, custom synthesis and analytical grade raw materials. Metabolism studies have been conducted to determine the metabolic pathways of (S)-5-chloronaproxen. The metabolite profile was analyzed by HPLC, and the impurity standard was developed for use in pharmacopoeia, niche research and development, and quality control laboratories.</p>

<p>2-(Aminomethyl)-1-ethylpyrrolidine is a pharmaceutical preparation that has been used in the analytical method for determining impurities in pharmaceuticals. It has also been used as an intermediate for pharmaceutical dosage preparations and as a reagent for chromatographic analysis of various substances. 2-(Aminomethyl)-1-ethylpyrrolidine is produced by acylation of pyrrole with ethyl chloride, followed by hydrolysis with sodium carbonate and hydrochloric acid. The substance can be separated into its two components using chromatography, which is based on the difference in their polarity. 2-(Aminomethyl)-1-ethylpyrrolidine is a dopamine receptor antagonist that blocks uptake of dopamine into cells by inhibiting the dopamine transporter (DAT). This leads to increased levels of extracellular dopamine and subsequent activation of postsynaptic D2 receptors.</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pruvanserin hydrochloride is a synthetic compound that belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs). It is used for research and development purposes. Pruvanserin hydrochloride has not been marketed as a drug product. This compound has shown to be an impurity in several commercial products and has been found to be present in two drugs, including fluoxetine HCl and sertraline HCl. Pruvanserin hydrochloride is metabolized by cytochrome P450 enzymes and glucuronidases. The half life of this drug is between 3-5 hours following oral administration, with higher doses leading to higher plasma concentrations.</p>

<p>Cis-1,2-dihydroperillic acid is an endogenous metabolite of perillyl alcohol. It is formed in the liver from perillyl alcohol and is excreted in the urine. Cis-1,2-dihydroperillic acid has been shown to inhibit cell growth and induce cancer in animals and humans. Its mechanism of action may be due to its ability to inhibit the production of a growth factor called growth factor β (GFβ). This hormone stimulates the proliferation of mammary carcinomas and may also be involved in carcinogenesis. Cis-1,2-dihydroperillic acid is present in plasma at low concentrations, which have been measured using a human bioassay.</p>

<p>N-Methyl metribuzin is a drug product that belongs to the class of organic compounds known as phenylureas. It is a natural substance, which can be found in plants such as dandelion and rhubarb. Metribuzin has been shown to have pharmacological effects on the human body, including antimetabolite activity, anticancer activity, and anti-inflammatory activities. Metribuzin is metabolized by cytochrome P450 enzymes to form metabolites that are excreted in urine or bile. The metabolites are also active substances and may contribute to the pharmacological effects of metribuzin. Metribuzin can be synthesized from 2-chloro-5-(trifluoromethyl)benzoyl chloride and 3-methylisoxazole.<br>Metribuzin is used as an analytical standard for HPLC analysis because it has a high purity level and analytical quality. It is also used in</p>

<p>2,3,3',4'-Tetrachlorobiphenyl is an inhibitor that has been shown to induce apoptosis in human and Chinese hamster cancer cells. It inhibits the activity of kinases, which are enzymes that play a critical role in regulating cell growth and division. The inhibition of these enzymes leads to the activation of apoptotic pathways, resulting in cell death. Additionally, 2,3,3',4'-Tetrachlorobiphenyl has been found to inhibit the uptake of d-xylose by cells and decrease protein synthesis. This compound has potential medicinal applications for the treatment of tumors and cancers. It can be detected in urine samples and is considered a marker for exposure to environmental pollutants.</p>

<p>Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Gatifloxacin has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Gatifloxacin has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.<br>4'-[(4'Methyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][</p>

<p>Valaciclovir Related Compound E is a white crystalline powder that has an appearance similar to acyclovir, with a melting point of 164-167°C. It is soluble in water and methanol. The compound is used as a medicament and also acts as an intermediate for the synthesis of other pharmaceutical products. Valaciclovir Related Compound E can be synthesized from valaciclovir by reacting it with ethyl chloroformate, followed by recrystallization from pyridine and chloroform. This process produces the desired product in high purity under good yield. Valaciclovir Related Compound E is a white crystalline powder that has an appearance similar to acyclovir, with a melting point of 164-167°C. It is soluble in water and methanol. The compound is used as a medicament and also acts as an intermediate for the synthesis of other pharmaceutical products. Valac</p>

<p>Roxithromycin is a macrolide antibiotic that inhibits protein synthesis in bacteria. It binds to the 50S ribosomal subunit, thereby inhibiting bacterial growth. Roxithromycin has been used to diagnose intestinal and esophageal diseases, inflammatory diseases, and cancer. There are some cardiac effects associated with Roxithromycin that may be related to its ability to inhibit serotonin reuptake. This drug also has anti-inflammatory properties and has been shown to be effective against influenza virus infections as well as other infectious diseases such as tuberculosis and HIV/AIDS.</p>

<p>Please enquire for more information about 3,5-Diiodo-4-hydroxymandelic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3,4-Difluoro-2-(trifluoromethyl)-benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bu 224 hydrochloride is an exogenous ligand that binds to the imidazoline I1 receptor. It is a potent and selective agonist for this receptor, which has been shown to be located in cardiac tissue. Bu 224 hydrochloride has been shown to increase the release of noradrenaline from cardiac cells, resulting in cardiostimulant effects. The binding of Bu 224 hydrochloride to the I1 receptor also increases blood pressure, heart rate, and myocardial contractility. The effect on blood pressure is dose-dependent: low doses result in a mild increase in blood pressure, whereas higher doses can lead to severe hypertension.</p>

<p>Carpropamide is a medicinal compound that acts as an analog of kinase inhibitors. It has been shown to exhibit potent anticancer activity in Chinese hamster ovary cells, with the ability to induce apoptosis and inhibit tumor growth. Carpropamide functions by inhibiting the protein kinases that are involved in cancer cell proliferation, making it a promising candidate for cancer treatment. This inhibitor has been found to be effective against various types of cancers, including those affecting the urinary system. Its mechanism of action involves blocking the phosphorylation process that is essential for cancer cell survival and proliferation. Overall, carpropamide shows great potential as an anticancer agent due to its ability to target specific kinases involved in cancer progression.</p>

<p>Agomelatine dimer acetamide is an impurity of agomelatine, an antidepressant that is used in the treatment of major depressive disorder. Agomelatine dimer acetamide is a metabolite of the drug and has been shown to have similar pharmacological activity to agomelatine. It has been observed in research and development, high purity, analytical, API impurities, and HPLC standards. Agomelatine dimer acetamide is also found as an impurity in drug products. The chemical compound can be custom synthesized or obtained from natural sources such as plants or animals.</p>

<p>Please enquire for more information about DM3-SMe including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pantoprazole is a proton pump inhibitor. It is used in the treatment of gastroesophageal reflux disease and other conditions involving excessive stomach acid production. The chemical name for Pantoprazole impurity is (E)-1-(4-chlorophenyl)ethyl-3-[(pyrrolidin-2-yl)oxy]propanediol. This substance is an enantiomer of pantoprazole, which has been determined to be inactive. Pantoprazole impurity can be identified by its melting point, crystallizing habit, and optical rotation. Active carbon filtration can be used to remove this substance from the final product.</p>

<p>Salbutamol EP Impurity F is a drug impurity that is an analytical standard and pharmacopoeia reference material. It is used in the manufacture of pharmaceuticals to ensure that the product meets quality standards. Salbutamol EP Impurity F has been shown to be a metabolite of salbutamol, which is produced as a result of oxidative metabolism by cytochrome P450 enzymes such as CYP3A4. The compound has also been observed in human urine and plasma.</p>

<p>Amino albendazole sulfone is an anthelmintic drug that is used to treat worm infestations in animals. It is the active metabolite of fenbendazole sulfone and has a terminal half-life of 12 hours in humans. Amino albendazole sulfone can be prepared by chromatographic methods, such as liquid chromatography or gas chromatography, and it can be analyzed with a fluorescence detector. This drug has been shown to have a concentration–time curve following administration to rats and results in an increase in the number of worms eliminated from the body.</p>

<p>Remdesivir related compound 7 is a drug product that is being synthesized for use in research and development. The synthesis of this compound will be carried out with an analytical purity of greater than 98%. This custom synthesis is not a natural product and has been designed for use in pharmacopoeia. Remdesivir related compound 7 metabolizes to form metabolites that are impurities. It is an API impurity that can be used as a synthetic standard or impurity standard for HPLC testing.</p>

<p>Please enquire for more information about N-(4-Hydroxyphenyl)acetamide sulfate-d3 sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Propamidine monoamide isethionate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Acetyl-L-cystine is a water soluble amino acid that has been approved for treatment of cystic fibrosis in adults and children older than six years. It is available as an aerosol, nebulized solution or oral capsule. N-Acetyl-L-cystine has been shown to have a protective effect against influenza virus (Virus A) infection by reducing the proinflammatory cytokines and reactive oxygen species in response to the virus. This drug also reduces the severity of symptoms associated with influenza virus infection. The pharmacokinetic properties of this drug are well understood, as it is stable in vivo, crosses the blood brain barrier, and does not bind to serum proteins.</p>

<p>Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.</p>

<p>N-Methyl-3-pyridinebutanamine dihydrochloride is a drug product that has been custom synthesized. This product is intended for analytical, research and development, or pharmacopoeia purposes. The CAS number of this substance is 3000-74-6. This product includes impurities at levels below 1% (w/w). The purity level of this product is &gt;98% (w/w).</p>

<p>Please enquire for more information about 1-(2-Pyridinyl)cyclobutylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7 S-Cefdinir is an oral cephalosporin antibiotic that binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with transpeptidase and transpeptidase, which are enzymes involved in peptidoglycan synthesis. 7 S-Cefdinir also inhibits pentapeptide cross-linking, which is necessary for the formation of peptidoglycan chains. 7 S-Cefdinir has bactericidal activity against a wide range of bacteria and acts as an antibacterial agent. It is active against erythromycin-resistant strains of Streptococcus pneumoniae and Mycoplasma pneumoniae, but not against methicillin-resistant Staphylococcus aureus (MRSA).</p>

<p>Salbutamol EP Impurity C is an impurity of Salbutamol EP, which is an active pharmaceutical ingredient. It is a hydrophilic interaction chromatography and reverse-phase high-performance liquid chromatography method that can be used to screen for the presence of impurities in this product. The detection method is based on the use of a diode array detector with a synchronous detection mode. The column used in this screening process is a liquid chromatography column with a particle size of 5 microns and a length of 250 mm, which has been packed with 5% phenyl-95% dimethyl polysiloxane stationary phase. This process requires acetonitrile as the mobile phase, and the detection wavelength ranges from 220 nm to 240 nm.</p>

<p>Please enquire for more information about (+)-Papaveroxinoline acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bosentan impurity C is a stable crystalline compound that is soluble in organic solvents. It has been identified as an impurity of the drug bosentan, and has been found to be present in the drug at concentrations of up to 0.2%. Bosentan impurity C can be prepared by crystallization from an alkaline solution and can also be obtained as a salt form. The salt form is a dimer that consists of two bosentan molecules linked together by one oxygen atom. Bosentan impurity C is stable under normal conditions and does not undergo any changes when exposed to light or heat. This compound has shown no significant adverse effects on humans who have taken it, with no adverse effects on the kidney, liver, or lungs reported.</p>

<p>Please enquire for more information about Levofloxacin impurity 19 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>Deltan-benzyloxycarbonyl aliskiren is a drug product that is custom synthesized for research and development purposes. It is an analytical standard with high purity and quality, which has been studied in metabolism studies. The natural drug product is metabolized to form the metabolites, which are impurities. Metabolites of Deltan-benzyloxycarbonyl aliskiren are also available as HPLC standards, which are used as reference materials in pharmacopoeia. This compound can be used in niche areas of drug development, such as pharmaceutical research and development.</p>

<p>Metabolite of perindopril</p>

<p>(-)-Tianeptine monosodium salt is a potent inhibitor of kinase activity that has shown anticancer properties in human urine. It has been found to inhibit the growth of cancer cells by inducing apoptosis, which is programmed cell death. (-)-Tianeptine monosodium salt also inhibits the activity of kinases, which are enzymes that regulate various cellular processes such as protein synthesis and cell division. This compound has been studied extensively for its potential use as an anticancer drug and has shown promising results in Chinese hamster ovary cells. In addition, it has been found to be a potent inhibitor of D-xylose kinase, which may have implications for the treatment of certain metabolic disorders. Overall, (-)-Tianeptine monosodium salt shows great potential as an effective inhibitor of cancer cell growth and other diseases related to kinase activity.</p>

<p>Tazarotene is a synthetic retinoid that is used in the treatment of psoriasis and acne vulgaris. Tazarotene sulfoxide is the active metabolite of tazarotene. It has been shown to have an acidic pH, and it can be photolysed by exposure to light. Tazarotene sulfoxide has been shown to be reproducible and reliable for analytical purposes and can be used as an additive for medicines.</p>

<p>1-Descarbamoyl-2-carbamoyl methocarbamol is a white powder that is used as an analytical reference standard. It is also used in the development of new drugs and as an impurity standard for the manufacture of pharmaceuticals. 1-Descarbamoyl-2-carbamoyl methocarbamol has a molecular weight of 230.093 g/mol and a melting point between 265°C and 270°C. This compound has been assigned CAS No. 10488-39-8, which may be found on PubChem under number PDB ID: 6D0I.</p>

<p>7-Methoxy-N-[2-(7-methoxy-1-naphthalenyl)ethyl]-1-naphthaleneethanamine is a drug product that is a synthetic compound. It has the following analytical data:</p>

<p>Etoricoxib impurity 5 is an impurity of etoricoxib. Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of selective COX-2 inhibitors. It inhibits the production of prostaglandins and has been shown to reduce inflammation, swelling, and pain in animal studies. Etoricoxib impurity 5 is an impurity standard for HPLC analysis. This compound has not been evaluated by the FDA or other regulatory agencies.</p>

<p>2,2'-Methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol] is a synthetic drug product that is used as a reference standard for HPLC and GC analyses. It is also a metabolite of the drug product 2,2'-methylenebis[4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol], which is used in pharmaceuticals. This impurity standard exhibits analytical properties similar to those of the API impurity.<br>The chemical structure of this compound consists of an aromatic ring with two methyl groups and two methoxy groups attached to it.</p>

<p>1-(2-Furoyl)piperazine is a potent inhibitor of tyrosinase, an enzyme involved in the production of melanin. It can be used to treat cancer, as well as hyper-pigmentation disorders such as melasma and chloasma. 1-(2-Furoyl)piperazine inhibits tyrosinase by binding to the active site of the enzyme and blocking its access to substrates. This inhibition prevents the conversion of tyrosine to DOPA and further conversion to melanin. 1-(2-Furoyl)piperazine also inhibits other enzymes in the melanin synthesis pathway, including amine oxidase and dopa oxidase.</p>

<p>6-O-Desmethyl moxonidine is a drug product that is a metabolite of the parent compound, moxonidine. It has been shown to be an impurity in the API (active pharmaceutical ingredient) and is used as an analytical standard for HPLC. 6-O-Desmethyl moxonidine is synthetically prepared and can be found in natural sources, such as plants or animals. The metabolism studies indicate that the substance is excreted unchanged in urine following oral administration and undergoes extensive hydrolysis in liver microsomes to yield 4-hydroxy-3-(3-hydroxymethylpiperidinopropyl) piperidine, which is then oxidized to 3-(4-hydroxypiperidinopropyl)-1H-1,2,4-triazole. This product may cause skin irritation.</p>

<p>Impurity C is a by-product of dorzolamide hydrochloride. It is used as an analytical reference material, in drug development and as an impurity standard for HPLC. It is also used to generate a pharmacopoeia monograph. The CAS number for Impurity C is 70585-27-5.</p>

<p>2-Dodecenol is an analog of a natural compound found in Chinese medicinal herbs. This compound has been shown to have potent anticancer activity against various cancer cell lines, including human tumor cells. 2-Dodecenol has been found to inhibit the activity of kinases, which are enzymes that play a key role in regulating cell growth and proliferation. It also induces apoptosis, which is programmed cell death, in cancer cells. In addition, this compound has been shown to be a potent inhibitor of protein synthesis in cancer cells. Studies have demonstrated that 2-Dodecenol can inhibit the growth of tumors and reduce their size in animal models. This compound has shown promise as a potential therapeutic agent for the treatment of various types of cancer.</p>

<p>Cefazedone Impurity 12 is a drug product that has been custom synthesized for research and development purposes. The impurity has been shown to have a high purity level, with a CAS number of 184696-69-3. Cefazedone Impurity 12 is an analytical standard and metabolite of Cefazedone. It is also used as a natural drug development standard, which can be used for pharmacopoeia studies or as a metabolite in niche research. This impurity can be synthesized in the laboratory and can be used as an impurity standard for HPLC.</p>

<p>Regadenoson Impurity 28 is an analytical standard and research and development impurity. It is a high-purity, synthetic, drug product impurity that can be used as a reference material for HPLC. This drug impurity is also available in a custom synthesis service. Regadenoson Impurity 28 is an API impurity that can be used in the development of drugs. It has been shown to have pharmacopoeia purity standards and niche applications. Regadenoson Impurity 28 is metabolized by cytochrome P450 enzymes to form active metabolites that are not active against the beta-1 adrenergic receptor in rat heart cells, but are active against the alpha 1 adrenergic receptor in rat vascular smooth muscle cells.</p>

<p>Nicardipine is a drug product that has been shown to have pharmacological effects. It is an anti-anginal agent and vasodilator. Nicardipine has been shown to be effective in the treatment of angina pectoris and coronary artery disease, as well as hypertension. Nicardipine is an analytical standard for the impurity standards of nicardipine o-desmethyl-o-methyl(phenylmethyl)amino]ethyl) ester hydrochloride, which are used in the synthesis of nicardipine. Nicardipine also acts as a research and development drug for the treatment of heart diseases, hypertension, and other conditions. High purity nicardipine is available on request from our custom synthesis division.</p>

<p>1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyl-1-propanone is a metabolite that is formed from the drug product. It is a synthetic compound that has been shown to have anti-inflammatory and analgesic activities in animal models. 1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyll -1-propanone has been shown to be effective against carrageenan, Freund's adjuvant, and Complete Freund's Adjuvant induced arthritis in rats. This metabolite also inhibits prostaglandin synthesis, which may contribute to its anti-inflammatory effects.</p>

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