APIs for research and impurities

<p>Please enquire for more information about M1-Enrofloxacin hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N,N-Dimethylglycylamido-minocycline dihydrochloride is a medicinal compound that is used as an inhibitor of protein kinases in cancer research. This analog of minocycline has been shown to induce apoptosis and inhibit the growth of tumor cells in vitro, making it a promising candidate for anticancer therapy. N,N-Dimethylglycylamido-minocycline dihydrochloride inhibits the activity of various kinases, including those involved in cell cycle regulation and survival signaling pathways. It has been tested on different human cancer cell lines and Chinese hamster ovary cells, demonstrating significant inhibitory effects on tumor growth. This compound may have potential as an anticancer drug due to its ability to selectively target cancer cells while sparing normal cells.</p>

<p>N,N-Didesmethyl tamoxifen is a metabolite of tamoxifen and belongs to the class of estrogen receptor modulators. It has been shown that this drug binds to liver cells and has a carcinogenic potential in animals. N,N-Didesmethyl tamoxifen is a substrate for cytochrome P450 2D6 (CYP2D6) and is converted to endoxifen. Endoxifen inhibits the growth of cancer cells by binding to estrogen receptors on the cell surface and preventing the natural ligand estradiol from binding with these receptors. The clinical response to tamoxifen treatment may be influenced by genetic polymorphisms in CYP2D6.</p>

<p>NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.</p>

<p>Please enquire for more information about FASN-IN-1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hydroxy dabrafenib is a drug product that has an analytical CAS number. It is a natural API impurity in the synthetic drug hydroxy dabrafenib. Hydroxy dabrafenib, also known as DAB-FEN-IB, is a synthetic drug with antioxidant and antiangiogenic properties. The compound inhibits the growth of cancerous cells by inhibiting the production of proteins vital for cell division. This drug product is used in research and development to assist in the discovery of new drugs.</p>

<p>Pyrrolcarbonyltaloside is a drug product that is used as an HPLC standard for the analysis of impurities in API. It is also used as a synthetic intermediate in the synthesis of other chemical compounds. Pyrrolcarbonyltaloside has been shown to have anti-inflammatory and analgesic properties, and may be useful as a treatment for cancer.</p>

<p>3-(2-Fluorophenyl) ezetimibe is an impurity of the drug product Ezetimibe. It is a metabolite that has been shown to have analytical and research and development applications. 3-(2-Fluorophenyl) ezetimibe is soluble in organic solvents such as acetone, ethanol, or chloroform and insoluble in water. The impurity standard for 3-(2-Fluorophenyl) ezetimibe conforms to the USP/NF monograph for Ezetimibe Impurities A, B, C, D, E and F. The CAS number for this impurity is 1798008-25-9.</p>

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is a drug product that has been custom synthesized and purified to high purity. It is an analytical standard for metabolism studies. This compound is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-O-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl] balsalazide is also used as a pharmacopoeia impurity standard and as a research and development HPLC standard.</p>

<p>Please enquire for more information about Carbidopa 4-phosphate trihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Losartan is an angiotensin II receptor antagonist. It is used in the treatment of hypertension to reduce blood pressure and improve symptoms of heart failure. Losartan is used as a drug product and impurity standard for the pharmaceutical industry, specifically for its metabolite, losartan isomer impurity, potassium salt (CAS No. 860644-28-6). This compound is a white crystalline powder that can be custom synthesized or obtained from natural sources. High purity Losartan Isomer Impurity, Potassium Salt (CAS No. 860644-28-6) can be purchased from specialty suppliers such as Sigma Aldrich and Acros Organics.</p>

<p>(S)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a drug product of the drug development industry. It is a metabolite of 3-(1,2,4-triazol-1-ylmethyl)thiazolidine-4-carboxylic acid and has been used as an analytical standard for HPLC methods. The compound has been shown to be naturally occurring in humans. (S)-3-(1,2,4-Triazol-1ylmethyl)thiazolidine 4 carboxylic acid is also used as the impurity standard for the API 3-(1,2,4 triazol 1ylmethyl)thiazolidine 4 carboxylic acid.</p>

<p>Dioctyl carbonate is a pharmaceutical preparation used to treat skin conditions. It is a fatty acid ester of carbonic and carbonyl groups in which the two esters are in the same molecule. Dioctyl carbonate is a reaction product obtained by reacting an inorganic acid, such as hydrochloric acid or sulfuric acid, with an alcohol containing two hydroxyl groups and one double bond. This reaction may be facilitated by heating. The film-forming polymer may be polyvinylpyrrolidone, polyvinyl alcohol, or polyacrylic acid. Dioctyl carbonate has been shown to stimulate colony-stimulating factor production and inhibit the proliferation of human epidermal keratinocytes.</p>

<p>Please enquire for more information about 1-(1-Cyclohexen-1-yl)-cyclohexanecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Desgadolinium gadoteridol is a contrast agent that is used in magnetic resonance imaging (MRI). It is a gadolinium-based contrast agent that contains an ester linkage. The chelate complex of gadolinium with desgadolinium has been shown to have high water permeability and target tissue affinity, as well as low toxicity. Desgadolinium gadoteridol is used to diagnose inflammatory bowel diseases by determining the thickness of the bowel wall. This agent may also be used to evaluate blood pressure and diagnose hemorrhoids or colorectal polyps.</p>

<p>Imatinib is a kinase inhibitor that inhibits the kinase activity of tyrosine-protein phosphatase receptor (c-Abl) and platelet-derived growth factor receptor (PDGFR), which are both involved in tumor cell proliferation. Imatinib has been shown to be effective in treating leukemia and other types of cancer, as well as regulating the production of cytokines and protein tyrosine phosphatases. It is also being studied for use in Alzheimer's disease. Imatinib has selectivity for c-Abl over PDGFR, which makes it an attractive drug candidate for cancer therapy.</p>

<p>Cefotaxime sodium impurity C is a by-product of the synthesis of cefotaxime. It is an impurity standard for drug product, custom synthesis and research and development. The CAS number for this substance is 66403-32-5. This compound has been shown to be a metabolite in metabolism studies. Impurity standard compounds are used in analytical methods such as HPLC.</p>

<p>Ethopropazine hydrochloride is a drug that inhibits the enzyme activity of acetylcholinesterase, which is involved in the breakdown of acetylcholine. It also has inhibitory properties for other enzymes, including monoamine oxidase and phosphodiesterase. Ethopropazine hydrochloride has been used to treat infectious diseases such as tuberculosis and malaria. Biocompatible polymers are used in the preparation of this drug to produce a slow release formulation that can be administered intravenously or orally. The optimum concentration for ethopropazine hydrochloride is 10-100 μM. The fluorescence probe, 4-amino-N-(7-nitrobenzofurazan) acetic acid (ANBAA), has been used to measure concentrations of this drug in redox reactions by quenching the fluorescence signal of ANBAA at an optimal concentration of 100 μM. Group P2 axonal growth was increased with ethop</p>

<p>Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol-2(3H)-ylidene]aminocarbonyl]-1,3,4-thiadiazole is a drug that belongs to the group of thiazolidinediones. It is an oral hypoglycemic agent that lowers blood sugar by stimulating insulin release from the pancreas and increasing peripheral tissue sensitivity to insulin. Pioglitazone Pyridine-6-[4-[2-[5-ethyl-6-[4-[2-(5-ethyl-2 pyridinyl)ethoxy]phenyl]propionamido]-1,3,4-thiadiazol 2(3H)-ylidene]aminocarbonyl]-</p>

<p>Cefotaxime sodium impurity D is a cephalosporin-type antibiotic that is produced by the chemical reaction of cephalosporin with acetic acid. Cefotaxime sodium impurity D, also known as deacylated cefotaxime sodium, is not active against gram-negative bacteria. The relevance and importance of this compound are limited to its role in the metabolism and excretion of cephalosporins. Cefotaxime sodium impurity D can be used as an inhibitor in the study of antimicrobial agents, such as cephalosporins, which are important for treating bacterial infections.</p>

<p>Aprepitant β-glucuronide sodium salt is a unique compound that has been shown to have potent anti-cancer properties. It works by inhibiting the cell cycle and inducing apoptosis in cancer cells. Aprepitant β-glucuronide sodium salt has been extensively studied in Chinese medicine and has shown promising results as an anticancer agent. This compound can be used to target specific proteins involved in the growth and proliferation of cancer cells, making it a highly effective treatment option for various types of tumors. Additionally, nanoparticles containing Aprepitant β-glucuronide sodium salt have been developed, which allows for targeted delivery and improved efficacy. Overall, this innovative compound holds great potential as a powerful tool in the fight against cancer.</p>

<p>Pentione is a potent kinase inhibitor that targets proteins involved in cell growth and division. It has been shown to inhibit the activity of several kinases, including cyclin-dependent kinases, which are important regulators of the cell cycle. Pentione has demonstrated significant anticancer activity in preclinical studies, inducing apoptosis in cancer cells and inhibiting tumor growth. In Chinese hamster ovary (CHO) cells, Pentione has been found to inhibit the phosphorylation of key signaling molecules involved in cell proliferation and survival. Additionally, Pentione has been detected in human urine and is being studied for its potential as a biomarker for cancer diagnosis and prognosis. Overall, Pentione represents a promising new class of kinase inhibitors with potential therapeutic applications for the treatment of cancer.</p>

<p>1,4-Bis(2,3,4-trimethoxybenzyl)piperazine (1,4BTMP) is a piperazine derivative that has been shown to have inotropic properties. 1,4BTMP appears to increase the force of contraction of the heart muscle by increasing intracellular calcium levels. This drug may also be useful in the treatment of ventricular fibrillation and other arrhythmias. It has been shown that 1,4BTMP protects against lipid peroxidation induced by hydrogen chloride and hydrochloric acid in isolated rat hearts. In addition, this compound has been shown to inhibit creatine kinase activity and reduce lipid peroxide formation.</p>

<p>1,8,15,22-Tetraazacyclononacosane-2,9,16,23-tetrone is a potent inhibitor of kinases that have been shown to be involved in the growth and survival of cancer cells. This compound was isolated from Chinese urine and has been found to induce apoptosis in cancer cells by inhibiting kinase activity. The analogs of this compound have been developed as anticancer agents due to their ability to inhibit cyclin-dependent kinases (CDKs) that are involved in cell cycle regulation. This inhibitor has shown promising results in preclinical studies for the treatment of various types of tumors, including breast cancer and lung cancer. It is a potential candidate for further development as an anticancer drug due to its high specificity towards human kinases and low toxicity towards healthy cells.</p>

<p>6-Iodo-2-propoxy-3-propylquinazolin-4(3H)-one is a potent anticancer agent that inhibits the activity of specific kinases involved in cancer cell growth and proliferation. It has been shown to induce apoptosis, or programmed cell death, in cancer cells by blocking the activity of certain proteins. This compound is structurally similar to other kinase inhibitors used in medicinal chemistry, such as gefitinib and erlotinib. 6-Iodo-2-propoxy-3-propylquinazolin-4(3H)-one has been tested on human and Chinese hamster ovarian cells and has demonstrated significant antitumor activity. It is a promising candidate for the development of new cancer therapies due to its potent inhibitory effects on kinases involved in tumor growth and progression. Additionally, this chemical analog can be detected in urine samples, making it a useful tool for studying kinase activities in vivo.</p>

<p>Clomiphene is a drug that is used to treat female infertility. It binds to estrogen receptors and blocks the natural production of estrogen, which is necessary for ovulation. Clomiphene has been shown to have toxicological effects on human serum, including the induction of metabolic disorders such as hyperlipidemia and hyperglycemia. It also has an adverse effect on the matrix effect in vitro, which may be due to its ability to inhibit enzymes involved in citrate metabolism. Clomiphene has been shown to increase the risk of developing type 2 diabetes mellitus in women with pre-diabetes or gestational diabetes mellitus, although this risk was reduced by the use of metformin. Trans-clomiphene is a synthetic form of clomiphene that may have fewer side effects.</p>

<p>NRX-252262 is an inhibitor that has shown potent anticancer activity in various types of cancer cells. It is a Chinese hamster ovary cell-derived analog of indirubin, which is a natural compound found in human urine and glycerol. NRX-252262 inhibits kinases, which are enzymes that play a role in cell division and proliferation. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. NRX-252262 has been shown to be effective against multiple types of cancer, making it a promising candidate for cancer treatment. Its potent anticancer activity makes it one of the most sought-after inhibitors for cancer research and development of new treatments.</p>

<p>Please enquire for more information about 2,4-DDE-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluorobexarotene is a fatty acid that has been shown to induce the expression of inflammatory genes in animal models. It has also been shown to inhibit the growth of human cancer cells in vitro and in vivo. Fluorobexarotene is used for the diagnosis of x-linked adrenoleukodystrophy and is currently being studied as a treatment for liver cancer. This molecule is also an agonist of retinoic acid receptors, which may be responsible for its effects on gene transcription.</p>

<p>7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester is an impurity in the synthesis of drugs. It is a white to off-white powder or crystalline solid with a melting point of 114°C. 7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester has been studied for its metabolism and toxicity. It is not naturally occurring and was synthesized in the laboratory. It may be used as a reference material for pharmacopoeia standards.</p>

<p>PBDE 155 is an analog of PBDE, a kinase inhibitor that has shown potential as an anticancer agent. It induces apoptosis in cancer cells and inhibits the activity of kinases involved in tumor growth. PBDE 155 has been studied extensively in Chinese hamster ovary cells and human urine samples, where it has demonstrated potent anticancer activity. It has also been shown to be effective against a variety of cancer types and may be useful as a therapeutic agent for the treatment of cancer. Additionally, PBDE 155 has been found to have cysteamine-like properties, which may contribute to its ability to inhibit protein kinases and induce apoptosis.</p>

<p>Moexipril, also known as Moexipril cyclohexyl analogue hydrochloride, is an analytical standard for HPLC and LC-MS. It is a white to off-white powder with a molecular weight of 461.84. Moexipril is soluble in ethanol and methanol, but insoluble in water. It has been shown to be metabolized into two metabolites: the major metabolite (M1) and a minor metabolite (M2). The CAS number for Moexipril is 1356019-89-0.</p>

<p>2,12-Dihydro-1,3-dimethyl-8-methoxy-12-thioxobenzo [4,5] pyrido [1,2-c] imidazo [1,2-a] imidazol-2-one is a metabolite of the drug 2-[2-(4,5,-dihydroimidazo[1,2a]imidazol -2(3H)-yl)ethoxy]-N-(methylsulfonyl)benzamide. It can be used as an impurity standard for the manufacture of drugs and as a research chemical.</p>

<p>(5E)-Calcipotriene is a synthetic, natural, and analytical chemical. It is a white to off-white powder with a melting point of about 122 °C. (5E)-Calcipotriene has been used as an analytical standard for HPLC and as an impurity in the synthesis of calcitriol. The International Union of Pure and Applied Chemistry (IUPAC) name for this compound is 5Z,7Z,11Z,15Z-eicosapentaenoic acid. It can also be found in the form of 5Z,8Z,11Z,14E-eicosapentaenoic acid.</p>

<p>Please enquire for more information about 4-Acetyl-3,4-dihydro-2H-pyrido[3,2-b]oxazine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N2-Losartanyl-losartan is a drug product that has a CAS number of 230971-72-9. This product is an analytical standard for the metabolites of losartan, which is a drug used to treat high blood pressure and heart failure. Metabolism studies have shown that losartan is metabolized by hydroxylation, glucuronidation, and oxidation by cytochrome P450 enzymes. Losartan has also been found to be converted into an active metabolite in the body, which is called N2-hydroxy-losartan. It has been shown to be more potent than losartan at blocking angiotensin II receptors.</p>

<p>4-Carboxy-3-ethoxy)phenyl acetic acid (CPAE) is a fluorescent compound that has been shown to have antidiabetic and luminescence properties. It absorbs light at wavelengths of 340, 405, and 455 nm and emits light at 525 nm. It also absorbs UV light at 310 nm and emits fluorescence at 495 nm. CPAE is formed by the condensation of two molecules of 4-carboxybenzaldehyde with one molecule of ethyl 3-ethoxypropanoate in the presence of a base. The crystals are monoclinic, with space group P2/c and lattice constants a = 12.872(1) Å, b = 7.319(1) Å, c = 17.814(2) Å, β = 98.664(9)°, Z = 2. The molecular weight is 182.24 g/mol and its molecular</p>

<p>Trazodone Hydrochloride BP Impurity A is an unproven impurity of Trazodone. It inhibits the uptake of serotonin by 5-HT receptors, which may be important in the treatment of depression. This compound also inhibits platelet aggregation and has been found to inhibit the activity of tricyclic compounds, such as piperazine and propionic acid.</p>

<p>Please enquire for more information about Allyl ester of atorvastatin cyclic (isopropyl) impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Hygrine-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[(4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methylsulfonyl]-1H-benzimidazole (MKC1807) is a synthetic drug product. MKC1807 is an analytical standard in the HPLC assay for the determination of Epiandrosterone sulfate and its metabolites. 1-[4-(3-Methoxypropoxy)-3,5,6,7,8 -pentamethylcyclohexyl]methyl 2-[(4-(3 -methoxypropoxy) 3,5,6,7,8 -pentamethylcyclohexyl)methylsulfonyl]-1H benzimidazole has been shown to be a natural metabolite of Epiandrosterone sulfate. This compound</p>

<p>Please enquire for more information about 4-Bromo-2-cyclobutylthiazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Eicosene is an analog that has been shown to have potent anticancer properties. It acts as an inhibitor of various protein kinases, including cyclin-dependent kinases, which are essential for cancer cell growth and division. Studies have demonstrated that 5-Eicosene induces apoptosis in Chinese hamster ovary cells and human cancer cells, suggesting its potential as an effective anticancer agent. Additionally, this compound inhibits the activity of certain urinary protein kinases, which may be valuable in the diagnosis and treatment of cancer. Overall, 5-Eicosene shows promise as a potent inhibitor with therapeutic potential against various types of cancer.</p>

<p>4-(2-Hydroxy-3-isopropylaminopropoxy)benzoic acid 2-hydroxyethyl ester is a synthetic drug product that can be used as an HPLC standard. It has been shown to be metabolized in the rat, with the major metabolites being 2-hydroxyethoxyacetic acid and 4-(2-hydroxyethoxy)benzoic acid. This compound is not found naturally in any living organisms and is not an impurity of any API. The purity of this compound is &gt;98%.</p>

<p>4-Epi-dolutegravir is the active metabolite of dolutegravir. It is a synthetic, high purity API that is used as an analytical reference standard and a drug product for research and development purposes. The CAS number for 4-epi-dolutegravir is 1357289-37-2. 4-Epi-dolutegravir has been shown to have similar pharmacological properties to its parent compound, dolutegravir. Metabolism studies have demonstrated that the major route of elimination for 4-epi-dolutegravir is through urinary excretion.</p>

<p>N-Debenzoyl-N-hexanoylpaclitaxel (DHBPTx) is an analog of paclitaxel. It inhibits cell proliferation by binding to the diketone group at the C-10 position of baccatin III, which inhibits the synthesis of taxol and other natural products with a diketone group at this position. DHBPTx is effective against colorectal carcinoma cells in culture, but has not been tested in vivo. This drug has also been shown to be effective against breast cancer cells that express high levels of 10-deacetylase activity. It is metabolized into 10-deacetylbaccatin III, which binds to cellular protein kinase C and causes inhibition of mitosis and apoptosis. In addition, DHBPTx can be conjugated with other drugs such as doxorubicin or vincristine to increase their effectiveness.</p>

<p>5-Chloro-1,3-dihydro-1-methyl-3-phenyl-2H-benzimidazol-2-one is a synthetic impurity that may be found in drug products. It is used as an analytical standard and is metabolized to 5,5'-dichloroquinoline by hydrolysis of the acetal linkage. The metabolite 5,5'-dichloroquinoline has been shown to have antiplatelet effects in vitro and may contribute to the antithrombotic activity of the parent compound. This substance is not intended for clinical use.</p>

<p>S-Nitroso-N-propionyl-D,L-penicillamine is a nitric oxide donor that can be used in the treatment of locomotor activity and renal injury. It has been shown to inhibit protein synthesis and growth factor production by light exposure. This drug has also been used to treat infectious diseases such as tuberculosis, as well as autoimmune diseases like lupus and lymphoproliferative disorders such as leukemia. S-Nitroso-N-propionyl-D,L-penicillamine is also used for the prevention of postoperative kidney damage after ischemia reperfusion during surgery. The drug was found to reduce the levels of neutrophils, which are cells that are responsible for inflammation. There have been no reports on its potential carcinogenicity or mutagenicity.</p>

<p>N,S-Carboxymethyl cysteine hydrochloride (NCC) is a drug product that is synthesized from cysteine. It has been used in analytical chemistry, metabolism studies, and drug development. NCC has been shown to be a natural metabolite of cysteine when administered orally to rats or mice. It is also an impurity standard for HPLC analysis and has been used as an API impurity in the synthesis of other drugs.<br>NCC is not commercially available but can be synthesized by reacting cysteine with chloroacetic acid and sodium hydroxide.</p>

<p>Please enquire for more information about 2,3-Diphospho-D-glyceric acid pentasodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2′,4′′-Bis-O-(trimethylsilyl)-erythromycin 9-[O-(1-ethoxy-1-methylethyl)oxime] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ergoline-8β-carboxylic acid methyl ester hydrochloride is a drug product that has been developed for research and development. It is an analytical standard, impurity standard, and HPLC standard. Ergoline-8β-carboxylic acid methyl ester hydrochloride is a metabolite of ergometrine, which is an ergot alkaloid with pharmacological properties similar to those of ergonovine. Ergoline-8β-carboxylic acid methyl ester hydrochloride is used as an impurity in the synthesis of ergometrine. The purity of this compound meets the requirements of pharmacopoeia standards for use as an analytical reference substance.</p>

<p>N-Desmethyl (E)-α-hydroxy tamoxifen is a metabolite of tamoxifen. This drug has been shown to be more reactive than its parent compound, with the potential for enhanced toxicity. N-Desmethyl (E)-α-hydroxy tamoxifen is thought to be responsible for the toxic effects of tamoxifen in women and rats. The metabolites are excreted in the bile, with 50% being reabsorbed from the gastrointestinal tract and then excreted into the urine. In human liver cells, N-desmethyl (E)-α-hydroxy tamoxifen inhibits the growth of cancer cells and induces apoptosis by binding to DNA. It also causes increased production of reactive oxygen species in liver cells, which may contribute to hepatotoxicity.</p>

<p>Acyclovir EP impurity R is a by-product of acyclovir, which has been shown to be stable in acidic and alkaline conditions. It is also linear with high reproducibility and low detection limits. Acyclovir EP impurity R can be detected using a validated RP-HPLC method with an acidified mobile phase. The compound is not photolyzed under the conditions of the assay. This impurity has been detected in batches of acyclovir that have been produced on two different production lines for more than 5 years without any changes in quality or yield.</p>

<p>Please enquire for more information about Defluoro paroxetine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vinorelbine N'B-oxide is a drug product that is used as an analytical or impurity standard. It is a natural product and its chemical structure has been determined by HPLC. Vinorelbine N'B-oxide is metabolized in vivo to vinorelbine and N'-desmethylvinorelbine, which are metabolites of vinorelbine. It has been shown to be useful for metabolism studies.</p>

<p>3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione is a research and development impurity standard. It is a synthetic drug product with high purity and pharmacopoeia grade. 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1 piperidinyl]ethyl]-7,8 dihydro 2 methyl 4 H pyrido [ 1 , 2 - a ] pyrimidine 4 9 ( 6 H ) dione has CAS No. 118951665 1 and is an analytical standard for HPLC analysis. 3-[2-[4-(6 Fluoro 1 , 2 benzisox</p>

<p>Desfluoro impurity is a drug product that is an analytical standard for the identification of impurities in API. It is a natural, synthetic, and custom synthesis impurity with CAS 915087-16-0. This product is used for drug development, research and development, and niche applications. Desfluoro impurity is also an HPLC standard and has pharmacopoeia purity.</p>

<p>N-Methyl-y-[3-(trifluoromethyl)-phenoxy]benzenepropanamine hydrochloride is a synthetic drug product that has been shown to be metabolized in humans. It is an impurity standard for HPLC and analytical methods. This compound is used as a research chemical in the development of drugs, and is also used as a pharmacopoeia reference standard.</p>

<p>Erythromycin E is a diluent that is used to make erythromycin solutions. It has been shown to have bioactive molecules by incubating it with chromatographic methods. These bioactive molecules are conjugates of erythromycin and methyl ethyl groups. Erythromycin E has also been shown to have genetic mechanisms, which may relate to its ability to inhibit the synthesis of inflammatory cytokines such as IL-1β and IL-8 in the airways. The acetate extraction method is used for the production of erythromycin E. This process involves extracting erythromycin from Streptomyces bacteria grown in an acetate buffer solution.</p>

<p>8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide (AZA) is a fluorogenic, low energy probe that emits light upon irradiation with ultraviolet light at 254 nm. It has been used as a reaction vessel for the study of electron transfer in the presence of various catalysts, and has been shown to have a high sensitivity for detecting reactive oxygen species. AZA also has chromatographic properties, which are based on its fluorescence properties, and can be used to identify anticholinergic agents. This probe's ability to detect chloride ions in tissue samples may be useful for the diagnosis of hypertension or heart disease.<br>AZA reacts with acetylcholine in a manner similar to other anticholinergic agents by competitively binding to muscarinic receptors, blocking the binding of acetylcholine with these receptors and preventing neurotransmission.</p>

<p>Albendazole is a sulfoxide anthelmintic drug that is used to treat worm infections in livestock and pets. Albendazole inhibits the synthesis of the parasitic cell membrane, which disrupts the integrity of the cell and leads to death. The analytical method for measuring albendazole includes extraction with hexane followed by analysis using gas chromatography. In humans, albendazole may be used to treat cancer, especially when it occurs in cavities or fatty tissues. It can also be used as a treatment for certain types of parasitic infections, such as toxoplasmosis, amebiasis, and cysticercosis. Albendazole is absorbed well after oral administration and plasma concentrations are proportional to dosage levels. The most common side effects are nausea and headache.</p>

<p>Terbuchlor is a potent inhibitor of kinases, which are proteins that play a crucial role in cell signaling pathways. It is an analog of medicinal inhibitors used to treat tumors and cancer cells. Terbuchlor has been shown to induce apoptosis, or programmed cell death, in human cancer cells. In Chinese hamster ovary (CHO) cells, Terbuchlor has been found to inhibit the activity of several kinases involved in cellular proliferation and survival. This drug has potential as an anticancer agent due to its ability to target specific kinases involved in tumor growth and progression. Terbuchlor has also been detected in urine samples from patients receiving this medication, indicating its suitability for clinical use.</p>

<p>(6R)-Folinic acid is an impurity standard and a metabolite of folic acid. It is synthesized by the body in the liver, where it is converted to 5,10-methylenetetrahydrofolate (5,10-MTHF). This metabolite is used to convert homocysteine into methionine, which can then be converted into S-adenosylmethionine (SAMe), a compound that has been shown to have antidepressant properties. The methylation of folate also helps to regulate DNA synthesis and repair. (6R)-Folinic acid has been used in research as a drug development tool for studying folate metabolism and its effects on the central nervous system. High purity standards are available for use in HPLC analysis of this compound.</p>

<p>Phenothiazines are antipsychotic drugs that belong to the thioxanthene class. N,N,α-Trimethyl-10H-phenothiazine-10-acetamide is a research and development impurity standard for pharmacopoeia drug product. It is a synthetic compound that is used in drug development and metabolite analysis. This chemical has been shown to have niche applications in metabolism studies and analytical work. It also has a high purity and is used as an HPLC standard. CAS No. 86382-43-6</p>

<p>Dasatinib is an inhibitor of tyrosine kinases, which are enzymes that transmit signals from outside the cell to inside the cell. Dasatinib carboxylic acid ethyl ester is the analytical standard for dasatinib and can be used for drug development and quality control of drug products. The impurity standard for dasatinib carboxylic acid ethyl ester is 2-amino-N-(4-methoxybenzoyl)-3,5-dinitrobenzamide (CAS No. 106560-78-1).</p>

<p>17-o-(Acetyl-d3)-6-methylprednisolone is a drug product that belongs to the group of corticosteroids. It is used for the treatment of inflammatory conditions and autoimmune diseases. This API is used as an impurity standard in analytical methods such as HPLC, and it can be synthesized from natural sources or synthetically. 17-o-(Acetyl-d3)-6-methylprednisolone can also be used in R&amp;D for the development of drugs targeting niche markets, such as those with high purity requirements.</p>

<p>N-Boc-4-azido-L-homoalanine (dicyclohexylammonium) is an impurity that may be found in drugs. It is a synthetic compound with CAS number 1217459-14-7. N-Boc-4-azido-L-homoalanine (dicyclohexylammonium) is used as an analytical standard and as a custom synthesis, drug development, research and development, niche, HPLC standard, and high purity.</p>

<p>Bisoprolol impurity G is a metabolite of bisoprolol. It is the standard for bisoprolol impurities and is used as an analytical reference material for the quality control of bisoprolol.</p>

<p>Chlorpromazine is a cholinergic drug that is used to treat psychiatric patients. It has been shown to be effective in the treatment of schizophrenia and other psychotic disorders. Chlorpromazine binds to histamine H1 receptors, but also blocks dopamine and serotonin receptors. This drug has a long half-life in plasma (14.4 hours) and tissues, which may be due to its metabolites. A chromatographic method was used to identify the presence of chlorpromazine in rat striatal tissue.</p>

<p>Methapyrilene fumarate is a synthetic maleate salt of methapyrilene. This drug is used in the treatment of high blood pressure. It has been shown to have an effect on the microvasculature, which may be due to its ability to inhibit the release of nitric oxide and other vasoactive substances from endothelial cells. Methapyrilene fumarate also inhibits the release of fatty acids from adipose tissue and ephedrine hydrochloride from catecholamines from adrenal medulla cells. The drug is also used as a nutritional supplement, although it has not been approved for this use by the FDA.</p>

<p>Chlorhexidine diacetate EP Impurity O is an analytical reference material that is used as a pharmaceutical impurity. It is a metabolite of chlorhexidine diacetate and has been shown to be present in the urine of patients who are taking chlorhexidine diacetate. Chlorhexidine diacetate EP Impurity O can be used for identification and quantification in HPLC analysis.</p>

<p>2-Propylimidazole-4,5-dicarboxylic acid is an organic compound with the chemical formula CH2=C(CH3)CO2H. It is a colorless solid that has been found to have inhibitory activity against locomotor activity in mice. 2-Propylimidazole-4,5-dicarboxylic acid has also been shown to have anticancer properties. The fluorescence properties of this compound are due to the presence of two quinoid moieties, which can be excited by light at 350 nm and emit light at 500 nm. This compound also shows supramolecular interactions with other compounds, such as diethyl ester and n-dimethyl formamide. 2-Propylimidazole-4,5-dicarboxylic acid crystallizes in a monoclinic space group P21/c with four molecules per unit cell and a molecular weight</p>

<p>Atropine impurity G is a natural metabolite that is found in the body as an impurity of atropine. It is a synthetic drug product that is used as an analytical standard for the quantification of atropine and other drugs. Atropine impurity G has been shown to inhibit metabolism studies, which may be due to its ability to inhibit CYP3A4 activity. This impurity can be detected using HPLC with UV detection.</p>

<p>Methyl 6-(1-hydroxyethyl)-3-methyl-4-phenylpicolinate is a synthetic chemical that is used as an analytical standard in chemical and pharmaceutical research. It has been shown to have a wide range of pharmacological effects, including antihypertensive, antidiabetic, and antiulcerogenic activities. Research into the drug product is ongoing.</p>

<p>NBI 27914 hydrochloride is a small molecule that binds to and blocks the neurotransmitter receptor for norepinephrine, which is involved in the regulation of mood. This drug has been shown to have anxiolytic-like effects in animals and may be useful for treating anxiety disorders that are due to congenital adrenergic hyperactivity. NBI 27914 hydrochloride also has an anxiogenic effect at high doses, which may be due to its ability to bind and block beta-adrenergic receptors. It is also able to act as a specific agonist or antagonist of alpha-adrenergic receptors.</p>

<p>Please enquire for more information about Mezlocillin impurity III including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Flumethasone Impurity 11 is a drug product that is used in the research and development of drugs. Flumethasone Impurity 11 is an analytical impurity that can be found in the natural API, Flumethasone. It has a molecular weight of 537.3 and its CAS number is 1069-81-4. Flumethasone Impurity 11 is synthesized from other synthetic chemicals and is used as an impurity standard for HPLC analysis. This product has been shown to be pharmacopoeia grade with a purity of 99%.</p>

<p>Please enquire for more information about (R)-L 888607 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about L-Piperacillin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-Des[2-(dimethylamino)ethyl] zolmitriptan acetonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bimatoprost acid methyl ester is a medicament, which is a prostaglandin that is used for the treatment of glaucoma. It has a number of analogues, including bimatoprost and latanoprost. Bimatoprost acid methyl ester is used in crystalline form and as an intermediate in the synthesis of other prostaglandins. This product can be found in polymorphic form.</p>

<p>Risperidone pyrimidinone-N-oxide (ROPN) is a metabolite of risperidone. It is an impurity that is used as a reference standard for HPLC in the drug development process. ROPN can be synthesized from risperidone, but it is also found naturally in some plants and fungi. It has been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Deacylated alfuzosin is an impurity of alfuzosin, which is a selective alpha-1A-adrenergic receptor antagonist. It has been shown to minimize the effects of impurities in alfuzosin by binding competitively to the alpha-1A-adrenergic receptors.</p>

<p>N-Formyl-D-leucine (1R)-1-[[(2R,3R)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a synthetic metabolite that is used as an impurity standard for the analysis of N-formylmetabolites in drugs. It is also used to study the metabolism of drugs. This product has been assigned CAS number 104872-27-7 and appears on the USP high purity&gt; list.</p>

<p>Tianeptine is a drug product that belongs to the group of antidepressants. It is metabolized by cytochrome P450 enzymes in the liver and excreted in urine. Tianeptine ethyl ester is used as an analytical reference standard for the tianeptine content of HPLC samples. The CAS number for tianeptine ethyl ester is 66981-77-9.</p>

<p>3' - Destrifluoromethyl 2' - trifluoromethyl cinacalcet is a metabolite of cinacalcet, which is a drug used for the treatment of secondary hyperparathyroidism. It is an impurity in the drug product and can be identified by HPLC.</p>