Amino Acids (AA)

<p>Applications 1-O-ALPHA-D-GLUCOPYRANOSYL-D-MANNITOL is used in the nutritional and biochemical investigations on disaccharide alcohols.<br>References Grupp, U., et al.: Nutr. Metab., 21, 63 (1977)<br></p>

<p>Applications 2,3-Diethyl-5-methylpyrazine-N4-oxide (cas# 1076200-01-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Amino-6-methylbenzimidazolone<br></p>

<p>Applications 1,2-Dichloro-2-methylpropane (cas# 594-37-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Methyl-5-(3-nitrophenyl)cyclohex-2-enone is derived from Acetone (A163800), which is a common organic building block in organic chemistry.<br>References Neubert, L., et al.: J. Am. Chem. Soc., 134, 12239 (2012); Zhai, J.J., et al.: J. Am. Soc. Mass. Spec., 20, 1366 (2009);<br></p>

<p>Applications 2-Methoxyphenylsulfate is used in the analysis of alkylsulfatases and their kinetics.<br>References Bateman, T. et al.: Biochem. J., 236, 401 (1986);<br></p>

<p>Applications 7,10-Dichloro-2-methoxybenzo[b][1,5]naphthyridine is used in the preparation of pyronaridine.<br>References Li, J., et al.: PCT Int. Appl., 2013:1701510 (2013)<br></p>

<p>Applications N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.<br>References Lopez, B., et al.: Chem. Commun., 47, 1054 (2011); Albert, J., et al.: Organometallics, 32, 649 (2013);<br></p>

<p>Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications Cyclic propano guanine adduct DNA acetaldehyde histone.<br>References Nath, R., et al.: Cancer Res., 58, 581 (1998), Wang, M., et al.: Chem. Res., 13, 1065 (2000), Terashima, I., et al.: Biochemistry, 40, 4106 (2001), Yokoyama, A., et al.: Carcinogenesis, 23, 1851 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications Used in peptide N-terminal amino acid determination.<br>References Prota, G., et al.: Biochimie, 53, 51 (1971),<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, R., et al.: J. Med. Chem., 52, 4481 (2009); Picard, F., et al.: J. Med. Chem., 45, 3406 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Methoxyphenyl)piperazine Hydrobromide is a useful reagent for improving the synthesis of Eapidil.<br>References Wang, H., et al.: Anhui Huagong, 37, 23 (2011)<br></p>

<p>Applications N-methyl-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diamine (cas# 101988-70-9) is a useful research chemical.<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Perfluoro-4-Methoxybutanoic Acid (cas# 863090-89-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,3-Dihydroxy-2-methylbutanoic Acid Sodium Salt is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-chloro-5-fluoro-2-methoxypyrimidine (cas# 1801-06-5) is a useful research chemical.<br></p>

<p>Applications (2E)-3-Methyl-1,3-benzothiazol-2(3H)-one Hydrazone Hydrochloride is used in method for synthesizing Methylbenzothiazolinone Hydrazone Hydrochloride Hydrate.<br>References Chen, W., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications (2R,3S,4S,5R,6S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an enantiomer of dapagliflozin(D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>

<p>Applications 6-Methylmercaptopurine Riboside (cas# 342-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(4-Methoxyphenyl)piperazine (cas# 38212-30-5) is a useful research chemical.<br></p>

<p>Applications 4-(Boc-amino)-1-methylpyrrole-2-carboxylic Acid is an unnatural amino acid for preparing heteroaromatic oligoamides for regulating gen expression in biotechnology.<br>References Baird, E., et al.: J. Am. Chem. Soc., 118, 6141 (1996); White, S., et al.: Nature, 391, 468 (1998)<br></p>

<p>Applications Methyl 4-Methoxybenzoate is also used in the synthesis of oxadiazole-based, GSK-3 inhibitors. Methyl 4-Methoxybenzoate is used in the synthesis of substituted hydrazides for their antitubercular properties.<br>References Lo Monte, F. et al.: Eur.J. Med. Chem., 61, 26 (2013); Gupta, R. et al.: Asian J. Pharm. Clin. Res., 5, 251 (2012);<br></p>

<p>Applications A product from thermal and hydrolytic degradation of Orlistat. Orlistat impurity.<br>References Stalder, H., et al.: Helv. Chimica Acta, 75, 1593 (1992),<br></p>

<p>Applications 2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma.<br>References Marino, K. et al.: J. Am. Chem. Soc., 12, 1664, (2002); Tilley, J. et al.: Bioorg. Med. Chem. Lett., 23, 1036 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Decanoyl-L-carnitine-d3 Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications 2-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications 2-amino-3-methylbutanamide Hydrochloride is a useful research chemical for the degradation studies of antibiotic MDL 62,879 (GE2270A), and a reagent for peptide synthesis.<br>References Tavecchia, P., et al.: Tetrahedron, 51, 4867 (1995); Gazis, E., et al.: Peptides, Proc. Eur. Symp., 6th, Athens, 1963, 107 (1966)<br></p>

<p>Applications 5-methyl-2-(1H-pyrrol-1-yl)aniline (cas# 59194-21-7) is a useful research chemical.<br></p>

<p>Applications MNC is on the metabolic pathway for 2,4-Dinitotoluene degradation.<br>References Spangoord, R.J., et al.: App. and Environ. Microbiology, 57, 11, 3200 (1991)<br></p>

<p>Applications 6-Methylheptanoic acid is used as a reagent to synthesize analogues of Eponemycin, an antibiotic that also exhibits anti-angiogenic activity by inhibiting proteasome function. 6-Methylheptanoic acid naturally occurs as a component of the scent chemical of the brushtail possum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McLean, S., et al.: J. Chem. Ecol., 38, 1318 (2012); Oikawa, T., et al.: Biochem. Biophys. Res. Comm., 181, 1070 (1991); Sin, N., et al.: Bioorg. Med. Chem., 6, 1209 (1998)<br></p>

<p>Applications Boc-L-aspartic Acid β-Methyl Ester is used to prepare isoxazoline glycoprotein IIb/IIIa antagonists. It is also used to synthesize glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.<br>References Xue, C., et al.: J. Med. Chem., 40, 2064 (1997); Kirkland, T., et al.: Bioorg. Med. Chem., 16, 4963 (2008)<br></p>

<p>Applications: Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999);<br></p>

<p>Applications L-3-Benzothienylalanine<br></p>

<p>Stability Hygroscopic<br>Applications Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is commonly used as a precursor in the food and pharmaceutical industries. Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.<br>References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);<br></p>

<p>Applications Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Prochazka, Z., et al.: Collection Czechoslov. Chem. Commun., 45, 1982 (1980), Yorek, M.A. &amp; Spector, A.A.: Prog. Clin. Biol. Res., 179, 361 (1985)<br></p>

<p>Applications Ac-lys(ac)-oh was used in the reaction of HOCl with amino acids and peptides with ESR evidence for rapid rearrangement and fragmentation reactions of nitrogen-centered radicals.<br>References Hawkins, C., et al.: J. Chem. Soc. Perkin Trans. 2, 9, 1937 (1998);<br></p>

<p>Applications 3-Methoxycatechol is used to prepare polyphenolic deoxybenzoins as potential antioxidants and tyrosinase inhibitors.<br>References Ng, L., et al.: Bioorg. Med. Chem., 17, 4360 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.<br>References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);<br></p>

<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>

<p>Applications Boc-4-azido-L-phenylalanine is used in the development of visible fluorogenic dyes for cellular imaging.<br>References Qi, Jianjun., et al.; Bioconjugate Chem., 22, 1758 (2011);<br></p>

<p>Applications Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.<br>References Senten, K., et al.: J. Med. Chem., 46, 5005 (2003);<br></p>

<p>Applications L-Allo-isoleucine-d10 is a derivative compound of L-allo-isoleucine (A548200), which has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications Isotope labelled Intermediate for transsulfuration whereby a mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Thompson, J.W., et al.: J. Biol. Chem., 266, 17011 (1991), Yoshida, Y., et al.: Microbiol., 148, 3961 (2002), Jiracek, J., et al.: J. Med. Chem., 49, 3982 (2006),<br></p>

<p>Stability Very Hygroscopic<br>Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells.<br>References Vallence, P., et al.: Lancet, 339, 572 (1992),<br></p>

<p>Applications 3-Methyl-1,2,3-butanetricarboxylic Acid Trimethyl Ester is an intermediate in the synthesis of derivatives of α-pinene, a tracer compound for atmospheric terpene secondary organic aerosol (SOA) particles.<br>References Dette, H.P., et. al.: J. Phys. Chem. A., 118, 7024 (2014)<br></p>

<p>Applications The main labelled metabolite of o-xylene.<br>References Gregus, Z., et al.: Drug Metab. Dispos., 26, 1082 (1998), Gregus, Z., et al.: Xenobiotica, 29, 547 (1999), Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications N-Pivaloylglycine is used in the biological study between dogs and rats. In a high dose toxicity study of pivalic acid (PA), PA caused skeletal muscle disorder in dog, and a significant increase of pivaloyl carnitine (PC) was observed in canine muscle, but not in rat muscle.<br>References Yamaguchi, T., et al.: Toxicol. Appl. Pharmacol., 214, 61-68 (2006)<br></p>

<p>Applications Used in the synthesis of Capsaicin analogues, useful for their anti-tumor activity.<br>References Fusco, B., et al.: Drugs, 53, 909 (1997), Buisman, G., et al.: Biotechnol. Lett., 20, 131 (1998), Kobata, K., et al.: Bios. Biotechnol. Biochem., 66, 319 (2002), Aluru, M., et al.: J. Exp. Bot., 54, 1655 (2003),; Wang, W. et al.: Gaodeng Xuexiao Huaxue Xuebao 31, 2400(2010)<br></p>

<p>Applications A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);<br></p>

<p>Applications 2,6-Di-tert-butyl-4-methyl-d3-phenol (CAS# 86819-59-2) is a useful isotopically labeled research compound. This compound has been shown to significantly have lower toxic potency in mice compared to butylated hydroxytolune (BHT).<br>References Mizutani, T., et.al., Toxicol. Appl. Pharmacol. 69,283-290,(1983);<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications A labelled metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Stability Air Sensitive<br>Applications L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.<br>References Liu, X.D., et al.: Org. BIomolec. Chem., 11, 4258 (2013); Chen, C.S., et al.: Nueroendocrinol., 97, 232 (2013);<br></p>

<p>Applications L-Cystine Bis(T-butyl Ester) Dihydrochloride is used as a reagent in the synthesis of chelate oxorhenium to create new integrin antagonists.<br>References Le Gal, J., et al.: J. Inorg. Biochem., 105, 880 (2011);<br></p>

<p>Applications A major metabolite of non-essential amino acid L-Cysteine.<br>References Parsons, R.B. et al.: Neurotoxicol., 19, 599 (1998);<br></p>

<p>Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.<br></p>

<p>Stability Temperature Sensitive, Light Sensitive<br>Applications 2-Ethyl-4-methylpentyl Acrylate<br></p>

<p>Applications N-Acetyl-S-phenyl-d5-DL-cysteine is the deuterium labelled form of N-Acetyl-S-phenyl-DL-cysteine, which is used as a reactant in the preparation of potent HIV-1 protease inhibitors that use D-amino acids as P2/P3 ligands.<br>References Jungheim, L., et al.: J. Med. Chem., 39, 96 (1996);<br></p>

<p>Applications 5-Methylfuran-2(3H)-one is an aromatic compound responsible for the aroma of caramel, dried and roated nori, wine, and brewed coffee.<br>References Paravisini, L., et. al.: Flavour Frag. J., 27, 424 (2012); Shu, N., Shen, H.: Flavour Frag. J., 27, 157 (2012); Chin, S., et. al.: J. Chrom. A, 1218, 7487 (2011)<br></p>

<p>Applications L-2-Aminobutyric Acid-d6 is the isotope labelled analog of L-2-Aminobutyric Acid (A602930); a receptor antagonist.<br>References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995)<br></p>

<p>Applications N-Methyl-N-nitroso-1-hexadecanamine is a compound found in a wide range of cosmetic products and cleaning emulsions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamp, E.. et al.: Food. Chem. Toxicol., 29, 203 (1991); Lalljie, S. P. D., et al.: Adv. Mass. Spec., 14, 33790 (1998); Abidi, S.L., et al.: J. Chroma., 324, 209 (1985);<br></p>