Amino Acids (AA)

<p>Applications L-Valine-d8-N-t-BOC (CAS# 153568-33-3) is a useful isotopically labeled research compound.<br></p>

<p>Impurity Ritonavir EP Impurity D<br>Applications [4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester, is an intermediate that can be used for the synthesis of Ritonavir (R535000), which is a selective HIV protease inhibitor.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Kempf, D., et al.: J. Med. Chem., 41, 602 (1998),<br></p>

<p>Applications Indanone derivative as α1-adrenoceptor antagonist.<br>References Han, C., et al.: Eur. J. Pharmacol., 190, 97 (1990), Cooper, K., et al.: Drugs, 57, 9 (1999), Robinson, D., et al.: J. Med. Chem., 42, 573(1999), Fang, H., et al.: J. Chin. Pharm. Sci., 12, 188 (2003), Koshimizu, T., et al.: Pharmacol. Ther., 98, 235 (2003),<br></p>

<p>Applications 5-Methyl-3-(nitromethyl)hex-4-enoic Acid is an intermediate in the synthesis of (R)-4,5-Dehydro Pregabalin (D230255), whih is derived from rac 4,5-Dehydro Pregabalin (D230050), which is an impurity of the anti-convulsnat, Pregabalin.<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications 2-fluoro-4-methoxybutan-1-amine hydrochloride (cas# 2098022-94-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Amino-7H-purin-6-yl)-1-methylpyrrolidinium Chloride (cas# 680622-68-8) is a compound useful in organic synthesis.<br>References Pauly, G., et al.: J. Med. Chem., 51, 7144 (2008),<br></p>

<p>Applications Di-tert-butyldimethylsilyl Ethers 2-Linoleoyl-rac-glycerol is an intermediate in the synthesis of 2-Linoleoyl-rac-glycerol (L467960), which is a fatty acid monoglycerides in vegetable oils with medium unsaturation.<br>References Compton, D., et al.: J. Pharmacol. Exp. Ther., 277, 586 (1996), Devane, W., et al.: Science, 258, 1946 (1992),<br></p>

<p>Applications Fmoc-t-butyl-L-alanine is used in the synthesis arylaminoethyl amides as noncovalent inhibitors of cathepsin S. It is also an intermediate used to prepare oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.<br>References Liu, H., et al.: Bioorg. Med. Chem. Lett., 15, 4979 (2005); Linton, S., et al.: Bioorg. Med. Chem. Lett., 14, 2685 (2004)<br></p>

<p>Applications DL-Lysine-3,3,4,4,5,5,6,6-d8 2HCl (CAS# 284664-87-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Acetoxy-3-methylpentane-1,5-dioic Acid Anhydride (cas# 87894-65-3) is a compound useful in organic synthesis.<br>References Gordon, E., et al.: Bioorg. Med. Chem. Lett., 1, 161 (1991),<br></p>

<p>Applications Fmoc-L-2-furylalanine<br></p>

<p>Applications (±)-2-Methylpiperazine-2,3,3,5,5,6,6-d7 (CAS# 1219802-98-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Cyano-1-methylbenzoimidazole<br></p>

<p>Applications 5-Methyl-3-heptanone is a useful intermediate commonly used in synthetic chemistry. 5-Methyl-3-heptanone is naturally used as a sexual pheromone by the Platynereis dumerilli, a marine worm.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Do Nascimento, R., et al.: J. Chem. Ecol., 19, 907 (1993); Zeeck, E., et al.: J. Exp. Zoo., 246, 285 (1988)<br></p>

<p>Applications 2,5-Difluoro-4-methoxyphenylboronic acid<br></p>

<p>Applications α-Methylstyrene-d5 Oxide is labelled α-Methylstyrene Oxide (M325390) which is structurally similar to rac Styrene Oxide (S687795), a major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications 3-(N-Methyl-N-pentyl-amino)propionitrile-d3 (cas# 1185103-36-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-[3-Methoxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-2-butanone is an intermediate used in the synthesis of [6]-Shogaol (S357800), which is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG.<br>References Suekawa, M. et al.: J. Pharm-Dyn., 7, 836 (1984); Yoshikawa, M. et al.: Chem. Pharmac. Bull., 40, 2239 (1992);<br></p>

<p>Applications [3-(2-Amino-6-methoxy-4-pyrimidinyl)phenyl](3,6-dihydro-4-methyl-1(2H)-pyridinyl)-methanone is a useful chemical for cancer immunotherapy research.<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>

<p>Applications 2-Methyl-4,5,7-trichloroquinoline (cas# 203626-80-6) is a useful research chemical.<br></p>

<p>Applications 4-Methylheptane (cas# 589-53-7) is a useful research chemical.<br></p>

<p>Applications [1,4]Dioxan-2-ylmethyl-methyl-amine<br></p>

<p>Applications Deferoxamine Trifluoroacetic Acid Salt is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients.<br>References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009)<br></p>

<p>Applications 1-(1,3-Benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol (cas# 106515-46-2) is a useful research chemical.<br></p>

<p>Applications N-Boc-4-phenyl-L-phenylalanine is a reactant used in the synthesis of novel phenylalanines derived diamides as factor XIa inhibitors used in the treatment.<br>References Smith, L. et al.: Bioorg. Med. Chem. Lett., 26, 472 (2016);<br></p>

<p>Applications N-(4-aminophenyl)-N2,N2-dimethylglycinamide (cas# 25786-09-8) is a useful research chemical.<br></p>

<p>Applications N,N-Diethyl-5-(phenylmethoxy)-1H-indole-3-methanamine is an intermediate used in the synthesis of 5-Hydroxyindole-3-acetic Acid (H953605), which is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications 2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 12, 3317 (2002)<br></p>

<p>Applications N-Benzoyl-3-methoxytyrosine is an intermediate used in the synthesis of rac 3-O-Methyl DOPA (M303805), which is an impurity of Levodopa (D533751). A useful marker that can be used to screen for the absense of Aromatic L-amino acid decarboxylase (AADC).<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003)<br></p>

<p>Applications D-Alanine-2-d1 (CAS# 56595-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications (S,S)-(+)-Pseudoephedrine Glycinamide is a commonly used precursor for the synthesis of α-amino acids.<br>References Myers, A.G., et. al.: Tetrahedron Lett., 36, 4555 (1995)<br></p>

<p>Applications 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-hydroxy-6-methoxy-3-quinolinecarbonitrile can be used to prepare 3-cyanoquinoline derivatives as protein kinase inhibitors for treating cancers.<br>References Wan, H., et al., PCT Int. Appl. WO 2014086284 A1 20140612 (2014); Wan, H., et al. Faming Zhuanli Shenqing CN 103304572 A 20130918 (2013)<br></p>

<p>Applications 2-Bromo-1-(2,2-difluoro-1-methylcyclopropyl)ethanone is used in the preparation of triazole fungicides.<br>References Gassen, K.R., et al.: Eur. Pat. Appl. (1990);<br></p>

<p>Applications 2-Ethyl-5-methylphenol (cas# 1687-61-2) is useful for the characterization of bio-​oil from hardwood and softwood lignin via pyrolysis.<br>References Zadeh, Z. E., et al.: Energies (Basel, Switzerland), 13, 887 (2020)<br></p>

<p>Stability Moisture and Acid Sensitive<br>Applications 3-Methyl-5-isoxazolemethanol acetate is a compound with an oxazole group that is known to contribute to agonist characteristics relating to glutamic acid.<br>References Krogsgaard-Larsen, et al.: Nature, 284, 64 (1980), Honore, T., et al.: J. Neurochem., 38, 173 (1982), MacDonald, J.F., et al.: Science, 253, 1132 (1991)<br></p>

<p>Applications γ-Valerolactone-d3 is the isotope labelled analog of γ-Valerolactone. γ-Valerolactone is a naturally occurring chemical found in fruits and is frequently used as a food additive. It can be converted to liquid alkenes which can be used as transportation fuels.<br>References Horvath, I.T., et al.: Green Chem., 10, 238 (2008); Bond, J.Q., et al.: Science, 327, 1110 (2010)<br></p>

<p>Applications 1-BOC-2-BENZYL-4-PIPERIDINONE (cas# 193480-28-3) is a useful research chemical.<br></p>

<p>Applications 4-Methoxylphenylboronic Acid is a phenylboronic acid used to investigate boron function in plants.<br>References Baldwin, T., et al.: Plant Physiol., 103, 115 (1993), Andeme-Onzighi, C., et al.: Planta, 215, 949 (2002), Brown, P., et al.: Plant Biol. 4, 205 (2005),<br></p>

<p>Applications (αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-phenylmethyl Ester L-Phenylalanine is used as a reagent in the preparation of peptides for inhibition of enzymes.<br>References Smyth, M. S., et al.: U.S. Pat. Appl. Publ. (2005), US 20050245435 A1 20051103;<br></p>

<p>Applications N-Methylurea is used as a reagent in the synthesis of bis(aryl)(hydroxyalkyl)(methyl)glycoluril derivatives and is a potential byproduct of caffeine.<br>References Antonova, M.M., et al.: Chem. Heterocycl. Comp., 50, 503 (2014); Zarrelli, A., et al.: Sci. Total Environ., 470, 453 (2014)<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Amino-3-methylbenzoate is used in the synthesis of neuroprotective hydrazides used in the treatment of Alzheimer’s. It is also used in the research and development of diphenylamine-based retinoids.<br>References Chiruta, C. et al.: Bioorg. Med. Chem. Lett., 21, 2733 (2013); Ohta, K. et al.: Bioorg. Med. Chem. Lett., 23, 81 (2013);<br></p>

<p>Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.<br>References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)<br></p>

<p>Applications Useful for the preparation of pseudopeptides as thrombolytic agents.<br>References Yabe, Y., et al.: J. Pharmacol. Exp. Ther., 289, 1176 (1999), Hines, I., et al.: Curr. Med. Chem., 10, 2661 (2003),<br></p>

<p>Applications 2-Amino-5-tert-butyldimethylsilyloxy-methyl-thiazole (cas# 1083059-77-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-((S)-1-(3-Methoxyphenyl)ethyl)-4-((S)-1-(4-methoxyphenyl)ethyl)piperazine-2,5-dione is an intermediate in the synthesis of labelled L-2-Aminobutyric Acid-d1 (A602931).<br>References O’Reilly, E., et al.: Amino. Acids., 39, 849 (2010);<br></p>

<p>Stability Moisture Sensitive<br>Applications Contains approximately 12% dichloromethane and 8% ethyl acetate<br></p>

<p>Stability Hygroscopic<br>Applications A heterobifunctional polyethyleneglycol (PEG) derivative used in the preparation of intramolecular linking agents.<br>References Moreau, J. et al.: Eur. J. Org. Chem., 9, 1641 (2011);<br></p>

<p>Applications N-(2-Hydroxyethyl) 4-methyl-2-nitroaniline<br></p>

<p>Applications Fmoc-d-3-pyridylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Stability Hygroscopic<br>Applications DL-Ornithine HCl<br></p>

<p>Applications N-Methoxy-N-methylpropionamide (cas# 104863-65-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(5-Methoxybenzo[d]isoxazol-3-yl)acetic Acid (cas# 34172-98-0) could have agricultural applications specifically as a regulator for plant growth.<br>References Amorosi, S., et al.: Plant Growth Regul. Soc. Am., 22, 338 (1995)<br></p>