Amino Acids (AA)

<p>Applications 1-BOC-1,2,3,4-Tetrahydroquinoline-6-boronic acid<br></p>

<p>Applications (3S,4R)-3-(Acetyloxy)-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone is an intermediate in the synthesis of optically active (+)​-​cis- and (-​)​-​trans-​α-​hydroxy-​β-​lactams.<br>References Banik, B.K., et al.: Mol Med Rep., 3, 317-318 (2010);<br></p>

<p>Applications 4-CHLOROMETHYL-5-METHYL-2-PHENYL-OXAZOLE (cas# 103788-61-0) is a useful research chemical.<br></p>

<p>Applications 6-Methyl-3-pyridoyl-2-pyrrolidinone (cas# 1076198-57-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Methyl-4-nitrobenzoic acid is used as a reagent to synthesize amino-1H-pyrazole amide derivatives, compounds that act as Raf kinase inhibitors in melanoma cells. 2-Methyl-4-nitrobenzoic acid is also used as a reagent to synthesize fluorogenic substrates, compounds that can be used for activity imaging within living cells.<br>References Fujikawa, Y., et al.: J. Am. Chem. Soc., 130, 14533 (2008); Kim, M., et al.: Bioorg. Med. Chem., 19, 1915 (2011)<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-methoxypropane-1-sulfonyl fluoride (cas# 1227250-19-2) is a useful research chemical.<br></p>

<p>Applications Labelled Des[(5-Methyl-1,3,4-thiadiazol-2-yl)thio] Cefazolin-3-methanol is an impurity of Cefazolin (C242500). Cefazolin impurity X3.<br>References Kidwai, M., et al.: Chem. Lett., 6, 487 (1999), Kidwai, M., et al.: Bioorg. Med. Chem., 8, 69 (2000),<br></p>

<p>Applications 1,5-Dichloro-2-methoxy-4-(4-nitrophenoxy)benzene, is used for the synthesis of three major ring-hydroxylated metabolites of Diclofop-methyl, acting as herbicide.<br>References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);<br></p>

<p>Applications gamma-D-Glutamylaminomethylsulfonic Acid is an AMPA/kainate receptor inhibitor used in reduction of renal hypoxia-​reoxygenation injury.<br>References Szoleczky, P., et al.: Arch. Biochem. Biophys., 517, 53 (2012);<br></p>

<p>Applications 4-Methylcyclohexanemethanol-d3 is labelled 4-Methylcyclohexanemethanol (M294915) which is patented for use as an ingridient of air fresheners. 4-Methylcyclohexanemethanol (M294915) can also be used to synthesize thiazolidinedione (2,4-thiazolidinedione, T344250) derivatives as 15-PGDH inhibitors.<br></p>

<p>Applications 4-[(4-Methoxyphenyl)methyl]-4-methyl-2-phenyl-5(4H)-oxazolone (cas# 172168-03-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose 3-p-Toluenesulfonate is used in the synthesis of a highly constrained adenosine derivative of 5’-Deoxy-5’-methylthioadenosine (MTA) which is 4’,4’-spirothietane-2’,N3-cycloadenosine.<br>References De Carvalho, G. S. G., et al.: Tetrahedron Lett., 50, 463-466 (2009)<br></p>

<p>Applications 1-methyl-2,3-dinitrobenzene (cas# 602-01-7) is a useful research chemical.<br></p>

<p>Applications Protected ethylenediamine, used for ethylenediamine addition.<br></p>

<p>Applications N1-(2-Aminophenyl)-N2,N2-dimethylglycinamide (cas# 35266-48-9) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-d3-propyl Alcohol (CAS# 95927-04-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-[(Aminocarbonyl)amino]-D-phenylalanine can be used a reactant in continuous flow solid-phase peptide synthesis.<br>References Fulop, Ferenc, et al.: PCT Int. Appl., WO 2015128687 A1 20150903 (2015)<br></p>

<p>Applications 1-Carboxy-1-methylethoxyammonium Hydrochloride is used as a reactant in the synthesis of carbon-11 labeled celecoxib derivatives as new candidate PET radioligands for imaging of inflammation.<br>References Gao, M., et al.: Appl. Radiat. Isot., 67, 2019 (2009);<br></p>

<p>Applications 4-Methoxyquinoline is used as a reactant in the synthesis of hybrid quinoline-4-yloxadiazoles/oxathiadiazoles as potent antifungal agents.<br>References Khan, Firoz A., et al.: Inter. J. of Pharmacy and Pharma. Sci., 7(4), 223-229 (2015)<br></p>

<p>Applications 4-Methyl-3-nitrobenzoic Acid-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol<br>References Learmonth, D.A., et al.: Bioconjug. Chem., 14, 262 (2003),<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications rac-6-Methyl-4-phenyl-2-chromanol-d6 is labelled rac-6-Methyl-4-phenyl-2-chromanol (M327070) which is an impurity of Tolterodine (T535800), an antimuscarinic agent used to treat patients with overactive bladder.<br>References Kaplan, S., et al.: JAmA, 296, 2319 (2006); Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997); Van Kerrebroeck, P., et al.: Urology, 57, 414 (2001)<br></p>

<p>Applications Methyl 3-O-Benzyl-D-glycerate (cas# 209907-54-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Methyl-3-furoic Acid-d3 is a deuterated version of 2-Methyl-3-furoic Acid (M304063), a useful reactant in the synthesis of therapeutic agents.<br>References Jin, Hong, et al.: Bioorg. Chem., 73, 76-82 (2017);Paul, Rakesh, et al.: ACS Chem. Bio., 12(6), 1576-1583 (2017)<br></p>

<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>

<p>Applications DL-Lysine-2-15N 2HCl (CAS# 2747-89-9) is a useful isotopically labeled research compound. This compound can be used for spectrophotometric analysis to determine the mechanism of electron-capture-induced dissociation of various peptides.<br>References Holm, A., et.al., J. Phy. Chem.A.,111,9641-9643,(2007); Nakamura, A. Nippon Kagaku Zasshi,86,500-505,(1965);<br></p>

<p>Applications 2-Chloroethyl 4-methylbenzenesulfonate is a useful reactant for the synthesis of triphenylethanamine derivatives, and fluorinated carbazole derivatives.<br>References Qiao, J.X., et al.: J. Med. Chem., 58, 9010-26 (2015); Mizuno, Y., et al.: J. Phys. Chem. C, 116, 20681-87 (2012);<br></p>

<p>Applications A useful deuterated synthetic intermediate.<br></p>

<p>Applications Tetrabutylammonium 8-Hydroxy-5-methyloctanoate is an intermediate in the synthesis of 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester-d8 (C987317), which is labelled 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester (C987315) which is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications Fmoc-1-pyrrolidine-3-carboxylic acid<br></p>

<p>Applications 2-Methyl-5-oxo-1-cyclopentenyl Propionate (cas# 87-55-8) is a useful research chemical.<br></p>

<p>Applications L-Phenylalanine-3,3-d2 (CAS# 221346-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (4R)-6-Methoxycarbonyl-4-phenyl-3,4-dihydrocoumarin is an intermediate in the synthesis of (R)-5-Hydroxymethyl Tolterodine Formate (H949480), a metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence.<br>References Palmer, L., et al.: J. Pharm. Biomed. Anal., 16, 155 (1997); Hills, C., et al.: Drugs, 55, 813 (1998); Wefer, J., et al.: World J. Urol., 19, 312 (2001)<br></p>

<p>Applications D-Leucine methyl ester hydrochloride is a protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.<br>References Chuan, Y., et al.: Chin. J. Anim. Vet. Sci., 4, 003 (1985); Fox, S., et al.: J. Biol. Chem., 155, 465 (1944); Gillillad, S. &amp; Speck, M.: J. Dairy Sci., 51, 1573 (1968); Schoenheimer, R., et al.: J. Biol. Chem., 130, 703 (1939); Seltzer, S., et al.: Pain, 11, 141 (1981)<br></p>

<p>Applications N-(2-Methylphenyl)-2-butenamide, is used as an intermediate in the synthesis of Crotamiton, which is a drug that can be used as scabicidal, and antipuritic (anti-itching drug).<br>References Hirota, M. et al.: Therp. Res., 34, 235 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications 1-Boc-3-Bromomethylazetidine<br></p>

<p>Applications Epsilon-n-methyl-l-lysine Hydrochloride<br></p>

<p>Applications Ethyl 3-Hydroxy-3-methyl-d3-butyrate-4,4,4-d3 (CAS# 30385-86-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Cbz-L-isoleucine is an N-Cbz-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications 2-Methyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxide is an intermediate used in the synthesis of Amido Methyl Meloxicam (A576790), which is an impurity of Meloxicam (M216100).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lazer, E., et al.: J. Med. Chem., 40, 980 (1997),<br></p>

<p>Applications Used for the preparation of antibacterial aminoglycoside analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, J., et al.: J. Antibiotics, 29, 714 (1976), Chanal, C., et al.: Antimicrob. Agents Chemother., 32, 1660 (!988),<br></p>

<p>Applications 5-Fluoro-2-methylbenzothiazole is a useful reactant in the preparation of antileishmanial drug candidates.<br>References Lasing, T., et al.: Bioorg. Med. Chem., 28, 115187 (2020)<br></p>

<p>Applications Ethyl 4-Methyl-3,5-dioxoheptanoic Acid Ester is an intermediate used in the synthesis of Helipyrone A (H230500), which is anti-inflammatory natural product related to Arzanol isolated from the flowering plant Helichrysum italicum of the Mediterranean coast.<br>References Appendino, G., et al.: J. Nat. Prod., 70, 608 (2007);<br></p>

<p>Applications L-3-Nitrophenylalanine is a derivative of L-Phenylalanine (P319415), and is used in the photocleavage of polypeptide backbones. L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine.<br>References Peters, F. et al.: Chem. Biol., 16, 148 (2009); Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications 4-Bromo-3-methylpyridine, HCl<br></p>

<p>Applications 1-[4-[3-(4-Acetyl-2-methoxyphenoxy)propoxy]-3-ethoxyphenyl]ethanone is an impurity of Iloperidone (I267200); an atypical antipsychotic drug used in the treatment of schizophrenia.<br>References Ichikawa, J., et al.: Brain Res., 956, 349 (2002); Potkin, S. G., et al.: J. Clin. Psychopharm., 28, S4 (2008)<br></p>

<p>Applications 1-methyl-1,2-dihydropyrimidin-2-one (cas# 3739-81-9) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-4'-methyl-3-nitrobenzophenone is a benzophenone derivative used in the preparation of nitrogen-containing heterocycles.<br>References Orlov, V.Y. et al.: Azot. Geterot. Alkal., 1, 452 (2001);<br></p>

<p>Applications DL-2-Pyrrolidone-5-carboxylic Acid is used in the preparation of AZT steroid conjugates as potent anti-HIV agents.<br>References You, Z. et al.: Nucleos. Nucleot. Nucl. Acids, 25, 37 (2006);<br></p>

<p>Applications α-methyl-DL-tryptophan is used as a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. It is also a substrate or non-transported inhibitor of the amino acid transporter PAT2 (slc36a2).<br>References Karunakaran, J., et al.: J. Biochem., 414, 343 (2008); Edwards, N., et al.: Biochimica et Biophysica Acta, Biomembranes, 1808, 260 (2011)<br></p>

<p>Applications 5-Bromo-2-(N-methylamino)pyridine is useful for the synthetic preparation of halo aminopyridines.<br>References Sun, C., et al.: ACS Omega, 4, 10534 (2019)<br></p>

<p>Applications L-tert-Leucine Methyl Ester Hydrochloride is used in the preparation of peptidomimetic protease inhibitors.<br>References Babine, R., et al.: PCT Int. Appl. (2002), WO 2002018369 A2 20020307<br></p>

<p>Applications 4-Fluoro-2-methylphenylboronic acid is a useful research chemical for organic synthesis and other chemical processes.<br>References Rock, Fernando L., et al.: Science, 316, 1759 (2007); Liu, G., et al.: Organomet., 38, 1459 (2019)<br></p>

<p>Applications N-Cbz-N'-isopropyl-DL-phenylglycinamide is a derivative of [α-​[(2-​Hydroxyethyl)​carbamoyl]​benzyl]​-carbamic Acid Benzyl Ester (CAS# 94068-23-2), which could have anticonvulsant properties.<br>References Schloegl, K., et al.: J. Med. Pharma. Chem., 4, 231 (1961)<br></p>

<p>Applications (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid (CAS# 53587-33-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications H-VAL-ARG-OH (cas# 37682-75-0) is a useful research chemical.<br></p>

<p>Applications 3-Methoxyphenylacetone is a substituted phenylacetone used in the preparation of optically active cyanohydrins. 3-Methoxyphenylacetone is also used in the preparation of CNS active compounds.<br>References Roberge, C. et al.: Tetrahed. Asymm., 18, 208 (2007); Hutchison, G.I. et al.: Aus. J. Chem., 33, 2699 (1980);<br></p>

<p>Applications 2-Methyl-6-(methylthio)pyrazine (cas# 2884-13-1) is a useful research chemical.<br></p>

<p>Applications bis(4-(2-Methoxyphenyl)piperazine-1-carboximidamide) Sulfuric Acid is an aminopyrimidines derivatives that are used as glycogen synthase kinase 3 inhibitors<br>References Nuss, John M. et al., U.S. Pat. Appl. Publ. (2002)<br></p>

<p>Applications 3-Methyl-2-phenylbutanenitrile is used as a reagent in the synthesis of disubstituted aminopiperidines as calcium channel blockers which are active on pain and neuropathic pain. 3-Methyl-2-phenylbutanenitrile is also used as a reagent in the synthesis of (methylethyl)(oxopropyl)benzeneacetonitrile and noremopamil enantiomers.<br>References Teodori, E., et al.: J. Med, Chem., 47, 6070 (2004); Gilmore, J., et al.: J. Chem. Soc., Perkin Trans. 1., no vol., 2845 (1996)<br></p>

<p>Applications 6-Methyloctanoic acid is a branched fatty acid derivative found in ewe's milk and cheese. 6-Methyloctanoic acid is converted to lactones via antimycin biosynthetic pathways.<br>References Zviely, M.: Perfumer &amp; Flavorist, 37, 30 (2012); Riclea, R.; et al.: ChemBioChem, 13, 1635 (2012).<br></p>

<p>Applications (±)-1-Bromo-2-ethyl-3-methyl-d3-butane-3,4,4,4-d4 (CAS# 1219805-84-1) is a useful isotopically labeled research compound.<br></p>