Amino Acids (AA)

<p>Applications 3-METHYL-4-(TRIFLUOROMETHYL)ANILINE (cas# 106877-31-0) is a useful research chemical.<br></p>

<p>Applications Labelled Isoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Isoferulic Acid (H946180). Isoferulic Acid 3-O-β-D-Glucuronide is one of the circulating metabolites in human plasma after coffee consumption.<br>References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications 4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.<br>References Panten, U. et al.: Naun.-Schmied. Arch. Pharmacol., 291, 405 (1975); Vague, P. et al.: Diab. Metab., 1, 185 (1975); Francois, G. et al.: Lancet, 1, 858 (1984);<br></p>

<p>Applications 1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.<br>References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009); Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); Yuan, Y., et al.: Zhongguo Yiyao Gongye Zazhi, 43, 5 (2012)<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications (+)-α-Methyl-β-alanine is a reactant for the chemoenzymatic assembly of cryptophycins as potent anticancer therapeutics.<br>References Magarvey, N.A., et al.: ACS Chem. Biol., 1, 766-779 (2006)<br></p>

<p>Applications 2-(3-Methoxyphenoxy)propanoic acid<br></p>

<p>Applications 2-(3,4-Diethoxyphenyl)ethanamine is a useful intermediate in the preparation of Drotaverine hydrochloride, an antispasmodic drug arising from papaverine class of biologically active compounds.<br>References Turks, M., et al.: Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija, 23, 107 (2011)<br></p>

<p>Applications L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.<br>References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994); Slusarchyk, W., et al.: Bioorg. Med. Chem. Lett., 5, 753 (1995)<br></p>

<p>Applications 3,5-Dihydroxy-4-methoxybenzoic Acid is a useful building block in organic synthesis.<br>References Ghosh, Koushik, et al.: Angewandte Chemie, I.E., 55(27), 7821-7825 (2016);Vergne, Fabrice, et al.: Bioorg. &amp; Medi. Chem. Let., 14(18), 4607-4613 (2004)<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Applications 6-Methylmercaptopurine Riboside (cas# 342-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)<br></p>

<p>Applications N-Acetyl-S-benzyl-d5-L-cysteine is deuterium labelled N-Acetyl-S-benzyl-L-cysteine, which is a metabolite of toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Stability Moisture Sensitive<br>Applications An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).<br>References Muth, W., et al.: J. Biol. Chem., 249, 7463 (1974), Hanukoglu, I., et al.: Eur. J. Biochem., 180, 479 (1989), Khaw, L., et al.: J. Bacteriol. 180, 809 (1998), Gallagher, D., et al.: J. Mol. Biol., 342, 119 (2004),<br></p>

<p>Applications 2-(4-methylphenyl)oxirane (cas# 13107-39-6) is a useful research chemical.<br></p>

<p>Applications 1-Ethyl-1-methylcyclopentane, is one of the chemical components of Gas-Phase organic carbon emissions from motor vehicles. It is also a volatile component of frying oils.<br>References Gentner, D. R., et al.: Environ. Sci. Tech., 47, 11937 (2013); Prevot, A. Frying Food, 155 (1988);<br></p>

<p>Applications 2-methyl-1-[4-(trifluoromethyl)phenyl]propan-1-one (cas# 64436-58-4) is a useful research chemical.<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Applications Tris(2-(2-methoxyethoxy)ethyl)amine (cas# 70384-51-9) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-3-methylaniline (cas# 29027-17-6) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>Applications A product from thermal and hydrolytic degradation of Orlistat. Orlistat impurity.<br>References Stalder, H., et al.: Helv. Chimica Acta, 75, 1593 (1992),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paterson, J.R., et al.: Biochem. Biophys. Res. Comm., 116, 449 (1983), Taurog, A., et al.: Endocrinology, 124, 30 (1989).<br></p>

<p>Applications 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Also used as a reagent in the synthesis of Metolachlor (M338700); a selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Titchenell, P.M., et al.: Bioorg. Med. Chem. Lett., 23, 3034 (2013); Zhang, H.: Nongyao Kexue Yu Guanli, 32, 26 (2011)<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications L-Leucine is an essential amino acid. L-Leucine acts as a nutrient signal to stimulate protein synthesis. It has also activates the mammalian target of rapamycin kinase that regulates cell growth.<br>References Demant, T. et al.: Am. J. Physiol., 270, E1022 (1996); Diraison, F. et al.: Am. J. Physiol., 277, E529 (1999); Suryawan, A. et al.: J. Anim. Sci., 89, 2004 (2011); Peyrollier, K. et al.: Biochem. J., 350, 361 (2000);<br></p>

<p>Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.<br>References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)<br></p>

<p>Applications 4,4'-Methylene-d2-dianiline (CAS# 215590-72-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-(2-Methoxy-5-methylphenyl)-3-phenyl-propanoic Acid (cas# 109089-77-2) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>